Applications of polymer-based membranes in the treatment of skin wounds: An integrative review




Polymers; Wounds; Healing.


Objective: To investigate the healing potential of skin wounds and its influence on treatment time with the use of polymer-based membranes. Methodology: To reach the intended objective, the study carried out research based on an Integrative Literature Review, through articles in the search bases in publications indexed in the following Virtual Health Library (BVS) and Pubmed databases, from 2018 to 2022 , through health descriptors with the Boolean operator AND: polymers, healing, wounds. Results: As a result, it was understood that the use of polymers in skin wounds has been used as a chemical joint, in order to increase the structural integrity of the membranes. The membranes used in the studies allowed an important decrease in the pain condition of the treated patients, without the occurrence of high infections. However, consolidation techniques need to occur for the length of stay. Conclusion: In cases where skin wounds are exaggerated, these techniques may have cytotoxic tendencies, preventing resorption and causing material failures. positive or not in healing.


Chen, L., Ma, J., Chen, Y., Huang, C., Zheng, Z., Gao, Y., Jiang, Z., Wei, X., Peng, Y., Yu, S., & Yang, L. (2022). Polydopamine modified acellular dermal matrix sponge scaffold loaded with a-FGF: Promoting wound healing of autologous skin grafts. Biomaterials advances, 136, 212790.

Crossetti, M. (2012). Revisión integrativa de la investigación en enfermería, el rigor científico que se le exige. Rev. Gaúcha Enferm. June; 33(2): 10-11.

Duarte, L. C. (2018). Desenvolvimento de película biocompatível para cicatrização de feridas. Universidade Federal da Grande Dourados. (60). Online. ISSN:6023

Beyond the Wound Edge: Periwound and Regional Skin Integrity. (2022). Advances in skin & wound care, 35(10), 527.

Freitas, A. L. (2018). Avaliação da cicatrização de feridas por hidrogel contendo extrato seco padronizado de Hyptis pectinata (L.) em ratos. 36 ( 24):255.

Fahimirad, S., & Ajalloueian, F. (2019). Naturally-derived electrospun wound dressings for target delivery of bio-active agents. International journal of pharmaceutics, 566, 307–328.

Guirao G. S. J. A. (2015). Utilidad y tipos de revisión de literatura. Ene, 9(2)

Hosseini, M. S., & Nabid, M. R. (2020). Synthesis of chemically cross-linked hydrogel films based on basil seed (Ocimum basilicum L.) mucilage for wound dressing drug delivery applications. International Journal of Biological Macromolecules, (163) Online. ISSN:336-347.

Hasatsri S, Pitiratanaworanat A, Swangwit S, et al.(2018). Comparação das propriedades morfológicas e físicas de diferentes pensos absorventes para feridas. Pesquisa e Prática em Dermatologia. 9: 9367034

Lipový, B., & Forostyak, S. (2020). Efficacy and safety of newly developed biologic material based on the amniotic membrane in acute burns management. Burns : journal of the International Society for Burn Injuries, 46(3), 743–745.

Leask, K. (2022). Skin and Wound Care: Challenges and Opportunities. Advances in Skin & Wound Care: September 2022 - Volume 35 - Issue 9 - p 471-472. doi: 10.1097/01.

Locilento, D. A. (2018). Produção e caracterização de mantas de nanofibras poliméricas eletrofiadas contendo proantocianidinas e sua potencial aplicação no tratamento de lesões cutâneas. 45 (8) 25-58

Notodihardjo, S. C., Morimoto, N., Munisso, M. C., Le, T. M., Mitsui, T., Kakudo, N., & Kusumoto, K. (2020). A comparison of the wound healing process after application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice. J. Plast. Reconstr. Aesthet. Surg,( 73) Online. ISSN: 1547–1555.

Ou Q, Zhang S, Fu C, Yu L, Xin P, Gu Z, Cao Z, Wu J, Wang Y (2021). More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing. J Nanobiotechnology. Aug 11;19(1)online, ISSN:237. doi: 10.1186/s12951-021-00973-7

Ribeiro, Caetano Pedro Evangelista (2021). Estabelecimento de um processo biotecnológico com emprego de manufatura aditiva para produção de biocurativos poliméricos associados a plasma rico em plaquetas (PRP) definidas morfologicamente a partir de escaneamento de feridas cutâneas virtuais. 46(3):743-745.

Sorg, H., Tilkorn, D. J., Hager, S., Hauser, J., & Mirastschijski, U (2017). Skin wound healing: An update on the current knowledge and concepts. Eur. Surg. Res, 58, 81–94; 58:81-94.

Silva, V. et al (2018). Chemical composition, antioxidant and antimicrobial activity of phenolic compounds extracted from wine industry by-products. Food control, v. 92, p. 516-522.

Takejima, M. L. et al (2021).Vegetable cellulose nanofiber dressing aids in the healing process of third-degree burns? Study on rats. Abcd. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) [online], 34(2), 1579-1586. //

Venegas-Cervera, G. A et al. (2021). Biocompatibility studies of polyurethane electrospun membranes based on arginine as chain extender. J Mater Sci Mater Med ; 32(9): 104. doi: 10.1007/s10856-021-06581-z

Zhong, Y., Xiao, H., Seidi, F., & Jin, Y (2020). Natural polymer-based antimicrobial hydrogels without synthetic antibiotics as wound dressings. Biomacromolecules, 21, 2983–3006. 2020. //

Wang, L., Du, L., Wang, M., Wang, X., Tian, S., Chen, Y., Wang, X., Zhang, J., Nie, J., Ma, G. (2022). Chitosan for constructing stable polymer-inorganic suspensions and multifunctional membranes for wound healing. Carbohydr Polym; 285, 119-209.



How to Cite

NÓBREGA, M. E. A. da .; OLIVEIRA, B. B. T. de .; TEIXEIRA, L. R. .; OLIVEIRA, T. K. B. de. Applications of polymer-based membranes in the treatment of skin wounds: An integrative review. Research, Society and Development, [S. l.], v. 11, n. 15, p. e597111537583, 2022. DOI: 10.33448/rsd-v11i15.37583. Disponível em: Acesso em: 9 feb. 2023.



Health Sciences