Stimulation of collagen production in facial rejuvenation with the application of platelet-rich plasma: a literature review
Keywords:Facial rejuvenation; Platelet-rich plasma; Platelet-derived growth factor.
Objective: The study aims to analyze the literature on collagen production in facial rejuvenation using platelet-rich plasma, analyzing which studies are already present in the literature and how this new method is approached by them. Methodology: The research is a integrative literature review, through a search in PubMed, Web of Science, Science Direct and MEDLINE databases, using the descriptors associated with Boolean operators: “((Facial rejuvenation) AND (Platelet-rich plasma)) AND (Platelet-derived growth factor)", in the period of April 2022. Results: The search returned primary and secondary articles, a total of 91 articles were found that were later analyzed and only 10 associated with the theme of this review were included. Final considerations: Platelet-rich plasma plays a positive role in tissue regeneration, with high level of platelets and growth factors. As well as its application in aesthetics, there has been increasing data in recent years, but the small number of randomized clinical trials limits the clarification of the technical application and the development of new studies, as they do not present standardization in their methods.
Agrawal, K. S., et al. (2016). Autologous fat transfer for esthetic contouring of face in posttraumatic nonfunctional maxillofacial deformities. Craniomaxillofac Trauma Reconstr, 9, 113–120.
Aldag, C., et al. (2016). Skin rejuvenation usin cosmetic products contaning growth factors, cytokines, and matrikines: a reviw of the literature. Clinical, Cosmetic and Investigational Dermatology, 9, 411-419.
Amini, F., et al. (2015). Efficacy of platelet rich plasma (PRP) on skin rejuvenation: A systematic review. Iran J Dermatol, 18(3), 119-21.
Badran, K. W., & Nabili, V. (2018) Lasers, microneedling, and platelet-rich plasma for skin rejuvenation and repair. Facial Plastic Surgery Clinics, 26(4), 455- 468.
Barone, F., et al. (2019). Clinical evidence of dermal and epidermal restructuring from a biologically active growth factor serum for skin rejuvenation. J Drugs Dermatol, 18, 290- 295.
Browning, S. R., et al (2012). Platelet-rich plasma increases matrix metalloproteinases in cultures of human synovial fibroblasts. JBJS 94(23), e172.
Cameli, N., et al. (2017). Autologous pure platelet-rich plasma dermal injections for facial skin rejuvenation: Clinical, Instrumental, and Flow Cytometry Assessment. Dermatol Surg, 43 (6), 826-835.
Cavallo, C., et al. (2016). Platelet-Rich Plasma: The Choice of Activation Method Affects the Release of Bioactive Molecules. BioMed Research International, 1-7.
Charles-de-sá, L., et al. (2018). Effect of Use of Platelet-Rich Plasma (PRP) in Skin with Intrinsic Aging Process. Aesthetic Surgery Journal, 38 (3), 321-28.
Chorazewska, M., et al. (2017). The use of platelet-rich plasma in anti-aging therapy (owerview). Journal of Education, Health and Sport, 7(11), 162-175. Costa, P. & Santos, P. (2016). Plasma rico em plaquetas: uma revisão sobre seu uso terapêutico. RBAC, 48(4), 311-9.
Elghblawi, E. (2018). Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering. Journal of Cosmetic Dermatology, 17, 423- 430,
sat, D. M., et al. (2016). Comparison of the effects of plateletrich plasma prepared in various forms on the healing of dermal wounds in rats. Wounds, 28(3), 99–108.
Everts, P. A., et al. (2018). Autologous pure platelet‐rich plasma injections for facial skin rejuvenation: Biometric instrumental evaluations and patientreported outcomes to support antiaging effects. J Cosmet Dermatol, 1-11.
Fabi, S., & Sundaram H. (2014). The potential of topical and injectable growth factors and cytokines for skin rejuvenation. Facial Plast Surg, 30, 157- 171. Gholami, M. et al. (2016). A systematic review and meta-analysis of the application of platelet rich plasma in sports medicine. Electron Phys, 8, 2325- 2332.
Hassan, H., et al. (2020). Injectable platelet‐rich fibrin for facial rejuvenation: A prospective, single‐center study. Journal of Cosmetic Dermatology, 19(12), 3213-3221.
Hui, Q., et al. (2017). The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CO2 Laser Therapy for Facial Rejuvenation. Rejuvenation research, 20(1), 25-31.
Izol, B. S., & Uner, D. D. (2019). A new approach for root surface biomodification using injectable platelet-rich fibrin (I-PRF). Med Sci Monit, 25, 4744- 4750. Kelm, R.C. & Ibrahim, O. (2022). Utility of platelet-rich plasma in aesthetics. Clinics in Dermatology, 40(1),19-28.
Kim, S. K., et al. (2020). The Effect of Hyaluronidase on the Fat Graft. Journal of Craniofacial Surgery, 31(3), 618-621. Krutmann, J. et al. (2017). The skin aging exposome. Journal of Dermatological Science, 85,152-161.
Leach, J. B., et al. (2004). Development of photocrosslinkable hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineering. J Biomed Mater Res, 70, 74–82.
Liang, Z., et al. (2018). Precise intradermal injection of nanofat-derived stromal cells combined with platelet-rich fibrin improves the efficacy of facial skin rejuvenation. Cellular Physiology and Biochemistry, 47(1), 316-329.
Liu, B., et al. (2013). The adjuvant use of stromal vascular fraction and platelet-rich fibrin for autologous adipose tissue transplantation. Tissue Eng Part C Methods, 19, 1–14.
Mokos, B. Z., et al. (2018). Facial Changes in the mature patient. Clinical in Dermatology, 36, 152-158.
Murray, T., & Khetarpal, S. Platelet-Rich Fibrin. Advances in Cosmetic Surgery, 5(1), 9-16, 2022.
Ozsagir, Z. B., et al. (2020). Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. J Clin Periodontol, 47, 489- 499.
Papakonstantinou, E., et al. (2012). Hyaluronic acid: a key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258.
Pavani, A. A., & Fernandes, T. R. L. (2017). Plasma rico em plaquetas no rejuvenescimento cutâneo facial: uma revisão de literatura. Uningá Review Journal, 29(1).
Peng, G. L. (2019). Platelet-rich plasma for skin rejuvenation: facts, fiction, and pearls for practice. Facial Plastic Surgery Clinics, 27(3), 405-411.
Rodrigues, P. L. N., et al. (2019). O uso do plasma rico em Plaquetas no Rejuvenescimento Facial: Uma Revisão Integrativa/Use of rich Plasma on platelets in Facial Rejuvenation: An Integrating Review. Revista de psicologia, 13(47), 563-575.
Ruivo, A. P. (2014.). Envelhecimento cutâneo: fatores influentes, ingredientes ativos e estratégias de veiculação. Dissertação de mestrado. Universidade João Pessoa. Portugal, Porto.
Samadi, P., et al. (2019). The use of platelet-rich plasma in aesthetic and regenerative medicine: a comprehensive review. Aesthetic plastic surgery, 43(3), 803- 814.
Semsarzadeh, N., & Khetarpal, S. (2020). Role of Platelet-Rich Plasma and the Science Behind Its Mechanism of Action: Its Many Uses Including Rejuvenation and Hair Growth. Advances in Cosmetic Surgery, 3(1), 1-13.
Sinno, S., et al. (2016). Current thoughts on fat grafting: Using the evidence to determine fact or fiction. Plast Reconstr Surg, 137, 818–824.
Teston, A. P., et al. (2010). Envelhecimento cutâneo: teoria dos radicais livres tratamentos visando a prevenção e rejuvenescimento. Revisão. UNINGÁ, Maringa – PR, 10, 71– 84.
Trojahn, C., et al. (2015). Characterizing facial skin ageing in humans: disentangling extrinsic from intrinsic biological phenomena. Biomed Res Int, 3185-86.
Wang, X., et al. (2019) .Fluid platelet‐rich fibrin stimulates greater dermal skin fibroblast cell migration, proliferation, and collagen synthesis when compared to platelet‐rich plasma. Journal of cosmetic dermatology, 18(6), 2004-2010.
Zhang, M., et al. (2018). Applications and efficacy of platelet-rich plasma in dermatology: A clinical review. J Cosmet Dermatol, 17(5), 660-5
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Copyright (c) 2023 Even Herlany Pereira Alves; Hélio Mateus Silva Nascimento; Odnir Silva Monteiro; Nikaely Brandão Barbosa; Denise Mayara Silva de Melo; Tereza Cristina de Carvalho Souza Garcês; Ivã Sales Magalhães; Artur Alexandre de Oliveira; Janyere Alexandrino de Sousa
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