Telomerase and its inhibitors in lung cancer: a literature review
DOI:
https://doi.org/10.33448/rsd-v12i8.42823Keywords:
Lung câncer; Telomerase; Telomeres; Cell senescence.Abstract
Lung cancer is the second most common cancer in men and women in Brazil and the most common malignant tumor worldwide, being the leading cause of cancer-related death worldwide. The main reasons for the increased incidence rate are smoking and air pollution (Câncer de pulmão, n.d.). However, genetic factors also play an important role in lung cancer carcinogenesis, with telomerase being a key point in this process, along with its role in cellular senescence. In this sense, this study aims to evaluate how telomerase and its inhibitors are associated in the development of lung cancer. The present study consists of an integrative literature review on the performance of telomerase and its inhibitors in lung cancer, in which the PICO strategy (Acromium for Patient, Intervention, Comparison and Outcome) was used and the descriptors “telomeres” were crossed; "cancer"; “lung cancer” in Portuguese and English, in the following databases: Virtual Health Library (BVS); National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (SCIELO). From the final analysis of the full text of the 24 duly selected articles, it was possible to observe that lung cancer is directly related to the length of telomeres and the activity of the enzyme telomerase. It is therefore concluded that, in an attempt to find an effective treatment for cancer, new study targets on the telomerase enzyme are still needed, along with the follow-up of studies that are already in progress.
References
Araújo, W. C. O. (2020). Recuperação da informação em saúde: construção, modelos e estratégias.
Autsavapromporn, N., Klunklin, P., Threeratana, C., Tuntiwechapikul, W., Hosoda, M., & Tokonami, S. (2018). Short telomere length as a biomarker risk of lung cancer development induced by high radon levels: A pilot study. International journal of environmental research and public health, 15(10), 2152.
Barnes, P. J., Baker, J., & Donnelly, L. E. (2019). Cellular senescence as a mechanism and target in chronic lung diseases. American journal of respiratory and critical care medicine, 200(5), 556-564.
van Batenburg, A. A., Kazemier, K. M., van Oosterhout, M. F., van der Vis, J. J., Grutters, J. C., Goldschmeding, R., & van Moorsel, C. H. (2021). Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease. ERJ Open Research, 7(2).
.
Cao, X., Huang, M., Zhu, M., Fang, R., Ma, Z., Jiang, T., ... & Hu, Z. (2019). Mendelian randomization study of telomere length and lung cancer risk in East Asian population. Cancer Medicine, 8(17), 7469-7476.
Córdoba-Lanús, E., Cazorla-Rivero, S., García-Bello, M. A., Mayato, D., Gonzalvo, F., Ayra-Plasencia, J., & Casanova, C. (2021). Telomere length dynamics over 10-years and related outcomes in patients with COPD. Respiratory Research, 22, 1-9.
Doherty, J. A., Grieshober, L., Houck, J. R., Barnett, M. J., Tapsoba, J. D. D., Thornquist, M., & Chen, C. (2018). Telomere length and lung cancer mortality among heavy smokers. Cancer Epidemiology, Biomarkers & Prevention, 27(7), 829-837.
Doherty, J. A., Grieshober, L., Houck, J. R., Barnett, M. J., De Dieu Tapsoba, J., Thornquist, M. D., & Chen, C. (2018). Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial. British Journal of Cancer, 118(11), 1513-1517.
Ferreira, A. M. P. D. S. D. C. (2019). Fisiopatologia dos telómeros (Doctoral dissertation).
Feurstein, S., Adegunsoye, A., Mojsilovic, D., Vij, R., West DePersia, A. H., Rajagopal, P. S., & Churpek, J. E. (2020). Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations. Blood Advances, 4(19), 4873-4886.
Frink, R. E., Peyton, M., Schiller, J. H., Gazdar, A. F., Shay, J. W., & Minna, J. D. (2016). Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner. Oncotarget, 7(22), 31639.
Câncer de pulmão. INCA - Instituto Nacional de Câncer. https://www.inca.gov.br/assuntos/cancer-de-pulmao
Hu, K., Ghandi, M., & Huang, F. W. (2021). Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines. ELife, 10. https://doi.org/10.7554/elife.66198
Forero, R., Nahidi, S., De Costa, J., Mohsin, M., Fitzgerald, G., Gibson, N., McCarthy, S., & Aboagye-Sarfo, P. (2018). Application of four-dimension criteria to assess rigour of qualitative research in emergency medicine. BMC Health Services Research, 18(1). https://doi.org/10.1186/s12913-018-2915-2
Li, J; Zhang, L; Zhu, H; Pan, W; Zhang, N; Li, Y; Yang, M. (2018). Leukocyte Telomere Length and Clinical Outcomes of Advanced Lung Adenocarcinoma Patients with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment. Dna And Cell Biology, 37(11), 903-908.
Li, Y., Cheng, X., Shen, N., Deng, L., Luo, X., Yuan, P., Ji, Z., Li, J., & Cheng, L. (2019). Functional polymorphisms on chromosome 5p15.33 disturb telomere biology and confer the risk of non‐small cell lung cancer in Chinese population. 58(6), 913–921. https://doi.org/10.1002/mc.22980
McDonough, J. E., Martens, D. S., Tanabe, N., Ahangari, F., Verleden, S. E., Maes, K., Verleden, G. M., Kaminski, N., Hogg, J. C., Nawrot, T. S., Wuyts, W. A., & Vanaudenaerde, B. M. (2018). A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis. Respiratory Research, 19(1). https://doi.org/10.1186/s12931-018-0838-4
Moura, H. F. (2021). Envelhecimento celular precoce em indivíduos com transtorno por uso de álcool ou cocaína/crack. Www.lume.ufrgs.br. https://www.lume.ufrgs.br/handle/10183/224417
Nguyen, M T; Saffery, R; Burgner, D; Lycett, K; Vryer, R; Grobler, A; Dwyer, T; Ranganathan, S; & Wake, M. (2019). Telomere length and lung function in a population‐based cohort of children and mid‐life adults. Pediatric Pulmonology, 54(12), 2044-2052 http://dx.doi.org/10.1002/ppul.24489.
Ruiz, A., Flores-Gonzalez, J., Buendia-Roldan, I., & Chavez-Galan, L. (2021). Telomere Shortening and Its Association with Cell Dysfunction in Lung Diseases. International Journal of Molecular Sciences, 23(1), 425. https://doi.org/10.3390/ijms23010425
Silva, L. D. G. da, Cunha, D. D. O., Cordeiro, J. A. B. L., Passos, X. S., Ataides, F. S., Vilanova-Costa, C. A. S. T., & Silva, A. M. T. C. (2019). A inibição da telomerase em oncócitos: o fim da imortalidade celular. Revista Brasileira Militar de Ciências, 5(12). https://doi.org/10.36414/rbmc.v5i12.12
Storti, C. B., de Oliveira, R. A., de Carvalho, M., Hasimoto, E. N., Cataneo, D. C., Cataneo, A. J. M., De Faveri, J., Vasconcelos, E. J. R., dos Reis, P. P., & Cano, M. I. N. (2020). Telomere-associated genes and telomeric lncRNAs are biomarker candidates in lung squamous cell carcinoma (LUSC). Experimental and Molecular Pathology, 112, 104354. https://doi.org/10.1016/j.yexmp.2019.104354
Xue, Y., Guo, X., Huang, X., Zhu, Z., Chen, M., Chu, J., Yang, G., Wang, Q., & Kong, X. (2020). Shortened telomere length in peripheral blood leukocytes of patients with lung cancer, chronic obstructive pulmonary disease in a high indoor air pollution region in China. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 858-860, 503250. https://doi.org/10.1016/j.mrgentox.2020.503250
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Gabriela Machado Silveira; Bruna Silveira Caixeta; João Gabriel Porto Lima; Ana Cecilia Cardoso de Sousa Mota
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
