Clinical resolution in diagnosis of leukoplastic lesion associated with oral dysplasia: case report
DOI:
https://doi.org/10.33448/rsd-v12i2.40105Keywords:
Oral diagnosis; Biopsy; Hairy leukoplakia.Abstract
The objective of the present study is to report a clinical case that emphasizes the diagnosis of mild epithelial dysplasia located in the unilateral region of the buccal mucosa. Patient, 49 years old, female, pheoderma, attended the dental clinic of the Nilton Lins University, referring a dental fracture as the main reason for the consultation. The intraoral clinical examination revealed a unilateral lesion in the buccal mucosa with plaque characteristics and whitish coloration. Initially, it was decided to perform an excisional biopsy of the lesion with a diagnostic hypothesis of lichen planus. The extracted pieces were sent to the Department of Pathology and Legal Medicine of the Federal University of Amazonas School of Medicine for confirmation of the diagnostic hypothesis, confirmed by the report as mild epithelial dysplasia. Subsequently, the patient was referred to perform the other dental procedures that were later scheduled and is under follow-up, with no complaints or adverse complications. Therefore, given the clinical resolution presented, the differential diagnosis was essential, enabling a satisfactory clinical conduct.
References
Abati, S., Bramati, C., Bondi, S., Lissoni, A., & Trimarchi, M. (2020). Oral cancer and precancer: a narrative review on the relevance of early diagnosis. Int J Environ Res Public Health, 17 (24), 9160.
Awadallah, M., Idle, M., Patel, k., & Kademani, D. (2018). Management update of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol, 125 (6), 628-636.
Bernard, C., Blanas, N., & Magalhães, M. (2021). Outcomes of oral epithelial dysplasia managed by observation versus excision at a Canadian Tertiary Centre. J Oral Maxillofac Surg, 79 (10), e98-e99.
Essat, M., Cooper, K., Bessey, A., Clowes, M., Chilcott, J. B., Hunter, K. D., & et al. (2022). Diagnostic accuracy of conventional oral examination for detecting oral cavity cancer and potentially malignant disorders in patients with clinically evident oral lesions: Systematic review and meta-analysis. Head & Neck, 44 (4), 998-1013.
Estrela, C. (2018). Metodologia Científica: Ciências, Ensino, Pesquisa. Editora Artes Médicas.
Freitas, B. S., Batista, D. C. R., Roriz, C. F. S., Silva, L. R., Normando, A. G. C., Silva, A. R. S., & et al. (2021). Binary and WHO dysplasia grading systems for the prediction of malignant transformation of oral leukoplakia and erythroplakia: a systematic review and meta-analysis. Clin Oral Investig, 25 (7), 4329-4340.
Gilvetti, C., Soneji, C., Bisase, B., & Barrett, A. W. (2021). Recurrence and malignant transformation rates of high grade oral epithelial dysplasia over a 10 year follow up period and the influence of surgical intervention, size of excision biopsy and marginal clearance in a UK regional maxillofacial surgery unit. Oral Oncol, 121, 105462.
Gupta, R. K., Kaur, M., & Manhas, J. (2019). Tissue level based deep learning framework for early detection of dysplasia in oral squamous epithelium. J Inf Syst, 6 (2), 81-86.
Hankinson, P. M., Mohammed-Ali, R. I., Smith, A. T., & Khurram, S. A. (2021). Malignant transformation in a cohort of patients with oral epithelial dysplasia. Br J Oral Maxillofac Surg, 59 (9), 1099-1101.
Kierce, J., Shi, Y., Klieb, H., Blanas, N., Xu, W., & Magalhães, M. (2021). Identification of specific clinical risk factors associated with the malignant transformation of oral epithelial dysplasia. Head Neck, 43 (11), 3552-3561.
Kim, E., Chung, M., Jeong, H. S., Baek, C. H., & Cho, J. (2022). Histological features of differentiated dysplasia in the oral mucosa: a review of oral invasive squamous cell carcinoma cases diagnosed with benign or low-grade dysplasia on previous biopsies. Hum Pathol, 126, 45-54.
Locca, O., Sollecito, T. P., Alawi, F., Weinstein, G. S., Newman, JG., & et al. (2020). Potentially malignant disorders of the oral cavity and oral dysplasia: a systematic review and meta-analysis of malignant transformation rate by subtype. Head Neck, 42 (3), 539-555.
Mello, F. W., Miguel, A. F. P., Dutra, K. L., Porporatti, A. L., Warnakulasuriya, S., Guerra, E. N. S., & et al. (2018). Prevalence of oral potentially malignant disorders: a systematic review and meta-analysis. J Oral Pathol Med, 47 (7), 633-640.
Moraes, E. F., Pinheiro, J. C., Lira, J. A., Mafra, R. P., Barbosa, C. A., Souza, L. B., & et al. (2020). Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia: a systematic review. Med Oral Patol Oral Cir Bucal, 25 (2), 205-216.
Nag, R., & Kumar, Das R., (2018). Analysis of images for detection of oral epithelial dysplasia; a review. Oral Oncol, 78, 8-15.
Odell, E., Kujan, O., Warnakulasuriya, S., & Sloan, P. (2021). Oral epithelial dysplasia: recognition, grading clinical significance. Oral Dis, 27 (8), 1947-1976.
Porter, S., Gueiros, L. A., Leão, J. C., & Fedele, S. (2018). Risk factors and etiopathogenesis of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol, 125 (6), 603-611.
Pritzker, K. P. H., Darling, M. R., Hwang, J. T., & Mock, D. (2021). Oral potentially malignant disorders (OPMD): what is the clinical utility of dysplasia grade? Expert Rev Mol Diagn, 21 (3), 289-298.
Ranganathan, K., & Kavitha, L. (2019). Oral epithelial dysplasia: classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol, 23 (1), 19-27.
Singh, H. P., Thippeswamy, S. H., Gandhi, P., Salgotra, V., Choudhary, S., & Agarwal, R., (2021). A retrospective study to evaluate biopsies of oral and maxillofacial Lesions. J Pharm Bioallied Sci, 13 (1), 116-119.
Singh, S., Singh, J., Chandra, S., & Samadi, F. M. (2020). Prevalence of oral cancer and oral epithelial dysplasia among north indian population: a retrospective institutional study. J Oral Maxillofac Pathol, 24(1), 87-92.
Speight, P. M., Khurram, S. A., & Kujan, O. (2018). Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol, 125 (6), 612-627.
Suter, V. G. A., Altermatt, H. J., & Bornstein, M. M. (2020). A randomized controlled trial comparing surgical excisional biopsies using CO2 laser, Er:YAG laser and scalpel. Int J Oral Maxillofac Surg, 49 (1), 99-106.
Tanriver, G., Soluk, T. M., & Ergen, O. (2021). Automated detection and classification of oral lesions using deep learning to detect oral potentially malignant disorders. Cancers, 13 (11), 2766.
Tilakaratne, W. M., Jayasooriya, P. R., Jayasuriya, N. S., & De Silva, R. K. (2019). Oral epithelial dysplasia: causes, quantification, prognosis, and management challenges. Periodontol 2000, 80 (1), 126-147.
Woo, S. B., (2019). Oral epithelial dysplasia and premalignancy. Head Neck Pathol, 13 (3), 423-439.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Angela Victoria de Souza Freire; Jefferson Pires da Silva Júnior; Bruna Mirely da Silva Cavalcante; Flávio Lima do Amaral Silva; Leandro Coelho Belém; Allysson Soares
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.