Breast cancer in the State of Piauí, Northeastern Brazil: from diagnosis to treatment
DOI:
https://doi.org/10.33448/rsd-v12i5.41455Keywords:
Breast neoplasms; Time-to-treatment; Epidemiology.Abstract
Breast cancer is the most common type of cancer in women worldwide, when non-melanoma skin cancers are excluded, accounting for more than 2 million new cases each year and being the leading cause of mortality in women from all over the world. Delay in starting treatment is related to a worse prognosis. In Brazil, law nº 12.732 of November 22, 2012 provides for a period of 60 days from the diagnosis to start treatment for neoplasms. Thus, the objective of this study was to discuss the epidemiology of breast cancer in the state of Piauí, from its diagnosis to the beginning of treatment in the Sistema Único de Saúde (SUS) network. The method used for the study was a retrospective analysis with a descriptive quantitative cross-sectional approach. Data collection took place between August 2022 and March 2023, using the Sistema Único de Saúde Database (DATASUS). The results obtained showed failure to carry out an early diagnosis, underutilization of the therapeutic modalities offered, in addition to the delay between diagnosis and the beginning of treatment.
References
An, D., Choi, J., Lee, J., Kim, J. Y., Kwon, S., Kim, J., Lee, S., Jeon, S., Lee, C., Lee, S., & Woo, H. (2022). Time to surgery and survival in breast cancer. BMC surgery, 22(1), 388. https://doi.org/10.1186/s12893-022-01835-1
Ayala, A. M., Anjos, J. C., Cassol, G. A. & Höfelmann, D. A. (2019). Sobrevida em 10 anos em mulheres com câncer de mama: coorte história de 2000-2014. Ciência & Saúde Coletiva, 24(4), 1537-1550.
Barrios C. H. (2022). Global challenges in breast cancer detection and treatment. Breast (Edinburgh, Scotland), 62 Suppl 1(Suppl 1), S3–S6. https://doi.org/10.1016/j.breast.2022.02.003
Brasil. Ministério da Saúde. (2019). Diretrizes diagnósticas e terapêuticas do carcinoma de mama.
Chen, H., Bai, F., Wang, M., Zhang, M., Zhang, P., & Wu, K. (2019). The prognostic significance of co-existence ductal carcinoma in situ in invasive ductal breast cancer: a large population-based study and a matched case-control analysis. Annals of translational medicine, 7(18), 484. https://doi.org/10.21037/atm.2019.08.16
Cutuli, B. (2019). Les carcinomes canalaires in situ em 2019: diagnostic traitement, pronostic. La Presse Médicale, 48(10), 1112-1122.
Feng, Y., Spezia, M., Huang, S., Yuan, C., Zeng, Z., Zhang, L., Ji, X., Liu, W., Huang, B., Luo, W., Liu, B., Lei, Y., Du, S., Vuppalapati, A., Luu, H. H., Haydon, R. C., He, T. C., & Ren, G. (2018). Breast cancer development and progression: risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes & diseases, 5(2), 77–106. https://doi.org/10.1016/j.gendis.2018.05.001
Fitzmaurice, C., Akinyemiju, T. F., Al Lami, F. H., Alam, T., Alizadeh-Navaei, R., Allen, C., Alsharif, U., Alvis-Guzman, N., Amini, E., Anderson, B. O., Aremu, O., Artaman, A., Asgedom, S. W., Assadi, R., Atey, T. M., Avila-Burgos, L., Awasthi, A., Ba Saleem, H. O., Barac, A., … Naghavi, M. (2018). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2016: a systematic analysis for the global burden of disease study. JAMA oncology, 4(11), 1553–1568. https://doi.org/10.1001/jamaoncol.2018.2706
Fundação CEPRO. (2012). Piauí em números (9a ed.).
Gil, A. C. (2013). Métodos e técnicas de pesquisa social. 8ª ed. Atlas.
Giordano, S. H. (2018). Breast cancer in men. New England Journal of Medicine, 378(24), 2311–2320.
Hanna, T. P., King, W. D., Thibodeau, S., Jalink, M., Paulin, G. A., Harvey-Jones, E., O'Sullivan, D. E., Booth, C. M., Sullivan, R., & Aggarwal, A. (2020). Mortality due to cancer treatment delay: systematic review and meta-analysis. BMJ (Clinical research ed.), 371, m4087. https://doi.org/10.1136/bmj.m4087
Hennequin, C., Belkacémi, Y., Bourgier, C., Cowen, D., Cutuli, B., Fourquet, A., Hannoun-Lévi, J. M., Pasquier, D., Racadot, S., & Rivera, S. (2022). Radiotherapy of breast cancer. Cancer radiotherapie: journal de la Societe francaise de radiotherapie oncologique, 26(1-2), 221–230. https://doi.org/10.1016/j.canrad.2021.11.013
Harbeck, N., Penault-Llorca, F., Cortes, J., Gnant, M., Houssami, N., Poortmans, P., Ruddy, K., Tsang, J., & Cardoso, F. (2019). Breast cancer. Nature reviews. Disease primers, 5(1), 66. https://doi.org/10.1038/s41572-019-0111-2
Hill, D. A., Friend, S., Lomo, L., Wiggins, C., Barry, M., Prossnitz, E., & Royce, M. (2018). Breast cancer survival, survival disparities, and guideline-based treatment. Breast cancer research and treatment, 170(2), 405–414. https://doi.org/10.1007/s10549-018-4761-7
IBGE – INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA. (2010). Censo Demográfico.
IBGE – INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA. (2022). Piauí – população.
INSTITUTO NACIONAL DE CÂNCER. (2022). Eu cuido da minha saúde todos os dias. E você?.
INSTITUTO NACIONAL DE CÂNCER JOSÉ ALENCAR GOMES DA SILVA. Ministério da Saúde. (2021). Detecção precoce do Câncer.
INSTITUTO NACIONAL DE CÂNCER JOSÉ ALENCAR GOMES DA SILVA. Ministério da Saúde. (2021). Parâmetros técnicos para o rastreamento do câncer de mama.
Kresovich, J. K., Xu, Z., O'Brien, K. M., Weinberg, C. R., Sandler, D. P., & Taylor, J. A. (2019). Methylation-based biological age and breast cancer risk. Journal of the National Cancer Institute, 111(10), 1051–1058. https://doi.org/10.1093/jnci/djz020
Lei n. 12.732, de 22 de novembro de 2012. (2012). Dispões sobre o primeiro tratamento de paciente com neoplasia maligna comprovada e estabelece o prazo para seu início. Brasília, DF. Recuperado de https://www.planalto.gov.br/ccivil_03/_ato2011-2014/2012/lei/l12732.htm.
Łukasiewicz, S., Czeczelewski, M., Forma, A., Baj, J., Sitarz, R., & Stanisławek, A. (2021). Breast cancer-epidemiology, risk factors, classification, prognostic markers, and current treatment strategies-an updated review. Cancers, 13(17), 4287. https://doi.org/10.3390/cancers13174287
Masood S. (2016). Neoadjuvant chemotherapy in breast cancers. Women's health (London, England), 12(5), 480–491. https://doi.org/10.1177/1745505716677139
Moo, T. A., Sanford, R., Dang, C., & Morrow, M. (2018). Overview of breast cancer therapy. PET clinics, 13(3), 339–354. https://doi.org/10.1016/j.cpet.2018.02.006
Negrao, E. S., Cabello, C., Conz, L., Mauad, E. C., Zeferino, L. C., & Vale, D. B. (2022). The COVID-19 pandemic impact on breast câncer diagnosis: a retrospective study. Revista Brasileira de Ginecologia e Obstetrícia, 44(9), 871-877.
Organização Mundial de Saúde. (2020). Assessing national capacity for the prevention and control of noncommunicable diseases.
Patel, J., Baptiste, B. A., Kim, E., Hussain, M., Croteau, D. L., & Bohr, V. A. (2020). DNA damage and mitochondria in cancer and aging. Carcinogenesis, 41(12), 1625–1634. https://doi.org/10.1093/carcin/bgaa114
Pintican, R., Fechete, R., Boca, B., Cambrea, M., Leonte, T., Camuescu, O., Gherman, D., Bene, I., Ciule, L. D., Ciortea, C. A., Dudea, S. M., & Ciurea, A. I. (2022). Predicting the Early Response to Neoadjuvant Therapy with Breast MR Morphological, Functional and Relaxometry Features-A Pilot Study. Cancers, 14(23), 5866. https://doi.org/10.3390/cancers14235866
Risom, T., Glass, D. R., Averbukh, I., Liu, C. C., Baranski, A., Kagel, A., McCaffrey, E. F., Greenwald, N. F., Rivero-Gutiérrez, B., Strand, S. H., Varma, S., Kong, A., Keren, L., Srivastava, S., Zhu, C., Khair, Z., Veis, D. J., Deschryver, K., Vennam, S., Maley, C., … Angelo, M. (2022). Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma. Cell, 185(2), 299–310.e18. https://doi.org/10.1016/j.cell.2021.12.023
Souza, C. B., Fustinoni, S. M., Amorim, M. C., Zandonade, E., Matos, J. C. & Schirmer, J. (2015). Estudo do tempo entre o diagnóstico e início do tratamento do câncer de mama em idosas de um hospital de referência em São Paulo, Brasil. Ciência & Saúde Coletiva, 20(12), 3805-3816.
Shien, T., & Iwata, H. (2020). Adjuvant and neoadjuvant therapy for breast cancer. Japanese journal of clinical oncology, 50(3), 225–229. https://doi.org/10.1093/jjco/hyz213.
Sousa, S. T., Carvalho, M. M., Júnior, L. S. & Mariano, S. C. (2019) Acesso ao tratamento da mulher com câncer de mama. Saúde Debate, 43(122), 727-741.
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
Tan, M. M., Ho, W. K., Yoon, S. Y., Mariapun, S., Hasan, S. N., Lee, D. S., Hassan, T., Lee, S. Y., Phuah, S. Y., Sivanandan, K., Ng, P. P., Rajaram, N., Jaganathan, M., Jamaris, S., Islam, T., Rahmat, K., Fadzli, F., Vijayananthan, A., Rajadurai, P., See, M. H., … Teo, S. H. (2018). A case-control study of breast cancer risk factors in 7,663 women in Malaysia. PloS one, 13(9), e0203469. https://doi.org/10.1371/journal.pone.0203469.
Trayes, K. P.; Cokenakes, S. H. (2021). Breast cancer treatment. American Family Physician, 104(2), 171–178.
Wang, Q., Aktary, M. L., Spinelli, J. J., Shack, L., Robson, P. J., & Kopciuk, K. A. (2022). Pre-diagnosis lifestyle, health history and psychosocial factors associated with stage at breast cancer diagnosis - potential targets to shift stage earlier. Cancer epidemiology, 78, 102152. https://doi.org/10.1016/j.canep.2022.102152.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Letícia Farias Oliveira; Alexandre de Sousa Barbosa; Iara de Carvalho Alencar; Cintia Maria de Melo Mendes; Tatiana Vieira Souza Chaves; João Paulo da Silva Sampaio
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
