Tourette Syndrome: a literary review of the treatments available for the alleviation of tics

Authors

DOI:

https://doi.org/10.33448/rsd-v12i1.39307

Keywords:

Tourette Syndrome; Treatment; Drug therapy; Reduction of tics.

Abstract

Tourette Syndrome (TS) is an early childhood disorder, marked by the presence of multiple motor tics and at least one vocal tic, which, sometimes, can be accompanied by psychiatric comorbidities, Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD). The objective was to carry out an analysis of studies that refer to the treatments currently available for TS, analyzing the priority of recommendation, its effectiveness, its possible harm and its contribution to improving the quality of life of patients. This is a literature review about the main treatments available for TS. The descriptors “tourette syndrome”, “treatments”, “drug therapy” and “obsessive compulsive disorder” were crossed in the Virtual Health Library (VHL), Scientific Electronic Library Online (SciELO), National Library of Medicine (PubMed), EbscoHost and Google Scholar. It has been found that initial treatment for Tourette's Syndrome should be based on Supportive Therapy along with the first line of treatment, with behavioral intervention. If there are no results in reducing tics, the second line of treatment, pharmacological intervention, should be implemented. On the other hand, the third line of treatment, is recommended in about 5% of cases of TS, cases in which previous treatments, like non-drug therapies and drugs, did not have the desired effect. Several lines of treatment act to alleviate the symptoms, thus, the treatment can be characterized as being multifaceted and individualized, as it needs to be developed taking into account the individual's specifications and the expressions of the disease on him.

References

Andrén, P., et al. (2021). European clinical guidelines for Tourette Syndrome and other tics disorders- version 2.0. Part II: psychological interventions. European Child & Adolescent Psychiatry, 31, 403-423.

Anis, S., et al. (2022). Medical Cannabis for Gilles de la Tourette Syndrome: An Open-Label Prospective Study. Hindawi, Behavioural Neurology, 5141773.

Badenoch, J., & Cavanna, A. E. (2020). Pharmacotherapy for tics in adult patients with Tourette syndrome and other tic disorders. Neurological Sciences, 41, 1923-1926.

Billnitzer, A., & Jankovic, J. (2020). Current Management of Tics and Tourette Syndrome: Behavioral, Pharmacologic, and Surgical Treatments. The American Society for Experimental NeuroTherapeutics, 17, 1681-1693.

Dantas, D. M., & Porto, R. M. (2022). Desafios no Tratamento do Indivíduo Portador da Síndrome de Tourette: Uma Revisão Integrativa. Contemporânea –Revista de Ética e Filosofia Política, 2 (3), 228-245.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Ferraz, K. F., et al. (2019). Aripiprazol na Sindrome de Tourette em Adultos: Relato de Caso e Revisão Narrativa. Revista Debates in Psychiatry, 9 (2), 61.

Frey, J., & Malaty, I. A. (2022). Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature. Current Neurology and Neuroscience Reports, 22, 123-142.

Hsu, C. J., Wong, L. C., & Lee, W. T. (2021). Immunological Dysfunction in Tourette Syndrome and Related Disorders. Int. J. Mol. Sci., 22, 853.

Katz, T. M., et al. (2022). Tourettic OCD: Current understanding and treatment challenges of a unique endophenotype. Front Psychiatry, Sec Child and Adolescent Psychiatry, 929526.

Liu, A., et al. (2022). Improved depressive symptoms in patients with refractory Gilles de la Tourette Syndrome after deep brain stimulation of posteroventral globus pallidus interna. Brain and Behavior published by Wiley Periodicals LLC, 12 (7).

Martino, D., et al. (2021). The 5 Pillars in Tourette Syndrome Deep Brain Stimulation Patient Selection. American Academy of Neurology, 96, 664-676.

Mendonça, M. J. M., & Mendes, L. P. B. (2022). Síndrome de Tourette na infância: uma abordagem farmacológica na resolução de tiques. Brazilian Journal of Health Review, 5 (1), 1647-1653.

Milosev, L. M., et al. (2019). Treatment of Gilles de la Tourette Syndrome with Cannabis-Based Medicine: Results from a Retrospective Analysis and Online Survey. Cannabis and Cannabinoid Research, 4 (4).

Muller-Vahl, K. R., et al. (2021). European clinical guidelines for Tourette Syndrome and other tics disorders: summary statment. European Child & Adolescent Psychiatry, 31, 377-382.

Nomura, Y. (2021). Pharmacological Therapy for Tourette Syndrome: What Medicine can do and cannot do. Science Direct Biomedical Journal, 45, 229-239.

Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., & & McKenzie, J. E. (2021). PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. bmj, 372.

Pringheim, T., et al. (2019). Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders. American Academy of Neurology, 92, 907-915.

Quezada, J., & Coffman, K. A. (2018). Current Approaches and New Developments in the Pharmacological Management of Tourette Syndrome. CNS Drugs, 32, 33-45.

Sjezco, N., et al. (2021). European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part IV: deep brain stimulation. European Child & Adolescent Psychiatry, 31 (3), 443-461.

Souza, M. T. d., Silva, M. D. d., & Carvalho, R. d. (2010). Integrative review: what is it? How to do it? Einstein (São Paulo), 8(1), 102–106.

Wang, X., et al. (2022). Stereotactic Surgery for Treating Intractable Tourette Syndrome: a Single-Center Pilot Study. Brain Sci, 12, 838.

Xu, W., et al. (2020). Deep brain stimulation for Tourette’s syndrome. Translational Neurodegeneration, 9 (4).

Published

01/01/2023

How to Cite

NAPOLEÃO, L. D.; ARAUJO, B. C. de .; GUIMARÃES, I. I. da S. M. .; AMÂNCIO, N. de F. G. . Tourette Syndrome: a literary review of the treatments available for the alleviation of tics. Research, Society and Development, [S. l.], v. 12, n. 1, p. e5212139307, 2023. DOI: 10.33448/rsd-v12i1.39307. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/39307. Acesso em: 27 jan. 2023.

Issue

Section

Review Article