The periodontal treatment and the prevention of cardiovascular diseases: integrative literature review
DOI:
https://doi.org/10.33448/rsd-v12i1.39462Keywords:
Periodontitis; Cardiovascular Diseases; Disease prevention.Abstract
Periodontal diseases (PDs) are among the most prevalent inflammatory diseases and have the etiology in microbial infections. Studies reveal the possibility of association between local inflammations and other organs of the body, favoring the spread of oral pathogens. The aim of this study was to conduct an integrative review in order to discuss the relevance of periodontal treatment as an ally in the prevention of cardiovascular diseases (CVDs) and as auxiliary treatment of these diseases. For this, the data were collected using the descriptors in English and Portuguese: ("cardiovascular disease and periodontal disease"; "cardiovascular disease and periodontal disease and inflammation"; cardiovascular disease and periodontal disease and prevention") with clipping between the years 2017-2022. After established inclusion criteria (human studies, regardless of gender, clinical studies, observational, meta-analyses, systematic reviews, publications in portuguese, english and spanish) and exclusion (articles with other approaches on PDs and CVDs different from aspects of the prevention of PDs), the articles were selected for analysis. The results revealed 52 articles that, after excluding the studies: presented theme leak, did not answer the research question or were duplicated, resulting in a total of 26 articles. The present study pointed out that most studies point to an association between apical periodontitis and cardiovascular disease, highlighting the need to approach the subject in the professional training of dentists and the importance of clinical research that corroborates existing studies, favoring greater elucidation of the theme and greater development in management of clinical cases.
References
Almoosawy, S. A. et al. (2021). The oral health status of patients with peripheral vascular disorders: A systematic review. Vascular, 4(29), 556-566.
Aoyama, N. et al. (2019). Increased heart failure prevalence in patients with a high antibody level against periodontal pathogen. International Heart Journal, 5(60), 1142-1146.
Arregocés, F. M. E. et al. (2021). Systemic inflammatory response to non-surgical treatment in hypertensive patients with periodontal infection. Medicine, 13(100).
Bergandi, L. et al. (2019). Endothelial dysfunction marker variation in young adults with chronic apical periodontitis before and after endodontic treatment. Journal of endodontics, 5(45), 500-506.
Bombino, L. P., Pimentel, F. T. P. & Cabarrocas, F. V. (2020). Enfermedad periodontal inflamatoria crónica y enfermedades cardiovasculares. Medicentro Eletrônica, 2(24), 337-359.
Botelho, J. et al. (2021). Periodontal Inflamed Surface Area Mediates the Link between Homocysteine and Blood Pressure. Biomolecules, 11(6), 875.
Czesnikiewicz-Guzik, M. et al. (2019). Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. Eur Heart J, 40(42), 3459-3470.
Erdal, E. et al. (2021). Investigation of patients with coronary slow flow in terms of periodontal health status. Revista da Associação Médica Brasileira, 4(67), 561-565.
Fischer, R. et al. (2021). What is the future of Periodontal Medicine?. Pesquisa oral brasileira, suppl 2(35), local. e102.
Goulart, A. C., Armani, F., Arap, A. M., Nejm, T., Andrade, J. B., Bufarah, H. B., & Dezen, D. H. S. (2017). Relationship between periodontal disease and cardiovascular risk factors among young and middle-aged Brazilians. Cross-sectional study. Sao Paulo Medical Journal, 135, 226-233.
Huang, J. (2019). Association between intensive periodontal treatment and spontaneous intracerebral hemorrhage-a nationwide, population-based cohort study. Medicine (Baltimore), 98(10), e14814.
Ishikawa et al. (2020). Association between presence of 20 or more natural teeth and all-cause, cancer-related, and cardiovascular disease-related mortality: Yamagata (Takahata) prospective observational study. BMC oral health, 20 (1), 353.
Isola, G., Giudice, A. L., Polizzi, A., Alibrandi, A., Patini, R., & Ferlito, S. (2019). Periodontitis and tooth loss have negative systemic impact on circulating progenitor cell levels: a clinical study. Genes, 10(12), 1022.
Isola, G., Polizzi, A., Santonocito, S., Alibrandi, A., & Ferlito, S. (2019). Expression of salivary and serum malondialdehyde and lipid profile of patients with periodontitis and coronary heart disease. International Journal of Molecular Sciences, 20(23), 6061.
Isola, G. et al. (2020). Analysis of Endothelin-1 concentrations in individuals with periodontitis. Scientific reports, 1(10), 1-8.
Isola, G. et al. (2021). Impact of Matrix Metalloproteinase-9 during Periodontitis and Cardiovascular Diseases. Molecules, 26(6), 1777.
Jönsson et al. (2020). Periodontal disease is associated with carotid plaque area: the Malmö Offspring Dental Study (MODS). Journal of internal medicine, 3(287), 301-309.
Kumar, A. & Rai, A. (2018). Oral health status, health behaviour and treatment needs of patients undergoing cardiovascular surgery. Brazilian journal of cardiovascular surgery, 33, 151-154.
Madeiro-Olivero et al. (2022). Mecanismos moleculares implicados en la etiopatogenia de la aterosclerosis coronaria asociada a la infección por Porphyromonas gingivalis. Revista Colombiana de Cardiologia, 2(29), 199-208.
Members, Writing Group et al. (2016). Executive Summary: Heart Disease and Stroke Statistics--2016 Update: A Report From the American Heart Association. Circulation, 4(133), 447-454.
Moras, L. et al. (2019). Impact of Periodontal Disease on Late Morbimortality (10 Years) of Pacientes with Acute Coronary Syndrome, 1(32), 35-40.
Morón-araújo, M. (2021). La periodontitis y su relación con las enfermedades cardiovasculares. Promoción de la salud cardiovascular desde el consultorio dental. Revista Colombiana de Cardiologia, 5(28), 464-472.
Noites et al. (2022). Apical Periodontitis and Cardiovascular Disease in Adults: A Systematic Review with Meta-Analysis. Rev Cardivascular Medicine, 23(3):100.
Nyvad, B. & Takahashi, N. (2020). Integrated hypothesis of dental caries and periodontal diseases. Journal of oral microbiology, 1(12), 1710953.
Okada, A. et al. (2021). Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial. PloS one, 9(16), e0257247.
Parveen, S. (2021). Impact of calorie restriction and intermittent fasting on periodontal health. Periodontology 2000, 1(87), 315-324.
Papapanou, P. N. et al. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Journal of periodontology, 89, S173-S182.
Roth, G. A. et al. (2018). Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 10159(392), 1736-1788.
Samulak, R., Suwała, M. & Dembowska, E. (2021). Nonsurgical periodontal therapy with/without 980 nm diode laser in patients after myocardial infarction: a randomized clinical trial. Lasers in Medical Science, 5(36), 1003-1014.
Teixeira, F. et al. (2020). Relationship between periodontitis and subclinical risk indicators for chronic non-communicable diseases, 34, local. e058.
Tonetti, M. S., Greenwell, H. & Kornman, K. S. (2018). Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. Journal of periodontology, 89, S159-S172.
Trombelli, L. et al. (2018). Plaque‐induced gingivitis: Case definition and diagnostic considerations. Journal of clinical periodontology, 45, S44-S67.
Van asch et al. (2010). Incidência, letalidade e resultado funcional da hemorragia intracerebral ao longo do tempo, de acordo com idade, sexo e origem étnica: uma revisão sistemática e meta-análise. Lancet Neurol, 9, 167–76.
Yang, L. et al. (2020). Study of cardiovascular disease prediction model based on random forest in eastern China. Scientific reports, 1(10), 1-8.
Yang, S. et al. (2018). Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis. BMC Cardiovasc Disord, 18(1), 141.
Ziebolz, D. et al. (2021). Comparison of periodontal parameters between patients with ischemic and dilative cardiomyopathy. BMC Cardiovasc Disord, 21(1), 304.
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Copyright (c) 2023 Handreza Régia Santos Siqueira Campos; Shirley Maria de Nazaré Rocha Cardoso; Roberta Priscilla Gonçalves Monteiro; Amandha Christine da Silva Souza ; Rosana Costa Casanovas; Cadidja Dayane Sousa do Carmo
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