Study of the safety and therapeutic efficacy of multipotent adult progenitor cells in the treatment of feline asthma




Stem cells; Feline asthma; Cell therapy; Therapeutic safety; Therapeutic efficacy.


Feline asthma is a disease that is prevalent in young or middle-aged cats, with the main clinical signs being dry cough, mouth breathing, expiratory dyspnea, wheezing, cyanosis, crackles and weight loss. However, current therapeutic approaches have proven to be ineffective in preventing or reversing all pathological aspects of feline asthma. In this way, the development of new treatments for feline asthma that prove to be safe and effective are of fundamental importance for veterinary medicine. Stem cell therapy is presented to the market as a promising therapeutic approach since it has been shown to be safe and effective in the treatment of several diseases that affect both large and small animals. Therefore, this study aims to analyze the safety and efficacy of the treatment of feline asthma through stem cell transplantation, which mainly aims to obtain a methodology that allows the improvement of the quality of cats.


Agusti, A., Gibson, P. G. & McDonald, V. M. (2023). Treatable Traits in Airway Disease: From Theory to Practice. Journal Allergy Clin Immunol Pract, 1(3), 713-723.

Assis, T. L. S., Winck, C. P. & Santos, E. J. C. (2017). Análise da Viabilidade Terapêutica das Células-Tronco Mesenquimais Alogênicas no Tratamento de Felino Acometido por Complexo Gengivite Estomatite Felina. Revista Científica Multidisciplinar Núcleo do Conhecimento. 2(1), 470-482.

Black, L. L., Gaynor, J., Gahring, D., Adams, C., Aron, D., Harman, S., Gingerich, D. A. & Harman, R. (2007). Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther. Winter; 8(4), 272-84.

Chang, C. H., Cohn, L. A., Declue, A. E., Liu, H. & Reinero, C. R. (2013). Oral glucocorticoids diminish the efficacy of allergen-specific immunotherapy in experimental feline asthma. Vetinary Journal,197(2), 268-72.

Choi, J. Y, Hur, J., Jeon, S., Jung, C. K. & Rhee, C. K. (2022). Effects of human adipose tissue- and bone marrow-derived mesenchymal stem cells on airway inflammation and remodeling in a murine model of chronic asthma. Scientific Reports, 12(1), 12032.

Depuydt, E., Broeckx, S. Y., Chiers, K., Patruno, M., Da Dalt, L., Duchateau, L., Saunders, J., Pille, F., Martens, A., Van Hecke, L. & Spaas, J. H. (2022). Cellular and Humoral Immunogenicity Investigation of Single and Repeated Allogeneic Tenogenic Primed Mesenchymal Stem Cell Treatments in Horses Suffering From Tendon Injuries. Front Vet Sci, 24(8), 789293.

Fu, X., Liu, G., Halim, A., Ju, Y., Luo, Q. & Song A. G. (2019). Mesenchymal Stem Cell Migration and Tissue Repair. Cells, 8(8), 784.

Gómez, N., Pisano, P., Castillo, V. & Fontanals, A. (2012). Asma felino: fisiopatología, diagnóstico y tratamiento. In Vet, 14(2), 191–207.

Grotheer, M., Hirschberger, J., Hartmann, K., Castelletti, N. & Schulz, B. (2020). Comparison of signalment, clinical, laboratory and radiographic parameters in cats with feline asthma and chronic bronchitis. J Feline Med Surg, 22(7), 649-655.

Kavanagh, H. & Mahon, B. P. (2011). Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy, 66(4), 523-31.

Leemans, J., Kirschvink, N., Clercx, C., Snaps, F. & Gustin, P. (2012). Effect of short-term oral and inhaled corticosteroids on airway inflammation and responsiveness in a feline acute asthma model. Veterinary Journal, 192(1), 41-8.

Moll, G., Rasmusson-Duprez, I., Von Bahr, L., Connolly-Andersen, A. M., Elgue, G., Funke, L., Hamad, O. A., Lönnies, H., Magnusson, P. U., Sanchez, J., Teramura, Y., NilssonEkdahl, K., Ringdén, O., Korsgren, O., Nilsson, B. & Le Blanc, K (2012). Are therapeutic human mesenchymal stromal cells compatible with human blood? Stem Cells, 30(7), 1565-74.

Nemeth, K., Keane-Myers, A., Brown, J. M., Metcalfe, D. D., Gorham, J. D., Bundoc, V. G., Hodges, M. G., Jelinek, I., Madala, S., Karpati, S. & Mezey, E. (2010). Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci U S A, 107(12), 5652-7.

Park, H. K., Cho, K. S., Park, H. Y., Shin, D. H., Kim, Y. K., Jung, J. S., Park, S. K. & Roh, H. J. (2010). Adipose-derived stromal cells inhibit allergic airway inflammation in mice. Stem Cells Dev, 19(11), 1811-8.

Prockop, D. J. & Olson, S. D. (2007). Clinical trials with adult stem/progenitor cells for tissue repair: Let’s not overlook some essential precautions. Blood, 109(8), 3147–51.

Santos, E. J. C. (2017). Avaliação de Diferentes Vias de Administração de Células Progenitoras Adultas Multipotentes Visando sua Utilização Terapêutica no Tratamento da Diabete. Revista Científica Multidisciplinar Núcleo do Conhecimento, 1(5), 1066–1075.

Santos, E. J. C. (2018a). Biologia das células-tronco mesenquimais de felinos obtidas a partir de nichos presentes no tecido adiposo objetivando sua aplicação terapêutica na medicina veterinária. Revista Eletrônica Científica da UERGS, 4(3), 368–379.

Santos, E. J. C., Poppi, F. P. & Braga, C. L. (2018b). Células progenitoras adultas multipotentes alogênicas no tratamento de doença renal em felinos. Science and Animal Health, 6(3), 266-285.

Santos, E. J. C., Winck, C. P., Alves, C. A. M. & Fernande, R. A. (2019). Células-tronco mesenquimais alogênicas no tratamento das sequelas neurológicas de cinomose canina. Medvep - Revista Científica de Medicina Veterinária. Pequenos Animais e Animais de Estimação, 3(49), 32-40.

Santos, E. J. C. (2023a). Aplicação terapêutica das células-tronco na medicina veterinária. Núcleo do Conhecimento.

Santos E. J. C., Mazzeo, A. & Braga, C. L (2023b) Potencial terapêutico de células progenitoras adultas multipotentes alogênicas no tratamento de aplasia medular secundária à erliquiose canina, Science and Animal Health, 11(1), 35-52.

Trzil, J. E. (2020). Feline Asthma: Diagnostic and Treatment Update. Vet Clin North Am Small Anim Pract, 50(2), 375-391.

Vientós-Plotts, A. I., Ericsson, A. C., McAdams, Z. L., Rindt, H., & Reinero, C. R. (2022) Respiratory dysbiosis in cats with spontaneous allergic asthma. Front Vet Sci. 8(9), 930385.

Wei, L. N., Wu, C. H., Lin, C. T. & Liu, I. H (2022). Topical applications of allogeneic adipose-derived mesenchymal stem cells ameliorate the canine keratoconjunctivitis sicca. BMC Vet Res, 18(1), 217.




How to Cite

SANTOS, E. J. C. .; MAZZEO, A.; BRAGA, C. L. . Study of the safety and therapeutic efficacy of multipotent adult progenitor cells in the treatment of feline asthma. Research, Society and Development, [S. l.], v. 13, n. 3, p. e2713340644, 2024. DOI: 10.33448/rsd-v13i3.40644. Disponível em: Acesso em: 25 jun. 2024.



Health Sciences