Environmental and genetic factors associated with the development of Type 2 Diabetes mellitus: systematic review
DOI:
https://doi.org/10.33448/rsd-v11i16.38325Keywords:
Type 2 diabetes mellitus; Genetic markers; Biomarkers.Abstract
Type 2 Diabetes mellitus is one in which the amount of insulin is unable to supply the supply of glucose, it is one of the diseases that affects people in the world. The developmental factors are environmental factors and genetic factors, both of which can be slowed down if people adhere to a healthy lifestyle. The main objective of this work is to seek to understand and describe the environmental and genetic factors in DM2. This is a systematic review of articles published from 2012 to 2022 written in Portuguese, Spanish and English. Exclusion criteria were: articles published before 2015, that are not written in Portuguese, Spanish or English and that do not have information related to DM2. 19 articles were selected for this study, only 10 were included and 9 supported the arguments suggested by the main ones. The following were described as environmental factors: obesity, poor eating habits, sedentary lifestyle, cardiovascular disease, tuberculosis and hypertension. Genetic factors: Polymorphism of the XRCC3 T241M, XRCC1 399Gln and FTO rs3751812 genes and genetic damage to β-pancreatic cells. It can be concluded that the basis of the pathogenesis of DMT2 comes from bad habits and sedentary lifestyle and underlying diseases, factors that are easily prevented with changes in quality of life, better eating habits and the practice of physical exercises. As for other factors such as genetics, their discovery may suggest a style that will delay the onset of DMT2.
References
Aquino, I. de S. (2017). Como escrever artigos científicos. Saraiva Educação SA.
Assumpção, D. D., Ruiz, A. M. P., Borim, F. S. A., Neri, A. L., Malta, D. C., & Francisco, P. M. S. B. (2022). Hábito alimentar de idosos diabéticos e não diabéticos: Vigitel, Brasil, 2016. Arquivos Brasileiros de Cardiologia, 118, 388-397. https://www.scielo.br/j/abc/a/JgCJhQJGDnhnzxTmxnxPkGS/ abstract/?lang=pt
Belén, L., Rossi, M. L., Alorda, M. B., Maffei, L., Squillace, C., Olivaa, M. L., & Torresani, M. E. (2018). Factores asociados a glucemia alterada en ayunas en mujeres adultas no diabéticas. Revista argentina de endocrinología y metabolismo, 55(4), 31-40. http://www.scielo.org.ar/scielo.php?pid=S1851-30342018000400031&script=sci_abstract&tlng=en
Boronat, M., Tugores, A., Saavedra, P., Garay, P., Bosch, E., Lorenzo, D., & García-Cantón, C. (2019). Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands. Endocrinología, Diabetes y Nutrición (English ed.), 66(10), 639-646. https://www.sciencedirect.com/science/article/pii/S2530018019301374
Brasil (2020). Secretaria de Atenção Primária à Saúde (SAPS). Pacientes com diabetes contam com investimentos e cuidados no SUS. Saps. https://aps.saude.gov.br/noticia/10336
Corredor, J. C. (2012). Prevalence and characteristics of type 2 diabetics in a Spanish city. DIABETCIEZA 2010. Semergen, 38(1), 9-15. https://pubmed.ncbi.nlm.nih.gov/24847534/
Crispim, D., Estivalet, A. A., Roisenberg, I., Gross, J. L., & Canani, L. H. (2008). Prevalência de 15 mutações no DNA mitocondrial entre pacientes diabéticos tipo 2 com ou sem características clínicas de diabetes e surdez herdados maternalmente. Arquivos Brasileiros de Endocrinologia & Metabologia, 52(8), 1228-1235. https://www.scielo.br/j/abem/a/YyybZtF53scZfT3JgFTwctJ/abstract/?lang=pt
Cruz, O. (2020). Centro Especializado em Obesidade e Diabetes - Tratamento da Obesidade. https://centrodeobesidadeediabetes.org.br/tudo-sobre-obesidade/tratamento-da-obesidade/
DC. Diabetes Care (2013). Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, vol 36; Suplement 1. https://diabetesjournals.org/care/article/36/Supplement_1/S67/27252/Diagnosis-and-Classification-of-Diabetes-Mellitus
DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., ... & Weiss, R. (2015). Type 2 diabetes mellitus. Nature reviews Disease primers, 1(1), 1-22. https://www.nature.com/articles/nrdp201519
de Oliveira, R. E. M., Ueta, J., & Franco, L. J. (2018). Adesão ao tratamento medicamentoso do diabetes mellitus tipo 2: diferenças de gênero. Revista de APS, 21(3). http://periodicos.ufjf.br/index.php/aps/article/view/16395
Díaz, M. S. (2014). Prevención de la diabetes tipo 2 mediante la dieta mediterránea y grasas vegetales: El estudio PREDIMED (PREvención con DIeta MEDiterránea). SEMERGEN, Soc. Esp. Med. Rural Gen.(Ed. impr.), 278-279. https://pesquisa.bvsalud.org/portal/resource/pt/ibc-125247
Fernandes, N. S. M. (2013). Alterações metabólicas no diabético (Dissertação em Ciências Farmacêuticas, Universidade Fernando Pessoa). https://bdigital.ufp.pt/handle/10284/4476
Gómez, O. G., Pérez, L. A. T., Vázquez, Y. E. G., Carralero, W. J. R., & Milord, R. B. (2021). Riesgo estimado de padecer diabetes mellitus tipo 2 en pacientes hipertensos con tratamiento farmacológico. Revista Cubana de Medicina General Integral, 37(1), 1-8.
Henzen, C. (2012). Monogenic diabetes mellitus due to defects in insulin secretion. Swiss medical weekly, (39). https://smw.ch/article/doi/smw.2012.13690/
IDF. International Diabetes Federation (2019). Diabetes Atlas. 10ª ed. Lisboa: IDF.
Izquierdo, D. M., & Jiménez, J. V. (2015). Detección precoz de pacientes con riesgo de diabetes mellitus en la atención primaria de salud. Revista Médica Electrónica, 37(5), 469-478. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242015000500006
Jehan, T., & Lakhanpaul, S. (2006). Single nucleotide polymorphism (SNP)–Methods and applications in plant genetics: A review. Indian Journal of Biotechnology, 5, 435-459.
Lima, A. C. S. (2011). Fatores de risco para diabetes mellitus tipo 2 em universitários de Fortaleza-CE. Dissertação (Mestrado em Enfermagem) - Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza.
Lima, A. C. S., Araújo, M. F. M., Freitas, R. W. J. F. D., Zanetti, M. L., Almeida, P. C. D., & Damasceno, M. M. C. (2014). Risk factors for Type 2 Diabetes Mellitus in college students: association with sociodemographic variables. Revista latino-americana de enfermagem, 22, 484-490. https://www.scielo.br/j/rlae/a/dSXkrfqdsYkLyKPpMYdCcCz/abstract/?lang=en
Mardones, L., Petermann-Rocha, F., Martínez-Sanguinetti, M. A., Leiva, A. M., CA, T. P., Martorell, M., ... & Villagrán, M. (2019). Association of rs3751812 polymorphism of the FTO gene with adiposity and metabolic markers in Chilean population. Results of the GENADIO study. Nutricion Hospitalaria, 36(3), 589-598. https://europepmc.org/article/med/30983372
Martínez, B. S., Falcón, V. V., & Martínez, N. G. (2021). Predicción de la diabetes mellitus tipo 2 en pacientes adultos mediante regresión logística binaria. Dilemas contemporáneos: educación, política y valores, 8(3). http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2007-78902021000200051
Oliveira, C. S., Furuzawa, G. K., & Reis, A. F. (2002). Diabetes mellitus do tipo MODY. Arquivos Brasileiros de Endocrinologia & Metabologia, 46, 186-192. https://www.scielo.br/j/abem/a/MxNLYQ3tczT3gjVtpFN3jPJ/?lang=pt&format=html
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2022). A declaração PRISMA 2020: diretriz atualizada para relatar revisões sistemáticas. Epidemiologia e Serviços de Saúde, 31(2). http://scielo.iec.gov.br/pdf/ess/v31n2/2237-9622-ess-31-02-e2022107.pdf
Petermann, F., Diaz-Martinez, X., Garrido-Mendez, A., Leiva, A. M., Martínez, M. A., Salas, C., ... & Celis-Morales, C. (2017). Association between type 2 diabetes and physical activity in individuals with family history of diabetes. Gaceta sanitaria, 32(3), 230-235. https://europepmc.org/article/med/29203323?testing&client=bot
Prados, M., Flores-Le Roux, J. A., Benaiges, D., Llauradó, G., Chillarón, J. J., Paya, A., & Pedro-Botet, J. (2019). Gestational diabetes mellitus in a multiethnic population in Spain: Incidence of and factors associated to impaired glucose tolerance one year after delivery. Endocrinología, Diabetes y Nutrición (English ed.), 66(4), 240-246. https://www.sciencedirect.com/science/article/pii/S253001801930054X
Reis, A. F., & Velho, G. (2002). Bases genéticas do diabetes mellitus tipo 2. Arquivos Brasileiros de Endocrinologia & Metabologia, 46, 426-432. https://www.scielo.br/j/abem/a/mW3n348zKRf3Csmtb88xkGm/abstract/?lang=pt
SBD. Sociedade Brasileira De Diabetes (2021). Diabetes cresce mais rapidamente entre mulheres, durante a pandemia. https://diabetes.org.br/diabetes-cresce-mais-rapidamente-entre-mulheres-durante-a-pandemia/
Schmidt, A. M. (2018). Highlighting diabetes mellitus: the epidemic continues. Arteriosclerosis, thrombosis, and vascular biology, 38(1), e1-e8. https://www.ahajournals.org/doi/abs/10.1161/ATVBAHA.117.310221
Souza, M. D. G. D., Vilar, L., Andrade, C. B. D., Cordeiro, L. H. D. O., Campos, J. M., & Ferraz, Á. A. B. (2015). Prevalência de obesidade e síndrome metabólica em frequentadores de um parque. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 28, 31-35. https://www.scielo.br/j/abcd/a/KSsgnBbQgmXPrQTpnNygh8p/?format=html&lang=en
Toprak, K., Görpelioglu, S., Özsoy, A., Özdemir, S., & Ayaz, A. (2022). Does fetuin-A mediate the association between pro-inflammatory diet and type-2 diabetes mellitus risk?. Nutrición hospitalaria: Organo oficial de la Sociedad española de nutrición parenteral y enteral, 39(2), 383-392. https://dialnet.unirioja.es/servlet/articulo?codigo=8403088
Üstay, Ö., Apaydın, T., Elbasan, O., Polat, H., Günhan, G., Dinçer, C., ... & Yavuz, D. G. (2022). When do we need to suspect maturity onset diabetes of the young in patients with type 2 diabetes mellitus? Archives of Endocrinology and Metabolism, 66, 32-39. https://www.scielo.br/j/aem/a/cDdmcHVx3Vwh6vrRCWKZhGM/abstract/?lang=en
Uyaguari-Matute, G. M., Mesa-Cano, I. C., Ramírez-Coronel, A. A., & Martínez-Suárez, P. C. (2021). Factores de riesgo para desarrollar diabetes mellitus II. Vive Revista de Salud, 4(10), 96-106. http://www.scielo.org.bo/scielo.php?pid=S2664-32432021000100096&script=sci_arttext
Velasco, J. R., Cunalema, J. A., Basurto, I. M., Eguiguren, M. R., & Lozano, M. M. (2020). Evaluación del riesgo de diabetes mellitus tipo 2 en pacientes afectados con tuberculosis. Enfermería Global, 19(57), 151-166. https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1695-61412020000100005
Velázquez-Paniagua, M., González-Sánchez, I., Díaz-Tamariz, A., García-Peláez, M. I., Ángeles-Aguilar, L. L., Ayala-Orta, S. X., ... & Coronel-Cruzc, C. (2021). Autofagia en las células beta pancreáticas y su papel en la diabetes mellitus tipo 2. Revista de la Facultad de Medicina (México), 64(6), 9-25. http://www.scielo.org.mx/scielo.php?pid=S0026-17422021000600009&script=sci_arttext
Yesil-Devecioglu, T., Dayan, A., Demirtunc, R., & Sardas, S. (2019). Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy. Endocrinología, Diabetes y Nutrición, 66(2), 90-98.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Alexandre Menezes Mendonça; Joane Araújo Moura; Paula Beatriz de Oliveira Araújo; Shirley Dantas Almeida
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
