Development of a pill based on the essential oil of Lippia alba
DOI:
https://doi.org/10.33448/rsd-v9i7.3973Keywords:
Lemongrass; Tablet; Anxiolytic.Abstract
The lemongrass (Lippia alba quimiotipo II; Verbenaceae), a plant species that is part of the list of medicinal plants of the program Live Pharmacy of Ceará, has in its leaves essential oil rich in citral, which accounts for its anxiolytic property. The accomplishment of the present research will aim at the implementation of a new pharmaceutical form based on lemongrass in “Farmácias Vivas” that can be used for the treatment of anxiety. This oil will be obtained by hydrodistillation method. The base of the tablet will consist of lactose, cellulose, alcohol, 10% starch solution and L. alba essential oil. The granulate was evaluated by the apparent density, compacted density, Hausner Ratio, Carr Index, resting angle, flow velocity, organoleptic property and humidity. The obtained mixture presents adequate flowability according to the analysis parameters. The tablet was evaluated by weight average, hardness, friability, disintegration and thin layer chromatography.
References
Abreu Matos, F. J., Machado, M. I. L., Craveiro, A. A., & Alencar, J. W. (1996). Essential oil composition of two chemotypes of Lippia alba grown in northeast Brazil. Journal of Essential Oil Research, 8(6), 695-698.
Delgado, L., & Schmachtenberg, O. (2008). Immunohistochemical localization of GABA, GAD65, and the receptor subunits GABA Aα1 and GABA B1 in the zebrafish cerebellum. The Cerebellum, 7(3), 444-450.
Emery, E., Oliver, J., Pugsley, T., Sharma, J., & Zhou, J. (2009). Flowability of moist pharmaceutical powders. Powder Technology, 189(3), 409-415.
Foster, A. C., & Kemp, J. A. (2006). Glutamate-and GABA-based CNS therapeutics. Current opinion in pharmacology, 6(1), 7-17.
Heldwein, C. G., Silva, L. L., Reckziegel, P., Barros, F. M. C., Bürger, M. E., Baldisserotto, B., ... & Heinzmann, B. M. (2012). Participation of the GABAergic system in the anesthetic effect of Lippia alba (Mill.) NE Brown essential oil. Brazilian Journal of Medical and Biological Research, 45(5), 436-443.
Januzzi, H. (2006). Caracterização de dezesseis acessos de Lippia alba (Mill) NE Brown, no Distrito Federal. Embrapa Recursos Genéticos e Biotecnologia-Tese/dissertação (ALICE).
Kim, Y. J., Nam, R. H., Yoo, Y. M., & Lee, C. J. (2004). Identification and functional evidence of GABAergic neurons in parts of the brain of adult zebrafish (Danio rerio). Neuroscience letters, 355(1-2), 29-32.
Lima Silva, L., Parodi, T. V., Reckziegel, P., de Oliveira Garcia, V., Bürger, M. E., Baldisserotto, B., ... & Heinzmann, B. M. (2012). Essential oil of Ocimum gratissimum L.: Anesthetic effects, mechanism of action and tolerance in silver catfish, Rhamdia quelen. Aquaculture, 350, 91-97.
Lorenzi, H., & Matos, F. J. (2002). Plantas medicinais no Brasil: nativas e exóticas.
Matos, J. F. B., MATOS, F., Matos, F. J. A., de Matos, F. L. A., Patrão-Neto, F. C., Matos, J., & Matos, F. (2007). Plantas medicinais: guia de seleção e emprego das plantas usadas em fitoterapia no Nordeste do Brasil.
Mamede, L. C., Caetano, B. L., Rocha, L. A., Ferreira, E. M., Cestari, A., Kfuri, C. R., & Nassar, E. J. (2009). Comportamento térmico de alguns fármacos e medicamentos. Revista de Ciências Farmacêuticas Básica e Aplicada, 27(2), 151-155.
Maximiano, F. P., Costa, G. H. Y., Souza, J. D., & Cunha-Filho, M. S. S. D. (2010). Caracterização físico-química do fármaco antichagásico benznidazol. Química nova, 33(8), 1714-1719.
Peixoto, M. M., Júnior, A. D. F. S., Santos, C. A. A., & Júnior, E. C. (2005). Avaliação da qualidade de comprimidos de captopril dispensados em Feira de Santana-BA. Infarma, 16(13-14), 69-73.
Pharmacopeia, U. S. (2006). The United States Pharmacopeia, USP 29/The National Formulary, NF 24; Rockville, MD: US Pharmacopeial Convention. Inc., p940.
Rates, S. M. K. (2001). Promoção do uso racional de fitoterápicos: uma abordagem no ensino de Farmacognosia. Revista Brasileira de Farmacognosia, 11(2), 57-69.
Robbers, J. E., Speedie, M. K., & Tyler, V. E. (1997). Farmacognosia e farmacobiotecnologia. São Paulo: Premier, 92-121.
Sousa Nunes, R., de Albuquerque Senna, B. A., da Silva, J. A., & de Santana, D. P. (2005). Validação de metodologia analítica para doseamento do timol em extratos vegetais de Lippia sidoides Cham por CLAE. Rev. Bras. Farm, 86(3), 87-91.
Vale, T. G., Furtado, E. C., Santos Jr, J. G., & Viana, G. S. B. (2002). Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) NE Brown. Phytomedicine, 9(8), 709.
Vale, T. G., Furtado, E. C., Santos Jr, J. G., & Viana, G. S. B. (2002). Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) NE Brown. Phytomedicine, 9(8), 709.
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