Consequences of the ketogenic diet in cancer patients: A narrative review
DOI:
https://doi.org/10.33448/rsd-v12i11.43637Keywords:
Diet; Ketogenic diet; Cancer; Chronic diseases.Abstract
The ketogenic diet (KD) consists of a nutritional regimen rich in lipids, moderate in proteins and low in carbohydrates, which has been shown to be important compared to conventional cancer treatments due to its role in the metabolic reprogramming of tumor cells. The objective of this research is to carry out a narrative review on the impact of using CD as a complementary strategy in cancer treatment. The methodology used was a narrative and qualitative review on the subject in question. 10 articles were selected for analysis, chosen from among 19 articles resulting from the database search. Among the studies evaluated, a higher incidence of studies was observed in the United States with 5 articles, then Iran with 2 articles and finally Germany, Canada and the United Kingdom with 1 study each. Regarding the types of CA, there was wide diversity involved in the studies. Ovarian and endometrial CA with 3 articles, Glioblastoma with 2, Prostate CA with 1 and breast CA, the latter being the most common, with 4 articles published. The year in which there were the highest number of studies on the subject was in 2020, with 4 articles published. After 2018 and 2019 with 2 articles. And finally 2021 and 2022 with only 1 article published on the topic in our chosen database. It was possible to conclude that the observed impact of CD on cancer patients is beneficial and promising as a complementary treatment. Its effectiveness in reducing tumors, regulating body weight, preventing loss of muscle mass, preventing cachexia and regulating blood glucose is evidente.
References
Cavalcanti A. (2017). Dieta cetogênica: como colocar em prática? Revista Brasileira de Nutrição Funcional.
https://www.vponline.com.br/portal/noticia/pdf/1abbe95a4073913f5e17fdaa9fe0fe17.pdf.
Chi, J. T., Lin, P. H., Tolstikov, V., Oyekunle, T., Chen, E. Y., Bussberg, V. & Freedland, S. J. (2020). Metabolomic effects of androgen deprivation therapy treatment for prostate cancer. Cancer Medicine, 9(11), 3691-3702.
Cohen, C. W., Fontaine, K. R., Arend, R. C., & Gower, B. A. (2020). A ketogenic diet is acceptable in women with ovarian and endometrial cancer and has no adverse effects on blood lipids: a randomized, controlled trial. Nutrition and cancer, 72(4), 584-594.
Cohen, C. W., Fontaine, K. R., Arend, R. C., Alvarez, R. D., Leath III, C. A., Huh, W. K., & Gower, B. A. (2018). A ketogenic diet reduces central obesity and serum insulin in women with ovarian or endometrial cancer. The Journal of nutrition, 148(8), 1253-1260.
Cohen, C. W., Fontaine, K. R., Arend, R. C., Soleymani, T., & Gower, B. A. (2018). Favorable effects of a ketogenic diet on physical function, perceived energy, and food cravings in women with ovarian or endometrial cancer: a randomized, controlled trial. Nutrients, 10(9), 1187.
Ferreira, F. D., de Souza Neto, I., Pontes, L. A. C., Borges, L. S. R., de Ávila Oliveira, T. V., & Rodrigues, F. G. (2022). Dieta Cetogênica Como Estratégia Complementar No Tratamento De Câncer. Revista Interdisciplinar Ciências Médicas, 6(2), 41-47.
Garófolo, A., Avesani, C. M., Camargo, K. G., Barros, M. E., Silva, S. R. J., Taddei, J. A. D. A. C., & Sigulem, D. M. (2004). Dieta e câncer: um enfoque epidemiológico. Revista de Nutrição, 17, 491-505.
Fonseca, J. J. S. (2002). Apostila de metodologia da pesquisa científica. João José Saraiva da Fonseca.
Godoy, A. S. (1995). Introdução à pesquisa qualitativa e suas possibilidades. Revista de administração de empresas, 35, 57-63.
Khodabakhshi, A., Akbari, M. E., Mirzaei, H. R., Mehrad-Majd, H., Kalamian, M., & Davoodi, S. H. (2020). Feasibility, safety, and beneficial effects of MCT-based ketogenic diet for breast cancer treatment: a randomized controlled trial study. Nutrition and cancer, 72(4), 627-634.
Khodabakhshi, A., Akbari, M. E., Mirzaei, H. R., Seyfried, T. N., Kalamian, M., & Davoodi, S. H. (2021). Effects of Ketogenic metabolic therapy on patients with breast cancer: A randomized controlled clinical trial. Clinical Nutrition, 40(3), 751-758.
Khodabakhshi, A., Seyfried, T. N., Kalamian, M., Beheshti, M., & Davoodi, S. H. (2020). Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled clinical trial. Nutrition journal, 19(1), 1-10.
Kirkham, A. A., King, K., Joy, A. A., Pelletier, A. B., Mackey, J. R., Young, K. & Prado, C. M. (2021). Rationale and design of the Diet Restriction and Exercise-induced Adaptations in Metastatic breast cancer (DREAM) study: A 2-arm, parallel-group, phase II, randomized control trial of a short-term, calorie-restricted, and ketogenic diet plus exercise during intravenous chemotherapy versus usual care. BMC cancer, 21(1), 1-14.
Martin-McGill, K. J., Marson, A. G., Tudur Smith, C., Young, B., Mills, S. J., Cherry, M. G., & Jenkinson, M. D. (2020). Ketogenic diets as an adjuvant therapy for glioblastoma (KEATING): a randomized, mixed methods, feasibility study. Journal of neuro-oncology, 147, 213-227.
Oliveira, G. S., de Oliveira Cunha, A. M., Cordeiro, E. M., & dos Santos Saad, N. (2020). Grupo focal: uma técnica de coleta de dados numa investigação qualitativa?. Cadernos da FUCAMP, 19(41).
Parenza, C. (N/A). Dieta cetogênica e câncer – SBNO. https://sbno.com.br/dieta-cetogenica-ecancer/#:~:text=Estudos%20adicionais%20mostraram%20que%20dietas.
Pereira, É. S., Alves, M., Sacramento, T., & Rocha, V. L. (2010). Dieta cetogênica: como o uso de uma dieta pode interferir em mecanismos neuropatológicos. R. Ci. méd. biol., 9(1), 78-82, 2010.
Pereira, É., Alves, M., Sacramento, T., & Rocha, V. L. (2010). Ketogenic diet: how to use a diet can interfere with mechanisms neuropathological. Revista de Ciências Médicas e Biológicas, 9(Supplement), 78-82.
Sousa, D. D., Silva, J. G. T. P., & da Costa Maynard, D. (2022). Dieta cetogênica e o tratamento do câncer. Research, Society and Development, 11(9), e28211931806-e28211931806.
Vosgerau, Dilmeire Sant’Anna Ramos, & Romanowski, Joana Paulin. (2014). Estudos de revisão: implicações conceituais e metodológicas. Revista Diálogo Educacional, 14(41), 165-190.
Voss, M., Wenger, K. J., von Mettenheim, N., Bojunga, J., Vetter, M., Diehl, B., & Rieger, J. (2022). Short-term fasting in glioma patients: analysis of diet diaries and metabolic parameters of the ERGO2 trial. European Journal of Nutrition, 61(1): 477-87.
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