Gestational complications resulting from Covid-19: an integrative literature review




Covid-19; Gestational risk; Obstetrics; Complications.


From the beginning, attention in relation to Covid-19 has drawn attention to the existence of risk groups, especially vulnerable to infection and it is known that, at the time of pregnancy, pregnancy changes are capable of making the woman susceptible, as well as previous comorbidities. Therefore, an integrative literature review was carried out, which sought to highlight the main complications resulting from SARS-CoV-2 infection during the gestational period. It has been found that physiological and immunological changes that accompany pregnancy can increase susceptibility to the newly emerging viral pathogen and the severity of the infection, such as fever and hypoxemia secondary to the acute hyperinflammatory stage of the disease, in addition to the presence of previous comorbidities such as hyperglycemia, heart disease, obesity, among others. In addition, in these cases, it is necessary to have an early diagnosis of the disease, adequate guidelines for the different levels of prevention, considering pregnant and postpartum women as a risk group for the development of severe or fatal forms, and, moreover, to maintain prenatal care. -sequential birth, as well as maintenance of gestational risk stratification at each appointment.


Albuquerque, L. P.; Monte, A. V. L. & Araújo, R. M. S. (2020). Implicações da COVID-19 para pacientes gestantes. Revista Eletrônica Acervo Saúde, 12 (10).

Arinkan, S. A. et al. (2021). Perinatal outcomes of pregnant women having SARS-CoV-2 infection. Taiwanese Journal of Obstetrics & Gynecology, 60 (8).

Ávila, W. S. & Carvalho, R. C. (2020). COVID-19: Um Novo Desafio para a Cardiopatia na Gravidez. Arq Bras Cardiol. 115 (1), 1-4.

Badran, E. F. et al. (2021). Resultados adversos da gravidez durante o bloqueio COVID-19. Um estudo descritivo. BMC Pregnancy Childbirth, 761 (8).

Benito, L. A. O. et al. (2021). Comorbidades e fatores de risco identificados em pessoas que vieram a óbito por Síndrome Respiratória Aguda Grave por Covid-19. REVISA, 10 (3), 607-626.

Brasil. (2020). Ministério da Saúde. Secretaria de Atenção Primária à Saúde. Departamento de Ações Programáticas e Estratégicas. Manual de Recomendações para a Assistência à Gestante e Puérpera frente à Pandemia de Covid-19 [recurso eletrônico] / Ministério da Saúde, Secretaria de Atenção Primária à Saúde. – Brasília: Ministério da Saúde.

Buekens, P. et al. (2020). A call for action for COVID-19 surveillance and research during pregnancy. Lancet Glob Health, 8 (7).

Eastin, C. (2020). Características Clínicas da Doença do Coronavírus 2019 na China. N Engl J Med., 58 (4), 711–712.

Ellington, S. et al. (2020). Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status. MMWR Morb Mortal Wkly Rep, 69 (8), 769–775.

Gajbhiye, R. K. et al. (2021). PregCovid Registry Network. Clinical characteristics, outcomes, & mortality in pregnant women with COVID-19 in Maharashtra, India: Results from PregCovid registry. Indian J Med Res. 153 (56), 629-636.

Giordano, G., et al. (2021). COVID-19 in pregnancy: placental pathological patterns and effect on perinatal outcome in five cases. Diagn Pathol., 16 (88).

Heidary, Z. et al. (2021). Maternal and Neonatal Complications, Outcomes and Possibility of Vertical Transmission in Iranian Women with COVID-19. Arch Iran Med., 24(9), 713-721.

Louchet, M. et al. (2020). Placental transfer and safety in pregnancy of medications under investigation to treat COVID-19. Am J Obstet Gynecol, 4 (8).

Roberton, T. et al. (2020). Early estimates of the indirect effects of the COVID-19 pandemic on maternal and child mortality in low-income and middle-income countries: a modelling study. Lancet Glob Health, 8 (1).

Rodríguez-Díaz, M. et al. (2021). Resultados da Gravidez e do Nascimento durante os Primeiros Meses da Pandemia COVID-19: The MOACC-19 Cohort. International Journal of Environmental Research and Public Health, 18 (20).

Rosner-Tenerowicz, A., et al. (2021) Patologia placentária em gestante com COVID-19 grave e tratamento com ECMO bemsucedido: relato de caso. BMC Gravidez, 21 (76).

Soares, A. L. B. et al. (2021). Complicações do Covid-19 na gravidez. Brazilian Journal of Development, 7 (9), 87820-87829.

Villar, J, et al. (2021). Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatr., 175 (8), 817-826.

Yan, J. et al. (2020). Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol., 223 (11).

Zhu, N. et al. (2020). A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med, 382 (8), 727-733.



How to Cite

FIGUEIREDO, B. Q. de .; LEMES, G. P.; MACHADO, K. S.; BRAZ, I. C.; NAVES, P. G. R.; SILVA, T. M. da .; FRANÇA, L. de A.; BORGES, Y. J. Gestational complications resulting from Covid-19: an integrative literature review. Research, Society and Development, [S. l.], v. 11, n. 14, p. e54111436221, 2022. DOI: 10.33448/rsd-v11i14.36221. Disponível em: Acesso em: 9 dec. 2022.



Health Sciences