Evaluation of the safety and therapeutic efficacy of multipotent adult progenitor cells in the treatment of canine bronchitis

Authors

DOI:

https://doi.org/10.33448/rsd-v13i4.41499

Keywords:

Stem cells; Canine bronchitis; Cell therapy; Therapeutic safety; Therapeutic effectiveness.

Abstract

Canine chronic bronchitis is a disease that is characterized by chronic inflammation of the airways, mucus hypersecretion and chronic cough lasting for periods longer than 2 months. However, current therapeutic approaches have been proving to be ineffective in preventing or reversing all the pathological aspects of the disease. Therefore, the development of new therapeutic approaches that are safe and effective are of fundamental importance in the treatment of patients affected by canine chronic bronchitis. Stem cell therapy has been presented to the veterinary market as a safe and effective therapeutic option in the treatment of different diseases that affect small and large animals. Thus, the present study aims to analyze the safety and efficacy of the treatment of canine chronic bronchitis, through stem cell transplantation.

References

Assis, T. L. S., Winck, C. P. & Santos, E. J. C. (2017). Análise da Viabilidade Terapêutica das Células-Tronco Mesenquimais Alogênicas no Tratamento de Felino Acometido por Complexo Gengivite Estomatite Felina. Revista Científica Multidisciplinar Núcleo do Conhecimento. 2(1), 470-482.

Black, L. L., Gaynor, J., Gahring, D., Adams, C., Aron, D., Harman, S., Gingerich, D. A. & Harman, R. (2007). Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther. Winter; 8(4), 272-84.

Braga, C. L. & Santos, E. J. C. (2020). Medvep - Revista Científica de Medicina Veterinária - Pequenos Animais e Animais de Estimação. 50 (4), 126-132.

Cristóbal JI, Duque FJ, Usón-Casaús JM, Ruiz P, Nieto EL & Pérez-Merino EM (2021). Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids. Animals (Basel). 11(7):2061.

Işık, S., Uzuner, N., Karaman, M., Karaman, Ö., Kıray, M., Kozanoğlu, İ., Alper Bağrıyanık, H., Arıkan-Ayyıldız, Z., Kartal Yandım, M., & Baran, Y. (2017). Effects of Intraperitoneal Injection of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells on Bronchiolitis Obliterans in Mice Model. Iranian journal of allergy, asthma, and immunology, 16(3), 205–218.

Leia mais em: https://forbes.com.br/forbes-money/2022/10/brasil-e-o-terceiro-pais-com-mais-pets-setor-fatura-r-52-bilhoes/

Lin, J., Deng, H., Zhang, Y., Zou, L., Fu, Z., & Dai, J. (2021). Effect of human umbilical cord-derived mesenchymal stem cells on murine model of bronchiolitis obliterans like injury. Pediatric pulmonology, 56(1), 129–137.

Mazzeo, A. & Santos, E. J. C. (2018). Nanotechnology and multipotent adult progenitor cells in Reparative Medicine: therapeutic perspectives. Einstein (Sao Paulo). 16(4):eRB4587.

McKiernan B. C. (2000). Diagnosis and treatment of canine chronic bronchitis. Twenty years of experience. The Veterinary clinics of North America. Small animal practice, 30(6), 1267–vii.

Rozanski, E.A. Canine chronic bronchitis (2014). Veterinary Clinics of North America: Small Animal Practice, 44(1): 107-116.

Zheng, G., Qiu, G., Ge, M., He, J., Huang, L., Chen, P., Wang, W., Xu, Q., Hu, Y., Shu, Q., & Xu, J. (2017). Human adipose-derived mesenchymal stem cells alleviate obliterative bronchiolitis in a murine model via IDO. Respiratory research, 18(1), 119.

Fu, X., Liu, G., Halim, A., Ju, Y., Luo, Q. & Song A.G. (2019). Mesenchymal Stem Cell Migration and Tissue Repair. Cells, 8(8), 784.

Gatti, A., Martins, D. S. & Santos, E. J. S (2014). Cell therapy in the treatment of myeloid aplasia - a case report. Revista Científica de Medicina Veterinária – Pequenos Animais e Animais de Estimação,12(41), 296-303.

Mendes, A. B. S., Silva, A. T. S., Castro, L. L., Silva, K. E. A. & Araripe, M. G. A. (2021). Therapeutic potencial of mesenquimal stem cells in equine laminitis. Research, Society and Development. 10 (10): e436101018902.

Mukhamedshina, Y., Shulman, I., Ogurcov, S., Kostennikov, A., Zakirova, E., Akhmetzyanova, E., Rogozhin, A., Masgutova, G., James, V., Masgutov, R., Lavrov, I., & Rizvanov, A. (2019). Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models. Biomolecules, 9(12), 811.

Moll, G., Rasmusson-Duprez, I., Von Bahr, L., Connolly-Andersen, A. M., Elgue, G., Funke, L., Hamad, O. A., Lönnies, H., Magnusson, P. U., Sanchez, J., Teramura, Y., NilssonEkdahl, K., Ringdén, O., Korsgren, O., Nilsson, B. & Le Blanc, K (2012). Are therapeutic human mesenchymal stromal cells compatible with human blood? Stem Cells, 30(7), 1565-74.

Prockop, D. J. & Olson, S. D. (2007). Clinical trials with adult stem/progenitor cells for tissue repair: Let’s not overlook some essential precautions. Blood, 109(8), 3147–51.

Santos, E. J. C., Winck, C. P., Alves, C. A. M. & Fernande, R. A. (2019). Células-tronco mesenquimais alogênicas no tratamento das sequelas neurológicas de cinomose canina. Medvep - Revista Científica de Medicina Veterinária. Pequenos Animais e Animais de Estimação, 3(49), 32-40.

Santos, E. J. C., Winck, C. P., & Braga, C. L. (2020). Utilização terapêutica das células progenitoras adultas multipotentes alogênicas em cães acometidos pela doença renal. Medicina Veterinária (UFRPE), 13(4), 534–543.

Santos, E. J. C. (2023). Aplicação terapêutica das células-tronco na medicina veterinária. Núcleo do Conhecimento.

Smith, R. K., & Webbon, P. M. (2005). Harnessing the stem cell for the treatment of tendon injuries: heralding a new dawn? British journal of sports medicine, 39(9), 582–584.

Villatoro, A. J., Fernández, V., Claros, S., Rico-Llanos, G. A., Becerra, J., & Andrades, J. A. (2015). Use of adipose-derived mesenchymal stem cells in keratoconjunctivitis sicca in a canine model. BioMed research international, 2015, 527926.

Villatoro, A. J., Hermida-Prieto, M., Fernández, V., Fariñas, F., Alcoholado, C., Rodríguez-García, M. I., Mariñas-Pardo, L., & Becerra, J. (2018). Allogeneic adipose-derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: clinical efficacy and safety. The Veterinary record, 183(21), 654.

Wei, L. N., Wu, C. H., Lin, C. T. & Liu, I. H (2022). Topical applications of allogeneic adipose-derived mesenchymal stem cells ameliorate the canine keratoconjunctivitis sicca. BMC Vet Res, 18(1), 217.

Published

30/04/2024

How to Cite

SANTOS, E. J. C. .; MAZZEO, A.; BRAGA, C. L. . Evaluation of the safety and therapeutic efficacy of multipotent adult progenitor cells in the treatment of canine bronchitis. Research, Society and Development, [S. l.], v. 13, n. 4, p. e12713441499, 2024. DOI: 10.33448/rsd-v13i4.41499. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41499. Acesso em: 22 dec. 2024.

Issue

Section

Health Sciences