Surgical excision combined with electrochemotherapy in the treatment of squamous cell carcinoma in a feline: Case report
DOI:
https://doi.org/10.33448/rsd-v12i10.43516Keywords:
SCC; Feline; Electrochemotherapy; Surgical resection.Abstract
Squamous cell carcinoma (SCC) is a malignant epithelial neoplasm derived from keratinocytes, commonly preceded by actinic (solar) keratosis, with unclear etiology but associated with host and environmental factors. The present study aimed to describe the therapeutic association of surgical resection with electrochemotherapy using carboplatin in a case of SCC. The work was conducted using qualitative methodology, providing a detailed case report of a domestic feline treated at a private hospital unit. The cat was of mixed breed, female, spayed, 12 years and 4 months old, with white and gray fur, weighing 5.1 kg. The patient presented with a unilateral ulcerative lesion on the lower right eyelid, which had been evolving for 2 years with a significant increase in size and ulceration for approximately 3 months. After an incisional biopsy for histopathological examination, the diagnosis of SCC was confirmed, and it was decided to perform surgical excision with 2 cm margins, along with two sessions of carboplatin electrochemotherapy. After 40 days from the second electrochemotherapy session, with no signs of recurrence, the patient was discharged.
References
Aquino, S. M. (2007). Management of Eyelid Neoplasms in the Dog and Cat. Clinical Techniques in Small Animal Practice, 22, 46-54.
Conceição, M. E. B. A. M., Martins, D. M., Bertolo, P. H. L., Bezerra, D. K. O., Silva, C. D. C. F., Aguirra, V. M. R. L., & Pereira, W. L. A. (2016). Carcinoma de células escamosas em terceira pálpebra de feline. Acta Scientiae Veterinariae, 44(Suppl 1), 170.
Cowell, R. L., Tyler, R. D., & Meinkoth, J. H. (2002). Diagnostic citology and hematology of the dog and cat (2a ed.). Mosby.
Guiduce, M. (2011). Eletroquimioterapia em cães e gatos. Trabalho de conclusão de curso (bacharelado - Medicina Veterinária) - Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia.
Delisle, E., & Devauchelle, P. (1999). Skin Tumours. In: Guaguère E. & Prélaud P. (Eds). A Practical Guide to Feline Dermatology. Paris: Merial, pp.15.1-15.14.
Dyce, K. M., Sack, W. O., & Wensing, C. J. G. (2010). Tratado de Anatomia Veterinária (4a ed.). Elsevier Editora Ltda.
Ferreira, F. M. (2009). Oftalmologia Veterinária. Programa de educação continuada em ciências agrárias da Universidade Federal do Paraná (PECCA). Curitiba, PR.
Fonsêca, M. C. I. F. (2022). Estudo retrospectivo das doenças oculares em felinos atendidos no hospital veterinário da UFPB no período de 2013 a 2019. TCC (Trabalho de Conclusão de Curso) - Centro de Ciências Agrárias, Universidade Federal da Paraíba. Areia.
Frandson, R. D., Wilke, W. L., & Fails, A. D. (2011). Anatomia e Fisiologia dos Animais de Fazenda (7a ed.). Guanabara Koogan.
Goldschmidt, M. H., & Goldschmidt, K. H. (2017). Epithelial and Melanocytic Tumors of the Skin. In: Meuten D. J. (Ed). Tumors in Domestic Animals (5th ed.). Ames: Iowa State Press, 88-141.
Guedes, A. G. P., Shmitt, I., & Pippi, N. L. (1998). Dermatite Solar Felina Associada a Carcinoma Epidermóide - Revisão Bibliográfica. Ciência Rural, 28(4), 203-209.
Guerios, S. D., Pês, M. S., Guimarães, F. V., Robes, R. R., Rodigheri, S. M., & Macedo, T. R. (2003). Carcinoma de células escamosas do plano nasal em felinos: Por que optar pelo tratamento cirúrgico? Medvep - Revista Científica de Medicina Veterinária – Pequenos animais e animais de estimação, 1(3), 203-209.
Grant, D. I. (1996). Skin Diseases in the Dog and Cat. Blackwell.
Grandi, F., & Rondelli, C. H. M. (2016). Neoplasias cutâneas. In: Daleck, C. R., & De Nardi, A. B. Oncologia em cães e gatos (2a ed.). Roca, Cap. 26, p.508 – 511.
Guimarães, M. R. (2003). Introdução à embriologia ocular. Curso de embriologia ocular. Hospital de Olhos de Minas Gerais, Belo Horizonte, 20p.
Jie, T. J., Reduan, M. F. H., Jasni, S., Shaari, R., Rajendren, S. K., Shaharulnizim, N., & Aziz, A. R. (2021). Squamous cell carcinoma in a left periorbital region in a domestic short hair cat: a case report. Journal of Animal Health and Production, 9(2), 136-139.
Kraegel, S. A., & Madewell, B. R. (2004). Tumores da Pele. In: Ettinger, S. J., & Feldmann, E. C. Tratado de Medicina Interna Veterinária (5.ed.). Rio de Janeiro: Guanabara/Koogan, cap. 99, p.555-557.
Larkin, J. O., Collins, C. G., Aarons, S., Tangney, M., Whelan, M., O’Reily, S., & O’Sullivan, G. C. (2007). Electrochemotherapy: aspects of preclinical development and early clinical experience. Annals of Surgery, 245(3), March.
Miller, P. E., & Teixeira, L. B. C. (2020). Ocular Tumors. In: Vail, D. M.; Thamm, D. H.; ¨& Liptak, J. M. Withrow & MacEwen’ Small Animal Clinical Oncology (6a ed.). cap. 23, p. 675-687.
Miller, W. H., Griffin, C. E., & Campbell, K. L. M. (2013). Muller and Kirk’s Small Animal Dermatology (7a ed.). Elsevier.
Murphy, S. (2013). Cutaneous Squamous Cell Carcinoma in the Cat: Current understanding and treatment approaches. Journal of Feline Medicine and Surgery, 15, 401-407.
Newkirk, K. M., & Rohrbach, B. W. (2009). A retrospective study of eyelid tumor from 43 cats. Veterinary Pathology, 46, 916-927.
Nishya, A. T., & Nardi, A. B. (2016). Neoplasias do Sistema Respiratório. In: Dalek, C. R.; Nardi, A. B., & Rodaski, S. (Ed). Oncologia em Cães e Gatos. Roca (2a ed.), 38, 479-481.
Oliveira, C. M. F., Barreto, L. F. G., Mendes, L. R. V., & Bentubo, H. D. L. (2023) Feline squamous cell carcinoma: case report. Research, Society and Development, 12(4), e17312440881. 10.33448/rsd-v12i4.40881.
Oliveira, L. O., & Telló, M. (2004). Pesquisas, em nível mundial, referentes à utilização da corrente contínua no tratamento do câncer. In: Telló, M., Raizer, A., Buzaid, A. C., Domenge, C., Dias, G. A. D., Almaguer, H. D., Oliveira, L. O., Farber, P. L., Oliveira, R. T., Silva, V. D. O uso da corrente elétrica no tratamento do câncer (3a ed.). EDIPUCRS, p. 77-96.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica [e-book]. UFSM. Disponível em: [link]. Acesso em: 03/04/2022.
Pérez-Enriquez, J. M., Romero-Romero, L., Alonso-Morales, R. A., & Fuentes-Pananá, E. M. (2020). Tumor prevalence in cats: experience from a reference diagnostic center in Mexico City (2006-2018). Veterinaria México OA, 7(4), 1-14.
Pinheiro, I. M. (2010). Estudo histopatológico dos carcinomas epidermóides de face de felinos domésticos e avaliação imuno-histoquímica de sua expressão de ki-67 e caspase-3-clivada. 101 f. Dissertação (Mestrado em Patologia Humana e Veterinária) – Universidade Federal Fluminense, Niterói.
Rosolem, M. C., Moroz, L. R., & Rodigheri, S. M. (2012). Carcinoma de células escamosas em cães e gatos: Revisão de literatura. PUBVET, 6, 1295-1300.
Silveira, L. M. G., Cunha, F. M., Brunner, C. H. M., & Xavier, J. G. (2016). Utilização de eletroquimioterapia para carcinoma de células escamosas tegumentar em felino. Pesq. Vet. Bras., 36(4), 297 – 302.
Silveira, L. M. G., et al. (2016). Utilização de eletroquimioterapia para carcinoma de células escamosas tegumentar em felino. Pesquisa Veterinária Brasileira, 36(4), 297-302
Soltero-Rivera, M. M., Krick, E. L., Reiter, A. M., Brown, D. C., & Lewis, J. R. (2014). Prevalence of regional and distant metastasis in cats with advanced oral squamous cell carcinoma: 49 cases (2005-2011). Journal of Feline Medicine and Surgery, 16, 164-169.
Straw, R. C. (2014). Resection of the nasal planum. In: Bojrab, M. J. et al. Current techniques in small animal surgery (5a ed.). Williams & Wilkins. Chap.4, p. 343-346.
Tozon, N., Pavlin, D., Sersa, G., Dolinsek, T., & Cemazar, M. (2014). Electrochemotherapy with intravenous bleomycin injection: an observational study in superficial squamous cell carcinoma in cats. Journal of Feline Medicine and Surgery, 16(4), 291–299.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Marcondes Pessoa de Freitas; Breno Conceição Silva; Beatriz Barreto Gomes; Victória Ranna Dias dos Santos; Milene Costa da Silva; Esthefany Dourado de Freitas; Nicolle Santos Ribeiro; Maria Madalena Souza Oliveira; Deusdete Conceição Gomes Junior
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
