Updates on Adenomyosis: evolution of epidemiological data, diagnosis and treatment in recent years

Authors

DOI:

https://doi.org/10.33448/rsd-v12i7.42804

Keywords:

Adenomyosis; Diagnosis; Treatment; Epidemiology.

Abstract

Adenomyosis is a benign gynecological condition, characterized by the presence of stroma and endometrial glands in the myometrium, and can be characterized in subtypes, such as focal, diffuse, deep and superficial. The etiopathogenesis is still not fully elucidated, but the two most accepted theories involve invagination of the basal layer of the endometrium into the myometrium and de novo metaplasia of the Mullerian ducts. The diagnosis, which was formerly histopathological, after performing a hysterectomy, can now be made by imaging tests, with transvaginal ultrasound being the first-line test. The evolution of the diagnosis represented a watershed for the classification of this pathogenesis, due to the better characterization of the epidemiological data, the possibility of a better detailing of the clinical picture and the opportunity to more accurately identify these women in earlier stages of life, which meant that the treatment is now individualized, according to the wishes, especially in relation to fertility, of women. Thus, the objective of this study is to analyze what is most recent in the medical scenario about adenomyosis, aiming to provide better care for patients who have this disease.

Author Biographies

João Vitor Dias Vasconcelos, Faculdade de Medicina de Itajubá

Acadêmico de Medicina.

Márcio José Rosa Requeijo, Faculdade de Medicina de Itajubá

Possui graduação em Medicina pela Faculdade de Medicina de Itajubá (1995). Residência em ginecologia e obstetrícia na PUCCAMP ( 1996 a 1998). De 2003 a 2009 foi colaborador do departamento de Ginecologia e Obstetrícia da Faculdade de Medicina da Universidade de São Paulo no qual atuou como professor para o quarto ano do curso de medicina na disciplina de obstetrícia. Mestrado em obstetrícia pela Faculdade de medicina da universidade de São Paulo - FMUSP( 2003). Doutorado em obstetrícia pela Faculdade de medicina da universidade de São Paulo - FMUSP. (2009). Titulo de especialista em GO pela FEBRASGO. Titulo de especialista em ultrassonografia em ginecologia e obstetrícia pelo CBR/AMB/FEBRASGO. Titulo de especialista em ultrassonografia geral pela AMB / colegio brasileiro de Radiologia e diagnóstico por imagem. Titulo de especialista em medicina fetal pela FEBRASGO/AMB. Tem experiência na área de Medicina, com ênfase em ginecologia e obstetrícia, atuando principalmente nos seguintes temas: Ultrassonografia geral, ultrassonografia em GO e Medicina fetal, com ênfase em Defeitos da Face e Defeitos do Tubo Neural. MBA em Gestão de organizações Hospitalares e Sistemas de Saúde pela Fundação Getúlio Vargas - FGV (2009). Ex- professor substituto no departamento de obstetrícia da UFMG em 2011/2012. Ex- professor de ginecologia e obstetrícia da Faculdade da Saúde e Ecologia Humana, FASEH, Vespasiano, MG ( 2014). Médico responsável pela clínica ULTRAMAX - BH- MG. Atualmente professor do departamento de ginecologia e obstetrícia da Faculdade de Medicina de Itajubá ( 2014 - atual) e chefe do setor de medicina fetal do hospital das clinicas de Itajubá ( MG ). Representante regional da SOGIMIG na cidade de Itajubá-MG.

References

Bourdon, M., Santulli, P., Marcellin, L., Maignien, C., Maitrot-Mantelet, L., Bordonne, C., Plu Bureau, G., & Chapron, C. (2021a). Adenomyosis: An update regarding its diagnosis and clinical features. Journal of Gynecology Obstetrics and Human Reproduction, 50(10), 102228. https://doi.org/10.1016/j.jogoh.2021.102228

Bourdon, M., Oliveira, J., Marcellin, L., Santulli, P., Bordonne, C., Maitrot Mantelet, L., Millischer, A. E., Plu Bureau, G., & Chapron, C. (2021). Adenomyosis of the inner and outer myometrium are associated with different clinical profiles. Human reproduction (Oxford, England), 36(2), 349–357. https://doi.org/10.1093/humrep/deaa307

Celli, V., Dolciami, M., Ninkova, R., Ercolani, G., Rizzo, S., Porpora, M. G., Catalano, C., & Manganaro, L. (2022). MRI and Adenomyosis: What Can Radiologists Evaluate? International Journal of Environmental Research and Public Health, 19(10), 5840. https://doi.org/10.3390/ijerph19105840

Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., Gordts, S., Guo, S. W., Just, P. A., Noël, J. C., Pistofidis, G., Van den Bosch, T., & Petraglia, F. (2020). Diagnosing adenomyosis: an integrated clinical and imaging approach. Human reproduction update, 26(3), 392–411. https://doi.org/10.1093/humupd/dmz049

De Souza, M. T., Silva, M. D., Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102-106.

Guo, S.-W., Benagiano, G., & Bazot, M. (2022). In Search of an Imaging Classification of Adenomyosis: A Role for Elastography? Journal of Clinical Medicine, 12(1), 287–287. https://doi.org/10.3390/jcm12010287

Guo, S.-W. (2022). Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology. Reproduction, 164(5), R101–R121. https://doi.org/10.1530/rep-22-0224

Gunther, R., & Walker, C. (2022). Adenomyosis. In StatPearls. StatPearls Publishing.

Habiba, M., & Benagiano, G. (2021). Classifying Adenomyosis: Progress and Challenges. International journal of environmental research and public health, 18(23), 12386. https://doi.org/10.3390/ijerph182312386

Harada, T., Taniguchi, F., & Harada, T. (2022). Increased risk of obstetric complications in patients with adenomyosis: A narrative literature review. Reproductive medicine and biology, 21(1), e12473. https://doi.org/10.1002/rmb2.12473

Harmsen, M. J., Van den Bosch, T., de Leeuw, R. A., Dueholm, M., Exacoustos, C., Valentin, L., Hehenkamp, W. J. K., Groenman, F., De Bruyn, C., Rasmussen, C., Lazzeri, L., Jokubkiene, L., Jurkovic, D., Naftalin, J., Tellum, T., Bourne, T., Timmerman, D., & Huirne, J. A. F. (2022). Consensus on revised definitions of Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis: results of modified Delphi procedure. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 60(1), 118–131. https://doi.org/10.1002/uog.24786

Khan, K. N., Fujishita, A., & Mori, T. (2022). Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility. Journal of clinical medicine, 11(14), 4057. https://doi.org/10.3390/jcm11144057.

Orlov, S., & Jokubkiene, L. (2022). Prevalence of endometriosis and adenomyosis at transvaginal ultrasound examination in symptomatic women. Acta obstetricia et gynecologica Scandinavica, 101(5), 524–531. https://doi.org/10.1111/aogs.14337

Orozco, R., Vilches, J. C., Brunel, I., Lozano, M., Hernández, G., Pérez-Del Rey, D., Meloni, L., & Alcázar, J. L. (2023). Adenomyosis in Pregnancy-Should It Be Managed in High-Risk Obstetric Units?. Diagnostics (Basel, Switzerland), 13(6), 1184. https://doi.org/10.3390/diagnostics13061184

Rasmussen, C. K., Hansen, E. S., & Dueholm, M. (2019). Two- and three-dimensional ultrasonographic features related to histopathology of the uterine endometrial-myometrial junctional zone. Acta obstetricia et gynecologica Scandinavica, 98(2), 205–214. https://doi.org/10.1111/aogs.13484

Sharara, F. I., Kheil, M. H., Feki, A., Rahman, S., Klebanoff, J. S., Ayoubi, J. M., & Moawad, G. N. (2021). Current and Prospective Treatment of Adenomyosis. Journal of clinical medicine, 10(15), 3410. https://doi.org/10.3390/jcm10153410

Upson, K., & Missmer, S. A. (2020). Epidemiology of Adenomyosis. Seminars in reproductive medicine, 38(2-03), 89–107. https://doi.org/10.1055/s-0040-1718920

Van den Bosch, T., & Van Schoubroeck, D. (2018). Ultrasound diagnosis of endometriosis and adenomyosis: State of the art. Best practice & research. Clinical obstetrics & gynaecology, 51, 16–24. https://doi.org/10.1016/j.bpobgyn.2018.01.013

Vannuccini, S., & Petraglia, F. (2019). Recent advances in understanding and managing adenomyosis. F1000Research, 8, F1000 Faculty Rev-283. https://doi.org/10.12688/f1000research.17242.1.

Yeh, C. C., Su, F. H., Tzeng, C. R., Muo, C. H., & Wang, W. C. (2018). Women with adenomyosis are at higher risks of endometrial and thyroid cancers: A population-based historical cohort study. PloS one, 13(3), e0194011. https://doi.org/10.1371/journal.pone.0194011

Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020). Adenomyosis: Mechanisms and Pathogenesis. Seminars in reproductive medicine, 38(2-03), 129–143. https://doi.org/10.1055/s-0040-1716687

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Published

03/08/2023

How to Cite

VENEROSO, A. A. .; VASCONCELOS, J. V. D. .; REQUEIJO, M. J. R. . Updates on Adenomyosis: evolution of epidemiological data, diagnosis and treatment in recent years. Research, Society and Development, [S. l.], v. 12, n. 7, p. e20012742804, 2023. DOI: 10.33448/rsd-v12i7.42804. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/42804. Acesso em: 22 dec. 2024.

Issue

Vol. 12 No. 7

Section

Health Sciences

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Copyright (c) 2023 André Azzi Veneroso; João Vitor Dias Vasconcelos; Márcio José Rosa Requeijo

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