A systematic review about the possibility of transmission of the SARS-CoV-2 antibody during breastfeeding
DOI:
https://doi.org/10.33448/rsd-v12i7.42616Keywords:
Breastfeeding; Colostrum; COVID-19; SARS-CoV-2; Serology; Systematic review.Abstract
Breastfeeding by COVID-19 positive mothers still deserves attention and care regarding the consequences for the baby. To date, studies demonstrate no risk. In view of this, there is a need to perform a systematic review and collect studies that have shown the presence of SARS-CoV-2 in human milk, by measuring IgM, IgG and IgA in biological material. After searching PubMed, Web of Science, Scopus, Google Scholar databases, 147 studies were identified, of which 37 at some point addressed breastfeeding and COVID-19, and 14 of which addressed antibody dosages in breast milk. Of these, one used the ELISA test for IgA detection. In the other studies, the methodology used was RT-PCR to detect the SARS-CoV-2 virus in breast milk, where the presence of the virus was detected in a few samples. These studies confirmed that SARS-CoV-2 can be identified in breast milk, but could not elucidate about the validation of the method and its sensitivity. In addition, there was no description if the viral load present in the milk would be sufficient to infect the baby. Furthermore, no completed research involving serological tests for the detection of antibodies in human colostrum has been found. Thus, more serological studies on COVID-19 positive breastfeeding mothers are mandatory.
References
Bohn, M., Lippi, G., Horvath, A., Sethi, S., Koch, D., Ferrari, M., Wang, C., Mancini, N., Steele, S., & Adeli, K. (2020). Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation of the latest evidence. Clinical Chemistry and Laboratory Medicine (CCLM), 58(7), 1037-1052. https://doi.org/10.1515/cclm-2020-0722
Bryant, J. E., Azman, A. S., Ferrari, M. J., Arnold, B. F., Boni, M. F., Boum, Y., Hayford, K., Luquero, F. J., Mina, M. J., Rodriguez-Barraquer, I., Wu, J. T., Wade, D., Vernet, D., & Leung, D. T. (2020). Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward. Science Immunology, 5(47), eabc6347. 10.1126/sciimmunol.abc6347
Chen, H., Guo, J., Wang, C., Luo, F., Yu, X. B., Zhang, W., Li, J., Zhao, D., Xu, D., Gong, Q., Liao, J., Yang, H., Hou, W., & Zhang, Y. (2020). Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet, 395(10226), 809–815. https://doi.org/10.1016/s0140-6736(20)30360-3
Dong, L., Tian, J., He, S., Zhu, C., Wang, J., Liu, C., & Yang, J. (2020). Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA, 323(18), 1846–1848. https://doi.org/10.1001/jama.2020.4621
Fan, C., Lei, D., Fang, C., Li, C., Wang, M., Liu, Y., Bao, Y., Sun, Y., Huang, J., Guo, Y., Yu, Y., & Wang, S. (2021). Perinatal Transmission of 2019 Coronavirus Disease-Associated Severe Acute Respiratory Syndrome Coronavirus 2: Should We Worry? Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 72(5), 862–864. https://doi.org/10.1093/cid/ciaa226
Fox, A., Marino, J., Amanat, F., Krammer, F., Hahn-Holbrook, J., Zolla-Pazner, S., & Powell, R. L. (2020). Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human Milk. iScience, 23(11), 101735. https://doi.org/10.1016/j.isci.2020.101735
Groß, R., Conzelmann, C., Müller, J. A., Stenger, S., Steinhart, K., Kirchhoff, F., & Münch, J. (2020). Detection of SARS-CoV-2 in human breastmilk. The Lancet, 395(10239), 1757–1758. https://doi.org/10.1016/S0140-6736(20)31181-8
Hand, I. L., & Noble, L. (2020). Covid-19 and breastfeeding: what's the risk? Journal of perinatology: official journal of the California Perinatal Association, 40(10), 1459–1461. https://doi.org/10.1038/s41372-020-0738-6
Kutti-Sridharan, G., Vegunta, R., Vegunta, R., Mohan, B. P., & Rokkam, V. R. P. (2020). SARS-CoV2 in Different Body Fluids, Risks of Transmission, and Preventing COVID-19: A Comprehensive Evidence-Based Review. International journal of preventive medicine, 11, 97. https://doi.org/10.4103/ijpvm.IJPVM_255_20
Li, Y., Zhao, R., Zheng, S., Chen, X., Wang, J., Sheng, X., Zhou, J., Cai, H., Fang, Q., Yu, F., Fan, J., Xu, K., Chen, Y., & Sheng, J. (2020). Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China. Emerging Infectious Diseases, 26(6), 1335-1336. https://doi.org/10.3201/eid2606.200287
Liu, W., Wang, J., Li, W., Zhou, Z., Liu, S., & Rong, Z. (2020). Clinical characteristics of 19 neonates born to mothers with COVID-19. Frontiers of medicine, 14(2), 193–198. https://doi.org/10.1007/s11684-020-0772-y
Lowe, B., & Dopp, B. (2020). COVID-19 vaginal delivery - A case report. The Australian & New Zealand journal of obstetrics & gynaecology, 60(3), 465–466. https://doi.org/10.1111/ajo.13173
Ministério da Saúde. (2020). Coronavírus: conheça as orientações para amamentação. Portal da Secretaria de Atenção Primária à Saúde. https://aps.saude.gov.br/noticia/7717
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, L. A., Stewart, L. A., Thomas, J., Tricco, A. C., Welch, V. A., Whiting, P., & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical research ed.), 372, n71. https://doi.org/10.1136/bmj.n71
Passanha, A., Cervato-Mancuso, A. M., & Silva, M. E. M. P. (2010). Protective elements of breast milk in the prevention of gastrointestinal and respiratory diseases. Journal of Human Growth and Development, 20(2), 351-360. http://pepsic.bvsalud.org/scielo.php?script=sci_arttext&pid=S0104-12822010000200017&lng=pt&tlng=en.
Peng, Z., Wang, J., Mo, Y., Duan, W., Xiang, G., Yi, M., Bao, L., & Shi, Y. (2020). Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report. Journal of infection and public health, 13(5), 818–820. https://doi.org/10.1016/j.jiph.2020.04.004
Piersigilli, F., Carkeek, K., Hocq, C., van Grambezen, B., Hubinont, C., Chatzis, O., Van der Linden, D., & Danhaive, O. (2020). COVID-19 in a 26-week preterm neonate. The Lancet. Child & adolescent health, 4(6), 476–478. https://doi.org/10.1016/S2352-4642(20)30140-1
Salvatori, G., De Rose, D. U., Concato, C., Alario, D., Olivini, N., Dotta, A., & Campana, A. (2020). Managing COVID-19-Positive Maternal-Infant Dyads: An Italian Experience. Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine, 15(5), 347–348. https://doi.org/10.1089/bfm.2020.0095
Tam P.L., Ly, K. N., Kernich, M. L., Spurrier, N., Lawrence, D., Gordon, D. L., & Tucker, E. (2020). Detectable Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Human Breast Milk of a Mildly Symptomatic Patient With Coronavirus Disease 2019 (COVID-19). Clinical infectious diseases: an official publication of the Infectious Diseases Society of America, 72(1), 128-130. https://doi.org/10.1093/cid/ciaa673
Vassilopoulou, E., Feketea, G., Koumbi, L., Mesiari, C., Berghea, E. C., & Konstantinou, G. N. (2021). Breastfeeding and COVID-19: From Nutrition to Immunity. Frontiers in immunology, 12, 661806. https://doi.org/10.3389/fimmu.2021.661806
Wang, L., Shi, Y., Xiao, T., Fu, J., Feng, X., Mu, D., Feng, Q., Hei, M., Hu, X., Li, Z., Lu, G., Tang, Z., Wang, Y., Wang, C., Xia, S., Xu, J., Yang, Y., Yang, J., Zeng, M., Zheng, J., Zhou, W., Zhou, X., Zhou, X., Du, L., Lee, S. K. & Zhou, W. (2020). Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition). Annals of translational medicine, 8(3), 47. https://doi.org/10.21037/atm.2020.02.20
World Health Organization (WHO). (2020) Breastfeeding and COVID-19. Scientific brief. WHO/2019-nCoV/Sci_Brief/Breastfeeding/2020
Wu, Y., Liu, C., Dong, L., Zhang, C., Chen, Y., Liu, J., Zhang, C., Duan, C., Zhang, H., Mol, B. W., Dennis, C. L., Yin, T., Yang, J., & Huang, H. (2020). Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG an international journal of obstetrics and gynaecology, 127(9), 1109–1115. https://doi.org/10.1111/1471-0528.16276
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Copyright (c) 2023 Lysandro Pinto Borges; Catharina Corrêa Costa; Otávio Cabral-Marques; Eloia Emanuelly Dias Silva; Pamela Chaves de Jesus; Jessiane Bispo de Souza; Deise Maria Rego Rodrigues Silva; Pedro Henrique Macedo Moura; Beatriz Soares da Silva; Ronaldy Santana Santos; Marina dos Santos Barreto; Leticia Milena Machado dos Santos; Adriana Gibara Guimarães
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