Analysis of oral changes in hospitalized patients with Covid-19: a retrospective cohort study

Authors

DOI:

https://doi.org/10.33448/rsd-v11i17.38243

Keywords:

Coronavirus infections; Oral manifestations; Hospital assistance.

Abstract

The outbreak of a new coronavirus was identified in Wuhan, China in late 2019. SARS-CoV-2, spreads through salivary droplets from a carrier causing a respiratory illness. Its clinical behavior is variable and manifests itself with mild symptoms, moderate or developing a severe respiratory infection. The oral cavity was identified as a gateway for the virus and evaluating its possible role as an aggravating factor in the infectivity and progression of the infection was the objective of this study. A retrospective cohort study was performed with data from 274 medical records of patients with COVID-19. They were collected at the patient's admission, with seven and fourteen days to analyze the occurrence of oral alterations and relate them to the severity of the infection. In total, 154 patients had oral alterations. The most frequent oral alteration was the presence of ulcerations in the mucosa at the three collection times (T0, T1 and T2). Complementary tests were red blood cells, platelets, leukocytes, bleeding time, TGP, TGO, albumin, creatinine, CRP, urea, d-dimer and leukocyte-lymphocyte ratio. No predictors were observed for the development of oral changes in patients with COVID 19. Changes in the oral mucosa were observed in most of the patients analyzed. An association between diabetic patients and the presence of oral lesions was observed in the evaluated patients, after 7 and 14 days. The study revealed that patients with changes in the oral mucosa had a more severe evolution of COVID-19, including death, indicating that the presence of oral changes may be related to an unfavorable prognosis of the infection.

References

Al-khatib, A. (2020).Oral manifestations in COVID-19 patients. Oral Diseases. 1–2.

Amorim, dos S., et al.(2020). Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? Int J Infect Dis. 97:326-328.

Association Of Brazilian Intensive Medicine (AMIB). In the ICU, the safety of the team is fundamental!

Baeder, F. M., et al. (2021). Oral lesions in patients infected with SARS-CoV-2: a case series. Research, Society and Development, 10(4), e45410414349-e45410414349. Accessed on: 1 Mar.

Special Epidemiological Bulletin 71| Health Surveillance Secretariat | Ministry of Health. (2021).Coronavirus disease COVID-19. Epidemiological Week 27 (7/4 to 7/10/2021);2021.

Brandão, et al. (2021). Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? Oral Surg Oral Med Oral Pathol Oral Radiol. 131(2), e45-e51, 10.1016/j.oooo.2020.07.014.

Carrillo-Larco, R. M., & Altez-fernandez, C.(2021). Anosmia and dysgeusia in COVID-19: A systematic review. Wellcome Open Res, 94(5).

Chaux-Bodard, A. G., Deneuve, S., & Desoutter, A. (2021). Oral manifestation of Covid-19 as an inaugural symptom? J Oral Med Oral Surg; 26(2), 18.

De Maria, A. et al.(2021). High prevalence of olfactory and taste disorder during SARS-CoV-2 infection in outpatients. J Med Virol, 92(11), 2310-1. 10.1002/jmv.25995.

Diaz Rodriguez, M., Jimenez Romera, A., & Villarroel, M. (2020). Oral manifestations associated with Covid-19. Oral Diseases.

Dietz, L., et al. (2019). Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission. mSystems, 5(2), e00245-20, 2020. 10.1128/mSystems.00245-20.

González-Moles, M. A., & Ramos-García, P. (2021). State of Evidence on Oral Health Problems in Diabetic Patients: A Critical Review of the Literature. J Clin Med. Nov 18;10(22):5383.

Guan, W., Ni. Z, Hu, Y., Liand, W., Or, C., et al. (2021). Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med; v. 382, no. 18, 2020, p. 1708-1720. Accessed on: 1 Mar.

Hockova, B., Riad, A., Valky, J., Šulajová, Z., Stebel, A., Slávik, R., Beˇcková, Z., Pokorna, A., Klugarová, J., & kplace. M. (2021). Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases. J.Clin. Med.10, 581.

Machhi, J., Herskovitz, J., SEnan, A. M., Dutta, D., Nath, B., et al. (2021). The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. J Neuroimmune Pharmacol, p.1-28, 2020. 10.1007/s11481-020-09944-5.

World Health Organization. Smoking and COVID-19. (2020). Scientific Brief, 30 June 2020; World Health Organization: Geneva, Switzerland,

Pedrosa, M., Sipert, C. R., & Nogueira, F. N. (2020). Salivary Glands, Saliva and Oral Presentations in COVID-19 infection. SCIelo.

Pedrosa, M. D. S., & Neves Nogueira, F. (2020). COVID-19 and Diabetes: What Should We Expect? J Diabetes Sci Technol. 14 (6): 1133-4. https://doi.org/ 10.1177/1 932296820948041.

Petrescu, N., Lucaciu, O., & Roman, A. (2020). Oral mucosal lesions in COVID-19. Oral Dis. Jun 19:10.1111/odi.13499. 10.1111/odi.13499. Epub ahead of print. PMID: 32558983; PMCID: PMC7323044.

Pfützner, A., Lazzara, M., & Jantz, J. (2021). Why do People with Diabetes Have a High Risk for Severe COVID-19 Disease? A Dental Hypothesis and Possible Prevention Strategy. J Diabetes Sci Technol. 2020; 14(4):769-71. https://doi. org / 10.1177 / 1932296820930287.

Riad, A., Klugar, M., & krsek, M. (2020). COVID-19 Related Oral Manifestations, Early Disease Features? Oral Dis. 10.1111/odi.13516. (Online before printing).

Rohani B. ((2019). Oral manifestations in patients with diabetes mellitus. World J Diabetes. Sep 15;10(9):485-489. 10.4239/wjd.v10.i9.485.

Sinadinos, A., & Shelswell, J. (2020). Oral ulceration and blistering in patients with COVID-19. Evid Based Dent. 21(2):49

Stanko, P., & Izakovicova Holla, L. (2014). Bidirectional association between diabetes mellitus and inflammatory periodontal disease. The review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. Jan 158(1):35-8.

Wang, C., Wu, H., Ding, X., JI, H., JIao, P., et al. (2020). Does infection of 2019 novel coronavirus cause acute and/or chronic sialadenitis? Med Hypotheses, v. 140, p. 109789.

Xu, H., zhong, L., Deng, J., Peng, J., Dan, H., et al. (2021). High expression of the SARS-CoV-2 ACE2 receptor in oral mucosal epithelial cells. Int J Oral Sci, 12(1), 8, 2020.

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., et al. (2021). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet, 395(10229), 1054-1062

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Published

23/12/2022

How to Cite

SERRÃO, M. do C. P.; BAEDER, F. M. .; SILVA, D. F. .; ALBUQUERQUE, A. C. L. de .; OLIVEIRA, P. T. de . Analysis of oral changes in hospitalized patients with Covid-19: a retrospective cohort study. Research, Society and Development, [S. l.], v. 11, n. 17, p. e137111738243, 2022. DOI: 10.33448/rsd-v11i17.38243. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/38243. Acesso em: 5 nov. 2024.

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Section

Health Sciences