The cognitive effects presented by post-COVID-19 syndrome: A systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i6.40043

Keywords:

Coronavirus; Syndrome; Sequels; Cognitive.

Abstract

Introduction: Post-COVID-19 syndrome is the term applied to various symptoms, some cognitive, persistent, of COVID-19, even after the end of the acute phase of the infection. Objective: to present the cognitive effects of the post-COVID-19 syndrome through collected data and to analyze the relationship between SARS-CoV-2 infection and the development of these clinical manifestations. Methodology: a systematic literature review was performed, based on the search for clinical trials in PubMED and Scielo. Six studies were selected for review. Results: Overall, studies on the cognitive effects of post-COVID-19 syndrome were small and were based on tests and self-assessments, but show that mental confusion, memory loss and difficulty concentrating are the main complaints reported by patients. Discussion: Evidence points out that the cognitive effects of post-COVID-19 syndrome may be related to the severity of COVID-19 infection and previous neurological diseases. The relationship between viral diseases and cognitive effects is already well established, which makes it possible to think that COVID-19 is also capable of affecting the nervous system. The health system must prepare itself to face a great demand related to cognitive sequelae, being necessary to carry out reforms in its structure. Conclusion: the continuation of studies on the post-COVID-19 syndrome is essential for the understanding of a condition that is related to so many cognitive effects.

References

Asadi-Pooya, A. A., Akbari, A., Emami, A., Lotfi, M., Rostamihosseinkhani, M., Nemati, H., Barzegar, Z., Kabiri, M., Zeraatpisheh, Z., Farjoud-Kouhanjani, M., Jafari, A., Sasannia, F., Ashrafi, S., Nazeri, M., Nasiri, S., & Shahisavandi, M. (2021). Risk Factors Associated with Long COVID Syndrome: A Retrospective Study. Iranian Journal of Medical Sciences, 46(6), 428–436. https://doi.org/10.30476/ijms.2021.92080.2326

Bardin, L. (1977). Análise de Conteúdo. Edições 70.

Berger, J. R., Moskowitz, L., Fischl, M., & Kelley, R. E. (1987). Neurologic disease as the presenting manifestation of acquired immunodeficiency syndrome. Southern Medical Journal, 80(6), 683–686. https://doi.org/10.1097/00007611-198706000-00004

Bernardo, M. H. & Garbin, A. D. C. (2011). A atenção à saúde mental relacionada ao trabalho no SUS: desafios e possibilidades. Revista Brasileira de Saúde Ocupacional, 36(123), 103–117. https://www.scielo.br/j/rbso/a/Ym7kpRZmty9fFxPkLVg4hPC/?lang=pt

Boesl, F., Audebert, H., Endres, M., Prüss, H., & Franke, C. (2021). A Neurological Outpatient Clinic for Patients With Post-COVID-19 Syndrome - A Report on the Clinical Presentations of the First 100 Patients. Frontiers in Neurology, 12, 738405. https://doi.org/10.3389/fneur.2021.738405

Bonizzato, S., Ghiggia, A., Ferraro, F., & Galante, E. (2022). Cognitive, behavioral, and psychological manifestations of COVID-19 in post-acute rehabilitation setting: preliminary data of an observational study. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 43(1), 51–58. https://doi.org/10.1007/s10072-021-05653-w

Catalán, I. P., Martí, C. R., Sota, D. P., Álvarez, A. C., Gimeno, M. J. E., Juana, S. F., Rodríguez, G. H., Bajo, E. D., Gaya, N. T., Blasco, J. U., & Rincón, J. M. R. (2022). Corticosteroids for COVID-19 symptoms and quality of life at 1 year from admission. Journal of Medical Virology, 94(1), 205–210. https://doi.org/10.1002/jmv.27296

Chaumont, H., Meppiel, E., Roze, E., Tressières, B., de Broucker, T., Lannuzel, A., & contributors to the French NeuroCOVID registry (2022). Long-term outcomes after NeuroCOVID: A 6-month follow-up study on 60 patients. Revue Neurologique, 178(1-2), 137–143. https://doi.org/10.1016/j.neurol.2021.12.008

Cordeiro, A. M., Oliveira, G. M. de ., Rentería, J. M., & Guimarães, C. A.. (2007). Revisão sistemática: uma revisão narrativa. Revista Do Colégio Brasileiro De Cirurgiões, 34(6), 428–431. https://doi.org/10.1590/S0100-69912007000600012

Crivelli, L., Calandri, I., Corvalán, N., Carello, M. A., Keller, G., Martínez, C., Arruabarrena, M., & Allegri, R. (2022). Cognitive consequences of COVID-19: results of a cohort study from South America. Arquivos de Neuro-psiquiatria, 80(3), 240–247. https://doi.org/10.1590/0004-282X-ANP-2021-0320

Fruchter, E., Goldberg, S., Fenchel, D., Grotto, I., Ginat, K., & Weiser, M. (2015). The impact of Herpes simplex virus type 1 on cognitive impairments in young, healthy individuals - A historical prospective study. Schizophrenia Research, 168(1-2), 292–296. https://doi.org/10.1016/j.schres.2015.08.036

Leite, S. A. (2021). Reabilitação das funções mentais, cognitivas e psicológicas após quadro de COVID-19. In Universidade Aberta do SUS & Universidade Federal do Maranhão. Reabilitação do paciente com condições pós-covid. UNA-SUS UFMA.

Miranda, D. A. P., Gomes, S. V. C., Filgueiras, P. S., Corsini, C. A., Almeida, N. B. F., Silva, R. A., Medeiros, M. I. V. A. R. C., Vilela, R. V. R., Fernandes, G. R., & Grenfell, R. F. Q. (2022). Long COVID-19 syndrome: a 14-months longitudinal study during the two first epidemic peaks in Southeast Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 116(11), 1007–1014. https://doi.org/10.1093/trstmh/trac030

Novakovic-Agopians, T., & Abrams, G. M. (2014). Cognitive Rehabilitation Therapy. In J. A. Michael, & B. D. Robert (Eds.), Encyclopedia of the Neurological Sciences (2a ed., pp. 824-826). Academic Press.

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Revista Española de Cardiología (English Edition), 74(9), 790–799. https://www.sciencedirect.com/science/article/pii/S1885585721002401?via%3Dihub.%20Acesso%20em:%2024%20jul.%202022

Santos, C. M. da C., Pimenta, C. A. de M., & Nobre, M. R. C.. (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-americana De Enfermagem, 15(3), 508–511. https://doi.org/10.1590/S0104-11692007000300023

Schouten, J., Cinque, P., Gisslen, M., Reiss, P., & Portegies, P. (2011). HIV-1 infection and cognitive impairment in the cART era: a review. AIDS 25(5), 561-575. https://journals.lww.com/aidsonline/fulltext/2011/03130/hiv_1_infection_and_cognitive_impairment_in_the.3.aspx

Tabacof, L., Tosto-Mancuso, J., Wood, J., Cortes, M., Kontorovich, A., McCarthy, D., Rizk, D., Rozanski, G., Breyman, E., Nasr, L., Kellner, C., Herrera, J. E., & Putrino, D. (2022). Post-acute COVID-19 Syndrome Negatively Impacts Physical Function, Cognitive Function, Health-Related Quality of Life, and Participation. American Journal of Physical Medicine & Rehabilitation, 101(1), 48–52. https://doi.org/10.1097/PHM.0000000000001910

Tarter, K. D., Simanek, A. M., Dowd, J. B., & Aiello, A. E. (2014). Persistent viral pathogens and cognitive impairment across the life course in the third national health and nutrition examination survey. The Journal of Infectious Diseases, 209(6), 837–844. https://doi.org/10.1093/infdis/jit616

Venkatesan, P. (2021). NICE guideline on long COVID. The Lancet Respiratory Medicine, 9(2), 129. https://doi.org/10.1016/S2213-2600(21)00031-X

Wilson, B. A. (2008). Neuropsychological rehabilitation. Annual Review of Clinical Psychology, 4, 141–162. https://doi.org/10.1146/annurev.clinpsy.4.022007.141212

World Health Organization. (2020, March 11). WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-COVID-19---11-march-2020

World Health Organization. (2021, December 4). Coronavirus disease (COVID-19): Variants of SARS-COV-2. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-%28COVID-19%29-variants-of-sars-cov-2?gclid=Cj0KCQjw2_OWBhDqARIsAAUNTTF4siZKsvbA2ZfvAtEdFFBOE-Gk1aaMWNHof2CxriWU6Dj4H_vHFD0aAmNoEALw_wcB

World Health Organization. (2022, June 17). Interim statement on the composition of current COVID-19 vaccines. https://www.who.int/news/item/17-06-2022-interim-statement-on--the-composition-of-current-COVID-19-vaccines

World Health Organization. (n.d.). Coronavirus disease (COVID-19). https://www.who.int/health-topics/coronavirus#tab=tab_1

Published

14/06/2023

How to Cite

SANTANA, A. J. de .; PEREIRA, C. de B. .; ANDRADE , F. T. de .; PINTO, G. M. da S. .; MARQUES, G. D. .; SANTOS JÚNIOR, N. N. dos . The cognitive effects presented by post-COVID-19 syndrome: A systematic review. Research, Society and Development, [S. l.], v. 12, n. 6, p. e13312640043, 2023. DOI: 10.33448/rsd-v12i6.40043. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40043. Acesso em: 12 nov. 2024.

Issue

Section

Health Sciences