Polycystic Ovary Syndrome in adolescents and particularities in its treatment: integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.37291

Keywords:

Polycystic Ovary Syndrome; Pharmacotherapy; Women's health.

Abstract

Polycystic Ovary Syndrome is a complex and heterogeneous disorder that constitutes one of the endocrinological disorders that most affect women of reproductive age so that manifestations of its symptoms usually appear during adolescence. Still, specific studies on the health of women and girls are quite scarce, since in most societies they are harmed by discrimination based on sociocultural factors. Thus, this article proposes to analyze the most current literature available on the occurrence of PCOS in adolescents and its pharmacotherapy assuming that its diagnosis and treatment present particularities age related. The descriptors were used in combination “Polycystic Ovary Syndrome” AND “pharmacotherapy” AND “adolescents” in Portuguese and considering publications from the last five years (2017 to 2022). The search resulted in the selection of six articles in the databases of Google academic, Scientific Electronic Library Online (SCIELO) and Biblioteca Virtual em Saúde - BVS (with Medline and Lilacs) consistent with the inclusion and exclusion criteria defined first. The articles were discussed in two thematic categories: one addressing general features of PCOS in adolescents and the second focusing on pharmacotherapy and alternative treatments. It is noticed that there are still divergences regarding the diagnosis, however, the most recommended treatments are the use of contraceptives combined with insulin sensitizers, in addition to lifestyle changes adopting healthy habits.

References

Alves, M. L. S., Donne , R. D. D. ., Romano, R. M. ., & Romano, M. A. (2022). Polycystic ovary syndrome (PCOS), pathophysiology and treatment, a review. Research, Society and Development, 11(9), e25111932469. https://doi.org/10.33448/rsd-v11i9.32469

Baptista, D., Vieira, M. J. & Meireles, C. (2016). Síndrome do ovário poliquístico na adolescência. Revista Pediatrica Centro Hospitalar Porto. 25 (4). 227-235. http://hdl.handle.net/10400.16/2032

Campos, A. E., Leão, M. E. B. & Souza, M. A. (2021) O impacto da mudança do estilo de vida em mulheres com síndrome dos ovários policísticos. Revista Eletrônica Acervo Saúde, 13, (2), 43-54. https://doi.org/10.25248/reas.e4354.2021

Carolo, A. L. Mendes, M. C., Silva, A. C. J., Vieira, C. S., Sá , M. F. S., Ferriani , R. A. & Reis, R. M. (2017) Nutritional Counseling Promotes Changes in the Dietary Habits of Overweight and Obese Adolescents with Polycystic Ovary Syndrome. Revista Brasileira de Ginecologia e Obstetrícia. 39 (12) 692-696. https://doi.org/10.1055/s-0037-1607458

Christensen, S. B., Black, M. H., Smith, N., Martinez, M. M., Jacobsen, S. J., Porter, A. H & Koebnick, C. (2013) Prevalence of polycystic ovary syndrome in adolescents. Fertil Steril. 100 (2) 470–477. https://doi.org/10.1016/j.fertnstert.2013.04.001

Faria, F. R., Gusmão, L. S., Faria, E. R., Gonçalves, V. S. S., Cecon, R. S., Franceschini, S. C. C. & Priore, S. E. (2013) Síndrome do ovário policístico e fatores relacionados em adolescentes de 15 a 18 anos. Revista da Associação Médica Brasileira. 59 (4) 341-346. https://doi.org/10.1016/j.ramb.2013.02.003

Fauser, B. C.; Tarlatzis, B. C.; Rebar, R. W.; Legro, R. S., Balen A. H., Lobo R., ... Barnhart, K. (2012) Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 97(1) 28–38. https://doi.org/10.1016/j.fertnstert.2011.09.024

Federação Brasileira das Associações de Ginecologia e Obstetrícia (2021). Especial SOP: das repercussões metabólicas às complicações gestacionais da síndrome dos ovários policísticos. Feminina. 49 (9) 3. FeminaZ2021Z49Z09ZWEBZ1.pdf (febrasgo.org.br)

Flannery, C.A.; Rackow, B.; Cong, X, Duran, E.; Selen, D.J. & Burgert, T.S. (2013) Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI. Pediatr Diabetes, 14 (1) 42–9. https://doi.org/10.1111/j.1399-5448.2012.00902.x

Freitas, G. B. L. (2021) Saúde da Mulher. (vol. 2, 2ª ed., p. 244). Irati, PR: Pasteur.

García-Beltran, C., Cereijo, R., Quesada-López, T., Malpique, R., Lopez-Bermejo, A., Zegher, F., Ibáñez, L. & Villarroya, F. (2020). Reduced circulating levels of chemokine CXCL14 in adolescent girls with polycystic ovary syndrome: Normalization after insulin sensitization. BMJ Open Diabetes Research & Care. 8 (10). Article e001035. https://doi.org/10.1136/bmjdrc-2019-001035

Gil, A. C. (2008) Como elaborar projetos de pesquisa. (4a ed.), Atlas. https://wwwp.fc.unesp.br/Home/helber-freitas/tcci/gil_como_elaborar_projetos_de_pesquisa_-anto.pdf

Gomes, P.C.A. Aspectos ultrassonográficos na síndrome dos ovários policísticos: novas recomendações. (2021) Brazilian Journal of Health Review. v. 4 (2) p. 6525-6535. https://doi.org/10.34119/bjhrv4n2-202

Hickey, M.; Doherty, D.A.; Atkinson, H.; Sloboda, D.M.; Franks S.; Norman R.J & Hart, R. (2011) Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis. Hum Reprod., 26 (6) 69–77. https://doi.org/10.1093/humrep/der102

Lei 8.069 de 13 de julho de 1990. Dispõe sobre o Estatuto da Criança e do Adolescente e dá outras providências. Diário Oficial [da] República Federativa do Brasil, Brasília, DF, 16 jul. 1990. L8069 (planalto.gov.br)

Mccartney, C.R. & Marshall, J.C. (2016) Polycystic Ovary Syndrome. New England Journal of Medicine. 375 (1) 54-64. https://doi.org/10.1056/nejmcp1514916

Nicolaides, N. C., Matheou, A., Vlachou, F., Neocleous, V. & Skordis, N. (2020) Polycystic ovarian syndrome in adolescents: from diagnostic criteria to therapeutic management. Acta Biomed. 91 (3) e2020085. https://doi.org/10.23750/abm.v91i3.10162

Oliveira, T. F. de, Silva, M. J. A. A. da, & Salomon, A. L. (2022). Polycystic ovary syndrome: nutrition in the treatment of insulin resistance and inflammatory processes . Research, Society and Development, 11(8), e56011831425. https://doi.org/10.33448/rsd-v11i8.31425

Pkhaladze, L., Russo, M., Unfer, V., Nordio, M., Basciani S. & Khomasuridze A. (2021) Treatment of lean PCOS teenagers: a follow-up comparison between Myo-Inositol and oral contraceptives. Eur Rev Med Pharmacol Sci. 25(23) 7476-7485. https://doi.org/10.26355/eurrev_202112_27447

Rotterdam, ESHRE/ASRM - Sponsored PCOS consensus workshop group. (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 19 (1) 4–7. Recuperado de: https://doi.org/10.1093/humrep/deh098

Santos, R. M. & Álvares, A. C. M. (2018). Revisão de literatura sobre a síndrome do ovário policístico. Revista de Iniciação Científica e Extensão. 1 (2) 261-265. https://revistasfacesa.senaaires.com.br/index.php/iniciacao-cientifica/article/view/92

Souza, M. T., Silva, M. D. & Carvalho, R. (2010) Integrative review: what is it? How to do it?. Revista Einstein. 8 (1) 102-106. https://doi.org/10.1590/S1679-45082010RW1134

Weffort VRS & Oliveira NAL. (2019) Prevenção. In: Sociedade Brasileira de Pediatria. Departamento Científico de Nutrologia. Obesidade na infância e adolescência: manual de orientação (vol. 2, 3ª ed., p. 163-81). São Paulo, SP: SBP.

Ybarra M, Franco RR, Cominato L, Sampaio RB, Sucena da Rocha SM & Damiani D. (2018) Polycystic Ovary Syndrome among Obese Adolescents. Gynecol Endocrinol. 34(1) 45-48. https://doi.org/10.1080/09513590.2017.1359250

Yela, D. A. (2018). Particularidades do diagnóstico e da terapêutica da síndrome dos ovários policísticos na adolescência. In: Síndrome dos ovários policísticos. (Série Orientações e Recomendações Febrasgo, nº 4, Comissão Nacional de Ginecologia Endócrina). (Cap. 2, p. 16-28) São Paulo, SP: Federação Brasileira das Associações de Ginecologia e Obstetrícia (FEBRASGO).

Published

25/11/2022

How to Cite

VIEIRA, L. S.; ANDRADE, R. L. C.; VINHAS, A. C. A. . Polycystic Ovary Syndrome in adolescents and particularities in its treatment: integrative review. Research, Society and Development, [S. l.], v. 11, n. 15, p. e515111537291, 2022. DOI: 10.33448/rsd-v11i15.37291. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37291. Acesso em: 26 nov. 2024.

Issue

Section

Health Sciences