Ozonetherapy: Treatment perspective in scar dehiscence
DOI:
https://doi.org/10.33448/rsd-v12i6.41645Keywords:
Cicatrización de Heridas; Dehiscencia de la Herida Operatoria; Ozonoterapia; Piel.Abstract
Introduction: One of the surgical wound complications is scarring dehiscence, which generates clinical and socioeconomic impact. Coadjuvant therapies such as (O3) therapy, ozone therapy, have been widely used in clinical practice and show promising results in the context of skin wounds. Objective: The purpose of this study is to present, through a narrative review, an understanding of the available evidence regarding the importance of ozone therapy in skin repair and possible applicability in the treatment of cicatricial dehiscence. Methods: The bibliographic databases of PubMed/MEDLINE, Virtual Health Library (VHL), Web of Science and SciELO were used. Results: Of the 159 identified articles, 13 eligible articles were established to evaluate the effect of O3 on skin repair. Evidence shows that ozone therapy can be considered an effective strategy in enhancing skin repair, such as acute and chronic skin wounds, as it modulates the inflammatory process, helps the proliferation of cells responsible for skin repair, increases the expression of factors responsible for the formation of components of the extracellular matrix, improves vascularization with consequent optimization of granulation tissue formation and wound closure. Conclusion: In this way, the findings of the study direct that ozone therapy could be proposed as a promising therapeutic strategy in the treatment of cicatricial dehiscence, justified due to the positive effects in the repair of cutaneous and acute and chronic wounds. However, experimental studies and clinical trials are needed to endorse its safety and dosimetric efficacy in the treatment of cicatricial dehiscence.
References
Al-Saadi, H., Potapova, I., Rochford, E.T., Moriarty, T.F., & Messmer, P. (2016). Ozonated saline shows activity against planktonic and biofilm growing Staphylococcus aureus in vitro: a potential irrigant for infected wounds. Int Wound J., 13(5), 936-942,
Amaral, F.V. (2013). Reparação de Tecidos In: Bastos, Francisco Reis. Anais do V Simpósio Internacional de Flebologia - Blucher Medical Proceedings, 1(1) Blucher.
Azarpazhooh, A., & Limeback, H., (2008). The application of ozone in dentistry: a systematic review of literature. J Dent., 36, 104- 116.
Bocci, V., & Aldinucci, C., (2006). Biochemical modifications induced in human blood by oxygenation-ozonation. J Biochem Mol Toxicol. 20(3):133-8.
Bomfim, T.L., Gomes, I., Meneses, D.V.C., & Araujo, A.A.S., (2021). Effectiveness of ozone therapy as na adjunct treatment for lower-limb ulcers: A systematic Review. adv skin wound care 34:1–9.
Borges, G.A., Elias, S.T., Silva, S.M.M., Magalhães, P.O., Macedo, S.B., Ribeiro, A.P.D., & Guerra, E.N.S., (2017). Avaliação in vitro da cicatrização de feridas e potencial antimicrobiano da terapia com ozônio. Journal of Cranio-Maxillo-Facial Surgery.
Chagas, N.T.C., Rocha, C.L.R., Silva, R.B.T., Santos, K.M.M., & Hirano, L.Q.L., (2019). Tratamento de ferida em Coendou prehensilis (Rodentia: Erethizontidae) com laserterapia e ozonioterapia: relato de caso / Wound treatment of Coendou prehensilis (Rodentia: Erethizontidae) with laser and ozone therapy: case report. Arq. Bras. Med. Vet. Zootec., 71(3), 953-958.
Chirumbolo, S., Valdenassi, L., Simonetti, V., Bertossi, D., Ricevuti, G., Franzini, M., & Pandolfi, S. (2021). Insights on the mechanisms of action of ozone in the medical therapy against COVID-19. Int Immunopharmacol. 6(10777).
Di Paolo, N., Bocha, V., & Gaggiotti, E., (2004). Ozone Therapy. The International Journal of Artificial Organs, 27(3), 168-175.
Fitzpatrick, E., Holland, O.J., & Vanderlelie,J.J., (2018). Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J. 15(4), 633-644
Fitzpatrick, E; Holland, O.J., & Vanderlelie, J.J., (2018). Ozone therapy for the treatment of chronic wounds: A systematic review. Int Wound J. 15(4), 633-644
Goodarzi, P., Falahzadeh, K., Nematizadeh, M., Farazandeh, Parham., Payab, M., Larijani, B., Beik, A.T., & Arjmand, B., (2018). Tissue Engineered Skin Substitutes. Advances In Experimental Medicine And Biology, 143-188
Hasan, S., Tuncer, S., Hakan, T., Yildiray, K., Faruk, O. M., Turgut, A. O., Mesut, E., Ugur, A., & Yavuz, D., (2016). Os efeitos agudos da ozonoterapia pré-operatória na cicatrização de feridas cirúrgicas. Research, Society and Development, 10(17), e229101724682.
Izadi, M., Bozorgi, M., Hosseine, M.S., Khalili, N., & Jonaidi-Jafari, N., (2018). Health-related quality of life in patients with chronic wounds before and after treatment with medical ozone. Medicine, 97(48), 12505.
Izadi, M., Kheirjou, R., Mohammadpour, R., Aliyoldashi, M.H., Moghadam, S.J., Khorvash, F., Jafari, N.J., Shirvani, S., & Khalili, H., (2018). Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing. Diabetes Metab Syndr. 13(1), 822-825.
Kargozar, S., Baino, F., Hamzehlou, S., Hamblin, M.R., & Mozafri, M., (2020). Nanotechnology for angiogenesis: opportunities and challenges. Chemical Society Reviews, 49(14), 5008-5057.
Koçyiğit, A., Gülmen, S., Kurtoğlu, T., Doğuç, D.K., Meteoğlu, İ., Okutan, H., & Solmaz, F.A., (2018). The effect of ozone treatment on remote organ myocardial injury in an aortic ischemia-reperfusion model. The Turkish Journal of Thoracic and Cardiovascular Surgery, 26(2), 207-218
Laureti, S., Aborajooh, E., Mattioli, B., & Poggioli, G., (2016). Tratamento de pequenas deiscências após retalho do avanço endorretal em fístulas de Crohn perianais com óleo ozonizado NOVOX. Tech Coloproctol 20:139–140.
Macedo, D. B., Tim, C. R., Macedo, J. B., Macedo, G. B., Martignago, C. C. S., & Garcia, L. A., (2020). Perspectiva terapéutica de la luz para el tratamiento del coronavirus. Research, Society and Development. http://dx.doi.org/10.33448/rsd-v9i8.6320.
Malagutti, W., & Kakihara, C.T., (2014). Curativos, Estomias e Dermatologia: uma abordagem multiprofissional. (3a ed.), Martinari, Pág. 46.
Marchesini, B.F., & Ribeiro, S.B., (2020). Efeitos da ozonioterapia na cicatrização de feridas/ Effect of ozonotherapy on wound healing: Relato de caso. Fisioter. Bras; 21(3): 281-288.
Marques, G. S., Almeida¸ P.F., Farias, L. R. C., & Nascimento, D. C., (2017). Estudo preliminar sobre registros de deiscência de ferida operatória em um hospital universitário. Revista Hospital Universitário Pedro Ernesto, 15(4).
Martínez-Sánchez, G., Menéndez-Cepero, S., Re, L., & Sa’Ed M. Aldelaien., (2005). Therapeutic efficacy of ozone in patients with diabetic foot. European Journal of Pharmacology, 523(1-3), 151-161.
Medrado, A. R. A. P., Marchionni, A. M. T., Leite, M. M. P., Badaró, P. S., & Andrade, T.O.S., (2021). Impacto da ozonioterapia no reparo tecidual à luz da termografia infravermelha. In: II ENEIS - Encontro Nacional de Empreendedorismo e Inovação em Saúde - Escola Bahiana de Medicina e Saúde Pública https://www.doity.com.br/anais/eneis/trabalho/137253.
Morteza, I., Ramin. K., Roya, M., Mohammad, H. A., Saeedreza, J. M., Farzin, K., Nematolá, J.J., Shahram, S., & Nahid, K., (2018). Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing/ Eficácia da terapia abrangente com ozônio na cicatrização de úlceras do pé diabético. Diabetes & Metabolic Syndrome: Clinical Research & Reviews https://doi.org/10.1016/j.dsx.2018.11.060.
Patil, S., Valdramidis, V.P., Karatzas, KAG., Cullen, P.J., & Bourke, P., (2011). Assessing the microbial oxidative stress mechanism of ozone treatment through the responses of Escherichia coli mutants. J Appl Microbiol., 111(1), 136-144.
Pavlidis, T. E., Galatianos, I. N., Lazaridis, C. N., Atmatzidis, K. S., Makris, J. G., et al. (2001). Complete dehiscence of the abdominal wound and incriminating factors. Eur J Surg 167: 351–354.
Pires, J.R., Karam, A. M., Garcia, V. G., Ribeiro, F.S., Pontes, A.E.F., Andrade, C. R., et al. (2021). Effect of systemic ozone therapy as a biomodulator of tissue regeneration and inflammatory response in rats. Rev Odontol UNESP;50: e20210046. https://doi.org/10.1590/1807-2577.0462.
Pivotto, A.P., Banhuk, F.W., Staffen, I.V., Daga, M.A., Ayala, T.S., & Menolli, R.A., (2020). Clinical uses and molecular aspects of ozone therapy: a review. Online J Biol Sci 20:37–49.
Polydorou, O., Halili, A., Wittmer, A., Pelez, K., & Hahn, P., (2012). The antibacterial effect of gas ozone after 2 months of in vitro evaluation. Clin Oral Investig 16:545–550.
Qing, W., Dongying, L., Xian, W., Yanli, Z., Song. F., Xianliang, Q., & Qiu, C., (2021). Uma revisão sistemática da terapia com ozônio para o tratamento de feridas e úlceras cronicamente refratárias. Int Wound J. 19:853-870.
Repciuc, C.C., Toma, C.G., Ober, C.A., & Oana, L.L., (2020). Management of surgical wound dehiscence by oxygen-ozone therapy in the IVF-positive Cat- a case report/ Manejo da deiscência da ferida operatória pela oxigenoterapia com ozônio em um gato FIV-positivo. Veter minutes brno 89: 189–194.
Scassellati, C., Costanzo, M., Cisterna, B., Nodari, A., Galiè, M., Cattaneo, A., Covi, V., Tabaracci, G., Bonvicini, C., & Malatesta, M., (2017). Effects of mild ozonisation on gene expression and nuclear domains organization in vitro. Toxicol. Vitr. 44, 100–110.
Soares, C. D., Morais, T. M. L., Araújo, R. M. F. G., Meyer, P. F., Oliveira, E. A. F., Silva, R. M. V., Carreiro, E. M., Carreiro, E. P., Belloco, V. G., Mariz, B. A. L. A., Jorge. J, & Jacks., (2019). Efeitos da injeção subcutânea de ozônio durante a cicatrização de feridas em ratos. Fatores de crescimento, volume 37– edição 1-2 Páginas 95-103.
Suh, Y., Patel, S., Kaitlyn, R., Gandhi, J., Joshi, G., Smith, N.L., & Khan, S.A., (2019). Clinical utility of ozone therapy in dental and oral medicine. Medical Gas Research, 9(3), 163-167.
Tacani, P. M., Toguchi, P. A. P. M., Machado, A. F. P., Tacani, R. E., & Freitas, J. O. G., (2014). Anterioralência e tratamento fisioterapêutico de deiscências da ferida operatória após cirurgias plásticas: análise retrospectivuma. Revista brasileira de Ciências da Saúde, 12(39)..
Travagli, V., Zanardi, I., Valacchi, G., & Bocci, V., (2010). Ozônio e óleos ozonizados em doenças de pele: uma revisão. Mediadores Inflamm 2010; 9.
Xavier, P. B., Silva, S.S., Almeida, J. L. S., Araujo, T. L. L. A., Santos, G. A., Braga, D. M. R., Negreiros, R. V., Alves, F. P. A., Morais, M. G. C., Silva, T. L. A., Crispiniano, E. C., & Freires, L. S. (2021). Application of ozonetherapy in the treatment of skin injuries in the elderly. Aplicação da ozonioterapia no tratamento de lesões de pele em idosos. Research, Society and Development, 10(17), e229101724682.
Zanardi, Eu., Borrelli, E., Valacchi, G., Travagli, V., & Bocha, V., (2016). Ozone: a multifaceted molecule with unexpected therapeutic activity. Curr Med Chem., 23, 304-314.
Zeng, J., Lei, L., Zeng, Q., Yao, Y., Wu, Y., Li, Q., Gao, L., Du, H., Xie, Y., Huang, J., Tan, W., & Lu, J., (2020). Ozone Therapy Attenuates NF-κB-Mediated Local Inflammatory Response and Activation of Th17 Cells in Treatment for Psoriasis. Int J Biol Sci; 16(11):1833-1845.
Zeng, J., & Lu, J., (2018). Mechanisms of action involved in ozone-therapy in skin disease. International Immunopharmacology 56 235–241.
Zhang, J., Guan, M., Xie, C., Luo, X., Zhang, Q., & Xue, Y., (2014). Increased Growth Factors Play a Role in Wound Healing Promoted by Noninvasive Oxygen-Ozone Therapy in Diabetic Patients with Foot Ulcers. Oxidative Medicine and Cellular Longevity, 2014, 273475.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Elaine dos Santos Batista Bittencourt; Jynani Pichara Morais; Lívia Assis
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
