Clinical use of oral antibiotics in the treatment of acne vulgaris: Safety and therapeutic efficacy
DOI:
https://doi.org/10.33448/rsd-v12i11.43147Keywords:
Acne vulgaris; Treatment acne; Antibiotic drugs.Abstract
The objective of this study is to present the latest in terms of good quality scientific evidence on the clinical use of oral antibiotics in the treatment of acne vulgaris, monitoring whether there is proof of their efficacy and safety in patients. This is a narrative literature review, where the electronic databases Scielo, Pubmed and Lilacs were used, with evidence published in the last ten years. Know that systemic based treatment should be considered in the presence of inflammatory acne and those that are difficult to control. In this case, it may involve antibiotic therapy, where the drugs in this line have as a mechanism of action a suppression of P. acnes, increased addition and free circulation fatty acids. However, the prolonged use of antibiotics, regardless of their class, constitutes a risk factor for the appearance of antimicrobial resistance, evidencing the fact that improper prescriptions of oral antibiotics for the treatment of acne must be avoided, and also that in the need to adopt this therapy, it is to consider the most appropriate class for the patient's needs, avoiding misuse. With this, it is important for prescribed professionals to have a broad knowledge of the classes and mechanisms of action of these drugs, in order to promote evidence-based treatment. In addition, it is imperative that new clinical studies be carried out with greater methodological rigor, in order to verify the best choice of acne treatment in its different degrees, guaranteeing the efficacy and safety of the patient.
References
Azevedo, I. A. et al. (2017). Estudo retrospectivo sobre a prevalência do uso de contraceptivos orais e de medicamentos convencionais no tratamento da acne inflamatória. Revista Científica UMC, 2(2).
Barbosa, G. S. L., Costa, C. P. M., Borges, M. V. R., Attem, M. S., Cacau, B. L., Lopes, M. S., & Fontenelle, L. F. V. (2021). Tratamentos medicamentosos para acne vulgar em adolescentes e jovens adultos. Research, Society and Development, 10(5), e39010515094-e39010515094.
Barros, A. B. (2020). Acne vulgar: aspectos gerais e atualizações no protocolo de tratamento. BWS Journal, 3, e201000125: 1-13.
Bienenfeld, A., Nagler, A.R., & Orlow, S. J. (2017). Oral antibacterial therapy for acne vulgaris: An evidence-based review. Am J Clin Dermatol 18(4):469–490, doi: 10.1007/s40257-017-0267-z.
Borem, M. (2022). Acne na mulher adulta e seus tratamentos. Estética em movimento 1(2), 77-90.
Costa, C. S., & Bagatin, E. (2013). Evidências sobre o tratamento da acne. Diagn Tratamento., 18(1):10-4.
Costa, I. V., & Velho, C. C. (2018). Acne vulgar no adulto. Revista SPDV 76(3).
Deusschle, V. C. K. N. et al. (2016). Caracterização das lesões e tratamentos utilizados na acne. Revista interdisciplinar de ensino, pesquisa e extensão 3(1).
Freitas, T. E. C. M., & Velho, G. M. C. C. (2021). Opções terapêuticas farmacológicas na acne vulgar. J Port Soc Dermatol Venereol 79(2), https://dx.doi.org/10.29021/spdv.79.2.1370.
Keri, J. E. (2022). Ance vulgar. https://www.msdmanuals.com/pt-br/profissional/dist%C3%BArbios-dermatol%C3%B3gicos/acne-e-doen%C3%A7as-relacionadas/acne-vulgar.
Koca, S., & Oral, A. Y. (2023). Assessments of the ocular surface and meibomian gland morphology in patients with treatment-naive acne vulgaris. Original Article, Arq. Bras. Oftalmol. 86(2), https://doi.org/10.5935/0004-2749.20230025.
Melnik, B. C. (2015). Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update. Clin Cosmet Investig Dermatol, 8:371-88.
Melnik, B. C. (2016). Is Sebocyte-Derived Leptin the Missing Link between Hyperseborrhea, Ductal Hypoxia, Inflammation and Comedogenesis in Acne Vulgaris? Exp Dermatol. 25:181-2.
Oliveira, A. Z., Torquetti, C. B., & Nascimento, L. P. R. (2020). O tratamento da acne associado à limpeza de pele. Revista brasileira interdisciplinar de Saúde – ReBIS, 2(3):60-6.
Organização Pan-Americana da Saúde (OPAS). (2022). Como fazer tratamento da acne na Atenção Primária? https://aps-repo.bvs.br/aps/como-fazer-tratamento-da-acne-na-atencao-primaria-2/.
Resende, L. G. A. L., Silva, G. C. O., & Caldas, E. C (2021). O impacto psicossocial da acne vulgar. ID Online. Revista de Psicologia 15(58), 351-367.
Roieski, E. F., & Gonçalves, V. P. (2020). A influência dos fatores emocionais na acne vulgar: revisão de literatura. Unisul.
Santos, M. S. S. (2020). Mestrado Integrado em Ciências Farmacêuticas. Universidade de Lisboa, Faculdade de Farmácia.
Silva, J. P. O. P. (2017). Influência do índice de massa corporal e da dieta na fisiopatologia da acne vulgaris. Instituto de Ciências Biomédicas Abel Salazar – Universidade de Porto.
Silva, P. R. S., Souza, M. L. P., Sena, N. V., Alves, A. F. V., Pontes, L. M., Amarante, M. S. L. D., & Brandão, B. J. F. (2020). Perfil epidemiológico dos pacientes com acne vulgar atendidos na BWS, São Paulo – SP. BWS Journal. 3, e20070077: 1-7.
Zaenglein, A. L. et al. (2016). Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 74(5).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Lizandra Laila de Souza Silva; Roberta Maria da Silva Lima ; Ellaine Ramos da Silva Sousa ; Victor Gabriel Sebastião da Silva ; Caroliny Henrique Pereira da Silva ; Tarcila Karinny Henrique da Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
