Adverse events associated with excessive use of vitamin D a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v12i6.41994

Keywords:

Vitamin D; Toxicity; Hypercalcemia; Hypercalciuria; Adverse events.

Abstract

Introducción: La vitamina D es una hormona esteroide cuya función principal es la regulación del metabolismo óseo. El exceso de vitamina D es capaz de causar toxicidad al organismo, provocando hipercalcemia, hipercalciuria, hiperfosfatemia y dando como resultado debilidad, calcificaciones de tejidos blandos, entre otros. Objetivo: Destacar los efectos asociados al uso excesivo de vitamina D. Metodología Se trata de un estudio de revisión sistemática Resultados: Se seleccionaron 12 artículos para componer la revisión y responder a los objetivos establecidos en este trabajo. Los principales motivos que llevan al uso no guiado y/o excesivo de vitamina D son los errores de prescripción, la automedicación por fácil acceso y los errores en el manejo de las fórmulas que contienen vitamina D. Los hallazgos indican que los principales eventos adversos causados ​​por la Hipervitaminosis D son mareos, dolor abdominal, debilidad mediada principalmente por hipercalcemia e hipercalciuria. Los hallazgos indican que algunos eventos adversos pueden ser graves y causar convulsiones, problemas cardiovasculares y daño renal. Conclusión: La intoxicación por vitamina D es causada por múltiples factores como la automedicación, errores de prescripción y errores en el manejo de fórmulas que contienen vitamina D. Los eventos adversos son muy variados y pueden incluir dolor abdominal, náuseas, fatiga, poliuria, cólico renal y cálculos mediados por hipercalcemia e hipercalciuria, que pueden causar serios problemas para la salud de la comunidad.

References

Anık, A., Çatlı, G., Abacı, A., Dizdarer, C., & Böber, E. (2013). Acute vitamin D intoxication possibly due to faulty production of a multivitamin preparation. J Clin Res Pediatr Endocrinol. 5(2):136-9. 10.4274/Jcrpe.896.

Barbosa, K., Silva, D., Giancarlos, A, et al. (2018). Deficiency of vitamin D (250H) and its impact on the quality of life: a literature review. Revista Brasileira de Análises Clínicas. 50. 10.21877/2448-3877.201800686.

Billington, E. O., Burt, L. A., Rose, M. S., at al. (2020). Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial. J Clin Endocrinol Metab. 105(4):dgz212. 10.1210/clinem/dgz212. Erratum in: J Clin Endocrinol Metab. 106(4):e1932.

Fallahzadeh, M. H., Zare, J., Al-Hashemi, G. H., Derakhshan, A., Basiratnia, M., Arasteh, M. M., Fallahzadeh, M. A., & Fallahzadeh, M. K. (2012). Elevated serum levels of Vitamin D in infants with urolithiasis. Iran J Kidney Dis. 6(3):186-91. PMID: 22555482.

Azorin, F. L., Rodriguez, N. S. et al. (2012). Intoxicación por sobredosificación de vitamina D en un lactante, Revista del Laboratorio Clínico, 5(1), 49-53, https://doi.org/10.1016/j.labcli.2011.10.004.

Denyer, D, &Tranfield, D. (2006). Using qualitative research synthesis to build an actionable knowledge base. Management Decision, 44,213-227. 10,1108 / 00251740610650201.

Galvão, L. O., Galvão, M. F., Reis, C. M. S., Batista, C. M. Á., & Casulari, L. A. (2013). Considerações atuais sobre a vitamina D. Brasília Med 50(4):324-332

Guerra, V., et al. (2016). Hypercalcemia and renal function impairment associated with vitamin D toxicity: case report. Jornal Brasileiro de Nefrologia [online]. 38(4) 466-469. https://doi.org/10.5935/0101-2800.20160074.qw

Houghton, C. C., & Lew, S. Q. (2020). Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates. BMJ Case Rep. 13(4), e233853. 10.1136/bcr-2019-233853.

Lichtenstein, A. et al. (2013). Vitamina D: ações extraósseas e uso racional. Revista da Associação Médica Brasileira [online]. 59, 5, 495-506. <https://doi.org/10.1016/j.ramb.2013.05.002>.

Misgar R. A., Sahu D., Bhat M. H, Wani A. I., & Bashir M. I. (2019) Vitamin D Toxicity: A Prospective Study from a Tertiary Care Centre in Kashmir Valley. Indian J Endocrinol Metab. 23(3):363-366.

Muneer S, Siddiqui I, Majid H, Zehra N, Jafri L, Khan A. H. (2022) Practices of vitamin D supplementation leading to vitamin D toxicity: Experience from a Low-Middle Income Country. Ann Med Surg (Lond). 73:103227. 10.1016/j.amsu.2021.103227.

Pop TL, Sîrbe C, Benţa G, Mititelu A, & Grama A. (2022) The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases. Int J Mol Sci. 23(18):10705. 10.3390/ijms231810705.

Rahesh, J., Chu, V., & Peiris, A. N. (2019). Hipervitaminose D sem toxicidade. Proc (Bayl Univ Med Cent). 33(1):42-43. 10.1080/08998280.2019.1674052.

Shea, R. L., & Berg, J. D. (2017). Self-administration of vitamin D supplements in the general public may be associated with high 25-hydroxyvitamin D concentrations. Ann Clin Biochem. 54(3):355-361. 10.1177/0004563216662073.

Sharma, N., Landsberg, E., Kumar, V., & Gambhir, H. S. S. (2020). A Curious Case of Hypervitaminosis D. Cureus, 12(6):e8515. 10.7759/cureus.8515.

Salim, N., Rahman, M. N. A., & Wahab, D. A. (2019) A systematic literature review of internal capabilities for enhancing eco-innovation performance ofmanufacturing firms. ournal of Cleaner Production, 209, 1445-1460. https://doi.org/10.1016/j.jclepro.2018.11.105

Taylor, P. N., & Davies, J. S. (2018). A review of the growing risk of vitamin D toxicity from inappropriate practice. Br J Clin Pharmacol. 84(6):1121-1127. 10.1111/bcp.13573.

Tranfield, D., Denyer, D., & Smart, P. (2003). Towards a methodology for developing evidence-informed management knowledge by means of systematic review. British Journal Management, 14,207-222. https://doi.org/10.1111/1467-8551.00375

Tebben, P. J., Singh, R. J., et al. Kumar, R. (2016). Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment. Endocr 37(5):521-547. 10.1210/er.2016-1070.

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Published

03/06/2023

How to Cite

PANTOJA, J. da S. .; BACCHUS, K. C. .; PASSOS , V. L. C. dos .; ALMEIDA, A. C. G. de .; BRITO , M. A. M. Adverse events associated with excessive use of vitamin D a systematic review. Research, Society and Development, [S. l.], v. 12, n. 6, p. e3212641994, 2023. DOI: 10.33448/rsd-v12i6.41994. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/41994. Acesso em: 16 nov. 2024.

Issue

Vol. 12 No. 6

Section

Review Article

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Copyright (c) 2023 Jeiciely da Silva Pantoja; Karoline Chagas Bacchus; Vitoria Lara Costa dos Passos ; Anne Cristine Gomes de Almeida; Marcelo Augusto Mota Brito

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