Impacts of gestational depression on fetal development: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i5.41617

Keywords:

Depression; Gestation; Fetal development.

Abstract

During pregnancy, several physiological and psychological changes can occur in the pregnant woman's body, including the development or worsening of psychiatric pathologies, such as depression, which are influenced by the various hormonal, social and behavioral changes of women during this period. Objective: This work aims to evaluate the consequences of gestational depression on fetal development. Methodology: This integrative literature review was carried out by searching the SciELO, PubMed and BVS databases using the following Boolean descriptors and operators: antepartum depression OR gestational depression AND fetal development NOT postpartum. Results: The vast majority showed positive results of the influence of maternal depression on fetal development, with only three articles not finding evident relations. There are associations between gestational depression and fetal brain development, alterations in genetic expressions and unfavorable outcomes, including premature birth, shorter length and weight at birth and decreased head circumference. Of the thirteen articles included, all are analytical observational, twelve are cohort and one case-control. Conclusion: Despite the positive results, it is essential to have a methodological standard for research on the subject, in order to eliminate doubts generated by contradictory articles on specific points. In addition, taking into account other factors, such as social and economic, so that there are reliable results to reinforce the importance of care involving the mental health of pregnant women.

References

Adhikari, K., Patten, S. B., Lee, S., & Metcalfe, A. (2019). Risk of adverse perinatal outcomes among women with pharmacologically treated and untreated depression during pregnancy: A retrospective cohort study. Em Paediatric and Perinatal Epidemiology 33(5), 323–331. Wiley. https://doi.org/10.1111/ppe.12576

Baudry, A., Mouillet-Richard, S., Launay, J. M., & Kellermann, O. (2011). New views on antidepressant action. Current opinion in neurobiology, 21(6), 858–865. https://doi.org/10.1016/j.conb.2011.03.005

Cryan, J. F., & Mombereau, C. (2004). In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Molecular psychiatry, 9(4), 326–357. https://doi.org/10.1038/sj.mp.4001457

Diego, M. A., Field, T., Hernandez-Reif, M., Schanberg, S., Kuhn, C., & Gonzalez-Quintero, V. H. (2009). Prenatal depression restricts fetal growth. Early human development, 85(1), 65–70. https://doi.org/10.1016/j.earlhumdev.2008.07.002

Doktorchik, C., Premji, S., Slater, D., Williamson, T., Tough, S., & Patten, S. (2018). Patterns of change in anxiety and depression during pregnancy predict preterm birth. Journal of affective disorders, 227, 71–78. https://doi.org/10.1016/j.jad.2017.10.001

Dunkel Schetter, C., & Tanner, L. (2012). Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice. Current opinion in psychiatry, 25(2), 141–148. https://doi.org/10.1097/YCO.0b013e3283503680

Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J., Vos, T., & Whiteford, H. A. (2013). Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS medicine, 10(11), e1001547. https://doi.org/10.1371/journal.pmed.1001547

Field T. (2011). Prenatal depression effects on early development: a review. Infant behavior & development, 34(1), 1–14. https://doi.org/10.1016/j.infbeh.2010.09.008

Freedman, R., Hunter, S. K., Noonan, K., Wyrwa, A., Christians, U., Law, A. J., & Hoffman, M. C. (2021). Maternal Prenatal Depression in Pregnancies With Female and Male Fetuses and Developmental Associations With C-reactive Protein and Cortisol. Biological psychiatry. Cognitive neuroscience and neuroimaging, 6(3), 310–320. https://doi.org/10.1016/j.bpsc.2020.08.003

Furber, C. M., Garrod, D., Maloney, E., Lovell, K., & McGowan, L. (2009). A qualitative study of mild to moderate psychological distress during pregnancy. International journal of nursing studies, 46(5), 669–677. https://doi.org/10.1016/j.ijnurstu.2008.12.003

Gaiva, M. A. M., Fujimori, E., & Sato, A. P. S. (2014). Neonatal mortality in infants with low birth weigh. Revista Da Escola De Enfermagem Da USP, 48(5), 778–786. https://doi.org/10.1590/S0080-6234201400005000002

Garcia-Martin, I., Penketh, R. J. A., Garay, S. M., Jones, R. E., Grimstead, J. W., Baird, D. M., & John, R. M. (2021). Symptoms of Prenatal Depression Associated with Shorter Telomeres in Female Placenta. International Journal of Molecular Sciences, 22(14), 7458. http://dx.doi.org/10.3390/ijms22147458

Grote, N. K., Bridge, J. A., Gavin, A. R., Melville, J. L., Iyengar, S., & Katon, W. J. (2010). A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Archives of general psychiatry, 67(10), 1012–1024. https://doi.org/10.1001/archgenpsychiatry.2010.111

Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biological psychiatry, 54(12), 1389–1398. https://doi.org/10.1016/s0006-3223(03)00465-7

Hoffman, S., & Hatch, M. C. (2000). Depressive symptomatology during pregnancy: evidence for an association with decreased fetal growth in pregnancies of lower social class women. Health psychology: official journal of the Division of Health Psychology, American Psychological Association, 19(6), 535–543.

Hunter, S. K., Freedman, R., Law, A. J., Christians, U., Holzman, J. B. W., Johnson, Z., & Hoffman, M. C. (2021). Maternal corticosteroids and depression during gestation and decreased fetal heart rate variability. Neuroreport, 32(14), 1170–1174. https://doi.org/10.1097/WNR.0000000000001711

Jones, N. A., & Sloan, A. (2018). Neurohormones and temperament interact during infant development. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 373(1744), 20170159. https://doi.org/10.1098/rstb.2017.0159

Josefsson, A., Berg, G., Nordin, C., & Sydsjö, G. (2001). Prevalence of depressive symptoms in late pregnancy and postpartum. Acta obstetricia et gynecologica Scandinavica, 80(3), 251–255. https://doi.org/10.1034/j.1600-0412.2001.080003251

Karsli-Ceppioglu S. (2016). Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy. Drug development research, 77(7), 407–413. https://doi.org/10.1002/ddr.21340

Kessler, R. C., Angermeyer, M., Anthony, J. C., DE Graaf, R., Demyttenaere, K., Gasquet, I., DE Girolamo, G., Gluzman, S., Gureje, O., Haro, J. M., Kawakami, N., Karam, A., Levinson, D., Medina Mora, M. E., Oakley Browne, M. A., Posada-Villa, J., Stein, D. J., Adley Tsang, C. H., Aguilar-Gaxiola, S., Alonso, J., … Ustün, T. B. (2007). Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative. World psychiatry : official journal of the World Psychiatric Association (WPA), 6(3), 168–176.

Lefkovics, E., Baji, I., & Rigó, J. (2014). Impact of maternal depression on pregnancies and on early attachment. Infant mental health journal, 35(4), 354–365. https://doi.org/10.1002/imhj.21450

Li, J., Tang, S., Liu, M., Liu, W., Cheng, C., Li, Y., Sun, M., & Qin, C. (2019). The relationship between salivary cortisol and perinatal depression in women undergoing termination of pregnancy for fetal anomaly: A prospective cohort study. Midwifery, 75, 103–109. https://doi.org/10.1016/j.midw.2019.04.010

Litzky, J. F., Deyssenroth, M. A., Everson, T. M., Lester, B. M., Lambertini, L., Chen, J., & Marsit, C. J. (2018). Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth. Pediatric research, 83(5), 1075–1083. https://doi.org/10.1038/pr.2018.27

Liu, Z., Tyo, K. E., Martínez, J. L., Petranovic, D., & Nielsen, J. (2012). Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae. Biotechnology and bioengineering, 109(5), 1259–1268. https://doi.org/10.1002/bit.24409

Lundholm, C., Rejnö, G., Brew, B., Smew, A. I., Saltvedt, S., & Almqvist, C. (2022). Associations Between Maternal Distress, Cortisol Levels, and Perinatal Outcomes. Psychosomatic medicine, 84(3), 288–296. https://doi.org/10.1097/PSY.0000000000001049

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H., Boomsma, D. I., Cichon, S., Heath, A. C., Holsboer, F., Lucae, S., Madden, P. A., Martin, N. G., McGuffin, P., Muglia, P., Noethen, M. M., Penninx, B. P., … Sullivan, P. F. (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular psychiatry, 18(4), 497–511. https://doi.org/10.1038/mp.2012.21

Pampaka, D., Papatheodorou, S. I., AlSeaidan, M., Al Wotayan, R., Wright, R. J., Buring, J. E., Dockery, D. W., & Christophi, C. A. (2018). Depressive symptoms and comorbid problems in pregnancy - results from a population based study. Journal of psychosomatic research, 112, 53–58. https://doi.org/10.1016/j.jpsychores.2018.06.011

Pereira, P. K., & Lovisi, G. M.. (2008). Prevalência da depressão gestacional e fatores associados. Archives of Clinical Psychiatry (São Paulo), 35(4), 144–153. https://doi.org/10.1590/S0101-60832008000400004

Peyrot, W. J., Milaneschi, Y., Abdellaoui, A., Sullivan, P. F., Hottenga, J. J., Boomsma, D. I., & Penninx, B. W. (2014). Effect of polygenic risk scores on depression in childhood trauma. The British journal of psychiatry: the journal of mental science, 205(2), 113–119. https://doi.org/10.1192/bjp.bp.113.143081

Phua, D. Y., Kee, M. K. Z. L., Koh, D. X. P., Rifkin-Graboi, A., Daniels, M., Chen, H., Chong, Y. S., Broekman, B. F. P., Magiati, I., Karnani, N., Pluess, M., Meaney, M. J., & Growing Up In Singapore Towards Healthy Outcomes Study Group (2017). Positive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal study. Development and psychopathology, 29(5), 1573–1587. https://doi.org/10.1017/S0954579417001249

Reissland, N., Froggatt, S., Reames, E., & Girkin, J. (2018). Effects of maternal anxiety and depression on fetal neuro-development. Journal of affective disorders, 241, 469–474. https://doi.org/10.1016/j.jad.2018.08.047

Reno, R., Burch, J., Stookey, J., Jackson, R., Joudeh, L., & Guendelman, S. (2021). Preterm birth and social support services for prenatal depression and social determinants. PloS one, 16(8), e0255810. https://doi.org/10.1371/journal.pone.0255810

Souza, M. T. de ., Silva, M. D. da ., & Carvalho, R. de .. (2010). Integrative review: what is it? How to do it?. Einstein (são Paulo), 8(1), 102–106. https://doi.org/10.1590/S1679-45082010RW1134

Stewart, R. C., Ashorn, P., Umar, E., Dewey, K. G., Ashorn, U., Creed, F., Rahman, A., Tomenson, B., Prado, E. L., & Maleta, K. (2019). Associations between antenatal depression and neonatal outcomes in Malawi. Maternal & child nutrition, 15(2), e12709. https://doi.org/10.1111/mcn.12709

Südekum, L., Redlich, A., Radusch, A., Seeger, S., Kropf, S., Zhou, L., Costa, S. D., Jorch, G., & Rissmann, A. (2019). The impact of neuropsychiatric disease on fetal growth: a case-control study. Archives of gynecology and obstetrics, 300(6), 1591–1600. https://doi.org/10.1007/s00404-019-05361-z

Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. The American journal of psychiatry, 157(10), 1552–1562. https://doi.org/10.1176/appi.ajp.157.10.1552

Teng, C. T., Humes, E. de C., & Demetrio, F. N.. (2005). Depressão e comorbidades clínicas. Archives of Clinical Psychiatry (são Paulo), 32(3), 149–159. https://doi.org/10.1590/S0101-60832005000300007

Teti, D. M., & Gelfand, D. M. (1991). Behavioral competence among mothers of infants in the first year: the mediational role of maternal self-efficacy. Child development, 62(5), 918–929. https://doi.org/10.1111/j.1467-8624.1991.tb01580.x

Uguz, F., Yakut, E., Aydogan, S., Bayman, M. G., & Gezginc, K. (2019). The impact of maternal major depression, anxiety disorders and their comorbidities on gestational age, birth weight, preterm birth and low birth weight in newborns. Journal of affective disorders, 259, 382–385. https://doi.org/10.1016/j.jad.2019.08.076

Van den Bergh, B. R., Mulder, E. J., Mennes, M., & Glover, V. (2005). Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neuroscience and biobehavioral reviews, 29(2), 237–258. https://doi.org/10.1016/j.neubiorev.2004.10.007

Van Niel, M. S., & Payne, J. L. (2020). Perinatal depression: A review. Cleveland Clinic journal of medicine, 87(5), 273–277. https://doi.org/10.3949/ccjm.87a.19054

Villar, J., Fernandes, M., Purwar, M., Staines-Urias, E., Di Nicola, P., Cheikh Ismail, L., Ochieng, R., Barros, F., Albernaz, E., Victora, C., Kunnawar, N., Temple, S., Giuliani, F., Sandells, T., Carvalho, M., Ohuma, E., Jaffer, Y., Noble, A., Gravett, M., Pang, R., … Kennedy, S. (2019). Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations. Nature communications, 10(1), 511. https://doi.org/10.1038/s41467-018-07983-4

Werner, E., Zhao, Y., Evans, L., Kinsella, M., Kurzius, L., Altincatal, A., McDonough, L., & Monk, C. (2013). Higher maternal prenatal cortisol and younger age predict greater infant reactivity to novelty at 4 months: an observation-based study. Developmental psychobiology, 55(7), 707–718. https://doi.org/10.1002/dev.2106638-39-40

Wisner, K. L., Gelenberg, A. J., Leonard, H., Zarin, D., & Frank, E. (1999). Pharmacologic treatment of depression during pregnancy. JAMA, 282(13), 1264–1269. https://doi.org/10.1001/jama.282.13.1264

Wu, Y., Lu, Y. C., Jacobs, M., Pradhan, S., Kapse, K., Zhao, L., Niforatos-Andescavage, N., Vezina, G., du Plessis, A. J., & Limperopoulos, C. (2020). Association of Prenatal Maternal Psychological Distress With Fetal Brain Growth, Metabolism, and Cortical Maturation. JAMA network open, 3(1), e1919940. https://doi.org/10.1001/jamanetworkopen.2019.19940

Wu, Y., Zhang, H., Wang, C., Broekman, B. F. P., Chong, Y. S., Shek, L. P., Gluckman, P. D., Meaney, M. J., Fortier, M. V., & Qiu, A. (2021). Inflammatory modulation of the associations between prenatal maternal depression and neonatal brain. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 46(2), 470–477. https://doi.org/10.1038/s41386-020-0774-0

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12/05/2023

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SANTOS, P. V. M. dos .; MENEZES, L. L. S. de .; CAETANO, F. M.; DANAGA, A. R.; MODA, L. M. R. . Impacts of gestational depression on fetal development: an integrative review. Research, Society and Development, [S. l.], v. 12, n. 5, p. e12812541617, 2023. DOI: 10.33448/rsd-v12i5.41617. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41617. Acesso em: 21 nov. 2024.

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Vol. 12 No. 5

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Copyright (c) 2023 Paulo Vinícius Magalhães dos Santos; Larissa Lorrayne Soares de Menezes; Francine Mariana Caetano; Aline Roberta Danaga; Lívia Maria Rosatto Moda

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