Analysis of the correlation between obesity, oro-naso-sensory alterations, inflammatory process and COVID-19: a narrative review
DOI:
https://doi.org/10.33448/rsd-v11i16.37936Keywords:
COVID-19; Obesity ; Otolaryngology.Abstract
Introduction: The acute inflammatory syndrome caused by COVID-19 amplifies the chronic inflammatory process caused by obesity, leading to an even more severe inflammatory cascade, exacerbating the cellular destruction of the different tissues affected by the disease, including the olfactory and gustatory tissues. Objectives: to elucidate and summarize the correlation between obesity, oro-naso-sensory alterations, the inflammatory process and COVID-19. Methodology: This is a narrative review, which used PubMed, Research Gate and Google Scholar databases. Results and discussion: As a direct and indirect consequence of the infection of the goblet cells secreting the nasal mucosa and epithelial cells of the tongue, two of the most striking symptoms are the oro-naso-sensory impairment, which in its most advanced stage can lead to ageusia and /or anosmia, which may only last for the active phase of COVID-19 or last long after the disease resolves. As for anosmia and its relationship to inflammation and obesity, a recent connection has been discovered between apoptosis and inflammation of the olfactory mucosa, where a significant increase in caspase-3 activity is associated with a marked loss of olfactory neurons and their axonal projections. paralleled an increased expression of Iba-1, suggesting an increase in pro-inflammatory cells. Conclusion: Both obesity and SARS-CoV-2 infection lead the body to an inflammatory state that is sometimes acute, sometimes chronic, but in both, uncontrolled. This inflammatory state most often ends up affecting the olfactory and gustatory epithelium, causing an important and sometimes even irreversible impairment of function.
References
Aminian, A., Bena, J., Pantalone, K. M., & Burguera, B. (2021). Association of obesity with postacute sequelae of COVID ‐19. Diabetes, Obesity and Metabolism, 23(9), 2183–2188. https://doi.org/10.1111/dom.14454
Bardin, L. (2016). Análise de conteúdo. São Paulo: Edições 70
Benkirane, H., Heikel, J., Laamiri, F. Z., Bouziani, A., Lahmam, H., Al-Jawaldeh, A., El Haloui, N., Ennibi, K., Akhtar-Khan, N., El Fahime, E. M., Obtel, M., Barkat, A., & Aguenaou, H. (2020). Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction. Frontiers in Physiology, 11, 595005. https://doi.org/10.3389/fphys.2020.595005
Bhutani, S., Coppin, G., Veldhuizen, M. G., Parma, V., & Joseph, P. V. (2021). COVID-19 Related Chemosensory Changes in Individuals with Self-Reported Obesity. Rhinology Journal. https://doi.org/10.1101/2021.02.28.21252536
Chen, M., Shen, W., Rowan, N. R., Kulaga, H., Hillel, A., Ramanathan, M., & Lane, A. P. (2020). Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. European Respiratory Journal, 56(3), 2001948. https://doi.org/10.1183/13993003.01948-2020
Chudzik, M., Babicki, M., Mastalerz-Migas, A., & Kapusta, J. (2022). Persisting Smell and Taste Disorders in Patients Who Recovered from SARS-CoV-2 Virus Infection—Data from the Polish PoLoCOV-CVD Study. Viruses, 14(8), 1763. https://doi.org/10.3390/v14081763
Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2017). Obesity and inflammation: the linking mechanism and the complications. Archives of Medical Science, 13(4), 851–863. https://doi.org/10.5114/aoms.2016.58928
Ferrante, A. W. (2007). Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. Journal of Internal Medicine, 262(4), 408–414. https://doi.org/10.1111/j.1365-2796.2007.01852.x
Fu, Y., Cheng, Y., & Wu, Y. (2020). Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Virologica Sinica, 35. https://doi.org/10.1007/s12250-020-00207-4
García, L. F. (2020). Immune Response, Inflammation, and the Clinical Spectrum of COVID-19. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01441
Karuppan, M. K. M., Devadoss, D., Nair, M., Chand, H. S., & Lakshmana, M. K. (2021). SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism. Molecular Neurobiology, 58(6), 1–16. https://doi.org/10.1007/s12035-020-02245-1
Khan, A. S., Hichami, A., & Khan, N. A. (2020). Obesity and COVID-19: Oro-Naso-Sensory Perception. Journal of Clinical Medicine, 9(7), 2158. https://doi.org/10.3390/jcm9072158
Li, S., Zhang, Y., Guan, Z., Li, H., Ye, M., Chen, X., Shen, J., Zhou, Y., Shi, Z.-L., Zhou, P., & Peng, K. (2020). SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation. Signal Transduction and Targeted Therapy, 5. https://doi.org/10.1038/s41392-020-00334-0
Liskova, A., Samec, M., Koklesova, L., Samuel, S. M., Zhai, K., Al-Ishaq, R. K., Abotaleb, M., Nosal, V., Kajo, K., Ashrafizadeh, M., Zarrabi, A., Brockmueller, A., Shakibaei, M., Sabaka, P., Mozos, I., Ullrich, D., Prosecky, R., La Rocca, G., Caprnda, M., & Büsselberg, D. (2021). Flavonoids against the SARS-CoV-2 induced inflammatory storm. Biomedicine & Pharmacotherapy, 138, 111430. https://doi.org/10.1016/j.biopha.2021.111430
Lowery, S. A., Sariol, A., & Perlman, S. (2021). Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19. Cell Host & Microbe, 29(7), 1052–1062. https://doi.org/10.1016/j.chom.2021.05.004
Morais, A. H. de A., Passos, T. S., Vale, S. H. de L., Maia, J. K. da S., & Maciel, B. L. L. (2020). Obesity and the increased risk for COVID-19: mechanisms and nutritional management. Nutrition Research Reviews, 34(2), 1–13. https://doi.org/10.1017/S095442242000027X
Mullol, J., Alobid, I., Mariño-Sánchez, F., Izquierdo-Domínguez, A., Marin, C., Klimek, L., Wang, D.-Y., & Liu, Z. (2020). The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries. Current Allergy and Asthma Reports, 20(10). https://doi.org/10.1007/s11882-020-00961-1
Nyambuya, T. M., Dludla, P. V., Mxinwa, V., & Nkambule, B. B. (2019). Obesity-induced inflammation and insulin resistance: A mini-review on T-cells. Metabolism Open, 3, 100015. https://doi.org/10.1016/j.metop.2019.100015
Passarelli, P. C., Lopez, M. A., Mastandrea Bonaviri, G. N., Garcia-Godoy, F., & D’Addona, A. (2020). Taste and smell as chemosensory dysfunctions in COVID-19 infection. American Journal of Dentistry, 33(3), 135–137. https://pubmed.ncbi.nlm.nih.gov/32470238/#:~:text=Only%20one%20study%20recorded%20both
Polat, B., Yilmaz, N. H., Altin, G., Atakcan, Z., & Mert, A. (2021). Olfactory and Gustatory Dysfunctions in COVID-19 Patients. Journal of Craniofacial Surgery, Publish Ahead of Print. https://doi.org/10.1097/scs.0000000000007412
Prete, M., Favoino, E., Catacchio, G., Racanelli, V., & Perosa, F. (2020). SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment. International Journal of Molecular Sciences, 21(9), 3377. https://doi.org/10.3390/ijms21093377
Riel, D. van, Verdijk, R., & Kuiken, T. (2014). The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system. The Journal of Pathology, 235(2), 277–287. https://doi.org/10.1002/path.4461
Rother, E. T. (2007). Revisão sistemática X revisão narrativa. Acta Paulista de Enfermagem, 20(2), v–vi. https://doi.org/10.1590/s0103-21002007000200001
Strauss, S. B., Lantos, J. E., Heier, L. A., Shatzkes, D. R., & Phillips, C. D. (2020). Olfactory Bulb Signal Abnormality in Patients with COVID-19 Who Present with Neurologic Symptoms. American Journal of Neuroradiology, 41(10), 1882–1887. https://doi.org/10.3174/ajnr.a6751
Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. P. (2020). The trinity of COVID-19: immunity, inflammation and intervention. Nature Reviews Immunology, 20(6), 1–12. https://doi.org/10.1038/s41577-020-0311-8
Thomas, D. C., Chablani, D., Parekh, S., Pichammal, R. C., Shanmugasundaram, K., & Pitchumani, P. K. (2021). Dysgeusia. Journal of the American Dental Association (1939), 153(3). https://doi.org/10.1016/j.adaj.2021.08.009
Umakanthan, S. (2020). Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad Med J ., 96(1142). https://doi.org/10.1136/postgradmedj-2020-138234
Wang, Z., Zhou, J., Marshall, B., Rekaya, R., Ye, K., & Liu, H.-X. (2020). SARS-CoV-2 Receptor ACE2 Is Enriched in a Subpopulation of Mouse Tongue Epithelial Cells in Nongustatory Papillae but Not in Taste Buds or Embryonic Oral Epithelium. ACS Pharmacology & Translational Science, 3(4), 749–758. https://doi.org/10.1021/acsptsci.0c00062
Xavier, A. R., Silva, J. S., Almeida, J. P. C. L., Conceição, J. F. F., Lacerda, G. S., & Kanaan, S. (2020). COVID-19: clinical and laboratory manifestations in novel coronavirus infection. Jornal Brasileiro de Patologia E Medicina Laboratorial, 56. https://doi.org/10.5935/1676-2444.20200049
Zhang, J., & Wirtz, S. (2022). Does Pyroptosis Play a Role in Inflammasome-Related Disorders? International Journal of Molecular Sciences, 23(18), 10453. https://doi.org/10.3390/ijms231810453
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