Clinical, histopathological aspects and treatment of patients diagnosed with actinic cheilitis: literature review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i7.4407

Keywords:

Cheilitis; Pathology oral; Dental care.

Abstract

Objective: To describe the clinical and histological aspects, as well as to discuss the diagnosis, treatment and preventive measures of actinic cheilitis (AC). Methodology: A literature review was carried out through the collection of articles indexed in the PubMed, Scielo and Regional Portal of the Virtual Health Library databases in the period 2002 to 2020, in addition to books on Oral Pathology and Stomatology. Results: It is important that, in dental practice, the professional is properly trained, especially the dental surgeon, as it is up to him the role of prevention, diagnosis, treatment and preservation of this clinical condition, with the necessary knowledge for this type of disease , because apparently simple lesions can potentially respond to progression to cancer. Conclusion: To prevent AC, the use of wide-brimmed hats and lip balm with sunscreen is recommended. The ideal treatment should be chosen according to the individual situation of each patient, and for acute AC prevention and conservative treatment is the best option, for chronic AC, total removal of the lesion is necessary.

References

Abreu MAMM, Silva OMP, Pimentel DRN, Hirata CHW, Alchorne MMA & Michalany NS (2006). Queilite actínica adjacente ao carcinoma espinocelular do lábio como indicador de prognóstico. Revista Brasileira de Otorrinolaringologia, 72(6), 767-71.

Araújo CP, Vidal MTA, Gurgel CAS, Ramos EAG, Jr AAB, Ramalho LMP & Santos JNI (2012). Queilite actínica: um estudo de 35 casos com destaque para os aspectos morfológicos. Rev. pós-grad, 19(1), 21-7.

Arnaud, R. R., Soares, M. S. M., Paiva, M. A. F., Figueiredo, C. R. L. V., Santos, M. G. C. & Lira, C. C. (2014). Queilite actínica: avaliação histopatológica de 44 casos. Rev Odontol UNESP, 43(6), 384-389.

Barros, C. C., Medeiros, C. K., Rolim, L. S., Cavalcante, I. L., Santos, P. P., Silveira, E. J. & Oliveira, P. T. (2020). A retrospective 11-year study on lip lesions attended at an oral diagnostic service. Medicina Oral, Patologia Oral y Cirugia Bucal, 25(3), 370-374.

Brito, L. N. S., Bonfim, A. C. E. A., Gomes, D. Q. C., Alves, P. M., Nonaka, C. F. W. & Godoy, G. P. (2019). Clinical and histopathological study of actinic cheilitis. Rev Odontol UNESP, 48(No issue).

Cabral, R., Teixeira, V., Vieira, R. & Figueiredo, A. (2013). Queilite actínica ablação com laser CO2 versus vermelhectomia-análise de 11 anos. Journal of the Portuguese Society of Dermatology and Venereology, 71(2), 177-183.

Cavalcante, A. S., Anbinder, A. L. & Carvalho, Y. R. (2008). Actinic cheilitis: clinical and histological features. J Oral Maxillofac Surg, 66(3), 498-503.

Dancyger, A., Heard, V., Huang, B., Suley, C., Tang, D. & Ariyawardana, A. (2018). Malignant transformation of actinic cheilitis: A systematic review of observational studies. Journal of investigative and clinical dentistry, 9(4), e12343.

De Godoy Peres, F. F., Brandão, A. A. H., Carvalho, Y. R., Dória Filho, U. & Plapler, H. (2009). A study of actinic cheilitis treatment by two low-morbidity CO 2 laser vaporization one-pass protocols. Lasers in medical science, 24(3), 375-385.

De Souza Lucena, E. E., Costa, D. C., da Silveira, E. J. & Lima, K. C. (2012). Prevalence and factors associated to actinic cheilitis in beach workers. Oral Dis, 18(6), 575-579.

Dos Santos, H. T., Cunha, J. L., Santana, L. A. M., Trento, C. L., Marquetti, A. C., de Albuquerque-Júnior, R. L. C. & de Sousa, S. F. (2019). Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. Autops Case Rep, 9(2), e2018075.

Dos Santos, J. N., de Sousa, S. O., Nunes, F. D., Sotto, M. N. & de Araújo, V. C. (2003). Altered cytokeratin expression in actinic cheilitis. J Cutan Pathol, 30(4), 237-241.

Fu, W. & Cockerell, C. J. (2003). The actinic (solar) keratosis: a 21st-century perspective. Archives of dermatology, 139(1), 66-70.

Gonzaga, A. K. G., Mafra, R. P., da Silva, L. P., de Almeida Freitas, R., de Souza, L. B. & Pinto, L. P. (2020). Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia. Acta Histochemica, 122(1), 151452.

Jadotte, Y. T. & Schwartz, R. A. (2012). Solar cheilosis: an ominous precursor: part I. Diagnostic insights. J Am Acad Dermatol, 66 (2): 173–186.

Lai, M., Pampena, R., Cornacchia, L., Pellacani, G., Peris, K. & Longo, C. (2019). Treatments of actinic cheilitis: A systematic review of the literature. J Am Acad Dermatol, [Epub ahead of print]. doi: 10.1016/j.jaad.2019.07.106.

Larizza, L., Roversi, G. & Volpi, L. (2010). Rothmund-thomson syndrome. Orphanet journal of rare diseases, 5(1), 2-16.

Lima Gda, S., Silva, G. F., Gomes, A. P., de Araújo, L. M. & Salum, F. G. (2010). Diclofenac in hyaluronic acid gel: an alternative treatment for actinic cheilitis. J Appl Oral Sci, 18(5), 533-537.

Lugovic-Mihic, L., Pilipovic, K., Crnaric, I., Šitum, M. & Duvancic, T. (2018). Differential diagnosis of cheilitis – how to classify cheilitis? Acta Clin Croat, 57(2), 342-351.

Luz, A. A., Faria, T. G. S., Catanoze, I. A., Ferreira, L. L., Bernabé, D. G. & Miyahara, G. I. (2014). Rev Odontol UNESP, 43(N Especial):116

Martins, M. D., Marques, L. O., Martins, M. A. T. M., Bussadori, S. K. & Fernandes, K. P. S. (2007). Queilite actínica: relato de caso clínico. Conscientiae saúde, 6(1), 105-110.

Mello, F, W., Melo, G., Modolo, F. & Rivero, E. R. (2019). Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. J Clin Exp Dent, 11(1), 62-69.

Migliari, D. A., Birman, E. G., Silveir, F. R. X., Santos, G. G., Marcucci, G., Wwinfeld, I., Guimarães Junior, J., Sugaya, N. N, Silva, S. S. & Crivello Junior, O. (2005). Fundamentos da odontologia: estomatologia (monografia). São Paulo: Repositório USP.

Muthukrishnan, A. & Kumar, L. B. (2017). Actinic cheilosis: early intervention prevents malignant transformation. BMJ Case Rep, Published online. doi:10.1136/bcr-2016-218654.

Neville, B. W., Damm, D. D., Allen, C. M. & Bouquot, J. E. (2002). Patologia Oral & Maxilofacial. Rio de Janeiro: Guanabara Koogan.

Neville, B. W. Damm, D. D., Allen, C. M. & Bouquot, J. E. (2016). Patología Epitelial. Patologia oral e maxilofacial. Rio de Janeiro: Elsevier.

Pennini, S. N., Rebello, P. F. B. & Silva, M. R. (2006) Queilites. J Bras Med, 78(6), 104-108.

Philipp-Dormston, W. G., Hilton, S. & Nathan, M. (2014). A prospective, open-label, multicenter, observational, postmarket study of the use of a 15 mg/mL hyaluronic acid dermal filler in the lips. J Cosmet Dermatol, 13(2), 125-134.

Pires, F. R., Barreto, M. E., Nunes, J. G., Carneiro, N. S., Azevedo, A. B. & Dos Santos, T. C. (2020). Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population. Med Oral Patol Oral Cir Bucal, 25(1), 84-88.

Poulopoulos, A., Aramuni, G., Meyer, G., Soykan, T., Hoon, M., Papadopoulos, T., Zhang, M., Paarmann, I., Fuchs, C., Harvey, K., Jedlicka, P., Schwarzacher, S. W., Betz, H., Harvey, R. J., Brose, N., Zhang, W. & Varoqueaux, F. (2009). Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron, 63(5), 628-642.

Reddy, R., Davidova, L., Bhattacharyya, I., Cohen, D. M., Islam, M. N. & Fitzpatrick, S. G. (2018). Dermatologic Lesions Submitted to an Oral and Maxillofacial Pathology Biopsy Service: An Analysis of 2487 Cases. Head and Neck Pathology, 12:(4), 493–499.

Rodríguez-Blanco, I., Florez, A., Paredes-Suárez, C., Rodríguez-Lojo, R., González-Vilas, D., Ramírez-Santos, A., Paradela, S., Conde, I. S. & Pereiro-Ferreirós, M. (2019a). Use of lip photoprotection in patients suffering from actinic cheilitis. Eur J Dermatol, 29(4), 383-386.

Rodríguez-Blanco, I., Flórez, Á., Paredes-Suárez, C., Rodríguez-Lojo, R., González-Vilas, D., Ramírez-Santos, A., Paradela, S., Conde, I. S. & Pereiro-Ferreirós, M. (2019b). Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage. Acta Derm Venereol, 99(10):931-932.

Salgueiro, A. P., de Jesus, L. H., de Souza, I. F., Rados, P. V. & Visioli, F. (2019). Treatment of actinic cheilitis: a systematic review. Clin Oral Investig, 23(5), 2041-2053.

Santana, T., Matuck, B., Tenório, J. R. & Braga, M. M. (2020). Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal, 25(1), 106–e116.

Santana, T., Nagata, G., Saturno, J. L. & Trierveiler, M. (2020). Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia. J Cutan Pathol, [Epub ahead of print]. doi: 10.1111/cup.13677.

Shah, A. Y., Doherty, S. D. & Rosen, T. (2010). Actinic cheilitis: a treatment review. International journal of dermatology, 49(11), 1225-1234.

Slama, B. (2019) Potentially malignant disorders of the oral mucosa. Rev Prat, 69(8), 856-860.

Savage, N. W., McKay, C. & Faulkner, C. (2010). Actinic cheilitis in dental practice. Aust Dent J, 55(1), 78-84.

Tenorio EP, Santos JAPD, Ferreira SMS, Peixoto FB & Ribeiro CMB (2018). Queilite actínica: relato de caso. Rev Med Minas Gerais, 28(No issue), 1970.

Tommasi AF (2014). Diagnóstico em patologia bucal. São Paulo: Pancast.

Varela-Centelles, P., Seoane-Romero, J., García-Pola, M. J., Leira-Feijoo, Y. & Seoane-Romero, J. M. (2020). Therapeutic approaches for actinic cheilitis: therapeutic efficacy and malignant transformation after treatment. Int J Oral and Maxillofac Surg. [Epub ahead of print] doi: 10.1016/j.ijom.2020.02.014.

Vetorazzo KRS, Rolim TFA, Rolim AKA, Guedes MCCM & Souza SLX (2020). Prevalência de alterações bucais em pacientes com necessidades especiais. Research, Society and Development, 9(2), e146922148.

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Published

31/05/2020

How to Cite

CARVALHO, G. A. O.; SOUZA, J. R. de; CÂMARA, J. V. F.; RIBEIRO, A. de O. P.; PIEROTE, J. J. A. Clinical, histopathological aspects and treatment of patients diagnosed with actinic cheilitis: literature review. Research, Society and Development, [S. l.], v. 9, n. 7, p. e557974407, 2020. DOI: 10.33448/rsd-v9i7.4407. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/4407. Acesso em: 19 apr. 2024.

Issue

Vol. 9 No. 7

Section

Health Sciences

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