COVID-19 infection and complications associated with pregnancy: an integrative review
DOI:
https://doi.org/10.33448/rsd-v11i14.36518Keywords:
Gestantes; Complicações; COVID-19.Abstract
COVID-19 is a disease caused by the SARS-CoV-2 virus discovered in Wuhan city, China, in November 2019. In view of the rapid transmissibility, the unknown virulence and the course of the disease, in March 2020, the WHO considered Covid a global emergency pandemic. That same month, pregnant women were classified as risk groups, having priority in intensive care and vaccination. Pregnant women in view of their physiology are at greater risk of not only becoming infected, but of developing the most severe forms of the disease. In this context, the present article had as main objective to perform an integrative literature review addressing the main clinical manifestations of the severe and critical form of COVID-19 in pregnant women. The search was conducted from the databases PUBMED and BVSalud during the months of August and September 2022. Initially, 888 articles were found that after the exclusion of duplicates and the selection through the inclusion and exclusion criteria resulted in 474 articles for the full reading. According to the review, the most frequent complications are respiratory, cardiovascular, neurological, and obstetric. Comorbidities, gestation time and the need for intensive care were significantly associated with negative outcomes in pregnant women.
References
Abedzadeh-kalahroudi, M., Sehat, M., & Vahedpour, Z. (2020). Clinical and obstetric characteristics of pregnant women with Covid-19: A case series study on 26 patients. Taiwanese Journal of Obstetrics & Gynecology, 60(January), 458–462.
Amini Moghadam, S., Dini, P., Nassiri, S., Motavaselian, M., Hajibaba, M., & Sohrabi, M. (2021). Clinical features of pregnant women in Iran who died due to COVID-19. International Journal of Gynecology and Obstetrics, 152(2), 215–219. https://doi.org/10.1002/ijgo.13461
Andrikopoulou, M., Madden, N., Wen, T., Aubey, J. J., Aziz, A., Baptiste, C. D., Breslin, N., D’Alton, M. E., Fuchs, K. M., Goffman, D., Gyamfi-Bannerman, C., Matseoane-Peterssen, D. N., Miller, R. S., Sheen, J. J., Simpson, L. L., Sutton, D., Zork, N., & Friedman, A. M. (2020). Symptoms and critical illness among obstetric patients with coronavirus disease 2019 (COVID-19) infection. Obstetrics and Gynecology, 136(2), 291–299. https://doi.org/10.1097/AOG.0000000000003996
Askary, E., Poordast, T., Shiravani, Z., Ashraf, M. A., Hashemi, A., Naseri, R., Moradialamdarloo, S., Karimi, Z., Izanloo, E., & Najib, F. S. (2021). Coronavirus disease 2019 (COVID-19) manifestations during pregnancy in all three trimesters: A case series. International Journal of Reproductive BioMedicine, 19(2), 191–204. https://doi.org/10.18502/ijrm.v19i2.8477
BBC. (2022). Vacina contra covid para grávidas: os dados que mostram importância da imunização. Recuperado: [23.09.2022]. https://www.bbc.com/portuguese/geral-59989626
Bartolomé, A. Á., Kassab, N. A. A., Melguizo, S. C., Conty, M. L. de la C., Acebal, L. F., Saiz, A. A., Recarte, P. P., Varea, A. M., Gonzalez, L. C., Fernández, J. G., & Pérez, O. M. (2022). Critical Care in SARS‐CoV‐2 Infected Pregnant Women: A Prospective Multicenter Study. Biomedicines, 10(2), 1–13. https://doi.org/10.3390/biomedicines10020475
Bastos, S. N. M. A. N., Barbosa, B. L. F., Cruz, L. G. B., Souza, R. P. de, Silva Melo, S. S. e., & Luz, C. C. B. da S. (2021). Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review. Revista Brasileira de Ginecologia e Obstetricia, 43(12), 949–960. https://doi.org/10.1055/s-0041-1733913
Bezerra, R. M., Arnozo, G. M., Junior, L. C. F. S., Mesquita, R. da R., Santana, F. M. S., Oliveira, T. F. de, Alcântara, R. C., Filho, E. R. da S., Santos, A. G. G. dos, Almeida, T. P., Brandão, I. M. J., Cunha, E. J. O. da, Luz, D. F. da, & Aquin, S. H. S. de. (2021). COVID-19 em gestantes: Uma revisão do perfil clínico e epidemiológico. Rev. Port. Saúde e Sociedade, 6(unico), 1–8.
Boushra, M. N., Koyfman, A., & Long, B. (2021). COVID-19 in pregnancy and the puerperium: A review for emergency physicians. The American Journal of Emergency Medicine, 40, 193–198. https://doi.org/https://doi.org/10.1016/j.ajem.2020.10.055
Carvalho, B. C. de, Kloppel, L. N., & Vieira, R. C. (2022). Infecção por COVID-19 na gestação. Femina, 54(5), 308–310. https://fi-admin.bvsalud.org/document/view/4j82t
Gajbhiye, R. K., Sawant, M. S., Kuppusamy, P., Surve, S., Pasi, A., Prusty, R. K., Mahale, S. D., & Modi, D. N. (2021). Differential impact of COVID-19 in pregnant women from high-income countries and low- to middle-income countries: A systematic review and meta-analysis. International Journal of Gynecology and Obstetrics, 155(1), 48–56. https://doi.org/10.1002/ijgo.13793
Gama, M. D. P., Angelo Júnior, J. R. L., & Cunha-Correia, C. da. (2021). Stroke in covid-19 and pregnancy: A case report. Revista Da Sociedade Brasileira de Medicina Tropical, 54, 6–9. https://doi.org/10.1590/0037-8682-0301-2021
Gara, M., Sahraoui, E., Dhouib, W., Toumi, D., Zoukar, O., Mehdi, M., Jlali, A., Faleh, R., & Grati, L. (2022). Complicated COVID-19 in pregnancy, maternal and neonatal outcomes: a case report. Pan African Medical Journal, 41. https://doi.org/10.11604/pamj.2022.41.191.31102
García-Espinosa, M., Moreno-Álvarez, O., Carranza-Lira, S., & Caldiño-Soto, F. (2022). Características clínicas, obstétricas y perinatales de embarazadas mexicanas con COVID-19 TT - Clinical, obstetric and perinatal characteristics of Mexican pregnant women with COVID-19. Rev. Méd. Inst. Mex. Seguro Soc, 60(2), 116–128. http://revistamedica.imss.gob.mx/editorial/index.php/revista_medica/article/view/4149/4358%0Ahttps://fi-admin.bvsalud.org/document/view/me87m
Gutiérrez-Alba, G., Muños-Hernández, J. A., Armenta-Arellano, S., Ángel-Aguilar, A. R. D., Ramírez-Cabrera, J. B., Gutiérrez-Polo, R., & Pavón-León, P. (2022). Caracterización clínica y sociodemográfica de mujeres embarazadas con COVID-19 hospitalizadas. Gaceta Medica de Mexico, 158(2), 69–77. https://doi.org/10.24875/GMM.M22000644
Katal, S., Balakrishnan, S., & Gholamrezanezhad, A. (2021). Neuroimaging and neurologic findings in COVID-19 and other coronavirus infections: A systematic review in 116 patients. Journal of neuroradiology = Journal de neuroradiologie, 48(1), 43–50. https://doi.org/10.1016/j.neurad.2020.06.007
Lassi, Z. S., Ana, A., Das, J. K., Salam, R. A., Padhani, Z. A., Irfan, O., & Bhutta, Z. A. (2021). A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: Clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity. Journal of Global Health, 11, 1–13. https://doi.org/10.7189/jogh.11.05018
Lokken E.M, Huebner E.M, Taylor G.G, et al. (2021) Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State. Am J Obstet Gynecol, 225(77),.e1-14.
Mahajan, N. N., Pophalkar, M., Patil, S., Yewale, B., Chaaithanya, I. K., Mahale, S. D., & Gajbhiye, R. K. (2021). Pregnancy Outcomes and Maternal Complications During the Second Wave of Coronavirus Disease 2019 (COVID-19) in India. Obstetrics and Gynecology, 138(4), 660–662. https://doi.org/10.1097/AOG.0000000000004529
Mirbeyk, M., Saghazadeh, A., & Rezaei, N. (2021). A systematic review of pregnant women with COVID-19 and their neonates. In Archives of Gynecology and Obstetrics (Vol. 304, Issue 1). Springer Berlin Heidelberg. https://doi.org/10.1007/s00404-021-06049-z
Oppenheimer, D., Fernandes, M. T., & Mesquita, N. L. (2022). COVID-19 e gestação : principais manifestações clínicas e laboratoriais , e suas possíveis complicações , uma revisão integrativa de literatura COVID-19 and pregnancy : main clinical and laboratory manifestations , and their possible. Research, Society and Development, 11(12), 1–10.
Ozsurmeli, M., Terzi, H., Hocaoglu, M., Bilir, R. A., Gunay, T., Unsal, D., Turgut, A., & Karateke, A. (2021). Clinical characteristics, maternal and neonatal outcomes of pregnant women with SARS-CoV-2 infection in Turkey. Bratisl Lek Listy, 122(2), 152–157. https://doi.org/10.4149/BLL_2021_023
Organização Pan-Americana de Saúde - OPAS. (2020) Folha Informativa sobre COVID-19. Recuperado [27.09.2022]. https://www.paho.org/pt/covid19
Organização Pam-Americana de Saúde – OPAS. (2022). Estudo da OPAS sobre mortalidade materna e COVID-19 mostra barreiras no acesso de gestantes a cuidados intensivos. Recuperado: [27.09.2022]. https://www.paho.org/pt/noticias/12-5-2022-estudo-da-opas-sobre-mortalidade-materna-e-covid-19-mostra-barreiras-no-acesso
Organização Mundial da Saúde - OMS. (2022) WHO Coronavirus (COVID-19) Dashboard. Recuperado: [02.10.2022]. https://covid19.who.int/
Pashaei, Z., SeyedAlinaghi, S. A., Qaderi, K., Barzegary, A., Karimi, A., Mirghaderi, S. P., Mirzapour, P., Tantuoyir, M. M., Dadras, O., Ali, Z., Voltarelli, F., & Mehraeen, E. (2022). Prenatal and neonatal complications of COVID-19: A systematic review. Health Science Reports, 5(2). https://doi.org/10.1002/hsr2.510
Péju, E., Belicard, F., Silva, S., Hraiech, S., Painvin, B., Kamel, T., Thille, A. W., Goury, A., Grimaldi, D., Jung, B., Piagnerelli, M., Winiszewski, H., Jourdain, M., Jozwiak, M., Argaud, L., Aubron, C., Bèle, N., Beloncle, F., Bertrand, P. M., … Thiery, G. (2022). Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study. Intensive Care Medicine, 48(9), 1185–1196. https://doi.org/10.1007/s00134-022-06833-8
Pereira, O. A., & Wendt, G. W. (2020). Manifestações clínicas e laboratoriais do novo coronavírus (COVID-19) em gestantes e análise do possível risco de transmissão vertical intrauterina: uma revisão sistemática. Revista de Medicina, 99(6), 601–608. https://doi.org/10.11606/issn.1679-9836.v99i6p601-608
Saleh Gargari, S., Rahmati, N., Fateh, R., Khandani, A., Nikfar, S., & Ghafouri-Fard, S. (2022). Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19. Scientific Reports, 12(1), 1–9. https://doi.org/10.1038/s41598-022-14112-1
Soheili, M., Moradi, G., Baradaran, H. R., Soheili, M., Mokhtari, M. M., & Moradi, Y. (2021). Clinical manifestation and maternal complications and neonatal outcomes in pregnant women with COVID-19: a comprehensive evidence synthesis and meta-analysis. Journal of Maternal-Fetal and Neonatal Medicine, 0(0), 1–14. https://doi.org/10.1080/14767058.2021.1888923
Souza, H. C. C. de, Matos, M. M. R. de, Costa, R. A., Lima, M. A. C., Cardoso, A. S., & Bezerra, M. M. (2020). COVID-19 e gestação: manifestações clínicas, alterações laboratoriais e desfechos maternos, uma revisão sistemática de literatura/COVID-19 and pregnancy: clinical manifestations, laboratorial alterations and maternal endpoints, a systematic review of the literature. Brazilian Journal of Health Review, 3(6), 15901–15918. https://doi.org/10.34119/bjhrv3n6-023
Tekin, R. C., Gökhaner, Y. T., & Tekin, R. (2022). Images in Infectious Diseases Acute hemorrhagic encephalitis in a pregnant woman with coronavirus disease-2019. 2021–2022.
Trocado, V., Silvestre-Machado, J., Azevedo, L., Miranda, A., & Nogueira-Silva, C. (2020). Pregnancy and COVID-19: a systematic review of maternal, obstetric and neonatal outcomes. Journal of Maternal-Fetal and Neonatal Medicine, 0(0), 1–13. https://doi.org/10.1080/14767058.2020.1781809
Wang, C.-L., Liu, Y.-Y., Wu, C.-H., Wang, C.-Y., Wang, C.-H., & Long, C.-Y. (2021). Impact of COVID-19 on Pregnancy. International Journal of Medical Sciences, 18(3), 763–767. https://doi.org/10.7150/ijms.49923
Yan, R., Zhang, Y., Li, Y., Xia, L., Guo, Y., & Zhou, Q. (2020). Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science (New York, N.Y.), 367(6485), 1444–1448. https://doi.org/10.1126/science.abb2762
Zúniga-Briceño, A. I., Erazo-Fino, L. E., & Burgos-Zúniga, C. C. (2022). Resultado materno perinatal de las gestantes con infección confirmada por COVID-19, hospital Santa Teresa, Comayagua, Honduras. Serie de casos. Revista Colombiana de Obstetricia y Ginecologia, 73(2), 11–19. https://doi.org/10.18597/RCOG.3762
Zúniga-Briceño, A. I., Erazo-Fino, L. E., & Burgos-Zúniga, C. C. (2022). Resultado materno perinatal de las gestantes con infección confirmada por COVID-19, hospital Santa Teresa, Comayagua, Honduras. Serie de casos. Revista Colombiana de Obstetricia y Ginecologia, 73(2), 11–19. https://doi.org/10.18597/RCOG.3762
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Copyright (c) 2022 Sarah Silva Caires; Ana Carla Terencio de Oliveira Moreira; Gabriela Machado Alves; Thamiris Santos Freitas; Mauro Fernandes Teles
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