Role of biomarkers under endotelial and neuronal injury in ischemic stroke: a literature review
DOI:
https://doi.org/10.33448/rsd-v12i6.41951Keywords:
Biomarkers; Stroke; Ischemic stroke.Abstract
Stroke is an important cause of death and long-term disability. Ischemic stroke results from cerebral artery occlusion that decreases cerebral blood flow and causes rapid loss of brain function. Improvements in current treatments for cerebral ischemia are limited by many factors. A prothrombotic and embolic environment, exacerbated by inflammatory conditions, becomes a disposition for cerebrovascular blockage and ischemia. After this ischemic event, a cascade of secondary damage occurs resulting in the breakdown of the blood-brain barrier (BBB), which has been noted to be mediated by inflammation and oxidative stress, leading to an influx of immune cells destructive for proper neurological function. Therefore, the performance of biomarkers on endothelial injury in ischemic stroke was avaluated in the study. This is an integrative descriptive bibliographical review, in which electronic databases were used. The results found were several biomarkers that may be associated with vascular cerebral lesions and the risk of stroke, which would allow an early diagnosis, prognosis and risk stratification. However, it is important to emphasize that many of these biomarkers are still being studied and are not widely used in clinical practice, more research is needed to validate and deepen knowledge about these biomarkers and their application in the diagnosis and risk stratification of stroke.
References
Backes, F. N. (2019). Biomarcadores séricos e prognóstico no acidente vascular cerebral isquêmico.
Dias, K. C., Duarte, M. A. N. M., Silva, N. B., Izabel, M., Lopes, R., & Nogueira, M. A. R. J. (2017). Caracterização do paciente acometido por acidente vascular encefálico atendido no Centro de Reabilitação Lucy Montoro de São José dos Campos. CEP, 12220, 280.
Ducci, R. D. P., Tessaro, C. L., Fontes, D. P., de Fraga, G. S., Cirino, R. H. D., Neto, F. D. N. L., Zetola, V. H. F., & Lange, M. C. (2022). Stroke-related mortality analysis in Paraná, Brazil, over 10 years. Arquivos de Neuro-psiquiatria, 80(11), 1083-1089.
Fernandes, E., Sobrino, T., Martins, VC, Lopez-Loureiro, I., Campos, F., Germano, J., Rodríguez-Pérez, M., Cardoso, S., Petrovykh, D. Y., Castillo, J., & Freitas, PP (2020). Quantificação no local de atendimento dos níveis séricos de fibronectina celular para estratificação de pacientes com AVC isquêmico. Nanomedicina: Nanotecnologia, Biologia e Medicina, 30, 102287.
Goulart, V. A. M. (2014). Análise do perfil de aminoácidos em amostras de pacientes com acidente vascular cerebral isquêmico (AVCI).
Henry, N., Frank, J., McLouth, C., Trout, A. L., Morris, A., Chen, J., Stowe, A. M., Fraser, J. F., & Pennypacker, K. (2022). Short chain fatty acids taken at time of thrombectomy in acute ischemic stroke patients are independent of stroke severity but associated with inflammatory markers and worse symptoms at discharge. Frontiers in Immunology, 12, 5883.
Hijazi, Z., Wallentin, L., Lindbäck, J., Alexander, J. H., Connolly, S. J., Eikelboom, J. W.; Ezekowitz, M. D., Granger, C. B., Lopes, R. D., Pol, T., Yusuf, S., Oldgren, J., & Siegbahn, A. (2020). Screening of multiple biomarkers associated with ischemic stroke in atrial fibrillation. Journal of the American Heart Association, 9(24), e018984.
Li, J., Lin, J., Pan, Y., Wang, M., Meng, X., Li, H., Wang, Y., Zhao, X., Qin, H., Liu, L., Wang, Y., & CNSR-III Investigators. (2022). Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study. Journal of Neuroinflammation, 19(1), 131.
Lopes, R. P., Gagliardi, V. D. B., Pacheco, F. T., & Gagliardi, R. J. (2022). Ischemic stroke with unknown onset of symptoms: current scenario and perspectives for the future. Arquivos de Neuro-Psiquiatria, 80(12), 1262-1273.
Lu, W. T., Du, W. T., Lu, D. S., You, J., & Li, H. Y. (2023). Predictive value of serum initial brain natriuretic peptide and troponin on functional prognosis in noncardiogenic patients with anterior and posterior circulation cerebral infarction. Arquivos de Neuro-Psiquiatria, 80, 985-993.
Meirelles, C. M., & Gomes, P. S. C. (2016). Combined effects of resistance training and carbohydrate-restrictive or conventional diets on weight loss, blood variables and endothelium function. Revista de Nutrição, 29, 543-554.
Menti, E., Zaffari, D., Galarraga, T., Lessa, J. R. D. C., Pontin, B., Pellanda, L. C., & Portal, V. L. (2016). Early markers of atherosclerotic disease in individuals with excess weight and dyslipidemia. Arquivos Brasileiros de Cardiologia, 106, 457-463.
Mourão, A. M., Vicente, L. C. C., Abreu, M. N. S., Sant’Anna, R. V., De Meira, F. C. A., Xavier, R. M. D. B., Tanure, M. T. A., Vieira, E. L. M., De Souza, L. C., Miranda, A. S., Rachid, M. A., & Teixeira, A. L. (2020). Clinical and molecular correlates of the ASPECTS in the acute phase of stroke. Arquivos de Neuro-Psiquiatria, 78, 262-268.
Pascotini, E. T. Pascotini, E. T. (2016). A função da MnSOD Ala16Val, O stress oxidativo e marcadores de apoptose como biomarcadores em pacientes com Acidente Vascular Encefálico Crônico. Blucher Medical Proceedings, 7, 77-83.
Pikula, A., Beiser, A. S., DeCarli, C., Himali, J. J., Debette, S., Au, R., Selhub, J., Toffler, G. H., Wang, T. J., Meigs, J. B., Kelly-Hayes, M., Kase, C. S., Wolf, P. A., Vasan, R. S. & Seshadri, S. (2012). Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation, 125(17), 2100-2107
Raj, V., Charles, S., Goenka, L., Ramamoorthy, T., Mala, K., Kumarasamy, S., & George, M. (2021). Avaliação da Senescência de Células Sanguíneas Mononucleares Periféricas e na Disfunção Endotelial entre Adultos com Alto Risco Cardiovascular. Arquivos Brasileiros de Cardiologia, 116, 37-47.
Salvarani, M. (2017). Biomarcadores moleculares relacionados à presença de acidente vascular encefálico e síndrome torácica aguda em anemia falciforme.
Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.
Wu, J., Dou, Y., Liu, W., Zhao, Y. & Liu, X. (2020). Osteocalcin improves outcome after acute ischemic stroke. Aging (Albany NY), 12(1), 387.
Zou, R., Zhang, D., Lv, L., Shi, W., Song, Z., Yi, B., Lai, B., Chen, Q., Yang, S., & Hua, P. (2019). Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke. Journal of translational medicine, 17(1), 1-12.
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Copyright (c) 2023 Sandrelly Gurgel Vanderley; Maria Beatriz Pereira de Paula Rocha; Jaira Porta Variolo; Maria Clara Sousa de Oliveira; Gabriela Leal Bezerra; Ana Rachel Oliveira de Andrade; Antonio de Pádua Rocha Nóbrega Neto
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