Myelomalacia in shih-tzu: case report
Keywords:Intervertebral disc disease; Spinal cord; Nervous system.
Progressive Hemorrhagic Myelomalacia (HpM) is a disease caused by a spinal cord injury that leads to necrosis of the affected spinal cord area, it can occur in focal form or ascending and descending way. After the injury, neurological clinical signs are observed in the animals and the progression of the disease is rapid. All dog breeds can have MHP, currently, shih-tzu and French bulldog are the most prevalent. For the diagnosis, a clinical and neurological evaluation is necessary, in addition to specific complementary exams such as magnetic resonance imaging. There is still no clinical treatment protocol for the disease, and one of the alternatives is surgical treatment or euthanasia, when there is a severity in the clinical signs, the prognosis of MHP, in general, is unfavorable. The objective of this study was to report the case of a Shih-tzu dog that after surgical referral for hemilaminectomy, presented diffuse alteration in the medulla and was diagnosed with myelomalacia through durotomy. Soon after the surgical procedure, the animal presented a stable clinical picture, normodipsia and normofagia, but presented irreversible paraplegia.
Balducci, F., Canal, S., Contiero, B., & Bernardini, M. (2017). Prevalence and risk factors for presumptive ascending/descending myelomalacia in dogs after thoracolumbar intervertebral disk herniation. Journal of veterinary internal medicine, 31(2), 498-504.
Blaser, A., Lang, J., Henke, D., Doherr, M.G., Adami, C., & Forterre, F. (2012). Influence of durotomy on laser-doppler measurement of spinal cord blood flow in chondrodystrophic dogs with thoracolumbar disk extrusion. Vet Surg, 41(2), 221-227.
Castel, A., Olby, N. J., Mariani, C. L., Muñana, K. R., & Early, P. J. (2017). Clinical characteristics of dogs with progressive myelomalacia following acute intervertebral disc extrusion. Journal of veterinary internal medicine, 31(6), 1782-1789.
Castel, A., Olby, N. J., Ru, H., & Early, P. J. (2019). Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study. BMC Vet Res 15, 433.
Cook, L. & Drost W. T. (2019). Hemorrhagic Myelomalacia in a Bichon Frise following lumbar spinal tap: a case report. Top Companion Anim Med, 34, 47- 50.
De Lahunta, A., Glass, E., & Kent, M. (2009). Lower motor neuron: general visceral efferent system. Veterinary neuroanatomy and clinical neurology, 3, 168- 191.
Edgerton, V. R., Kim, S. J., Ichiyama, R. M., Gerasimenjo, Y. P., Roy, R. R. (2006). Rehabilitative therapies after spinal cord injury. J Neurotrauma. 23(3-4), 560-570.
Fingeroth, J. M., Ad, L. & De Lahunta A. (2015). Ascending/descending myelomalacia secondary to intervertebral disc herniation. In: Fingeroth, J. M., Thomas,
W. B., editors. Advances in intervertebral disc disease in dogs and cats. Ames: Wiley-Blackwell, p. 115–20.
Gilmour L. J., Jeffery N. D., Miles K., & Riedesel E. (2017). Single-shot Turbo spin Echo pulse sequence findings in dogs with and without progressive Myelomalacia. Vet Radiol Ultrasound, 58(2), 197–205.
Henke, D., Gorgas, D., Doherr, M. G., Howard, J., Forterre, F., & Vandevelde, M. (2016). Longitudinal extension of myelomalacia by intramedullary and subdural hemorrhage in a canine model of spinal cord injury. The Spine Journal, 16(1), 82-90.
Hirano, R., Asahina, R., Hirano, T., et al. (2020). Resultados da hemilaminectomia extensa com durotomia em cães com mielomalácia progressiva presuntiva: um estudo retrospectivo em 34 casos. BMC veterinary research. v. 16.
Inzana, K. D. (2003). Mielomalácia hemorrágica difusa (hematomielia). Consulta Veterinária em, 5, 975
Lecouteur, R. A., & Child, G. (2002). Afecções da medula espinhal. ETTINGER, SJ, FELDMAN, EC Tratado de medicina interna veterinária, 4, 963-964. Lu D., Lamb C. R. & Targett M. P. (2002). Results of myelography in seven dogs with myelomalacia. Veterinary Radiol Ultrasound, 4, 326– 330.
Marquis, A., Packer, R. A., Borgens, R. B. & Duerstock, B. S. (2015). Increase in oxidative stress biomarkers in dogs with ascending-descending myelomalacia following spinal cord injury. Journal of the neurological sciences. p. 63-69.
Mayer, D., Oevermann, A., Seuberlich, T., Vandevelde, M., Casanova‐Nakayama, A., Selimovic‐Hamza, S., & Henke, D. (2016). Endothelin‐1 immunoreactivity and its association with intramedullary hemorrhage and myelomalacia in naturally occurring disk extrusion in dogs. Journal of veterinary internal medicine, 30(4), 1099-1111.
Millis, D. L., Levine, D. (2014). Biomechanics of Physical Rehabilitation and Kinematics of Exercise. In: Millis, D. L., Levine, D, editors. Canine Rehabilitation and Physical Therapy. 2nd ed. Philadelphia: Elsevier Saunders. p. 431-446.
Nelson, R. W. & Couto, C. G. (2015). Medicina interna de pequenos animais. (5a ed.), Elsevier.
Nye, C. J., Mustonen, A. M. & Cook, L. (2020). Progressive Myelomalacia in a Pomeranian following spinal fracture and surgical stabilization: a case report.
Topics in Companion Animal Medicine, 39.
Okada, M., Kitagawa, M., Ito, D., Itou, T., Kanayama, K. & Sakai, T. (2010). Magnetic resonance imaging features and clinical signs associated with presumptive and confirmed progressive myelomalacia in dogs: 12 cases (1997-2008). Journal of the American Veterinary Medical Association, 237(10), 1160-1165.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J. & Shitsuka, R. Metodologia da pesquisa científica. Santa Maria, RS: UFSM, NTE.
Platt S. R., McConnell J. F. & Bestbier M. (2006). Magnetic resonance imaging characteristics of ascending hemorrhagic myelomalacia in a dog. Veterinary Radiol Ultrasound, 47, 78– 82.
Sato Y., Shimamura S., Mashita T., & Yasuda, J. (2013). Serum glial fibrillary acidic protein as a diagnostic biomarker in dogs with progressive myelomalacia.
J Vet Med Sci, 75, 949– 953.
Schwab, M. L., Ferrarin, D. A., Wrzesinski, M. R., Rauber J. S., Ripplinger, A., Lamego, E. C., Flores, M. M., & Mazzanti, A. (2022). Clinical and histopathological findings of hemorrhagic progressive myelomalacia after lumbar tap in 2 dogs: case report. Topics in Companion Animal Medicine, 50.
Sharp, N. J. H. & Wheeler S. J. (2005). Thoracolumbar disc disease, p. 128-159. In: Sharp, N. J. H. & Wheeler, S. J. (Eds), Small Animal Spinal Disorders: Diagnosis and surgery. 2 ed. Mosby, Philadelphia.
Zachary, J. F. (2017). Base patológica da doença veterinária. St. Louis: Elsevier.
Zilio, D. D. M. & Arias, M. V. B. (2013). Mielomalácia hemorrágica progressiva em 14 cães. Pesquisa Veterinária Brasileira, 33, 219-228.
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Copyright (c) 2023 Jéssica Layane Oliveira Fontes; Tainah Santos Reis; Denise Aguiar Dias; Breno Fontes Fonseca; Izabelly Lima Correa; Danielle Domingos Duarte; Luana Souza Oliveira; Juliana Teixeira dos Santos; Laura Alexandre Esposito; Roseane Nunes de Santana Campos
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