Secondary infections caused by ESKAPE group bacteria and impact on the health of patients with Covid-19 complications – an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v11i15.37997

Keywords:

COVID-19; ESKAPE; Drug Resistant Bacteria; Coinfection.

Abstract

Introduction: Bacterial resistance described for the ESKAPE group is a considerable problem for global health that results in social, economic and mainly health damages. Objectives: To describe the harm associated with the health of hospitalized patients with complications from COVID-19 inherent to co-infections caused by the ESKAPE bacterial group. Methodology: This is an integrative literature review, studies were searched in the National Library of Medicine National Institutes of Health (PubMed) and Science Direct, using the PRISMA method, articles published between the years 2020 were included and 2021, in English. Results: The sample consisted of 17 articles, in which the occurrence of the ESKAPE group and inherent damage to the health of patients with COVID-19 was detected. Methicillin-sensitive Staphylococcus aureus (MSSA), followed by methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae and Enterococcus spp. were the main bacteria reported. The main damages inherent to the COVID-ESKAPE association were the prolonged hospitalization time, bacterial resistance to antimicrobials and a higher mortality rate. Conclusion: Therefore, the association between the presence of bacteria from the ESKAPE group and the inherent health damages of patients with COVID-19 cannot be underestimated. It is necessary to follow up with new studies to prevent diseases and promote health based on information about the main complications, promoting interventions and reducing the morbidity and mortality of these patients.

Author Biographies

Edlainny Araujo Ribeiro, Faculdade de Ensino Superior da Amazônia Reunida

Graduada em Biomedicina (Patologia clínica/ Análises clínicas) pela Faculdade
de Ensino Superior da Amazônia Reunida (2015). Especialista em Microbiologia Clínica pela Academia de Ciência e Tecnologia de São José do Rio Preto (2017).
Mestre em Ciências Ambientais e Saúde (Pontifícia Universidade Católica de Goiás- 2019). Atualmente é aluna de doutorado do programa de pós graduação em
infectologia pela Universidade Federal de São Paulo. O

Gleykciana Cavalcante Torres, Faculdade de Ensino Superior da Amazônia Reunida

Estudante no curso de Medicina.

Grazielly Ferreira Rodrigues, Faculdade de Ensino Superior da Amazônia Reunida

Estudante no curso de Medicina.

Joicy Araujo Gomes Alves, Sociedade Beneficente Israelita Brasileira Albert Einstein

Biomédica, Sociedade Beneficente Israelita Brasileira Albert Einstein: Aparecida de Goiânia, Goias, BR.

 

References

Adalbert, J. R., Varshney, K., Tobin, R., & Pajaro, R. (2021). Resultados clínicos em pacientes co-infectados com COVID-19 e Staphylococcus aureus: uma revisão de escopo. BMC Infectious Diseases. 21(1), 985.10.1186/s12879-021-06616-4

Chan, X. H. S., O’Connor, C. J., Martyn, E., Clegg, A. J., Choy, B. J. K., Soares, A. L., A. L., Shulman, R., Stone, N., De, S., Bitmead, J., Hail, L., Brealey, D., Arulkumaran, N., Singer, M., & Wilson, A. P. R. (2022). Reducing broad-spectrum antibiotic use in intensive care unit between first and second waves of COVID-19 did not adversely affect mortality. The Journal of Hospital Infection, 124, 37–46.10.1016/j.jhin.2022.03.007

Chong, W. H., Saha, B. K., Ramani, A., & Chopra, A. (2021). State-of-the-art review of secondary pulmonary infections in patients with COVID-19 pneumonia. Infection, 49(4), 591–605.10.1007/s15010-021-01602-z

De Pascale, G., De Maio, F., Carelli, S., De Angelis, G., Cacaci, M., Montini, L., Bello, G., Cutuli, S. L., Pintaudi, G., Tanzarella, E. S., Xhemalaj, R., Grieco, D. L., Tumbarello, M., Sanguinetti, M., Posteraro, B., & Antonelli, M. (2021). Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis. Critical Care (London, England), 25(1), 197.10.1186/s13054-021-03623-4

Deshommes, T., Nagel, C., Tucker, R., Dorcélus, L., Gautier, J., Koster, M. P., & Lechner, B. E. (2021). A Quality Improvement Initiative to Increase Hand Hygiene Awareness and Compliance in a Neonatal Intensive Care Unit in Haiti. Journal of tropical pediatrics, 67(3), fmaa029. https://doi.org/10.1093/tropej/fmaa029

Díaz, M. A., Durán-Manuel, E. M., Cruz-Cruz, C., Ibáñez-Cervantes, G., Rojo-Gutiérrez, M. I., Moncayo-Coello, C. V., Loyola-Cruz, M. Á., Castro-Escarpulli, G., Hernández, D., & Bello-López, J. M. (2021). Impact of the modification of a cleaning and disinfection method of mechanical ventilators of COVID-19 patients and ventilator-associated pneumonia: One year of experience. American journal of infection control, 49(12), 1474–1480. https://doi.org/10.1016/j.ajic.2021.09.012

Fernandes, T. P., Abreu, C. M. de, Rocha, J. O., Bianchetti, L. de O., Sales, L. de A., Alves, M. Q., Prates, M. E., Lemes, N. M., Vieira, S. D., & Corrêa, M. I. (2021). Infecções secundárias em pacientes internados por COVID-19: consequências e particularidades associadas. Revista Eletrônica Acervo Científico, 34, e8687.10.25248/reac.e8687.2021

Firth, A., & Prathapan, P. (2020). Azithromycin: The first broad-spectrum therapeutic. European Journal of Medicinal Chemistry, 207(112739), 112739.10.1016/j.ejmech.2020.112739

Foschi, C., Zignoli, A., Gaibani, P., Vocale, C., Rossini, G., Lafratta, S., Liberatore, A., Turello, G., Lazzarotto, T., & Ambretti, S. (2021). Respiratory bacterial co-infections in intensive care unit-hospitalized COVID-19 patients: Conventional culture vs BioFire FilmArray pneumonia Plus panel. Journal of microbiological methods, 186, 106259. https://doi.org/10.1016/j.mimet.2021.106259

Founou, R. C., Founou, L. L., & Essack, S. Y. (2017). Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis. PloS One, 12(12), e0189621. doi:10.1371/journal.pone.0189621

Fracarolli, I. F. L., Oliveira, S. A. de, & Marziale, M. H. P. (2017). Colonização bacteriana e resistência antimicrobiana em trabalhadores de saúde: revisão integrativa. Acta Paulista de Enfermagem, 30(6), 651–657.10.1590/1982-0194201700086

He, F., Xia, X., Nie, D., Yang, H., Jiang, Y., Huo, X., Guo, F., Fang, B., Hu, B., Jiang, H., Zhan, F., & Lv, J. (2020). Respiratory bacterial pathogen spectrum among COVID-19 infected and non–COVID-19 virus infected pneumonia patients. Diagnostic Microbiology and Infectious Disease, 98(4), 115199.10.1016/j.diagmicrobio.2020.115199

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., & Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395(10223), 497–506.10.1016/S0140-6736(20)30183-5

Hughes, S., Troise, O., Donaldson, H., Mughal, N., & Moore, L. S. P. (2020). Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical. Microbiology and Infectious Diseases, 26(10), 1395–1399.10.1016/j.cmi.2020.06.025

Husain, M., Valayer, S., Poey, N., Rondinaud, E., d’Humières, C., Visseaux, B., & Deconinck, L. (2022). Pulmonary bacterial infections in adult patients hospitalized for COVID-19 in standard wards. Infectious Diseases Now, 52(4), 208–213.10.1016/j.idnow.2021.12.001

Ibáñez, C. G., Bravata-Alcántara, J. C., Nájera-Cortés, A. S., Meneses-Cruz, S., Delgado-Balbuena, L., Cruz-Cruz, C., & Bello-López, J. M. (2020). Disinfection of N95 masks artificially contaminated with SARS-CoV-2 and ESKAPE bacteria using hydrogen peroxide plasma: Impact on the reutilization of disposable devices. American Journal of Infection Control, 48(9), 1037–1041.10.1016/j.ajic.2020.06.216

Jorge, G. P., Goes, I., & Gontijo, M. (2022). Les misérables: a Parallel Between Antimicrobial Resistance and COVID-19 in Underdeveloped and Developing Countries. Current infectious disease reports, 1–12. Advance online publication. https://doi.org/10.1007/s11908-022-00788-z

Karami, Z., Knoop, B. T., Dofferhoff, A., Blaauw, M., Janssen, N. A., van Apeldoorn, M., Kerckhoffs, A., van de Maat, J. S., Hoogerwerf, J. J., & Ten Oever, J. (2021). Few bacterial co-infections but frequent empiric antibiotic use in the early phase of hospitalized patients with COVID-19: results from a multicentre retrospective cohort study in The Netherlands. Infectious diseases (London, England), 53(2), 102–110. https://doi.org/10.1080/23744235.2020.1839672

Knight, G. M., Glover, R. E., McQuaid, C. F., Olaru, I. D., Gallandat, K., Leclerc, Q. J., Fuller, N. M., Willcocks, S. J., Hasan, R., van Kleef, E., & Chandler, C. I. (2021). Antimicrobial resistance and COVID-19: Intersections and implications. eLife, 10, e64139. https://doi.org/10.7554/eLife.64139

Kyriakidis, I., Vasileiou, E., Pana, Z. D., & Tragiannidis, A. (2021). Acinetobacter baumannii Antibiotic Resistance Mechanisms. Pathogens, 10(3), 373.10.3390/pathogens10030373

Lai, C. C., Chen, S. Y., Ko, W. C., & Hsueh, P. R. (2021). Increased antimicrobial resistance during the COVID-19 pandemic. International Journal of Antimicrobial Agents, 57(4), 106324.10.1016/j.ijantimicag.2021.106324

Loyola, M. Á. C., Durán, E. M. M., Cruz, C. C., Márquez, L. M. V., Bravata, J. C. A., Cortés, I. A. O., Cureño, M. A. D., Ibáñez, G. C., Fernández, V. S., Castro, G. E., & Bello, J. M. L. (2022). ESKAPE bacteria characterization reveals the presence of Acinetobacter baumannii and Pseudomonas aeruginosa outbreaks in COVID-19/VAP patients. American journal of infection control, S0196-6553(22)00625-3. Advance online publication. https://doi.org/10.1016/j.ajic.2022.08.012

Mahida, N., Winzor, G., Wilkinson, M., Jumaa, P., & Gray, J. (2022). Antimicrobial stewardship in the post COVID-19 pandemic era: an opportunity for renewed focus on controlling the threat of antimicrobial resistance. The Journal of hospital infection, 129, 121–123. https://doi.org/10.1016/j.jhin.2022.10.001

Melnyk, B. M., & Fineout-Overholt, E. (2005). Making the case for evidence-based practice. In: editor. Evidence-based practice in nursing & healthcare: a guide to best practice. Philadelphia: Lippincott Williams & Wilkins.

Nasir, N., Rehman, F., & Omair, S. F. (2021). Risk factors for bacterial infections in patients with moderate to severe COVID-19: A case-control study. Journal of medical virology, 93(7), 4564–4569. https://doi.org/10.1002/jmv.27000

Nicholson, A. M., Tennant, I. A., Martin, A. C., Ehikhametalor, K., Reynolds, G., Thoms-Rodriguez, C. A., Nagassar, R., Hoilett, T. K., Allen, R., Redwood, T., & Crandon, I. (2016). Hand hygiene compliance by health care workers at a teaching hospital, Kingston, Jamaica. Journal of infection in developing countries, 10(10), 1088–1092. https://doi.org/10.3855/jidc.7083

Oliveira, D., Forde, B. M., Kidd, T. J., Harris, P., Schembri, M. A., Beatson, S. A., Paterson, D. L., & Walker, M. J. (2020). Antimicrobial Resistance in ESKAPE Pathogens. Clinical microbiology reviews, 33(3), e00181-19. https://doi.org/10.1128/CMR.00181-19

OMS, Organização Mundial de Saúde. (2017). A OMS publica lista de bactérias para as quais novos antibióticos são necessários com urgência. https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed. Acesso em 7 de nov. de 2021.

OMS, Organização Mundial de Saúde. (2020). Resistência Antimicrobiana. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance .

O’Toole, R. F. (2021). The interface between COVID-19 and bacterial healthcare-associated infections. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 27(12), 1772–1776.10.1016/j.cmi.2021.06.001

Patel, A., Emerick, M., Cabunoc, M. K., Williams, M. H., Preas, M. A., Schrank, G., Rabinowitz, R., Luethy, P., Johnson, J. K., & Leekha, S. (2021). Rapid Spread and Control of Multidrug-Resistant Gram-Negative Bacteria in COVID-19 Patient Care Units. Emerging infectious diseases, 27(4), 1234–1237. https://doi.org/10.3201/eid2704.204036

Pochtovyi, A. A., Vasina, D. V., Kustova, D. D., Divisenko, E. V., Kuznetsova, N. A., Burgasova, O. A., & Gintsburg, A. L. (2021). Contamination of hospital surfaces with bacterial pathogens under the current COVID-19 outbreak. International Journal of Environmental Research and Public Health, 18(17), 9042. doi:10.3390/ijerph18179042

Rhoades, N. S., Pinski, A. N., Monsibais, A. N., Jankeel, A., Doratt, B. M., Cinco, I. R., & Messaoudi, I. (2021). Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose. Cell Reports, 36(9), 109637.10.1016/j.celrep.2021.109637

Rodríguez, M. A., López, Y. V., Soto, J. L. H., Miranda, M. G. N., Flores, K. M., & Ponce de León, S. R. (2021). COVID-19: Clouds over the antimicrobial resistance landscape. Archives of Medical Research, 52(1), 123–126.10.1016/j.arcmed.2020.10.010

Rossato, L., Negrão, F. J., & Simionatto, S. (2020). Could the COVID-19 pandemic aggravate antimicrobial resistance?. American Journal of Infection Control, 48(9), 1129–1130.10.1016/j.ajic.2020.06.192

Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., Sigfrid, L., Harrison, E. M., Docherty, A. B., de Silva, T. I., Egan, C., Pius, R., Hardwick, H. E., Merson, L., Girvan, M., Dunning, J., Nguyen-Van-Tam, J. S., Openshaw, P., Baillie, J. K., Semple, M. G., & ISARIC4C investigators (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. The Lancet. Microbe, 2(8), e354–e365. https://doi.org/10.1016/S2666-5247(21)00090-2

Saha, M., & Sarkar, A. (2021). Review on multiple facets of drug resistance: A rising challenge in the 21st century. Journal of Xenobiotics, 11(4), 197–214:10.3390/jox11040013

Segala, F. V., Bavaro, D. F., Di Gennaro, F., Salvati, F., Marotta, C., Saracino, A., Rita, M., & Fantoni, M. (2021). Impact of SARS-CoV-2 epidemic on antimicrobial resistance: A literature review. Viruses, 13(11), 2110.10.3390/v13112110

Sharifipour, E., Shams, S., Esmkhani, M., Khodadadi, J., Fotouhi-Ardakani, R., Koohpaei, A., Doosti, Z., & Ej Golzari, S. (2020). Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU. BMC infectious diseases, 20(1), 646. https://doi.org/10.1186/s12879-020-05374-z

Silva, D. L., Lima, C. M., Magalhães, V., Baltazar, L. M., Peres, N., Caligiorne, R. B., Moura, A. S., Fereguetti, T., Martins, J. C., Rabelo, L. F., Abrahão, J. S., Lyon, A. C., Johann, S., & Santos, D. A. (2021). Fungal and bacterial coinfections increase mortality of severely ill COVID-19 patients. The Journal of hospital infection, 113, 145–154. https://doi.org/10.1016/j.jhin.2021.04.001

Stringhetta, G. R., Saad, B. A. A., & Almeida, E. B. (2022). Mortalidade e alterações de parâmetros laboratoriais na presença de culturas positivas para bactérias e fungos em pacientes críticos com COVID-19 em hospital terciário de ensino de Mato Grosso do Sul, Brasil. Brasil. Research, Society and Development, 11(2), e51011225992.

Wade, T., Heneghan, C., Roberts, N., Curtis, D., Williams, V., & Onakpoya, I. (2021). Healthcare-associated infections and the prescribing of antibiotics in hospitalized patients of the Caribbean Community (CARICOM) states: a mixed-methods systematic review. The Journal of Hospital Infection, 110, 122–132.10.1016/j.jhin.2021.01.012

Westblade, L. F., Simon, M. S., & Satlin, M. J. (2021). Bacterial Coinfections in Coronavirus Disease 2019. Trends in microbiology, 29(10), 930–941. https://doi.org/10.1016/j.tim.2021.03.018

Wu, H. Y. (2022). Coronavirus disease 2019 (COVID-19) associated bacterial coinfection: Incidence, diagnosis and treatment. Wei mian yu gan ran za zhi. Journal of microbiology.

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England), 395(10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3

Published

27/11/2022

How to Cite

RIBEIRO, E. A.; TORRES, G. C. .; RODRIGUES, G. F. .; ALVES, J. A. G. Secondary infections caused by ESKAPE group bacteria and impact on the health of patients with Covid-19 complications – an integrative review. Research, Society and Development, [S. l.], v. 11, n. 15, p. e289111537997, 2022. DOI: 10.33448/rsd-v11i15.37997. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/37997. Acesso em: 13 nov. 2024.

Issue

Section

Health Sciences