Lateral epicondylitis treatment using mesenchymal stem cells: a narrative review
DOI:
https://doi.org/10.33448/rsd-v11i16.37965Keywords:
Lateral epicondylitis; Mesenchymal stem cells; Bone marrow cells.Abstract
Tendons diseases are frequently seen in clinical practice, even more in athletes. This disease can be accompanied of a disabling musculoskeletal pain, being of a substantial impact in the patients’ lives. Although the diverse ways to treat LE, most of the results are not satisfactory, and there is no evidence of a therapy that is more effective than placebo or no treatment at all. Therefore, throughout the last decades, new perspectives towards LE management appeared, such as mesenchymal stem cells therapy (MSCs), that demonstrated promising results in a fair number of studies. This study presents itself with the purpose to revise the existing literature towards the use of mesenchymal stem cells as a treatment to lateral epicondylitis, summarizing the existing clinical evidences and evaluating its efficacy, as to create a clear vision of the current researches and its progress in such therapy. Revise literature towards the effectiveness of stem cells use in lateral epicondylitis treatment. The review occurred in July, 2022, using original and high scientific evidence level publications in MEDLINE and Cochrane Library databases. Also, the references in which the studies were based, were also analyzed. There were selected five prospective studies that evaluated the efficacy of mesenchymal stem cells in lateral epicondylitis and other tendon diseases. All of the studies concluded that there was a significant recovery of the tendinopathy. Even though the studies show mesenchymal stem cells therapeutic potential toward lateral epicondylitis treatment, the lack o clinical trials makes it difficult to determine what type of transplant should be made, where the cells should come from and how many cells are ideal for clinical use.
References
Aydın, A., & Atiç, R. (2018). Comparison of extracorporeal shock-wave therapy and wrist-extensor splint application in the treatment of lateral epicondylitis: a prospective randomized controlled study. Journal of Pain Research, Volume 11, 1459–1467. https://doi.org/10.2147/jpr.s166679
Barros, A. J. S., & Lehfeld, N. A. S. (2000) Fundamentos de metodologia científica: um guia para a iniciação científica.Makron Editora.
Branson, R., et al. (2017). Comparison of corticosteroid, autologous blood or sclerosant injections for chronic tennis elbow. Journal of Science and Medicine in Sport, 20(6), 528–533. https://doi.org/10.1016/j.jsams.2016.10.010
Cho, W. S., et al. (2021). Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review and Meta-Analysis of Prospective Clinical Studies. Annals of Rehabilitation Medicine, 45(4), 274–283. https://doi.org/10.5535/arm.21078
Evans, J. P., et al. (2019). Patient-centred outcomes in lateral elbow tendinopathy: A systematic review of available evidence in UK populations. Shoulder & Elbow, 11(6), 440–449. https://pubmed.ncbi.nlm.nih.gov/32269604/
Fujihara, Y., et al. (2018). The Effect of Impactful Articles on Clinical Practice in the United States. Plastic and Reconstructive Surgery, 141(5), 1183–1191. https://doi.org/10.1097/prs.0000000000004317
Gianakos, A. L., et al. (2017). Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review. World Journal of Orthopedics, 8(6), 491. https://doi.org/10.5312/wjo.v8.i6.491
Hare, J. M., et al. (2012). Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA, 308(22), 2369–2379. https://doi.org/10.1001/jama.2012.25321
Havlas, V., et al. (2015). [Use of cultured human autologous bone marrow stem cells in repair of a rotator cuff tear: preliminary results of a safety study]. Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca, 82(3), 229–234. https://pubmed.ncbi.nlm.nih.gov/26317295/
Houck, D. A., et al. (2019). Treatment of Lateral Epicondylitis With Autologous Blood, Platelet-Rich Plasma, or Corticosteroid Injections: A Systematic Review of Overlapping Meta-analyses. Orthopaedic Journal of Sports Medicine, 7(3), 232596711983105. https://doi.org/10.1177/2325967119831052
Imam, M. A., et al. (2017). A systematic review of the concept and clinical applications of Bone Marrow Aspirate Concentrate in Orthopaedics. SICOT-J, 3, 17. https://doi.org/10.1051/sicotj/2017007
Imam, M. A., et al. (2017). A systematic review of the concept and clinical applications of bone marrow aspirate concentrate in tendon pathology. SICOT-J, 3, 58. https://doi.org/10.1051/sicotj/2017039
Itro, A., et al. (2022). Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review. Pharmaceutics, 14(6), 1151. https://doi.org/10.3390/pharmaceutics14061151
Lee, S. Y., et al. (2015). Treatment of Lateral Epicondylosis by Using Allogeneic Adipose-Derived Mesenchymal Stem Cells: A Pilot Study. STEM CELLS, 33(10), 2995–3005. https://doi.org/10.1002/stem.2110
Lenoir, H., Mares, O., & Carlier, Y. (2019). Management of lateral epicondylitis. Orthopaedics & Traumatology: Surgery & Research, 105(8). https://doi.org/10.1016/j.otsr.2019.09.004
Linnanmäki, L., et al. (2020). Platelet-rich Plasma or Autologous Blood Do Not Reduce Pain or Improve Function in Patients with Lateral Epicondylitis: A Randomized Controlled Trial. Clinical Orthopaedics & Related Research, 478(8), 1892–1900. https://doi.org/10.1097/corr.0000000000001185
Lu, V., et al. (2021). Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tendon and Ligament Repair—A Systematic Review of In Vivo Studies. Cells, 10(10), 2553. https://doi.org/10.3390/cells10102553
Pascual-Garrido, C., Rolón, A., & Makino, A. (2012). Treatment of Chronic Patellar Tendinopathy with Autologous Bone Marrow Stem Cells: A 5-Year-Followup. Stem Cells International, 2012, 1–5. https://doi.org/10.1155/2012/953510
Jo, C. H., et al. (2018). Intratendinous Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Rotator Cuff Disease: A First-In-Human Trial. STEM CELLS, 36(9), 1441–1450. https://doi.org/10.1002/stem.2855
Rhatomy, S., et al. (2020). Prospect of stem cells conditioned medium (secretome) in ligament and tendon healing: A systematic review. STEM CELLS Translational Medicine, 9(8), 895–902. https://doi.org/10.1002/sctm.19-0388
Singh, A., Gangwar, D., & Singh, S. (2014). Bone marrow injection: A novel treatment for tennis elbow. Journal of Natural Science, Biology and Medicine, 5(2), 389. https://doi.org/10.4103/0976-9668.136198
Torres-Torrillas, M., et al. (2019). Adipose-Derived Mesenchymal Stem Cells: A Promising Tool in the Treatment of Musculoskeletal Diseases. International Journal of Molecular Sciences, 20(12), 3105. https://doi.org/10.3390/ijms20123105
Trebinjac, S., & Gharairi, M. (2020). Mesenchymal Stem Cells for Treatment of Tendon and Ligament Injuries-clinical Evidence. Medical Archives, 74(5), 387. https://doi.org/10.5455/medarh.2020.74.387-390
van den Boom, N. A. C., et al. (2020). Efficacy of Stem Cell Therapy for Tendon Disorders: A Systematic Review. Orthopaedic Journal of Sports Medicine, 8(4), 2325967120915857. https://doi.org/10.1177/2325967120915857
Yao, G., et al. (2020). Efficacy of Extracorporeal Shock Wave Therapy for Lateral Epicondylitis: A Systematic Review and Meta-Analysis. BioMed Research International, 2020, 1–8. https://doi.org/10.1155/2020/2064781
Young, M. (2012). Stem Cell Applications in Tendon Disorders: A Clinical Perspective. Stem Cells International, 2012, 1–10. https://doi.org/10.1155/2012/637836
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Copyright (c) 2022 Thiago Meloni Stecca; Evelin Leonara Dias da Silva; Fernanda Avila Rocha; Fernanda Marinho de Souza; Paulo Fernandor Alves da Silveira Junior; Romero Fonseca Vieira Júnior; Samuel Henrique Jakoski Gehhlen
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