Relationship of human papillomavirus infection with adverse outcomes in pregnancy and childbirth: an integrative review
DOI:
https://doi.org/10.33448/rsd-v11i17.39192Keywords:
HPV Human Papillomavirus; Pregnancy; Adverse Pregnancy Outcome; Teaching.Abstract
The Human Papilloma Virus (HPV) is one of the viruses that most affects the world's population. Its dissemination can lead to negative outcomes, including some types of cancer. However, when present during pregnancy, it seems to be linked to numerous pathological conditions ranging from premature birth to fetal death. Thus, it is imperative to investigate such an occurrence. Our aim was to assess the relationship between HPV infection and adverse outcomes in pregnancy and childbirth. For this, an integrative review on the subject was conducted in the PubMed, CINAHL and Scopus databases. Other findings were identified on the AskMEDLINE platform. After crossing the terms HPV, Pregnancy and Adverse Pregnancy Outcome, 115 studies were identified. Of these, only 10 fit the question proposed and the eligibility criteria outlined. When identified in pregnant women, the main adverse outcomes caused by HPV infection were premature rupture of membranes, premature birth, and spontaneous abortion. New studies need to expand investigations about the subtype of HPV and its complications in pregnancy.
References
Aldhous, M.C., Bhatia, R., Pollock, R., Vragkos, D., Cuschieri, K., Cubie, H.A., Norman, J.E. & Stock S.J. (2019). HPV infection and pre-term birth: a data-linkage study using scottish health data. Wellcome Open Res, 4, 48.
Alfadhli, E.M. (2021). Maternal obesity influences birth weight more than gestational diabetes. BMC Pregnancy Childbirth, 21, 111.
Bardin, L. (2011). Análise de conteúdo. Edições 70.
Bober, L., Guzowski, G., Moczulska, H. & Sieroszewski, P. (2019). Influence of human Papilloma Virus (hPV) infection on early pregnancy. Ginekol Pol, 90(2), 72-75.
Caballero, A., Dudley, D., Ferguson, J., Pettit, K. & Boyle, A. (2019). Maternal human papillomavirus and preterm premature rupture of membranes: a retrospective cohort study. Journal of Women's Health, 28(5), 606-611.
Cacchione, P. Z. (2016). The evolving methodology of scoping reviews. Clin Nurs Res, 25:115-9.
Cho, G., Min, K. J., Hong, H. R., Kim, S., Hong, J. H., Lee, J. K. et al. (2013). High-risk human papillomavirus infection is associated with premature rupture of membranes. BMC Pregnancy Childbirth, 13, 173.
Conde-Ferráez, L., May, A. D. A. C., Carrillo-Martínez, J. R., Ayora-Talavera, G., del Refugio González-Losa, M. (2013). Human papillomavirus infection and spontaneous abortion: A case-control study performed in Mexico. Eur. J. Obstet. Gynecol. Reprod. Biol, 170, 468–473.
Condrat, C. E., Filip, L., Gherghe, M., Cretoiu, D. & Suciu, N. (2021). Maternal HPV infection: effects on pregnancy outcome. Viruses, 13(12), 2455.
Cotton-Caballero, A., Dudley, D., Ferguson, J., Pettit, K. & Boyle, A. (2017). Maternal human papillomavirus infection increases the risk of premature rupture of membranes. Obstet. Gynecol, 129, S137.
Ford, J. H., Li, M., Scheil, W. & Roder, D. (2019). Human papillomavirus infection and intrauterine growth restriction: a data-linkage study. J Matern Fetal Neonatal Med, 32, 279-285.
Galvão, C. M. (2006). Níveis de evidência. Acta Paulista de Enfermagem, 19(2): 1-5.
Glick, I., Kadish, E. & Rottenstreich, M. (2021). Management of pregnancy in women of advanced maternal age: improving outcomes for mother and baby. Int. J. Womens Health, 13, 751-759.
Hong, J. N., Berggren, E. K., Campbell, S. L., Smith, J. S. & Rahangdale, L. (2014). Abnormal cervical cancer screening in pregnancy and preterm delivery. Paediatr Perinat Epidemiol, 28(4), 297-301.
Hooda, R., Baghla, N., Malik, N. & Kaushik, S. (2022). To evaluate the role of placental human papilloma virus (HPV) infection as a risk factor for spontaneous preterm birth: a prospective case control study. J Perinat Med, 50(4):427-432.
Kim, Y. H., Park, J. S., Norwitz, E. R., Park, J. W., Kim, S. M., Lee S. M. et al. (2014). Genotypic prevalence of human papillomavirus infection during normal pregnancy: a cross-sectional study. J Obstet Gynaecol Res, 40(1), 200-207.
Liu, P., Xu, L., Sun, Y. & Wang, Z. (2014). The prevalence and risk of human papillomavirus infection in pregnant women. Epidemiol. Infect, 142, 1567-1578.
Luo, D., Peng, M., Wei, X, Pan, D., Xue, H., Xu, Y. & Dong, B. (2021). Prevalence of Human Papillomavirus and genotype distribution in pregnant and non-pregnant women in China. Risk Manag. Healthc Policy, 14, 3147–3157.
Marković, S., Bogdanović, G. & Cerovac, A. (2020). Premature and preterm premature rupture of membranes in adolescent compared to adult pregnancy. Med Glas (Zenica), 17(1), 136-140.
McDonnold, M., Dunn, H., Hester, A., Pacheco, L. D., Hankins, G. D., Saade, G. R. & Costantine M. M. (2014). High risk human papillomavirus at entry to prenatal care and risk of preeclampsia. Am. J. Obstet. Gynecol, 210(138), e1–138.
Nadeau, H. C., Subramaniam, A. & Andrews, W. W. (2016). Infection and preterm birth. Semin Fetal Neonatal Med, 21, 100-105.
Nimrodi, M., Kleitman,V., Wainstock, T., Gemer, O., Meirovitz, M., Maymon, E. et al. (2018). The association between cervical inflammation and histologic evidence of HPV in PAP smears and adverse pregnancy outcome in low risk population. Eur J Obstet Gynecol Reprod Biol, 225, 160-165.
Niyibizi, J., Zanré, N., Mayrand, M.-H. & Trottier, H. (2020). Association between maternal human papillomavirus infection and adverse pregnancy outcomes: systematic review and meta-analysis. J Infect Dis, 221(12), 1925-1937.
Pandey, D., Solleti, V., Jain, G., Das, A., Prasada, K. S., Acharya, S. & Satyamoorthy, K. (2019). Human Papillomavirus (HPV) infection in early pregnancy: prevalence and implications. Infectious Diseases in Obstetrics and Gynecology, 2019, e4376902.
Pereira, C. E. P., Lira Neto, J. C. G. & Ferreira, B. O. (2022). Análise dos riscos do uso de cigarros eletrônicos na gravidez: uma revisão integrativa. Research, society and development, 11(10), e185111032797.
Rombaldi, R.L., Serafini, E.P., Mandelli, J., Zimmermann, E. & Losquiavo, K.P. (2009). Perinatal transmission of human papilomavirus DNA. Virol. J, 6, 83.
Salcedo, M. M. B. P., Damin, A. P. S. & Agnes, G. et al. (2015). Prevalence of human papillomavirus infection in pregnant versus non-pregnant women in Brazil. Archives of Gynecology and Obstetrics, 292(6): 1273–1278.
Sehnal, B., Zikan, M., Nipcova, M., Dusek, L., Cibula, D. & Slama, J. (2019). The association among cervical, anal, and oral HPV infections in high-risk and low-risk women. Eur. J. Obstet. Gynecol. Reprod. Biol, 4, e100061.
Slatter, T. L., Hung, N. G., Clow, W. M., Royds, J. A., Devenish, C. J. & Hung, N. A. (2015). A clinicopathological study of episomal papillomavirus infection of the human placenta and pregnancy complications. Mod. Pathol, 28, 1369-1382.
Subramaniam, A., Lees, B. F., Becker, D. A., Tang, Y., Khan, M. J. & Edwards. R. K. (2016). Evaluation of Human Papillomavirus as a risk factor for preterm birth or pregnancy-related hypertension. Obstet. Gynecol, 127, 233-240.
Wiik, J., Nilsson, S., Kärrberg, C., Strander, B., Jacobsson, B. & Sengpiel, V. (2021). Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study. PLoS Med, 18(5), e1003641.
World Health Organization. (2017). Human papillomavirus vaccines: WHO position paper. Vaccine, 35, 5753-5755.
Wu, X., Wang, L. & Xing, Z. (2021). Impact of HPV infection on vaginal microecology and maternal and neonatal outcomes. Journal of Central South University Medical Science, 46(5), 497-502.
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Copyright (c) 2022 Alessandra Aziz Borges Bitar; Naiá Lauria da Silva; José Claudio Garcia Lira Neto; Breno de Oliveira Ferreira
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