Conservative treatment for open pyometra with aglepristone in a prize-winning breeding bitch of the French Bulldog breed




Reproductive disorder; Hormone therapy; Pyometra; Conservative treatment.


Pyometra is the most common infectious disease of the reproductive system in bitches. It is considered a disease of great complexity and if not diagnosed and treated in time, it can lead to the death of the bitch. The purpose of this article is to report the efficacy of conservative treatment in a bitch diagnosed with pyometra and her subsequent return to reproductive function. This is a 12-month-old female French Bulldog that presented with apathy, dehydration, hyperthermia, hyporexia, abdominalgia, and mucopurulent vulvar discharge. The presumptive diagnosis of pyometra was based on the extravasation of purulent contents through the vulva, which was confirmed by ultrasonography. The treatment initiated was based on the administration of aglepristone (Alizin® Virbac) and combinations with antibiotic therapy, antiphlogistic drugs, analgesic, and gastric protector, which proved to be effective for the clinical cure of the animal. After three years, the animal was subjected to artificial insemination and pregnancy was confirmed, with uneventful gestation and birth of two puppies. The treatment in question was considered effective because it promoted the clinical cure of the animal, the complete involution of the uterus and the return of reproductive viability.

Author Biography

Vinícius José de Oliveira, Universidade Federal de Uberlândia

Doutor em Imunologia Aplicada e Parasitologia; Doutorando em Ciências Veterinárias; Especialista em Zoonose e Saúde Pública; Estudante de Medicina Veterinária, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brasil.


Ahn, S., Bae, H., Kim, J., Kim, S., Park, J., Kim, S. K., ... & Yu, D. (2021). Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy. Canadian Journal of Veterinary Research, 85(4), 271-278.

Arendt, M., Ambrosen, A., Fall, T., Kierczak, M., Tengvall, K., Meadows, J. R., ... & Hagman, R. (2021). The ABCC4 gene is associated with pyometra in golden retriever dogs. Scientific Reports, 11(1), 16647.

Bartoskova, A., Vitasek, R., Leva, L., & Faldyna, M. (2007). Hysterectomy leads to fast improvement of haematological and immunological parameters in bitches with pyometra. Journal of Small Animal Practice, 48(10), 564-568.

Batista, P. R., Blanco, P. G., & Gobello, C. (2015). Treatment of canine pyometra with the gonadotropin-releasing hormone antagonist acyline: A case series. Topics in Companion Animal Medicine, 30(1), 25-27.

Chen, Y. M., Wright, P. J., Lee, C. S., & Browning, G. F. (2003). Uropathogenic virulence factors in isolates of Escherichia coli from clinical cases of canine pyometra and feces of healthy bitches. Veterinary microbiology, 94(1), 57-69.

Cunha, H. C. B., Promissia, S. G., & Almeida, C. B. (2020). Piometra: infecção uterina em cadelas jovens e adultas. Revista Científica, 1(1).

Dąbrowski, R., Szczubiał, M., Kostro, K., Wawron, W., Ceron, J. J., & Tvarijonaviciute, A. (2015). Serum insulin-like growth factor-1 and C-reactive protein concentrations before and after ovariohysterectomy in bitches with pyometra. Theriogenology, 83(4), 474-477.

Egenvall, A., Hagman, R., Bonnett, B. N., Hedhammar, A., Olson, P., & Lagerstedt, A. S. (2001). Breed risk of pyometra in insured dogs in Sweden. Journal of veterinary internal medicine, 15(6), 530-538.

Fieni, F. (2006). Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches. Theriogenology, 66(6-7), 1550-1556.

Fieni, F., Topie, E., & Gogny, A. (2014). Medical treatment for pyometra in dogs. Reproduction in domestic animals, 49, 28-32.

Goudie, A. (2013). Detection of intraperitoneal free gas by ultrasound. Australasian journal of ultrasound in medicine, 16(2), 56-61.

Hagman, R. (2017). Molecular aspects of uterine diseases in dogs. Reproduction in Domestic Animals, 52, 37-42.

Hagman, R. (2018). Pyometra in small animals. Veterinary Clinics: Small Animal Practice, 48(4), 639-661.

Hagman, R. (2022). Pyometra in small animals 2.0. Veterinary Clinics: Small Animal Practice, 52(3), 631-657.

Hagman, R., Kindahl, H., Fransson, B. A., Bergström, A., Holst, B. S., & Lagerstedt, A. S. (2006). Differentiation between pyometra and cystic endometrial hyperplasia/mucometra in bitches by prostaglandin F2α metabolite analysis. Theriogenology, 66(2), 198-206.

Hagman, R., Lagerstedt, A. S., Hedhammar, Å., & Egenvall, A. (2011). A breed-matched case-control study of potential risk-factors for canine pyometra. Theriogenology, 75(7), 1251-1257.

Henriques, S., Silva, E., Silva, M. F., Carvalho, S., Diniz, P., Lopes-da-Costa, L., & Mateus, L. (2016). Immunomodulation in the canine endometrium by uteropathogenic Escherichia coli. Veterinary research, 47(1), 1-17.

Jitpean, S., Hagman, R., Ström Holst, B., Höglund, O. V., Pettersson, A., & Egenvall, A. (2012). Breed variations in the incidence of pyometra and mammary tumours in Swedish dogs. Reproduction in domestic animals, 47, 347-350.

Johnston, S. D., Root Kustritz, M. V., & Olson, P. S. (2001). Canine and feline theriogenology. Saunders.

Jurka, P., Max, A., Hawryńska, K., & Snochowski, M. (2010). Age‐related pregnancy results and further examination of bitches after aglepristone treatment of pyometra. Reproduction in domestic animals, 45(3), 525-529.

Kempisty, B., Bukowska, D., Wozna, M., Piotrowska, H., Jackowska, M., Zuraw, A., ... & Nowicki, M. (2013). Endometritis and pyometra in bitches: a review. Veterinarni medicina, 58(6).

Macente, B., Gutierrez, R. R., Apparício, M., Mansano, C. F. M., Padilha, L. C., Tiosso, C. F., & Toniollo, G. H. (2016). Uso da Aglepristone no tratamento de piometra em cadela com gestação no estro subsequente. Revista Investigação Medicina Veterinária, 15(1), 46-48.

Maddens, B., Daminet, S., Smets, P., & Meyer, E. (2010). Escherichia coli pyometra induces transient glomerular and tubular dysfunction in dogs. Journal of veterinary internal medicine, 24(6), 1263-1270.

Mattei, C., Fabbi, M., & Hansson, K. (2018). Radiographic and ultrasonographic findings in a dog with emphysematous pyometra. Acta Veterinaria Scandinavica, 60(1), 1-5.

Maya-Pulgarin, D., Gonzalez-Dominguez, M. S., Aranzazu-Taborda, D., Mendoza, N., & Maldonado-Estrada, J. G. (2017). Histopathologic findings in uteri and ovaries collected from clinically healthy dogs at elective ovariohysterectomy: a cross-sectional study. Journal of veterinary science, 18(3), 407-414.

Melandri, M., Veronesi, M. C., Pisu, M. C., Majolino, G., & Alonge, S. (2019). Fertility outcome after medically treated pyometra in dogs. Journal of veterinary science, 20(4).

Mello Corrêa, T. (2020). Avaliação ultrassonográfica da hiperplasia endometrial cística-piometra em cadelas senis após tratamento com farmacoterapia específica–relato de três casos. Revista Panorâmica online, 2.

Pailler, S., Slater, M. R., Lesnikowski, S. M., J’mai, M. G., Duvieusart, C. B., Ledesma, E. J., ... & DeClementi, C. (2022). Findings and prognostic indicators of outcomes for bitches with pyometra treated surgically in a nonspecialized setting. Journal of the American Veterinary Medical Association, 260(S2), S49-S56.

Pawlak, P., Warzych, E., Madeja, Z. E., Nowak, T., & Lechniak, D. (2021). Pyometra does not affect some molecular quality-related parameters of canine oocytes. Annals of Animal Science, 21(1), 193-204. https://doi:

Pretzer, S. D. (2008). Clinical presentation of canine pyometra and mucometra: a review. Theriogenology, 70(3), 359-363.

Qian, C., & Hou, J. (2017). Escherichia coli virulence influences the roles of sex hormone receptors in female dogs with simulated pyometra. Experimental and therapeutic medicine, 14(4), 3013-3021.

Qian, C., Jiang, C., & Hou, J. (2020). The endometrium histopathology and cell ultrastructure in bitches with pyometra induced using progesterone and Escherichia coli. Tissue and Cell, 67, 101414.

Riquelme, A. S., & Beato, C. R. (2021). Un caso de mucohematometra en una perra: descripción y análisis de un tratamiento con aglepristona y cloprostenol. Revista de Investigaciones Veterinarias del Perú, 32(6).

Ros, L., Holst, B. S., & Hagman, R. (2014). A retrospective study of bitches with pyometra, medically treated with aglepristone. Theriogenology, 82(9), 1281-1286.

Rosa Filho, R. R. D., Brito, M. M., Faustino, T. G., Almeida, L. L. D., Gardés, T. P., Leite, R. F., & Vannucchi, C. I. (2020). Clinical changes and uterine hemodynamic in pyometra medically treated bitches. Animals, 10(11), 2011.

Rybska, M., Billert, M., Skrzypski, M., Kubiak, M., Woźna-Wysocka, M., Łukomska, A., ... & Wąsowska, B. (2022). Canine cystic endometrial hyperplasia and pyometra may downregulate neuropeptide phoenixin and GPR173 receptor expression. Animal Reproduction Science, 238, 106931.

Sá, M. A. F., Salles, S. P. X., & Fagundes, A. S. (2016). Principais métodos diagnósticos da piometra canina–revisão de literatura. Revista Científica do UBM, 105-123.

Schlafer, D. H. (2012). Diseases of the canine uterus. Reproduction in Domestic Animals, 47, 318-322.

Trasch, K., Wehrend, A., & Bostedt, H. (2003). Follow‐up examinations of bitches after conservative treatment of pyometra with the antigestagen aglepristone. Journal of Veterinary Medicine Series A, 50(7), 375-379.

Veiga, G. A. L., Miziara, R. H., Angrimani, D. S. R., Papa, P. C., Cogliati, B., & Vannucchi, C. I. (2017). Cystic endometrial hyperplasia–pyometra syndrome in bitches: identification of hemodynamic, inflammatory, and cell proliferation changes. Biology of reproduction, 96(1), 58-69.

Verstegen, J., Dhaliwal, G., & Verstegen-Onclin, K. (2008). Mucometra, cystic endometrial hyperplasia, and pyometra in the bitch: advances in treatment and assessment of future reproductive success. Theriogenology, 70(3), 364-374.

Woźna-Wysocka, M., Rybska, M., Błaszak, B., Jaśkowski, B. M., Kulus, M., & Jaśkowski, J. M. (2021). Morphological changes in bitches endometrium affected by cystic endometrial hyperplasia-pyometra complex–the value of histopathological examination. BMC Veterinary Research, 17, 1-11.



How to Cite

DADONA, N. F. .; PEREIRA, D. A. .; OLIVEIRA, V. J. de .; CARVALHO, A. C. F. de .; SANARELLI, N. P. .; REIS, L. C. N. .; MACHADO, L. B. .; MACHADO, J. C. B. .; BORGES, L. W. . Conservative treatment for open pyometra with aglepristone in a prize-winning breeding bitch of the French Bulldog breed. Research, Society and Development, [S. l.], v. 12, n. 2, p. e29712240337, 2023. DOI: 10.33448/rsd-v12i2.40337. Disponível em: Acesso em: 7 jun. 2023.



Agrarian and Biological Sciences