Is there a dental protocol for the prevention and treatment of oral diseases in children undergoing cancer treatment? Integrative review




Oral prophylaxis and oncology; Oral hygiene and oncology; Paediatric dentistry; Children.


Oral health care is an integral component of interprofessional collaborative care for children and adolescents diagnosed with cancer. The current literature emphasizes that dental interventions before, during and after cancer treatment improve the quality of life and the integral restoration of health in these patients. The objective of this work was to carry out an integrative literature review on the existence of a dental protocol for the prevention and treatment of oral diseases in children undergoing cancer treatment. Articles published without restriction of years and languages and that included any of the terms as keywords: protocol, childhood cancer, oral disease, oral pathology and oral health were included. The databases used were Pubmed and, as gray literature, an open gray search was performed. The evidence presented here suggests that oral health promotion strategies can reduce the incidence, however it is necessary to develop guidelines to contribute and identify early oral diseases in these children. Thus, it is important to draw up a guide with information on prevention and treatments on oral health for hospitals and clinics specializing in the treatment of childhood cancer, as well as the presence of a pediatric dentist to work collaboratively in the team and thus track, guide, prevent and treat oral pathologies.


Allen, G., Logan, R., & Gue, S. (2010). Oral manifestations of cancer treatment in children: a review of the literature. Clin J Oncol Nurs, 14(4), 481-490. doi:10.1188/10.CJON.481-490

Chen, C. F., Wang, R. H., Cheng, S. N., & Chang, Y. C. (2004). Assessment of chemotherapy-induced oral complications in children with cancer. J Pediatr Oncol Nurs, 21(1), 33-39. doi:10.1177/1043454203259947

Cheng, K. K., Molassiotis, A., & Chang, A. M. (2002). An oral care protocol intervention to prevent chemotherapy-induced oral mucositis in paediatric cancer patients: a pilot study. Eur J Oncol Nurs, 6(2), 66-73. doi:10.1054/ejon.2001.0161

Chi, D. L. (2017). The Science and Art of Evidence-Based Pediatric Dentistry. Dent Clin North Am, 61(3), xi-xii. doi:10.1016/j.cden.2017.04.001

Costa, L. S., Côrrea, M. S. N. P., Imparato, J. C. P., & Rezende, K. M. (2021). Panorâma das manifestações bucais decorrente do tratamento do câncer infantil: uma revisão integrativa. Research, Society and Development, 10(8), 9. doi:

Cruz, L. B., Ribeiro, A. S., Rech, A., Rosa, L. G., Castro, C. G., Jr., & Brunetto, A. L. (2007). Influence of low-energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy. Pediatr Blood Cancer, 48(4), 435-440. doi:10.1002/pbc.20943

Estrela, C. (2018). Metodologia cientifica: ciênica, ensino, pesquisa (A. Médicas Ed.). Porto Alegrea.

Glumac, M., Qin, L., Chen, J., & Ritzoulis, C. (2019). Saliva could act as an emulsifier during oral processing of oil/fat. J Texture Stud, 50(1), 83-89. doi:10.1111/jtxs.12375

Gonzalez Gravina, H., Gonzalez de Moran, E., Zambrano, O., Lozano Chourio, M., Rodriguez de Valero, S., Robertis, S., & Mesa, L. (2007). Oral Candidiasis in children and adolescents with cancer. Identification of Candida spp. Med Oral Patol Oral Cir Bucal, 12(6), E419-423. Retrieved from

Hurrell, L., Burgoyne, L., Logan, R., Revesz, T., & Gue, S. (2019). The Management of Pediatric Oncology Inpatients With Oral Mucositis. J Pediatr Hematol Oncol, 41(8), e510-e516. doi:10.1097/MPH.0000000000001546

James, P., Worthington, H. V., Parnell, C., Harding, M., Lamont, T., Cheung, A., & Riley, P. (2017). Chlorhexidine mouthrinse as an adjunctive treatment for gingival health. Cochrane Database Syst Rev, 3(3), CD008676. doi:10.1002/14651858.CD008676.pub2

Kasi, S. R., Ozcan, M., & Feilzer, A. J. (2022). Side effects of sodium lauryl sulfate applied in toothpastes: A scoping review. Am J Dent, 35(2), 84-88. Retrieved from

Kostler, W. J., Hejna, M., Wenzel, C., & Zielinski, C. C. (2001). Oral mucositis complicating chemotherapy and/or radiotherapy: options for prevention and treatment. CA Cancer J Clin, 51(5), 290-315. doi:10.3322/canjclin.51.5.290

Ludke, M., & Andre, M. E. D. A. (2013). Pesquisas em educação: uma abordagem qualitativa. (E.P.U. Ed.). São Paulo.

O'Sullivan, E. A., & Curzon, M. E. (2000). A comparison of acidic dietary factors in children with and without dental erosion. ASDC J Dent Child, 67(3), 186-192, 160. Retrieved from

Qutob, A. F., Allen, G., Gue, S., Revesz, T., Logan, R. M., & Keefe, D. (2013). Implementation of a hospital oral care protocol and recording of oral mucositis in children receiving cancer treatment : a retrospective and a prospective study. Support Care Cancer, 21(4), 1113-1120. doi:10.1007/s00520-012-1633-2

Richards, D. (2016). Impact of diet on tooth erosion. Evid Based Dent, 17(2), 40. doi:10.1038/sj.ebd.6401164

Ritwik, P., & Chrisentery-Singleton, T. E. (2020). Oral and dental considerations in pediatric cancers. Cancer Metastasis Rev, 39(1), 43-53. doi:10.1007/s10555-020-09842-5

Tolentino Ede, S., Centurion, B. S., Ferreira, L. H., Souza, A. P., Damante, J. H., & Rubira-Bullen, I. R. (2011). Oral adverse effects of head and neck radiotherapy: literature review and suggestion of a clinical oral care guideline for irradiated patients. J Appl Oral Sci, 19(5), 448-454. doi:10.1590/s1678-77572011000500003

Venkataraghavan, K., Patil, S., Guvva, S., Karthik, S., & Bhandi, S. (2013). Abnormal odontogenesis following management of childhood cancer (retinoblastoma): review and a new variant. J Contemp Dent Pract, 14(2), 360-364. doi:10.5005/jp-journals-10024-1328



How to Cite

BUZETTO, J. C.; BRITO, R. C. de M. .; IMPARATO, J. C. P. .; REZENDE, K. M. Is there a dental protocol for the prevention and treatment of oral diseases in children undergoing cancer treatment? Integrative review . Research, Society and Development, [S. l.], v. 12, n. 2, p. e15512240100, 2023. DOI: 10.33448/rsd-v12i2.40100. Disponível em: Acesso em: 11 dec. 2023.



Health Sciences