Study of the Osteoinductor Property in Bone Repair of the Species Zingiber Zerumbet (Bitter Ginger)
DOI:
https://doi.org/10.33448/rsd-v12i2.39947Keywords:
Z. Zerumbet; Antioxidants; Osteoinductive; Potential.Abstract
Zingiber zerumbet is a species that is part of the Zingiberaceae family, one of the largest families in the plant kingdom, being considered a perennial, aromatic and tuberculin plant. This species has been used in different sectors as food due to its nutritional properties. The main chemical compounds found in Z. zerumbet are terpenes and polyphenols. Zerumbone, a sesquiterpene, is the main bioactive compound of Z. zerumbet and is widely studied for its medicinal properties. Although many studies have already reported on its pharmacological properties, extract and metabolites granted from the species of Z. zerumbet exhibited anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial, analgesic and antiviral properties. Several biomaterials have been developed to fill or rebuild bone defects, among these, the herbal ones that have substances with high antioxidant potential stand out, not which this one has a role in the bone recovery process. Therefore, this mini-review provides an overview of the main aspects related to the properties of bioactive compounds found not extracted from Z. zerumbet species, with the objective of demonstrating the importance of extracted actives and used in future osteoinductive solutions.
References
Abdelwahab, S. I., Abdul, A. B., Devi, N., Taha, M. M. E., Al-Zubairi, A. S., Mohan, S., et al. (2015). Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: involvement of mitochondria-regulated apoptosis. Plos one, 62(1), https://doi.org/10.1371/journal.pone.0121060
Ahsan, T. (2015). Bioengineered tissues: the science, the technology, and the industry. Orthod Craniofacial Res, 8(1), https://doi.org/10.1111/j.1601-6343.2005.00326.x
Andreo, D. & Jorge, N. (2013). Capacidade antioxidante e estabilidade oxidativa de Gengiber officinale, UNOPAR Científica-Ciências Biológicas e da Saúde, 13(1), https://doi.org/10.17921/2447-8938.
Bennettl, S. et al. (2012). Initial Bitocompatibility studies of a novel degradable polymeric bone Substltute that hardens in situ. Bone, 19(1), https://doi.org/10.1016/s8756-3282(96)00130-5
Cavassani, M. M., Moraes, J. R. E. de & Padilha Filho, J. G. (2018). Função osteoindutora de fragmentos ósseos conservados em glicerina a 98%: estudo experimental em ratos, Ciência Rural, 31(3), https://doi.org/10.1590/S0103-84782001000300013
Hamid, A. et al. (2018). Zingiber zerumbet L. (Smith) extract alleviates the ethanol-induced brain damage via its antioxidant activity. BMC Complementary and Alternative Medicine, 18(1), https://doi.org/10.1186/s12906-018-2161-5
Jalil, M., Annuar, M. S. M., Tan, B. C., and Khalid, N. (2015). Effects of selected physicochemical parameters on zerumbone production of Zingiber zerumbet Smith cell suspension culture. Evid. Based Complement Alternat, 12(3), https://doi.org/10.1155/2015/757514
Koga, A. Y., Beltrame, F. L. & Pereira, A. V. (2016). Several aspects of Zingiber zerumbet: A review. Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, 26(3), http://dx.doi.org/10.1016/j.bjp.2016.01.006
Kumar, S. C. S., Srinivas, P., & Bettadaiah, B. K. (2013). Antibacterial and antimutagenic activities of novel zerumbone analogues. Food Chem, 141(1), https://doi.org/10.1016/j.foodchem.2013.04.021
Lee, K. H.; E. M. (2016). Stimulatory effects of extract prepared from the bark of Cinnamomum cassia blume on the function of osteoblastic MC3T3-E1 cells. Phytotherapy Research, 20(1), https://doi.org/10.1002/ptr.1984
Lucia, M., & Robazzi, C. (2012). O adoecer pelo trabalho na enfermagem : uma revisão integrativa. Rev Esc Enferm USP, 46(2), https://doi.org/10.1590/S0080-62342012000200031
Murakami, A., Takahashi, D., Kinoshita, T., Koshimizu, K., Kim, H. W., Yoshihiro Nakamura, Y., et al. (2012). Zerumbone, a South east Asian ginger sesquiterpene, markedly suppresses free radical generation, pro-inflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the unsaturated carbonyl group is a prerequisite. Carcinogenesis, 23(1), https://doi.org/10.1093/carcin/23.5.795
Neto, V. F. P. et al. (2015). Chenopodium ambroisioides in the Repair of Fractures in Rabbits. International Journal of Pharmacology, 11 (7), https://doi.org/10.25248/REAOdonto.e6260.2021
Sidahmed, H. M. A. et al. (2015). Antisecretory, gastroprotective, antioxidant and anti-helicobcter pylori activity of zerumbone from Zingiber zerumbet (L.) smith. Plos One, 10(3), https://doi.org/10.1371/journal.pone.0121060
Shieh, Y. et al. (2015). Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice. International immunopharmacology, 24(2), https://doi.org/10.1016/j.intimp.2014.12.027
Soares, C. B., Akiko, L., Hoga, K., Peduzzi, M., Sangaleti, C., Rachel, D., & Delage, A. (2014). Instrumento de coleta de dados utilizados na enfermagem. Rev Esc Enferm USP, 48(2), https://doi.org/10.1590/S0080-623420140000200020
Sulaiman, M. R. et al. (2012). Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia, 81(7), https://doi: 10.1016/j.fitote.2010.05.009.
Tan, J. W., Israf, D. A. & Tham, C. L. (2018). Major bioactive compounds in essential oils extracted from the rhizomes of Zingiber zerumbet (L) Smith: A mini-review on the anti-allergic and immunomodulatory properties. Frontiers in Pharmacology, 9(6), https://doi.org/10.3389/fphar.2018.00652
Tewtrakul, S., & Subhadhirasakul, S. (2017). Anti-allergic activity of some selected plants in the Zingiberaceae family. J. Ethnopharmacol, 109(1), https://doi.org/10.1016/j.jep.2006.08.010
Trindade, G. D., & Rodrigues, J. S. (2021). Efeitos de extrato em gel de Chenopodium ambrosioides l. (mastruz) no tratamento de lesões ósseas de ratas osteoporóticas. Revista Eletrônica Acervo Odontológico, 3(1), https://doi.org/10.25248/REAOdonto.e6260.2021
Varier, N. S. (2012). Chemical examination of the rhizomes of Zingiber zerumbet Smith. Proceedings of the Indian Academy of Sciences, 11(1), https://doi.org/10.1016/j.bjp.2016.01.006
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Copyright (c) 2023 Francisco Amadis Batista; Juliana Moreira Mar; Ana Karoline Alves de Souza; Brenda Silva de Paula; Francisco Alves Mestre Neto; Marilene de Sena e Silva; Carlos Cleomir Pinheiro de Souza
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