Evidence that polypharmacy makes difficulty adherence to treatment of patients with Diabetes Mellitus
DOI:
https://doi.org/10.33448/rsd-v11i17.38721Keywords:
Polypharmacy; Treatment adherence; Diabetes Mellitus.Abstract
The present study aimed at the association between polypharmacy and adherence to treatment in patients with Diabetes Mellitus. It constitutes an integrative literature review. The integrative review was carried out in six stages: 1) Identification of the theme and selection of the research's guiding question; 2) Establishment of criteria for inclusion and exclusion of studies and search in the literature; 3) Definition of the information to be extracted from the selected studies; 4) Categorization of studies; 5) Evaluation of studies included in the integrative review and interpretation and 6) Presentation of the review. It was concluded, therefore, that polypharmacy is one of the consequences of the treatment of Diabetes Mellitus, and that, in most cases, this practice is essential for good control and treatment of this morbidity. On the other hand, with regard to adherence, the need for patient education regarding medication, professional involvement and respect for the beliefs of patients with this disease are shown. Therefore, it is essential that there are more studies and data collection that address this theme, since the selected ones presented limitations, with no relationship between polypharmacy, treatment and adherence explicitly pointed out.
References
Al‐Musawe, L., Torre, C., Guerreiro, J. P., Rodrigues, A. T., Raposo, J. F., Mota‐Filipe, H., & Martins, A. P. (2020). Polypharmacy, potentially serious clinically relevant drug‐drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life. Pharmacology research & perspectives, 8(4), e00621.
Atinga, R. A., Yarney, L., & Gavu, N. M. (2018). Factors influencing long-term medication non-adherence among diabetes and hypertensive patients in Ghana: a qualitative investigation. PloS one, 13(3), e0193995.
Botrel, F. Z., Faria, K. J. Batista, B. A., Nascimento, G. F., Diniz, M. M., Morais, A. A., & Cortez, D. N. (2021). Adesão à terapêutica medicamentosa e fatores associados em Diabetes Mellitus tipo 2. Medicina (Ribeirão Preto), 54(4).
Brum, H. C., dos Santos, A. M., Carneiro, L. S. Chaud, L. C. S., & Urias, G. M. P. C. (2016). Estudo do perfil farmacoterapêutico de pacientes idosos portadores de diabetes tipo II. Revista Ciência e Saúde On-line, 1(3).
Cândido, R.C.F. (2019). Desprescrição – reduzindo a polifarmácia e prevenindo erros de medicação. https://www.ismp-brasil.org/site/noticia/desprescricao-reduzindo-a-polifarmacia-e-prevenindo-erros-de-medicacao.
Chemello, C., & de CASTRO, M. S. (2007). Adaptação de método de orientação de pacientes sobre medicamentos por uma análise de compreensão. Acta Farmacêutica Bonaerense, 25(4), 613.
Coutinho, D. F., de Figueiredo, R. C., Duncan, B. B., Schmidt, M. I., Barreto, S. M., & Diniz, M. D. F. H. S. (2021). Association between control of diabetes mellitus and polypharmacy at the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil). Pharmacoepidemiology and Drug Safety, 30(6), 749-757.
da Silva Córralo, V., Marconatto Binotto, V., Bohnen, L. C. Gonzaga dos Santos, G. A., & De-Sá, C. A. (2018). Polifarmácia e fatores associados em idosos diabéticos. Revista de Salud Pública, 20, 366-372.
da Silva, A. C. B., Freitas, B. C. G., de Carvalho, B. F., da Conceição Rodrigues, E. L., de Oliveira, F. S., da Costa, I. V., & da Trindade, E. L. (2021). A polifarmácia entre pacientes hipertensos e diabéticos em uma unidade de saúde. Revista Eletrônica Acervo Saúde, 13(8), e8006-e8006.
de Sá Godoi, D. R., Nascimento, K. B. R. Nunes, K. J. F., Silva, T. T. A., & Da Silva, T. K. D. A. (2021). Polifarmácia e ocorrência de interações medicamentosas em idosos. Brazilian Journal of Development, 7(3), 30946-30959.
Geitona, M., Latsou, D., Toska, A., & Saridi, M. (2018). Polypharmacy and adherence among diabetic patients in Greece. The Consultant Pharmacist®, 33(10), 562-571.
Horii, T., Momo, K., Yasu, T., Kabeya, Y., & Atsuda, K. (2019). Determination of factors affecting medication adherence in type 2 diabetes mellitus patients using a nationwide claim-based database in Japan. PloS one, 14(10), e0223431.
Horii, T., Iwasawa, M., Kabeya, Y., & Atuda, K. (2019). Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis. Scientific reports, 9(1), 1-6.
International Diabetes Federation. (2021). IDF Diabetes Atlas 10th ed.
Klinedinst, T. C., Nelson, T. L., Gloeckner, G. W., & Malcolm, M. P. (2022). Depression and polypharmacy are risk factors for activity limitation in type 2 diabetes. Chronic Illness, 18(2), 320-329.
Kubaski, M. L., de Oliveira Nodari, R., & do Amaral, V. (2022). A tênue relação entre polifarmácia e iatrogenia no idoso portador de diabetes mellitus e/ou hipertensão. Saúde Coletiva (Barueri), 12(74), 9782-9793.
Mainardes, V. C., Boregas, F. C. B., Catelan-Mainardes, S. C., & Milani, R. G. (2018). Estudo sobre a polifarmácia e seus fatores associados entre idosos de uma instituição de longa permanência em Maringá-PR.
Oliveira, A. M. D. (2018). Fatores de risco associados à polifarmácia no idoso. Trabalho de Conclusão de Curso (Especialização). UFMG.
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Systematic reviews, 10(1), 1-11.
Peeters, B., Van Tongelen, I., Duran, Z., Yüksel, G., Mehuys, E., Willems, S., ... & Boussery, K. (2015). Understanding medication adherence among patients of Turkish descent with type 2 diabetes: a qualitative study. Ethnicity & Health, 20(1), 87-105.
Penaforte, K. L., Araújo, S. T., Fernandes, V. O., Barbosa, I. V., Cestari, V. R. F., & Montenegro, R. M. (2017). Associação entre polifarmácia e adesão ao tratamento farmacológico em pacientes com diabetes. Rev Rene, 18(5), 632-638.
Peron, E. P., Ogbonna, K. C., & Donohoe, K. L. (2015). Antidiabetic medications and polypharmacy. Clinics in geriatric medicine, 31(1), 17-27.
Santos, C. M. D. C., Pimenta, C. A. D. M., Nobre, M. R. C. (2007). The PICO strategy for the research question construction and evidence search. Revista latino-americana de enfermagem, 15, 508-511.
Sociedade Brasileira de Diabetes. (2019). Diretrizes da Sociedade Brasileira de Diabetes 2019-2020. Clannad Editora Científica.
Silva, P. S., Assis, R. R. L., Taveira, R. A. V., Souza, A. A., Rabelo, C. P. G., & Fagundes, M. J. D. (2010). Educação em Saúde: A Dose Certa para uma Vida Saudável. Agência Nacional de Vigilância Sanitária–Anvisa-Brasília.
Silva, M. R. R. D., Diniz, L. M. Santos, J. B. R. D., Reis, E. A., Mata, A. R. D., Araújo, V. E. D., ... & Acurcio, F. D. A. (2018). Uso de medicamentos e fatores associados à polifarmácia em indivíduos com diabetes mellitus em Minas Gerais, Brasil. Ciência & Saúde Coletiva, 23, 2565-2574.
Świątoniowska-Lonc, N., Tański, W., Polański, J., Jankowska-Polańska, B., & Mazur, G. (2021). Psychosocial Determinants of Treatment Adherence in Patients with Type 2 Diabetes–A Review. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 14, 2701.
Tiktin, M., Celik, S., & Berard, L. (2016). Understanding adherence to medications in type 2 diabetes care and clinical trials to overcome barriers: a narrative review. Current medical research and opinion, 32(2), 277-287.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Natália Paniágua de Andrade; Nayara Francielle de Castro; Valter Paz do Nascimento Junior; Elisabete Aparecida Mantovani Rodrigues de Resende
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
