Restrictive diets on Type 2 Diabetes: remission and glycemic control




Calorie restriction; Endocrinology; Diabetes.


Introduction: Although lifestyle modifications are universally recognized as the first-line treatment for type 2 diabetes mellitus (T2DM), adequate glycemic control is difficult to achieve in most obese patients. Medications help control the symptoms of diabetes but cannot prevent disease progression. The aim of this study is to elucidate the role of restrictive diets in glycemic control and remission of type 2 diabetes. Methodology: This is an integrative review, in which the guiding question was "Does calorie restriction allow remission and improvement of glycemic control in patients with type 2 diabetes mellitus? The search for articles was performed in the main databases (PubMed, Scielo, and Google Scholar) using the terms "calorie restriction" and "type 2 diabetes" combined with Boolean operators. Results and discussion: There are several ways of nutritional intervention, with or without the addition of drugs, which may lead to improved glycemic control and even remission of T2DM. The superiority of carbohydrate restriction over calorie-restricted diets remains controversial, with studies showing benefits in both types of intervention. Intermittent periods of dieting have also been shown to be beneficial. Conclusion: Therefore, restrictive diets are effective in glycemic control and are able to lead to remission of type 2 diabetes mellitus in the medium to long term. Further studies should be done to clarify the best dietary change for this type of patient.


Artasensi, A., Pedretti, A., Vistoli, G., & Fumagalli, L. (2020). Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs. Molecules (Basel, Switzerland), 25(8), 1987.

Baudilio Belzarez Guedez, J., Ribeiro Lacerda, M., Dias do Nascimento, J., Tonin, L., & de Godoi Caceres, N. T. (2021). Nursing care in hemodialysis: integrative review / Cuidados de enfermagem na hemodiálise: revisão integrativa. Revista De Pesquisa Cuidado é Fundamental Online, 13, 653–660.

Chen, C., Cohrs, C. M., Stertmann, J., Bozsak, R., & Speier, S. (2017). Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis. Molecular metabolism, 6(9), 943–957.

Costa, B. B. da, & Moreira, T. A. (2021). Principais aspectos fisiopatológicos e clínicos presentes no Diabetes mellitus tipo I (autoimune). Research, Society and Development, 10(14), e153101421773.

Dambha-Miller, H., Day, A. J., Strelitz, J., Irving, G., & Griffin, S. J. (2020). Behaviour change, weight loss and remission of Type 2 diabetes: a community-based prospective cohort study. Diabetic Medicine: A Journal of the British Diabetic Association, 37(4), 681–688.

Esmaili, S., Hemmati, M., & Karamian, M. (2020). Physiological role of adiponectin in different tissues: a review. Archives of physiology and biochemistry, 126(1), 67–73.

Ference, B. A., Ginsberg, H. N., Graham, I., Ray, K. K., Packard, C. J., Bruckert, E., Hegele, R. A., Krauss, R. M., Raal, F. J., Schunkert, H., Watts, G. F., Borén, J., Fazio, S., Horton, J. D., Masana, L., Nicholls, S. J., Nordestgaard, B. G., van de Sluis, B., Taskinen, M. R., Tokgözoglu, L., … Catapano, A. L. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. European heart journal, 38(32), 2459–2472.

Furmli, S., Elmasry, R., Ramos, M., & Fung, J. (2018). Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ case reports, 2018, bcr2017221854.

Galaviz, K. I., Narayan, K. M. V., Lobelo, F., & Weber, M. B. (2015). Lifestyle and the Prevention of Type 2 Diabetes: A Status Report. American journal of lifestyle medicine, 12(1), 4–20.

Gram-Kampmann, E. M., Hansen, C. D., Hugger, M. B., Jensen, J. M., Brønd, J. C., Hermann, A. P., Krag, A., Olsen, M. H., Beck-Nielsen, H., & Højlund, K. (2022). Effects of a 6-month, low-carbohydrate diet on glycaemic control, body composition, and cardiovascular risk factors in patients with type 2 diabetes: An open-label randomized controlled trial. Diabetes, Obesity & Metabolism, 24(4), 693–703.

Han, Y., Cheng, B., Guo, Y., Wang, Q., Yang, N., & Lin, P. (2021). A Low-Carbohydrate Diet Realizes Medication Withdrawal: A Possible Opportunity for Effective Glycemic Control. Frontiers in Endocrinology, 12.

Kobayashi, M., Miura, T., Miura, K., Hiroyama, N., & Akashi, K. (2020). Effect of a Moderate Carbohydrate-Restricted Diet on DPP-4 Inhibitor Action among Individuals with Type 2 Diabetes Mellitus: A 6-Month Intervention Study. Journal of Nutritional Science and Vitaminology, 66(2), 114–118.

Laakso M. (2019). Biomarkers for type 2 diabetes. Molecular metabolism, 27S(Suppl), S139–S146.

Dal, K., Mendes, S., Cristina De Campos, R., Silveira, P., & Galvão, C. M. (2008). Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem, 17(4), 758–764.

Polito, R., Monda, V., Nigro, E., Messina, A., Di Maio, G., Giuliano, M. T., Orrù, S., Imperlini, E., Calcagno, G., Mosca, L., Mollica, M. P., Trinchese, G., Scarinci, A., Sessa, F., Salerno, M., Marsala, G., Buono, P., Mancini, A., Monda, M., Daniele, A., … Messina, G. (2020). The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity. Frontiers in physiology, 11, 356.

Richard, A. J., White, U., Elks, C. M., & Stephens, J. M. (2020). Adipose Tissue: Physiology to Metabolic Dysfunction. In K. R. Feingold (Eds.) et. al., Endotext., Inc.

Ruggenenti, P., Cortinovis, M., Trillini, M., Parvanova, A., Abbate, M., Satriano, C., Salvetti, F., Bossi, A. C., Trevisan, R., Perna, A., Peracchi, T., Rubis, N., Diadei, O., Martinetti, D., Gaspari, F., Fontana, L., & Remuzzi, G. (2022). Long-term kidney and systemic effects of calorie restriction in overweight or obese type 2 diabetic patients (C.Re.S.O. 2 randomized controlled trial). Diabetes Research and Clinical Practice, 185.

Silva, M. E. da, Silva, W. M. da, Silva, G. M. da, Souza, R. G. de, Santos, J. A. dos, Luz, M. K. S. da, Ferreira, M. D. F., Silva, T. M. L., Rocha, L. C. P. da, & Silva, C. A. de O. (2020). Manifestações neurológicas provocadas por COVID-19: uma revisão integrativa da literatura / Neurological manifestations caused by COVID-19: an integrative literature review. Brazilian Journal of Development, 6(7), 52155–52163.

Taylor, R. (2021). Type 2 diabetes and remission: practical management guided by pathophysiology. Journal of Internal Medicine, 289(6), 754–770.

Umphonsathien, M., Rattanasian, P., Lokattachariya, S., Suansawang, W., Boonyasuppayakorn, K., & Khovidhunkit, W. (2022). Effects of intermittent very-low calorie diet on glycemic control and cardiovascular risk factors in obese patients with type 2 diabetes mellitus: A randomized controlled trial. Journal of Diabetes Investigation, 13(1), 156–166.



How to Cite

CHERAIN, L. G. G. .; OLIVEIRA, I. P. de .; SILVA, J. R. .; OLIVEIRA, A. C. .; MASSOTE, M.; JUNQUEIRA, G. H. C. .; LEONARDO, F. M. .; OLIVEIRA, G. A. Z. de .; SANTOS, G. C. N. S. .; ROCHA, C. M. . Restrictive diets on Type 2 Diabetes: remission and glycemic control. Research, Society and Development, [S. l.], v. 12, n. 2, p. e25512240255, 2023. DOI: 10.33448/rsd-v12i2.40255. Disponível em: Acesso em: 4 oct. 2023.



Review Article