Nanotechnology applied to drug development: an integrative literature review
DOI:
https://doi.org/10.33448/rsd-v11i14.36115Keywords:
Drugs; Nanocarriers; Nanoparticles and nanotechnology.Abstract
Nanotechnology is a field of science responsible for studies on structured systems at the nanometer scale. In the pharmaceutical field, nanocarriers have been investigated as a vehicle for drugs in the synthesis of innovative drugs to solve difficulties regarding bioavailability, stability, and toxicity. Nanostructured pharmaceutical formulations are able to control the release of molecules and also direct these molecules to their specific site of action and thus maximize the beneficial effects of therapy, as well as assist in reducing adverse effects. Several studies have shown excellent results in the therapeutic efficacy of nanocarriers used in the development of new drugs. Moreover, these nanopharmaceuticals offer numerous advantages when compared to conventional pharmaceutical forms. The present work aims to perform an integrative literature review on the employability of nanotechnology in the development of new drugs, discussing the main nanocarriers that can be used to obtain drugs, such as liposomes, polymeric nanoparticles, lipidic nanoparticles, dendrimers, and cyclodextrins. Thirty-one articles were used that passed the inclusion criteria, which required academic articles with the language in Portuguese, English, Spanish and Chinese, published in the last five years retroactively. In view of the studies carried out by the authors, it is concluded that nanotechnology when applied to the production of drugs is very efficient because it allows a significant improvement in their pharmacokinetic properties, resulting in a safe and effective treatment to the patient.
References
Ahmadpour, E., Godrati-Azar, Z., Spotin, A., Norouzi, R., Hamishehkar, H., Nami, S., & Perez-Cordon, G. (2019). Nanostructured lipid carriers of ivermectin as a novel drug delivery system in hydatidosis. Parasites & Vectors, 12(1), 1-9.
Apolinário, A. C., Salata, G. C., Bianco, A. F., Fukumori, C., & Lopes, L. B. (2020). Abrindo a caixa de pandora dos nanomedicamentos: há realmente muito mais ‘espaço lá embaixo’. Química Nova, 43, 212-225.
Braga, S. S. (2019). Cyclodextrins: Emerging medicines of the new millennium. Biomolecules, 9(12), 801.
Braga, S. S. (2021). Peering into the Kaleidoscope of Cyclodextrins. Biomolecules, 11(1), 121.
Costa, A., Sarmento, B., & Seabra, V. (2018). Mannose-functionalized solid lipid nanoparticles are effective in targeting alveolar macrophages. European Journal of Pharmaceutical Sciences, 114, 103-113.
Costa, Í. C., Azevedo, S. G., Sanches, E. A., & Fonseca Filho, H. D. D. (2021). Caracterização de nanopartículas poliméricas preenchidas com óleo essencial de Piper nigrum por microscopia de força atômica. Matéria (Rio de Janeiro), 26.
da Rocha Pitta, M. G., dos Santos Silva, R. P., Alves, G. V. S., Angelo, I. C. B. L., de Souza, J. M., Pessôa, J. R. C. P., & de Souza, M. B. R. (2021). Nanocarreadores aplicados ao tratamento do câncer de mama. Research, Society and Development, 10(10), e392101018966-e392101018966.
de Melo, V. F., Coelho, J. L. G., Sousa, C. M. S., Fernandes, E. A. M. D., de Brito, R. T. B. E., & de Santana, W. J. (2020). Pharmacological Applications of Controlled Release Drugs. Amadeus International Multidisciplinary Journal, 5(9), 124-128.
de Morais, R., Viçozzi, G. P., Neto, L. T., Colomé, L. M., & Stopiglia, C. D. O. (2018). Desenvolvimento e caracterização de nanopartículas poliméricas contendo óleos vegetais. Anais do Salão Internacional de Ensino, Pesquisa e Extensão, 10(2).
Dias, B. D. P., Ribeiro, E. M. D. C., Gonçalves, R. L., Oliveira, D. S., Ferreira, T. H., & Silva, B. D. M. (2021). A nanotecnologia no brasil e o desenvolvimento de produtos com atividade antimicrobiana. Química Nova, 44, 1084-1092.
Guimarães, D., Cavaco-Paulo, A., & Nogueira, E. (2021). Design of liposomes as drug delivery system for therapeutic applications. International journal of pharmaceutics, 601, 120571.
Hasan, M., Elkhoury, K., Belhaj, N., Kahn, C., Tamayol, A., Barberi-Heyob, M., & Linder, M. (2020). Growth-inhibitory effect of chitosan-coated liposomes encapsulating curcumin on MCF-7 breast cancer cells. Marine drugs, 18(4), 217.
Huang, M., Ye, K., Hu, T., Liu, K., You, M., Wang, L., & Qin, H. (2021). Silver nanoparticles attenuate the antimicrobial activity of the innate immune system by inhibiting neutrophil-mediated phagocytosis and reactive oxygen species production. International Journal of Nanomedicine, 16, 1345.
Karami, M. A., Makhmalzadeh, B. S., & Rad, N. M. (2021). Preparation and characterization of topical solid lipid nanoparticles containing deferoxamine. Ars Pharmaceutica (Internet), 62(3), 224-234.
Li, J., Liang, H., Liu, J., & Wang, Z. (2018). Poly (amidoamine)(PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy. International journal of pharmaceutics, 546(1-2), 215-225.
Li, Y., Li, X., Lu, Y., Chaurasiya, B., Mi, G., Shi, D., & Shen, Y. (2020). Co-delivery of Poria cocos extract and doxorubicin as an ‘all-in-one’nanocarrier to combat breast cancer multidrug resistance during chemotherapy. Nanomedicine: Nanotechnology, Biology and Medicine, 23, 102095.
Luna-Herrera, J., Pérez-Martínez, D. E., Barradas-Hernández, V. M., & Zenteno-Cuevas, R. (2021). Nanopartículas como transportadores de fármacos: una herramienta prometedora contra la tuberculosis. Revista Peruana de Medicina Experimental y Salud Pública, 38, 143-152.
Matassoli, F. L., Leão, I. C., Bezerra, B. B., Pollard, R. B., Lütjohann, D., Hildreth, J. E., & Arruda, L. B. D. (2018). Hydroxypropyl-beta-cyclodextrin reduces inflammatory signaling from monocytes: possible implications for suppression of HIV chronic immune activation. Msphere, 3(6), e00497-18.
Regis, L. H. V., da Silva, A. F., & de Melo Guedes, J. P. (2021). O uso de nanotecnologia em fármacos no Brasil. Research, Society and Development, 10(15), e32101522294-e32101522294.
Rocha, H. V. A., & Tobler, J. P. (2020). Bases regulatórias para a avaliação da segurança de medicamentos à base de nanotecnologia. Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 8(2), 64-74.
Sandoval-Yañez, C., & Castro Rodriguez, C. (2020). Dendrimers: Amazing platforms for bioactive molecule delivery systems. Materials, 13(3), 570.
Santos-López, M., Jaque, D., Fuentes, E., González-Quintanilla, D., Santos-López, M., Jaque, D., & González-Quintanilla, D. (2020). Mouthwashes and Nasal Sprays as a Way to Prevent the Spread of SARS-CoV-2. Int J Odontostomatol, 14(4), 513-8.
Sbalqueiro, G., Balvedi, L., Bettiato, R., & Ribas, J. (2018). Uso da nanotecnologia para o desenvolvimento de fármacos. Revista Saúde e Desenvolvimento, 12(10), 242-252.
Singh, V., Sahebkar, A., & Kesharwani, P. (2021). Poly (propylene imine) dendrimer as an emerging polymeric nanocarrier for anticancer drug and gene delivery. European Polymer Journal, 158, 110683.
Siyal, F. J., Siddiqui, R. A., Memon, Z., Aslam, Z., Nisar, U., Imad, R., & Shah, M. R. (2021). Eugenol e seu nanocarreador à base de lipossoma reduzem a ansiedade ao inibir a expressão de glioxalase 1 em camundongos. Brazilian Journal of Biology, 83.
Souza, M T D, Silva, M D D, & Carvalho, R D (2010). Revisão integrativa: o que é e como fazer. Einstein, 8 , 102-106.
Tolentino, N. L. B., & Araújo, G. P. (2021). Sistemas lipossomais para administração de antibióticos: artigo de revisão.
Vargas-Martínez, M. G., & Ramírez-Galicia, G. (2018). Molecular modeling and chiral separation of benzodiazepines by capillary electrophoresis using highly sulfated cyclodextrins. Journal of the Mexican Chemical Society, 62(2), 358-370.
Vélez-Reséndiz, J. M., & Vélez-Arvízu, J. J. (2018). Nanodispositivos para la prevención y tratamiento de enfermedades cardiovasculares. Gac Med Mex, 154, 358-367.
Wang, D. Y., Van der Mei, H. C., Ren, Y., Busscher, H. J., & Shi, L. (2020). Lipid-based antimicrobial delivery-systems for the treatment of bacterial infections. Frontiers in chemistry, 7, 872.
Zhu, Y., Liu, C., & Pang, Z. (2019). Dendrimer-based drug delivery systems for brain targeting. Biomolecules, 9(12), 790.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Thaynara Paula Warren Bezerra; Ana Rosa Galdino Bandeira; Salatiel Henrique Pereira de Lima; Priscyla Lima de Andrade
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
