In silico analysis of the toxicity of Mellissa Officinalis L. metabolites in order to obtain new drugs

Authors

DOI:

https://doi.org/10.33448/rsd-v11i16.37606

Keywords:

Melissa officinalis L.; Anxiety; Natural products.

Abstract

Medicinal plants have been widely used for the treatment, prevention and cure of diseases, as they have been used for medicinal purposes by humanity since ancient times. Due to their therapeutic or toxic properties, they gained importance in popular and conventional medicine. Therefore, the present research aimed to evaluate, through in silico prediction, the toxicological parameters of Melissa officinalis L. in order to obtain new drug candidates from this species. It was a basic, experimental, cross-sectional, quantitative study carried out through the analysis of theoretical toxicity with a free admetSAR software. For the compound acetyl tributyl citrate, which for most parameters was not considered toxic, there is the possibility of being used alone as an antifungal, antibacterial, antileshimania and insecticide, since it belongs to the citral essential oil component. which is the majority present in M. officinallis. However, it is necessary that there is continuity of work using this species cultivated in the southern region of Tocantins, since it was verified a promising compound for future investigations in in vitro and in vivo tests, which may be a strong candidate for a new drug.

References

Bonil, L. N. & Bueno, S. M. (2017). Plantas Medicinais: Benefícios e Malefícios. Revista Medicina.

Bortoluzzi, M. M., Schnitt, V. & Mazur, C.E. (2020). Efeito fitoterápico de plantas medicinais sobre a ansiedade: uma breve revisão. Research, Society and Development, 9(2), 47.

Blumenthal, M. et al. (2018). The complete commission E monographs: therapeutic guide to herbal medicines. Boston: M. Integrative medicine communications. p.104-105.

Chehroudi, S., Fatemi, M. J., Isfeedvajani, M. S., Salahi, S. H., Akbari, H., Samimi, R. (2016). Effects of Melissa officinalis L. on reducing stress, alleviating anxiety disorders, depression, and insomnia, and increasing total antioxidants in burn patients. Trauma Monthly, 22(4).

Coleta, M., Campos, M. G., Cotrim, M. D., & Proença DA, A. C. (2001). Comparative Evaluation of Melissa officinalis L., Tilia europaea L., Passiflora edulis Sims. And Hypericum perforatum L. in the elevated plus maze anxiety test. Pharmacopsychiatry, 34: S20-1.

Kennedy do., Little W., & Scholey, A.B. (2004). Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med, 66: 607-613.

Leite, I. A., Morais, A. M., Do Ó, K. D. S., Carneiro, R. G., & Leite, C. A., A etnobotânica de plantas medicinais no município de São José de Espinharas, Paraíba, Brasil. Biodiversidade. 14(1), 22- 30, 2015. https://periodicoscientificos.ufmt.br/ojs/index.php/biodiversidade/article/view/2249.

Lorenzi H, Mato F J A Plantas medicinais no Brasil: nativas ou exóticas. Instituto Plantarum de Estudos da Flora LTDA, 2002. 512 p.

Martins, E. R., Castro, D. M. de., Castellani, D. C., Dias, J. E. (1998). Plantas Medicinais. UFS, 220p.

Muñoz, F.: (1996) Plantas Medicinales y Aromáticas: estúdio, cultivo y procesado. Madri. Ed.: Mundi-Prensa, 365p.

Müzell, D. P. Propriedades biológicas de extratos de Melissa officinalis L. (LAMIACEAE) em ratos wistar. 70f. Dissertação. Faculdade de Biociências da Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, 2006.

NUNES, X. P. et al. Constituintes químicos, avaliação das atividades citotóxica e antioxidante de Mimosa paraibana Barneby (Mimosaceae). Brazilian Journal of Pharmacognosy, v. 18, p. 718-723, 2008.

Pereira, A. S., Shitsuka, D. M., Parreira, F.J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica. pdf.

Reis, S. R., Pinto, J. E. B. P., Rosado, L. D. S., & Corrêa, R. M. (2009). Teor e composição química do óleo essencial de Melissa officinalis L. in vitro sob influência do meio de cultura. Acta Scientiarum Agronomy Maringá, 31(2), 331-335.

Santana, L. E. G. de S., Miranda, I. K. I., & Sousa, J. A. (2020). Análise in silico da farmacocinética, da farmacodinâmica e da toxicidade de dois compostos isolados da Moringa oleífera. Research, Society and Development, 9(11), e81991110469, 2020.

Shakeri, A., Sahebkar, A., & Javadi, B. (2016) Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology, v. 188, p.204–228.

Silva, B. Q., & Hahn, S. R (2015). Uso de plantas medicinais por indivíduos com hipertensão arterial sistêmica. R. Bras. Farm. Hosp. Serv. Saúde, 2(3), 36-40.

Sousa G.A., Martins I. V. O, Pimentel V. D., & Sousa J. A. (2020). Análise in silico da farmacodinâmica, farmacocinética e toxicidade de dois compostos isolados da Actinidia deliciosa para investigação do seu potencial anti-hiperlipêmico. Research, Society and Development, 9(7): 1-20, e790974679.

Souza, M.V.N. (2010). Fármacos Inibidores de Fusão: uma Nova Estratégia no Combate à Replicação do Vírus VIH. Rio de Janeiro: Acta Farm. Bonaerense24(2): 291-9.

Teixeira, N. A. de M., Teles, Y. C. F., Borges, N. H. P. B., Fernandes, M. M. O., Nunes, J. B. S. & Paulo, M. de Q. (2006). Análise da atividade toxicológica e citotoxicológica do extrato hidroalcóolico da erva cidreira (Melissa officinalis). Anais da 58ª Reunião Anual da SBPC - Florianópolis, SC - Julho/2006.

Downloads

Published

01/12/2022

How to Cite

NASCIMENTO, P. I. do .; OLIVEIRA, Y. S. de .; FRANCO, J. V. V. .; GAUDIOSO, K. G. C. .; LEÃO, N. M. L. .; SUZUKI, M. T.; FRANÇA JÚNIOR, M. F. de .; CONCEIÇÃO, O. de S. da .; SOUSA, S. F. de .; PEREIRA, M. A. B. . In silico analysis of the toxicity of Mellissa Officinalis L. metabolites in order to obtain new drugs. Research, Society and Development, [S. l.], v. 11, n. 16, p. e114111637606, 2022. DOI: 10.33448/rsd-v11i16.37606. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37606. Acesso em: 4 nov. 2024.

Issue

Vol. 11 No. 16

Section

Review Article

License

Copyright (c) 2022 Pamela Inácio do Nascimento; Yngrid Silva de Oliveira; Jéssyka Viana Valadares Franco; Kamila Gomes Costa Gaudioso; Natallia Moreira Lopes Leão; Marise Tanaka Suzuki; Mosaniel Falcão de França Júnior; Olívia de Souza da Conceição; Sara Falcão de Sousa; Miréia Aparecida Bezerra Pereira

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.