Maternal-fetal complications in pregnant women with sickle cell disease

Authors

DOI:

https://doi.org/10.33448/rsd-v11i17.39272

Keywords:

Sickle cell disease; Pregnancy; Pregnancy complications.

Abstract

Objectives: to identify the main maternal and fetal complications in pregnant women with sickle cell disease (SCD). Methods: Bibliographic survey through a literature review with exploratory-descriptive Character, defined by integrative literature review. The research was carried out in May and June 2022, through the Virtual Health Library (BVS) portal and the SciELO, MEDLINE and LILACS databases, totaling 308 materials found by crossing the descriptors: sickle cell anemia; pregnancy complications; pregnancy; maternal-fetal complications. Articles published before 2011 and articles with a sample of a non-pregnant population were excluded. Results: It was observed that most complications are more frequent among HbSS pregnant women, considered the most feared form. Among the complications observed, the following stand out: vaso-occlusive crises, IUGR, prematurity, birth of small-for-gestational age children and acute chest syndrome. Conclusions: SCD in pregnant women causes several serious maternal-fetal complications. Patient education and adequate access to specialized health services can minimize maternal-fetal morbidity and mortality. In addition, knowledge of the pathophysiological changes that occur in the pregnancy of patients with SCD, by health professionals, is essential for the correct management of possible complications that may occur during the gestational period, having great importance in the outcome of this binomial.

References

Babah, O. A., Aderolu, M. B., Oluwole A. A. & Afolabi B. B. (2019). Towards zero mortality in sickle cell pregnancy: A prospective study comparing haemoglobin SS and AA women in Lagos, Nigeria. Nigerian Postgrad Med J, 26(1), 1-7. doi: 10.4103/npmj.npmj_177_18.

Bardin, L. (2011) Análise de conteúdo. São Paulo: Edições 70.

Brasil, Ministério da Saúde. (2015a). Doença falciforme: atenção integral à saúde das mulheres. http://bvsms.saude. gov.br/bvs/publicacoes/doenca_falciforme_atencao_integral_saude_mulher.pdf.

Brasil. Ministério da Saúde. (2015b). Doença falciforme: diretrizes básicas da linha de cuidado. Brasília, 2015b. https://bvsms.saude.gov.br/bvs/publicacoes/doenca_falciforme_diretrizes_basicas_linha_cuidado.pdf.

Brasil, Ministério da Saúde. (2009). Centro de Educação e Apoio para Hemoglobinopatias – CEHMOB-MG [et al.]. Manual de acompanhamento da gestante com doença falciforme. https://www.nupad.medicina.ufmg.br/wp-content/uploads/2016/12/manual_gestante.pdf.

Campos, M. L. A. & Gomes, H. G. (2006). Metodologia de elaboração de tesauro conceitual: a categorização como princípio norteador. Perspectivas em Ciência da Informação, Belo Horizonte, 11 (3), 348-359. http://hdl.handle.net/20.500.11959/brapci/32349.

Cardoso, P. S. R., Aguiar, R. A. L. P. & Viana, M. B. (2014). Clinical complications in pregnant women with sickle cell disease: prospective study of factors predicting maternal death or near miss. Rev bras hematol hemoter, 36(4), 256–263. doi: 10.1016/j.bjhh.2014.05.007.

Costa, V. M. F. (2012). Gravidez na paciente com doença falciforme: resultados maternos e perinatais. [dissertação]. Belo Horizonte: Universidade Federal de Minas Gerais; 2012.

Costa, V. M. F., Viana, M. B. & Aguiar, R. A. L. P. (2015). Pregnancy in patients with sickle cell disease: maternal and perinatal outcomes. J Matern Fetal Neonatal Med., 28(6), 685–689. doi: 10.3109/14767058.2014.928855.

Dauphin-McKenzie, N., Gilles, J. M., Jacques, E. & Harrington, T. (2006). Sickle cell anemia in the female patient. Obstetrical and Gynecological Survey, 61(5), 343-352. doi: 10.1097/01.ogx.0000216976.15100.29.

Dalellaste, S., Reiser, M. N. & Kuse, E. A. (2022). anemia falciforme e gestação: principais complicações. Revista Científica da Faculdade de Educação e Meio Ambiente, 13 (2), 173-179. Doi: http://dx. doi.org/ 10.31072.

Desai, G., Anand, A., Shah, P., Shah, S., Dave, K., Bhatt, H., Desai, S. & Modi, D. (2017). Sickle cell disease and pregnancy outcomes: a study of the community-based hospital in a tribal block of Gujarat, India. Journal of health, population, and nutrition, 36(1), 3. doi: 10.1186/s41043-017-0079-z.

Faye, B. F., Kouame, K. B., Seck, M., Diouf, A. A., Gadji, M., Dieng, N., Touré, S. A., Sall A, Toure AO & Diop S. (2018). Challenges in the management of sickle cell disease during pregnancy in Senegal, West Africa. Hematology, 23(1), 61-64. doi: 10.1080/10245332.2017.1367534.

Galiba Atipo Tsiba, F. O., Itoua, C., Ehourossika, C., Ngakegni, N. Y., Buambo, G., Potokoue Mpia, N. S. B. & Elira Dokekias, A. (2020). Pregnancy Outcomes among Patients with Sickle Cell Disease in Brazzaville. Anemia, 1-4. doi: 10.1155/2020/1989134.

Ganong, L. H. (2010). Integrative reviews of nursing research. Res Nurs Health, 10(1), 1-11. doi: 10.1002/nur.4770100103.

Hernández-Padrón, C., Loreto, T. M., Espinosa-Estrada, E., Ramón-Rodríguez, L. G., Ávila-Cabrera, O. M., Pujadas-Ríos, X. & Agramonte-Llanes, O. (2012). Sickle cell disease and pregnancy. Experience at the Instituto de Hematologia e Inmunología, Cuba. Revista Cubana de Hematologia, 28(4), 416-422. https://www.medigraphic.com/pdfs/revcubheminmhem/rch-2012/rch124j.pdf.

Nomura, R. M. Y., Igai, A. M. K., Tosta, K., Fonseca, G. H. H., Gualandro, S. F. M. & Zugaib, M. (2012). Resultados maternos e perinatais em gestações complicadas por doenças falciformes. Revista Brasileira de Ginecologia e Obstetrícia, 32(8), 405-11. https://doi.org/10.1590/S0100-72032010000800008.

Oakley, L. L., Mitchell, S., von Rege, I., Hadebe, R., Howard, J., Robinson, S. E. & Oteng-Ntim, E. (2022). Perinatal outcomes in women with sickle cell disease: a matched cohort study from London, UK. British Journal of Haematology, 196(1), 1069–1075. doi: 10.1111/bjh.17983.

Obilade, O. A., Akanmu, A. S., Pipkin, F. B. & Afolabi, B. B. (2017). Prostaciclina, tromboxano e taxa de filtração glomerular são anormais na gravidez falciforme. PloS um, 12(9). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589233/.

Oliveira, A. B. M., Mesquita, M. V. N., Junior, E. S. M., Matos, L. F. L., Andrade, S. M., Vieira, J. F. P. N. & Oliveira, E. H. (2022). Perfil de hemoglobinopatias em gestantes: distribuição espacial e análise temporal de 2013 a 2019 no Estado do Piauí, Brasil. Research, Society and Development, 11( 5). doi: http://dx.doi.org/10.33448/rsd-v11i5.27119.

Oteng-Ntim, E., Meeks, D., Seed, P. T., Webster, L., Howard, J., Doyle, P. & Chappell, L. C. (2015). Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis. Blood, 125(21), 3316-25.1 doi: 10.1182/blood-2014-11-607317.

Proske, P.; Distelmaier, L.; Aramayo-Singelmann, C.; Koliastas, N.; Iannaccone, A.; Papathanasiou, M.; Temme, C.; Klump, H.; Lenz, V.; Koldehoff, M.; Carpinteiro, A.; Reinhardt, H.C.; Köninger, A.; Röth, A.; Yamamoto, R.; Dührsen, U & Alashkar, F. (2021). Pregnancies and Neonatal Outcomes in Patients with Sickle Cell Disease (SCD): Still a (High-)Risk Constellation?.. J Pers Med, 11(9), 870. doi: 10.3390/jpm11090870.

Rappaport, V. J., Velazquez, M. & Williams, K. (2004). Hemoglobinopathies in pregnancy. Obstetrics and Gynecology Clinics of North America, 31(2), 287–317. doi: 10.1016/j.ogc.2004.03.006.

Sales, E. K. R. B., Junior, R. N. C. M., Costa, R., Dias, J. C. S. (2019). Prevalência de hemoglobinopatias em gestantes do projeto cegonha, verificadas, no periodo de janeiro a junho de 2019 no estado do Piauí. Research, Society and Development, 9 (2). doi: http://dx.doi.org/10.33448/rsd-v9i2.2224.

Sampaio, S. S. C., Lima, A. A. S., Gonçalves, L. L. M., Neto, L. R. S., Verde, R. M. D. L., Oliveira, E. H. (2021). Prevalência de hemoglobinopatias em gestantes de uma maternidade de referência de Teresina, Piauí, Brasil. Research, Society and Development, 10 (3). doi: http://dx.doi.org/10.33448/rsd-v10i3.11499.

Silva-Pinto, A. C., Ladeira, S. O. D., Brunetta, D. M., De Santis, G. C., Ângulo, I. L. & Covas, D. T. (2014). Sickle cell disease and pregnancy: analysis of 34 patients followed at the Regional Blood Center of Ribeirão Preto, Brazil. Revista brasileira de hematologia e hemoterapia, 36(5), 329–333. doi: 10.1016/j.bjhh.2014.07.002.

Smith-Whitley, K. (2019). Complicações em mulheres grávidas com doença falciforme. Programa de Hematologia Am Soc Hematol Educ., 1 :359-366.

Wethers, D. L. (2000). Sickle cell disease in childhood: part I - laboratory diagnosis, pathophysiology and health maintenance. American Family Physician, 62(5), 1013– 1028. https://pubmed.ncbi.nlm.nih.gov/10997528/.

Wilson, N. O., Ceesay, F. K., Hibbert, J. M., Driss, A., Obed, S. A., Adjei, A. A., Gyasi, R. K., Anderson, W. A. & Stiles, J. K. (2012). Pregnancy outcomes among patients with sickle cell disease at Korle-Bu Teaching Hospital, Accra, Ghana: retrospective cohort study. The American journal of tropical medicine and hygiene, 86(6), 936-942. doi: 10.4269/ajtmh.2012.11-0625.

Published

26/12/2022

How to Cite

ARAÚJO, I. T. S.; GAMA, A. V. Maternal-fetal complications in pregnant women with sickle cell disease. Research, Society and Development, [S. l.], v. 11, n. 17, p. e227111739272, 2022. DOI: 10.33448/rsd-v11i17.39272. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/39272. Acesso em: 24 apr. 2024.

Issue

Section

Health Sciences