The importance of the application of in vitro tests to guarantee the safety of cosmetic products

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.37194

Keywords:

Cosmetics; In vitro; Safety.

Abstract

The physical appearance of the one reflected through an attractive human being is attractive to the eyes and to the Cosmetic Industry. To develop a new skin care need, a rigorous evaluation of all components present. Cosmetic products must and must not present any risks to humans in normal situations or when used in a predictable manner. Therefore, in vitro tests to be an alternative for evaluating the safety of cosmetic products, since in vivo tests the inconveniences. Thus, this research sought to review the importance of applying in vitro tests in ensuring the safety of cosmetic products. Where used as a methodology bibliographic research of data from the integrative review in the databases of the Virtual Health Library and PubMed using the insertion of  DeCS: Cosméticos, In vitro, Segurança; Cosmetics, In vitro, Safety; Cosméticos, In vitro, Seguridad; combined with the Boolean operator AND to perform the searches. After inclusion and exclusion, 8 articles were selected for discussion. The results of this review show the application of in vitro tests in evaluating the safety and efficacy of a pesticide-free lice treatment, verification of cytotoxicity when compared to retinol, investigation of hydroquinone depigmentation research, use to learn genotoxicity of some chemical products, among others. Concluding that the in vitro methods are a viable alternative, which guarantees the safety of the products.

References

Aardema, M. J., Barnett, B. B., Mun, G. C., Dahl, E. L., Curren, R. D., Hewitt, N. J., & Pfuhler, S. (2013). Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 750(1-2), 40-49.

Akhtar, N., Khan, B. A., Mahmood, T., Parveen, R., Qayum, M., Anwar, M., & Farooq, M. (2010). Formulation and evaluation of antisebum secretion effects of sea buckthorn w/o emulsion. Journal of Pharmacy And Bioallied Sciences, 2(1), 7-13.

Ashawat, M., Banchhor, M., Saraf, S., & Saraf, S. (2009). Herbal Cosmetics:" Trends in Skin Care Formulation". Pharmacognosy Reviews, 3(5), 9-82.

Datta, H. S., & Paramesh, R. (2010). Trends in aging and skin care: Ayurvedic concepts. Journal of Ayurveda and integrative medicine, 1(2), 3-110.

de Oliveira Ramos, M., de Oliveira Ramos, D., de Freitas, Z. M. F., Monteiro, M. S. D. S. B., & dos Passos, M. M. B. (2022). Perfil das notificações por cosméticos reportadas ao Notivisa, Brasil. Research, Society and Development, 11(2), e42511223050-e42511223050.

European Commission. (2003). Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the Member States relating to cosmetic products. Official Journal of the European Union, 46, 26-35.

González, S., Fernández-Lorente, M., & Gilaberte-Calzada, Y. (2008). The latest on skin photoprotection. Clinics in dermatology, 26(6), 26-614.

Greive, K. A., Lui, A. H., Barnes, T. M., & Oppenheim, V. J. (2012). Safety and efficacy of a non–pesticide‐based head lice treatment: Results of a randomised comparative trial in children. Australasian journal of dermatology, 53(4), 255-263.

Junqueira Luiz, C., & Carneiro, J. (2013). Histología básica. Texto y atlas. 12va ed. Brasil: Editorial Guanabara Koogan.

Kakushi, L. E., & Évora, Y. D. M. (2016). Social networking in nursing education: integrative literature review. Revista Latino-Americana de Enfermagem, 24.

Kale, S., Kavade, E., & Yadav, A. V. (2012). Formulation and in-vitro evaluation for sun protection factor of Crinum asiaticum Linn flower (Family-Amaryllidaceae) extract sunscreen creams. Indian J. Pharm. Educ, 46, 112-119.

Kim, K. H., Lim, D. G., Lim, J. Y., Kim, N. A., Park, S. H., Cho, J. H., & Jeong, S. H. (2015). Chemical stability and in vitro and clinical efficacy of a novel hybrid retinoid derivative, bis-retinamido methylpentane. International Journal of Pharmaceutics, 495(1), 93-105.

Lee, C., Eom, Y. A., Yang, H., Jang, M., Jung, S. U., Park, Y. O., & Jung, H. (2018). Skin barrier restoration and moisturization using horse oil-loaded dissolving microneedle patches. Skin Pharmacology and Physiology, 31(3), 163-171.

Maronpot, R. R., Hobbs, C. A., Davis, J., Swartz, C., Boyle, M., Koyanagi, M., & Hayashi, S. M. (2016). Genetic and rat toxicity studies of cyclodextrin glucanotransferase. Toxicology Reports, 3, 381-392.

Mendes, K. D. S., Silveira, R. C. D. C. P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto-enfermagem, 17, 758-764.

Nishida, H., Hirota, M., Seto, Y., Suzuki, G., Kato, M., Kitagaki, M., & Onoue, S. (2015). Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools. Regulatory Toxicology and Pharmacology, 72(3), 578-585.

Orton, D. I., & Wilkinson, J. D. (2004). Cosmetic allergy. American journal of clinical dermatology, 5(5), 327-337.

Roy, A., Sahu, R., Matlam, M., Deshmukh, V., Dwivedi, J., & Jha, A. (2013). In vitro techniques to assess the proficiency of skin care cosmetic formulations. Pharmacognosy reviews, 7(14), 97.

Sgardi, F. C., do Carmo, E. D., & Rosa, L. F. B. (2007). Radiação ultravioleta e carcinogênese. Revista de Ciencias Medicas, 16(4/6).

Soares, C. B., Hoga, L. A. K., Peduzzi, M., Sangaleti, C., Yonekura, T., & Silva, D. R. A. D. (2014). Integrative review: concepts and methods used in nursing. Revista da Escola de Enfermagem da USP, 48, 335-345.

Sousa, J. R. de, & Santos, S. C. M. dos. (2020). Análise de conteúdo em pesquisa qualitativa. Revista Pesquisa E Debate Em Educação, 10(2), 1396–1416.

UNION, P. (2009). Regulation (EC) No 1223/2009 of the european parliament and of the council. Official Journal of the European Union L, 342, 59-209.

Wang, F., Zhang, C., & Wang, B. (2021). Application of in vitro methods to evaluate the safety of baby care products. Toxicology in Vitro, 75, 105194.

Won, Y. K., Loy, C. J., Randhawa, M., & Southall, M. D. (2014). Clinical efficacy and safety of 4-hexyl-1, 3-phenylenediol for improving skin hyperpigmentation. Archives of dermatological research, 306(5), 455-465.

Published

15/11/2022

How to Cite

FRANCISCO, M. M.; VASCONCELOS , T. C. L. de. The importance of the application of in vitro tests to guarantee the safety of cosmetic products . Research, Society and Development, [S. l.], v. 11, n. 15, p. e211111537194, 2022. DOI: 10.33448/rsd-v11i15.37194. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37194. Acesso em: 26 apr. 2024.

Issue

Section

Review Article