Periodontal disease and Alzheimer's disease: current considerations

Authors

DOI:

https://doi.org/10.33448/rsd-v12i5.41537

Keywords:

Alzheimer Disease; Oral Hygiene; Periodontitis.

Abstract

This study aimed to investigate the possible correlation between periodontal disease and Alzheimer's disease through an integrative literature review. An integrative bibliographic survey was carried out to investigate works that focus on Periodontal Disease and Alzheimer's Disease, seeking original full-text articles published between 2017 and 2022 in Medline and LILACS databases. The guiding question of the study was "What is the evidence of the relationship between Periodontal Disease and Alzheimer's Disease?" The final sample of this review consisted of 11 scientific articles selected by the previously established inclusion criteria. Based on the literature studied, it is speculated that oral health may be linked to Alzheimer's disease. It was also observed that patients with Alzheimer's disease present a generally unfavorable state of oral health, mainly related to the presence of dental caries and chronic periodontitis. Therefore, preventing chronic inflammatory diseases appears as a possible way to prevent the progression of Alzheimer's disease.

References

Abreu, C., & Val, E. (2015). Políticas públicas de saúde para idosos com Alzheimer. Revista Novos Estudos Jurídicos, 20(2), 727-754).

Aragón, F., Zea-Sevilla, M. A., Montero, J., Sancho, P., Corral, R., Tejedor, C., ... & Albaladejo, A. (2018). Oral health in Alzheimer’s disease: a multicenter case-control study. Clinical oral investigations, 22, 3061-3070).

Barbosa, R., Morais, J., Resck, Z., & Dázio, E. (2012). O cuidador domiciliar de paciente idoso com mal de Alzheimer. Revista da Rede de Enfermagem do Nordeste, 13(5), 1191-1196).

Blennow, K., de Leon, M.J., & Zetterberg, H. (2006). Alzheimer’s Disease. The Lancet, 368(9554), 387-403).

Cambon, P.T. (2020). Alzheimer e doença periodontal (Dissertação de Mestrado). Instituto Universitário Egas Moniz, Portugal.

Choi, S., Kim, K., Chang, J., Kim, S.M., Kim, S.J., Cho, H. J., & Park, S.M. (2019). Association of Chronic Periodontitis on Alzheimer's Disease or Vascular Dementia. J Am Geriatr Soc, 67(6), 1234-1239).

Dadalto, E., & Cavalcante, F. (2021). O lugar do cuidador familiar de idosos com doença de Alzheimer: uma revisão de literatura no Brasil e Estados Unidos. Revista Ciência & Saúde Coletiva, 26(1),147-157).

D'Alessandro, G., Costi, T., Alkhamis, N., Bagattoni, S., Sadotti, A., & Piana, G. (2018). Oral Health Status in Alzheimer's Disease Patients: A Descriptive Study in an Italian Population. The Journal of Contemporary Dental Practice, 19(5), 483-489).

Dominy, S.S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., ... & Potempa, J. (2019). Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science advances, 5(1), 1-14).

Dos Santos, C., Martins, F., Pereira, A., Vasques, B., Barros, G., Quinones, E., Giovanni, E., & Ares, N. (2020). Mal de Alzheimer: uma revisão bibliográfica. Higeia - Revista de Enfermagem e Saúde, 2(4), 1-9).

Gurav, A.N. (2014). Alzheimer’s disease and periodontitis – an elusive link. Revista da Associação Médica Brasileira, 60(2), 173-180).

Jiang, Z., Shi, Y., Zhao, W., Zhou, L., Zhang, B., Xie, Y., Zhang, Y., Tan, G., & Wang, Z. (2021). Association between chronic periodontitis and the risk of Alzheimer disease: combination of text mining and GEO dataset. BMC Oral Health, 21(1), 466).

Kamer, A. R., Pirraglia, E., Tsui, W., Rusinek, H., Vallabhajosula, S., Mosconi, L., ... & de Leon, M. J. (2016). Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2(1), 49-57).

Laugisch, O., Johnen, A., Buergin, W., Eick, S., Ehmke, B., Duning, T., & Sculean, A. (2021). Oral and periodontal health in patients with Alzheimer's disease and other forms of dementia - a cross-sectional pilot study. PubMed, 19(1), 255-261).

Lin, J.W., Chang, C.H., & Caffrey, J.L. (2020). Examining the association between oral health status and dementia: a nationwide nested case-controlled study. Experimental Biology and Medicine, 245, 231-244).

Newman, M.G., Takei, H.H., Klokkevold, P.R., & Carranza, F.A. (2012). Periodontia Clínica. 11ª ed. Rio de Janeiro: Saunders-Elsevier.

Panzarella, V., Maureci, R., Baschi, R., Maniscalco, L., Campisi, G., & Monastero, R. (2022). Oral Health Status in Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: Data from the Zabút Aging Project. Journal of Alzheimer’s Disease, 83(1), 173-183).

Patel, S., Howard, D., Chowdhury, N., Derieux, C., Wellslager, B., Yilmaz, Ö., & French, L. (2021). Characterization of human genes modulated by Porphyromonas gingivalis highlights the ribosome, hypothalamus, and cholinergic neurons. Frontiers in Immunology, 12(1), 646259). doi: 10.3389/fimmu.2021.646259

Sun, Y.Q., Richmond, R.C., Chen, Y., & Mai, X.M. (2020). Mixed evidence for the relationship between periodontitis and Alzheimer's disease: A bidirectional Mendelian randomization study. PLoS One, 15(2), e0228206).

Teixeira, J. Junior, P., Higa, J. Filha, M. (2015). Doença de Alzheimer: estudo da mortalidade no Brasil, 2000-2009. Cadernos de Saúde Pública, 31(4), 850-860).

Tiisanoja, A., Syrjälä, A.M., Tertsonen, M., Komulainen, K., Pesonen, P., Knuuttila, M., ... & Ylöstalo, P. (2019). Oral diseases and inflammatory burden and Alzheimer's disease among subjects aged 75 years or older. Special Care in Dentistry, 39(2), 158-165).

Published

10/05/2023

How to Cite

PEREIRA, L. F. .; CARDOSO, L. C. .; PORTELA, K. C. M. .; ROCHA, G. S. .; PEREIRA, R. V. .; CASANOVAS, R. C. .; FEITOSA, M. Áurea L. . Periodontal disease and Alzheimer’s disease: current considerations. Research, Society and Development, [S. l.], v. 12, n. 5, p. e11012541537, 2023. DOI: 10.33448/rsd-v12i5.41537. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41537. Acesso em: 28 apr. 2024.

Issue

Section

Health Sciences