Relation between cannabidiol use and pain: a bibliographic review
DOI:
https://doi.org/10.33448/rsd-v12i5.41478Keywords:
Cannabidiol; Pain; Life quality.Abstract
Introduction: Pain can be incapacitating depending on its intensity and duration, causing the individual to have a loss in quality of life. Currently, the recommended treatments present beneficial effects that are scarce in the short term and their adverse effects make new pharmacological therapies indispensable. In this sense, the use of Cannabidiol is currently observed. Objective: To analyze the effect of Cannabidiol in individuals with chronic and acute pain. Method: This is an integrative literature review on the effects of Cannabidiol as a treatment for chronic and acute pain. The search will be conducted using the keywords based on the Descriptors in Health Sciences (DeCS) in the Portuguese languages: Cannabidiol, Pain, Chronic Pain, Acute Pain, Neuropathies. At the end of the project, it will use the PRISMA Protocol for the articles to be selected. Results: The work evidenced predominantly positive results regarding the use of cannabidiol (CBD) for pain management. Overall, in the analyzed studies, the cannabis-derived compound showed good efficacy in antinociceptive effects in the observed individuals. Conclusion: the use of cannabidiol for pain management is a promising therapy, but still needs more understanding about its prolonged use and mechanisms of action.
References
BRASIL. Ministério da Saúde. Gabinete do Ministro. Portaria nº 1083, de 02 de outubro de 2012. Aprova o Protocolo Clínico e Diretrizes Terapêuticas da Dor Crônica. Secretaria de Atenção à Saúde, Brasília, DF, 02 de outubro de 2012.
Boehnke, K. F., Scott, J. R., Litinas, E., Sisley, S., Williams, D. A., & Clauw, D. J. (2019). Pills to Pot: Observational Analyses of Cannabis Substitution Among Medical Cannabis Users With Chronic Pain. The journal of pain, 20(7), 830–841. https://doi.org/10.1016/j.jpain.2019.01.010
Clarke, S., Butcher, B. E., McLachlan, A. J., Henson, J. D., Rutolo, D., Hall, S., & Vitetta, L. (2022). Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain. PloS one, 17(10), e0270543. https://doi.org/10.1371/journal.pone.0270543
CORRÊA, D. A; et al. Uso de canabinóides para manejo da dor crônica. Revisa UMC, Moji das Cruzes. 2019. Disponível em: <http://seer.umc.br/index.php/revistaumc/article/viewFile/772/550#:~:text=A%20utiliza%C3%A7%C3%A3o%20de%20canabin%C3%B3ides%20para,e%20em%20outros%20quadros%20sintom%C3%A1ticos.>.
De Gregorio, D., McLaughlin, R. J., Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., Aboud, M., Maione, S., Comai, S., & Gobbi, G. (2019). Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain, 160(1), 136–150. https://doi.org/10.1097/j.pain.0000000000001386
Desroches, J., Guindon, J., Lambert, C., & Beaulieu, P. (2008). Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model. British journal of pharmacology, 155(6), 913–924. https://doi.org/10.1038/bjp.2008.322
Eeswara, A., Pacheco-Spiewak, A., Jergova, S., & Sagen, J. (2023). Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model. PloS one, 18(3), e0282920. https://doi.org/10.1371/journal.pone.0282920
Galzerano Guida, Julia, Orellana Navone, Cecilia Carina, Ríos Pérez, María Daniela, Coitiño González, Ana Laura, & Velázquez Ramos, Pablo Mariano. (2019). Cannabis medicinal como recurso terapéutico: estudio preliminar. Revista Médica del Uruguay, 35(4), 113-137. Epub 01 de diciembre de 2019.https://doi.org/10.29193/rmu.35.4.5
Genaro, K., Fabris, D., Arantes, A. L. F., Zuardi, A. W., Crippa, J. A. S., & Prado, W. A. (2017). Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats. Frontiers in pharmacology, 8, 391. https://doi.org/10.3389/fphar.2017.00391
Godoy-Matos, A. F. de ., Guedes, E. P., Souza, L. L. de ., & Valério, C. M.. (2006). O sistema endocanabinóide: novo paradigma no tratamento da síndrome metabólica. Arquivos Brasileiros De Endocrinologia & Metabologia, 50(2), 390–399. https://doi.org/10.1590/S0004-27302006000200025
Gulbransen, G., Xu, W., & Arroll, B. (2020). Cannabidiol prescription in clinical practice: an audit on the first 400 patients in New Zealand. BJGP open, 4(1), bjgpopen20X101010. https://doi.org/10.3399/bjgpopen20X101010
Hammell, D. C., Zhang, L. P., Ma, F., Abshire, S. M., McIlwrath, S. L., Stinchcomb, A. L., & Westlund, K. N. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European journal of pain (London, England), 20(6), 936–948. https://doi.org/10.1002/ejp.818
Hegazy, O., & Platnick, H. (2019). Cannabidiol (CBD) for Treatment of Neurofibromatosis-related Pain and Concomitant Mood Disorder: A Case Report. Cureus, 11(12), e6312. https://doi.org/10.7759/cureus.6312
Hill K. P. (2015). Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems: A Clinical Review. JAMA, 313(24), 2474–2483. https://doi.org/10.1001/jama.2015.6199
Holdcroft, A., Maze, M., Doré, C., Tebbs, S., & Thompson, S. (2006). A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Anesthesiology, 104(5), 1040–1046. https://doi.org/10.1097/00000542-200605000-00021
LOPES, J.M. Fisiopatologia da dor. Permanyer Portugal. Lisboa, 2003.
Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences of the United States of America, 97(17), 9561–9566. https://doi.org/10.1073/pnas.160105897
McDonagh, M. S., Morasco, B. J., Wagner, J., Ahmed, A. Y., Fu, R., Kansagara, D., & Chou, R. (2022). Cannabis-Based Products for Chronic Pain : A Systematic Review. Annals of internal medicine, 175(8), 1143–1153. https://doi.org/10.7326/M21-4520
Philpott, H. T., O'Brien, M., & McDougall, J. J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12), 2442–2451. https://doi.org/10.1097/j.pain.0000000000001052
Razavi, Y., Rashvand, M., Sharifi, A., Haghparast, A., Keyhanfar, F., & Haghparast, A. (2021). Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain. Neuroscience letters, 762, 136141. https://doi.org/10.1016/j.neulet.2021.136141
Reis, G. M., Ramos, M. A., Pacheco, D.daF., Klein, A., Perez, A. C., & Duarte, I. D. (2011). Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels. Life sciences, 88(15-16), 653–657. https://doi.org/10.1016/j.lfs.2011.01.017
Rocha, A. P. C., Kraychete, D. C., Lemonica, L., Carvalho, L. R. de ., Barros, G. A. M. de ., Garcia, J. B. dos S., & Sakata, R. K.. (2007). Dor: aspectos atuais da sensibilização periférica e central. Revista Brasileira De Anestesiologia, 57(1), 94–105. https://doi.org/10.1590/S0034-70942007000100011
Romero, T. R., Resende, L. C., Guzzo, L. S., & Duarte, I. D. (2013). CB1 and CB2 cannabinoid receptor agonists induce peripheral antinociception by activation of the endogenous noradrenergic system. Anesthesia and analgesia, 116(2), 463–472. https://doi.org/10.1213/ANE.0b013e3182707859
Smith, P. A., Selley, D. E., Sim-Selley, L. J., & Welch, S. P. (2007). Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors. European journal of pharmacology, 571(2-3), 129–137. https://doi.org/10.1016/j.ejphar.2007.06.001
Silva-Cardoso, G. K., Lazarini-Lopes, W., Hallak, J. E., Crippa, J. A., Zuardi, A. W., Garcia-Cairasco, N., & Leite-Panissi, C. R. A. (2021). Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors. Neuropharmacology, 197, 108712. https://doi.org/10.1016/j.neuropharm.2021.108712
TEIXEIRA, M; FORNI, J. Fisiopatologia da dor. São Paulo, 2019.
Van de Donk, T., Niesters, M., Kowal, M. A., Olofsen, E., Dahan, A., & van Velzen, M. (2019). An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. Pain, 160(4), 860–869. https://doi.org/10.1097/j.pain.0000000000001464
VARANDAS, C. M. B. Fisiopatologia da dor. Porto. João Pessoa, 2013.
Xu, D. H., Cullen, B. D., Tang, M., & Fang, Y. (2020). The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities. Current pharmaceutical biotechnology, 21(5), 390–402. https://doi.org/10.2174/1389201020666191202111534
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Maria Eduarda Comunello; Marcel Pereira Rangel
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
