Hearing loss in individuals infected with HIV/AIDS: Integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.36997

Keywords:

Hearing loss; HIV; Deafness; Antiretroviral therapy.

Abstract

Introduction: HIV infection has the potential to generate several damages to the human body, among them hearing loss has gained increasing attention and generating several studies. The hypotheses about the association of HIV/AIDS and hearing loss in the scientific literature include: the very action of the virus in the inner ear and central nervous system, opportunistic infections and their potentially ototoxic treatments and antiretroviral therapy (ART). Objective: To describe the scientific findings related to the causes of hearing loss in HIV-infected individuals in the last 15 years. Methodology: This article is an integrative review of the literature in the electronic databases PUBMED and LILACS, using combinations of the following descriptors: "Hearing loss", "HIV" (HIV), "Deafness”) and "Antiretroviral Therapy". We found 71 articles published between 2006 and 2021, in English and Portuguese, of which only 11 met the proposed criteria and were included in the review, plus 3 articles selected by manual search due to their relevance and recent publication. Results: After analyzing the studies, relevant factors that influence hearing loss in HIV-infected patients emerged: age and viral/CD4 load, and sensorineural loss was the most common type. Conclusion: It can be concluded that the causes of hearing loss in individuals with HIV are multifactorial, since no statistically significant association was found between antiretroviral therapy, opportunistic diseases and viral exposure with hearing loss in patients with HIV/AIDS.

References

Araújo, E. D. S., Zucki, F., Corteletti, L. C. B. J., Lopes, A. C., Feniman, M. R., & Alvarenga, K. D. F. (2012). Hearing loss and acquired immune deficiency syndrome: systematic review. Jornal da Sociedade Brasileira de Fonoaudiologia, 24, 188-192. https://doi.org/10.1590/s2179-64912012000200017

Assuiti, L. F. C., de Melo Lanzoni, G. M., dos Santos, F. C., Erdmann, A. L., & Meirelles, B. H. S. (2013). Hearing loss in people with HIV/AIDS and associated factors: an integrative review. Brazilian Journal of Otorhinolaryngology, 79(2), 248-255.

Bentivi, J. O., Lopes, M. K. D., Rocha, S. C. M., Costa, V. M., & Costa, A. B. S. (2020). Audiological assessment of children with HIV/AIDS: a meta-analysis. Jornal de Pediatria, 96, 537-545. https://doi.org/10.5935/1808-8694.20130042

Broome, M. E. (2000). Integrative literature reviews for the development of concepts. Concept development in nursing: foundations, techniques and applications, 231, 250.

Buriti, A. K. L., Oliveira, S. H. D. S., Muniz, L. F., & Soares, M. J. G. D. O. (2014). Avaliação da saúde auditiva em crianças com HIV/AIDS. Audiology-Communication Research, 19, 105-111.

Chimelli, L., & Rosemberg, S. (1993). Neuropatologia da síndrome de imunodeficiência adquirida (AIDS) [The neuropathology of the acquired immunodeficiency syndrome (AIDS)]. Revista da Sociedade Brasileira de Medicina Tropical, 26(2), 113–119. https://doi.org/10.1590/s0037-86821993000200007

Khoza-Shangase K. (2010). HIV/AIDS and auditory function in adults: the need for intensified research in the developing world. African journal of AIDS research : AJAR, 9(1), 1–9. https://doi.org/10.2989/16085906.2010.484531

Luque, A. E., Orlando, M. S., Leong, U. C., Allen, P. D., Guido, J. J., Yang, H., & Wu, H. (2014). Hearing function in patients living with HIV/AIDS. Ear and hearing, 35(6), e282–e290. https://doi.org/10.1097/AUD.0000000000000064

Maro, I. I., Fellows, A. M., Clavier, O. H., Gui, J., Rieke, C. C., Wilbur, J. C., Chambers, R. D., Jastrzembski, B. G., Mascari, J. E., Bakari, M., Matee, M., Musiek, F. E., Waddell, R. D., von Reyn, C. F., Palumbo, P. E., Moshi, N., & Buckey, J. C. (2016). Auditory Impairments in HIV-Infected Children. Ear and hearing, 37(4), 443–451. https://doi.org/10.1097/AUD.0000000000000276

Matas, C. G., Angrisani, R. G., Magliaro, F. C., & Segurado, A. A. (2014). Audiological manifestations in HIV-positive adults. Clinics (Sao Paulo, Brazil), 69(7), 469–475. https://doi.org/10.6061/clinics/2014(07)05

Matas, C. G., Marcon, B. D. A., Silva, S. M., & Gonçalves, I. C. (2010). Avaliação auditiva na síndrome da imunodeficiência adquirida. Revista da Sociedade Brasileira de Fonoaudiologia, 15, 174-178. https://doi.org/10.1590/S1516-80342010000200005

Matas, C. G., Samelli, A. G., Magliaro, F., & Segurado, A. (2018). Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy. Brazilian journal of otorhinolaryngology, 84(5), 574–582. https://doi.org/10.1016/j.bjorl.2017.07.003

Minhas, R. S., Iyengar, D. A., Thakur, J. S., & Azad, R. K. (2018). Effect of HIV and Antiretroviral Treatment on Auditory Functions. International archives of otorhinolaryngology, 22(4), 378–381. https://doi.org/10.1055/s-0038-1639594

Ministério da Saúde. O que é HIV. Disponível em: http://www.aids.gov.br/pt-br/publico-geral/o-que-e-hiv. Acesso em: 9 set. 2021

Ministério da Saúde. O que é sistema imunológico. Disponível em: http://www.aids.gov.br/pt-br/publico-geral/o-que-e-hiv/o-que-e-sistema-imunologico. Acesso em: 15 set. 2021

Organização Pan-Americana da Saúde (OPAS). HIV/AIDS. Disponível em: https://www.paho.org/pt/topicos/hivaids. Acesso em: 12 set. 2021

Quidicomo, S., & Matas, C. G. (2013). Estudo da função auditiva em indivíduos com HIV/AIDS submetidos e não submetidos à terapia antirretroviral. Audiology-Communication Research, 18, 10-16.

Romero, A. C., Alfaya, L. M., Gonçales, A. S., Frizzo, A. C., & Isaac, M. L. (2017). Auditory Alterations in Children Infected by Human Immunodeficiency Virus Verified Through Auditory Processing Test. International archives of otorhinolaryngology, 21(1), 86–91. https://doi.org/10.1055/s-0036-1580614

Schouten, J. T., Lockhart, D. W., Rees, T. S., Collier, A. C., & Marra, C. M. (2006). A prospective study of hearing changes after beginning zidovudine or didanosine in HIV-1 treatment-naïve people. BMC infectious diseases, 6, 28. https://doi.org/10.1186/1471-2334-6-28

Sebothoma, B., & Khoza-Shangase, K. (2021). Investigation of the Interaction between Hearing Function and Comorbidities in Adults Living with Human Immunodeficiency Virus. International journal of environmental research and public health, 18(22), 12177. https://doi.org/10.3390/ijerph182212177

Thein, P., Kalinec, G. M., Park, C., & Kalinec, F. (2014). In vitro assessment of antiretroviral drugs demonstrates potential for ototoxicity. Hearing research, 310, 27–35. https://doi.org/10.1016/j.heares.2014.01.005

Uju, I., & Dennis, A. (2021). Pure tone audiometric findings in HIV positive adults in university of Port Harcourt teaching hospital. International Journal of Research in Medical Sciences, 9(3), 685-690. https://dx.doi.org/10.18203/2320-6012.ijrms20210866

Van der Westhuizen, Y., Swanepoel, d., Heinze, B., & Hofmeyr, L. M. (2013). Auditory and otological manifestations in adults with HIV/AIDS. International journal of audiology, 52(1), 37–43. https://doi.org/10.3109/14992027.2012.721935

Vieira, A. B., Greco, D. B., Teófilo, M. M., & Gonçalves, D. U. (2008). Manifestações otoneurológicas associadas à terapia anti-retroviral [Otoneurological manifestations associated with antiretroviral therapy]. Revista da Sociedade Brasileira de Medicina Tropical, 41(1), 65–69. https://doi.org/10.1590/s0037-86822008000100012

Whittemore R, Knafl K. The integrative review: update methodology. J Adv Nurs. 2005;52(5):546-53

Published

11/11/2022

How to Cite

REIS, R. H. D.; SILVA FILHA, M. D. de A. .; OLIVEIRA, L. C. de; OLIVEIRA, G. F. de; GONÇALVES , J. B. S. Hearing loss in individuals infected with HIV/AIDS: Integrative review. Research, Society and Development, [S. l.], v. 11, n. 15, p. e94111536997, 2022. DOI: 10.33448/rsd-v11i15.36997. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36997. Acesso em: 19 apr. 2024.

Issue

Section

Health Sciences