Role of metalloproteinases and inhibitors in adhesion: Literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i14.36520

Keywords:

Metalloproteinases; Chlorhexidine; MMP; Dental care; Collagen matrix.

Abstract

Objective: The objective of this study is to establish the role of metalloproteinases (MMPs) and the importance of their inhibitors in development. Methodology: This review was carried out with an exhaustive search strategy of scientific literature using PUBMED, ScienceDirect and Scielo as databases, using “Metalloproteinases”, “MMPs” and “Dental adesão” as keywords, and connectors such as “e”. Results: During bonding to dentin, it is beneficial to apply MMP inhibitors capable of not inhibiting dentin collagen breakdown in hybrid beds, improving bond strength to dentin, but also preventing secondary lesions. Conclusion: During dentin collagen, it would be beneficial to apply MMP inhibitors capable of not only inhibiting dentin collagen breakdown in hybrid layers, as well as improving dentin bond strength, but also preventing secondary caries around the restoration. The metalloproteinases play an important role in the administration, however, compounds such as chlorhexidine, as studied, have not been shown to improve the administration for a long period of time, on the contrary to doxycycline, whose studies support a better administration over a long period of time.

References

Anshida, V. P., Kumari, R. A., Murthy, C. S., & Samuel, A. (2020). Extracellular matrix degradation by host matrix metalloproteinases in restorative dentistry and endodontics: An overview. Journal of Oral and Maxillofacial Pathology: JOMFP, 24(2), 352–360. https://doi.org/10.4103/jomfp.JOMFP_34_20

Balalaie, A., Rezvani, M. B. y Mohammadi Basir, M. (2018). Función dual de las proantocianidinas como inhibidor de MMP y reticulante en la biomodificación de la dentina: una revisión de la literatura. Revista de Materiales Dentales, 37(2), 173–182. https://doi.org/10.4012/dmj.2017-062

Breschi, L., Maravic, T., Cunha, S. R., Comba, A., Cadenaro, M., Tjäderhane, L., Pashley, D. H., Tay, F. R., & Mazzoni, A. (2018). Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications. Dental Materials: Official Publication of the Academy of Dental Materials, 34(1), 78–96. https://doi.org/10.1016/j.dental.2017.11.005

de Carvalho, R. V., Vieira, E. O., Gaviolli, E., Graunke, A., Chisini, L. A., Bacchi, A., Ghiggi, P. C., & van de Sande, F. H. (2020). Doxycycline as a dentin pretreatment agent for MMP-2 inhibition and maintaining hybrid layer stability over time. International Journal of Adhesion & Adhesives, 98(102510), 102510. https://doi.org/10.1016/j.ijadhadh.2019.102510

de Menezes, L. R., de Oliveira, D. C. R. S., Brito, C. A., & da Silva, E. O. (2021). Use of the adhesive layer as a controlled release platform for doxycycline, as promising advancement for longer durability of dentin adhesion. International Journal of Adhesion & Adhesives, 108(102889), 102889. https://doi.org/10.1016/j.ijadhadh.2021.102889

de Moraes, I. Q. S., do Nascimento, T. G., da Silva, A. T., de Lira, L. M. S. S., Parolia, A., & Porto, I. C. C. de M. (2020). Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion. Restorative Dentistry & Endodontics, 45(3), e31. https://doi.org/10.5395/rde.2020.45.e31

El Gezawi, M., Haridy, R., Abo Elazm, E., Al-Harbi, F., Zouch, M., & Kaisarly, D. (2018). Microtensile bond strength, 4-point bending and nanoleakage of resin-dentin interfaces: Effects of two matrix metalloproteinase inhibitors. Journal of the Mechanical Behavior of Biomedical Materials, 78, 206–213. https://doi.org/10.1016/j.jmbbm.2017.11.024

Favetti, M., Schroeder, T., Montagner, A. F., Correa, M. B., Pereira-Cenci, T., & Cenci, M. S. (2017). Effectiveness of pre-treatment with chlorhexidine in restoration retention: A 36-month follow-up randomized clinical trial. Journal of Dentistry, 60, 44–49. https://doi.org/10.1016/j.jdent.2017.02.014

Freitas, P. H., André, C. B., Fronza, B. M., Giannini, M., Rosalen, P. L., Consani, S., & França, R. (2021). Physicochemical properties, metalloproteinases inhibition, and antibiofilm activity of doxycycline-doped dental adhesive. Journal of Dentistry, 104, 103550.

Garcilazo-Gómez, A., Miguelena-Muro, K. E., Guerrero-Ibarra, J., Ríos-Szalay, E., & Bonilla-Haro, R. (2019). Factores que afectan y mejoran la adhesión en dentina, una puesta al día. Una revisión de la literatura. Revista ADM, 76(3), 162–168.

Ghazvehi, K., Saffarpour, A., & Habibzadeh, S. (2022). Effect of pretreatment with matrix metalloproteinase inhibitors on the durability of bond strength of fiber posts to radicular dentin. Clinical and Experimental Dental Research, 8(4), 893–899. https://doi.org/10.1002/cre2.569

Giacomini, M. C., Scaffa, P. M. C., Gonçalves, R. S., Zabeu, G. S., Vidal, C. de M. P., Carrilho, M. R. de O., Honório, H. M., & Wang, L. (2020). Profile of a 10-MDP-based universal adhesive system associated with chlorhexidine: Dentin bond strength and in situ zymography performance. Journal of the Mechanical Behavior of Biomedical Materials, 110(103925), 103925. https://doi.org/10.1016/j.jmbbm.2020.103925

Hardan, L., Bourgi, R., Kharouf, N., Mancino, D., Zarow, M., Jakubowicz, N., Haikel, Y., & Cuevas-Suárez, C. E. (2021). Resistencia de unión de adhesivos universales a la dentina: una revisión sistemática y un metanálisis. Polímeros, 13(5), 814. https://doi.org/10.3390/polym13050814

Kiuru O, Sinervo J, Vähänikkilä H, Anttonen V, Tjäderhane L. MMP inhibitors and dentin bonding: Systematic review and meta-analysis. Int J Dent [Internet]. 2021;2021:9949699. Disponible en: http://dx.doi.org/10.1155/2021/9949699.

Kiuru, O., Sinervo, J., Vähänikkilä, H., Anttonen, V., & Tjäderhane, L. (2021). MMP inhibitors and dentin bonding: Systematic review and meta-analysis. International Journal of Dentistry, 2021, 9949699. https://doi.org/10.1155/2021/9949699

Liu, Y., Chen, M., Yao, X., Xu, C., Zhang, Y., & Wang, Y. (2013). Enhancement in dentin collagen’s biological stability after proanthocyanidins treatment in clinically relevant time periods. Dental Materials: Official Publication of the Academy of Dental Materials, 29(4), 485–492. https://doi.org/10.1016/j.dental.2013.01.013

Mazzoni, A., Pashley, D. H., Nishitani, Y., Breschi, L., Mannello, F., & Tjäderhane, L. (2006). Reactivación de actividades proteolíticas endógenas inactivadas en dentina grabada con ácido fosfórico mediante adhesivos de grabado y lavado. Biomateriales, 27, 4470–4476.

Mazzoni, A., Scaffa, P., Carrilho, M., Tjäderhane, L., Di Lenarda, R., Polimeni, A., ... & Breschi, L. (2013). Effects of etch-and-rinse and self-etch adhesives on dentin MMP-2 and MMP-9. Journal of dental research, 92(1), 82-86.

Mazzoni, A., Tjäderhane, L., Checchi, V., Di Lenarda, R., Salo, T., Tay, F. R., Pashley, D. H., & Breschi, L. (2015). Role of dentin MMPs in caries progression and bond stability. Journal of Dental Research, 94(2), 241–251. https://doi.org/10.1177/0022034514562833

Nishitani, Y., Yoshiyama, M., Wadgaonkar, B., Breschi, L., Mannello, F., Mazzoni, A., ... & Pashley, D. H. (2006). Activation of gelatinolytic/collagenolytic activity in dentin by self‐etching adhesives. European journal of oral sciences, 114(2), 160-166.

Pereira Prado Vanesa, Asquino Natalia, Apellaniz Delmira, Bueno Rossy Luis, Tapia Gabriel, Bologna Molina Ronell. Metaloproteinasas de la matriz extracelular (mmps) en Odontología. Odontoestomatología [Internet]. 2016 Nov [citado 2022 Jul 29] ; 18( 28 ): 20-29. Disponible en: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-93392016000200004&lng=es.

Pereira Prado, V., Asquino, N., Apellaniz, D., Bueno Rossy, L., Tapia, G., & Bologna Molina, R. (2016). Metalloproteinases (MMPs) of the extracellular matrix in dentistry. Odontoestomatologia, 18(28), 20-29

Pinna, R., Maioli, M., Eramo, S., Mura, I., & Milia, E. (2015). Carious affected dentine: its behaviour in adhesive bonding. Australian Dental Journal, 60(3), 276–293. https://doi.org/10.1111/adj.12309

Rother, E.T. (2007). Revisão sistemática X revisão narrativa.Acta Paulista de Enfermagem,20 (2). https://www.scielo.br/j/ape/a/z7zZ4Z4GwYV6FR7S9FHTByr/.

Sabatini, C., & Kim, J. H. (2014). Ortiz Alias P. In vitro evaluation of benzalkonium chloride in the preservation of adhesive interfaces. Oper Dent, 39, 283–290.

Saffarpour, A., Valizadeh, S., Amini, A., Kharazifard, M.-J., & Rohaninasab, M. (2020). Effect of matrix metalloproteinase inhibitors on microtensile bond strength of dental composite restorations to dentin in use of an etch-and-rinse adhesive system. Clinical and Experimental Dental Research, 6(6), 686–692. https://doi.org/10.1002/cre2.313

Shen, J., Xie, H., Wang, Q., Wu, X., Yang, J., & Chen, C. (2020). Evaluation of the interaction of chlorhexidine and MDP and its effects on the durability of dentin bonding. Dental Materials: Official Publication of the Academy of Dental Materials, 36(12), 1624–1634. https://doi.org/10.1016/j.dental.2020.10.006

Stape, T. H. S., Tjäderhane, L., Abuna, G., Sinhoreti, M. A. C., Martins, L. R. M., & Tezvergil-Mutluay, A. (2018). Optimization of the etch-and-rinse technique: New perspectives to improve resin-dentin bonding and hybrid layer integrity by reducing residual water using dimethyl sulfoxide pretreatments. Dental Materials: Official Publication of the Academy of Dental Materials, 34(7), 967–977. https://doi.org/10.1016/j.dental.2018.03.010

Torres, A. F. C., Antunes, L. S., Oliveira, N. F. de, Küchler, E. C., Gomes, C. C., & Antunes, L. A. A. (2020). Genetic polymorphism and expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in periapical lesions: Systematic review. Journal of Endodontics, 46(1), 3-11.e1. https://doi.org/10.1016/j.joen.2019.10.011

Umer, D., Yiu, C. K. Y., Burrow, M. F., Niu, L.-N., & Tay, F. R. (2017). Effect of a novel quaternary ammonium silane on dentin protease activities. Journal of Dentistry, 58, 19–27. https://doi.org/10.1016/j.jdent.2017.01.001

Valério, R. A., Galo, R., Galafassi, D., Corona, S. A., & Borsatto, M. C. (2019). Seguimiento clínico prospectivo de cuatro años de la restauración de resina compuesta después de la eliminación selectiva de caries con láser Er:YAG. Clin Oral Investig.

Zheng, P., & Chen, H. (2017). Evaluate the effect of different mmps inhibitors on adhesive physical properties of dental adhesives, bond strength and mmp substarte activity. Scientific Reports, 7(1), 4975. https://doi.org/10.1038/s41598-017-04340-1

Published

30/10/2022

How to Cite

GARZÓN ORDÓÑEZ, J. M. .; IÑIGUEZ ESPINOZA, I. F. .; GONZÁLEZ ORTEGA, J. L. . Role of metalloproteinases and inhibitors in adhesion: Literature review. Research, Society and Development, [S. l.], v. 11, n. 14, p. e375111436520, 2022. DOI: 10.33448/rsd-v11i14.36520. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36520. Acesso em: 26 nov. 2022.

Issue

Section

Health Sciences