Gastric cancer: An approach to its risk factors and prevention

Authors

DOI:

https://doi.org/10.33448/rsd-v13i1.44524

Keywords:

Risk factors; Prevention; Gastric cancer; Helicobacter pylori.

Abstract

This research aimed to describe the main risk factors, in addition to the main ways to prevent gastric cancer. An integrative literature review was carried out, using articles found in the PubMed, SciELO, Lilacs and Sciencedirect databases, selecting works published between 2013 and 2023, in Portuguese, English and Spanish, considering the following descriptors: “factors risk”, “prevention”, “gastric cancer” and “Helicobacter pylori”. A total of 421 works were found, and 20 works were finally selected for study. The development process of gastric cancer is modulated by several conditions, with the main risk factors being: age, consumption of smoked foods, a positive family history and H. pylori infection. Gastric cancer prevention can be divided into primary and secondary. Primary prevention seeks to minimize risk factors, while secondary prevention focuses on early diagnosis. Therefore, knowledge of risk factors and preventive factors are important strategies for controlling the incidence of gastric cancer.

References

Alipour, M. (2021). Molecular mechanism of Helicobacter pylori-induced gastric cancer. Journal of gastrointestinal cancer, 52, 23-30.

Aziz, Z. W., Saleem, S. H., & Al-Nuaimy, H. A. (2020). Helicobacter pylori in gastric biopsy: a histochemical and immunohistochemical assessment. Annals of the College of Medicine, Mosul, 41(2), 139-147.

Bouras, E., Tsilidis, K. K., Triggi, M., Siargkas, A., Chourdakis, M., & Haidich, A. B. (2022). Diet and risk of gastric cancer: an umbrella review. Nutrients, 14(9), 1764.

Botelho, L. L. R., de Almeida Cunha, C. C., & Macedo, M. (2011). O método da revisão integrativa nos estudos organizacionais. Gestão e sociedade, 5(11), 121-136.

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68(6), 394-424.

Chauhan, N., Tay, A. C. Y., Marshall, B. J., & Jain, U. (2019). Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview. Helicobacter, 24(1), e12544.

Chmiela, M., Karwowska, Z., Gonciarz, W., Allushi, B., & Stączek, P. (2017). Host pathogen interactions in Helicobacter pylori related gastric cancer. World journal of gastroenterology, 23(9), 1521.

Choi, K. S., & Suh, M. (2014). Screening for gastric cancer: the usefulness of endoscopy. Clinical endoscopy, 47(6), 490-496.

Correa, P. (2013). Gastric cancer: overview. Gastroenterology Clinics, 42(2), 211-217.

Eusebi, L. H., Telese, A., Marasco, G., Bazzoli, F., & Zagari, R. M. (2020). Gastric cancer prevention strategies: A global perspective. Journal of gastroenterology and hepatology, 35(9), 1495-1502.

Instituto Nacional do Câncer - INCA (2023). Síntese de resultados e comentários. https://www.gov.br/inca/pt-br/assuntos/cancer/numeros/estimativa/sintese-de-resultados-e-comentarios

Hamashima, C. (2018). Systematic review group and guideline development group for gastric cancer screening guidelines. Update version of the Japanese guidelines for gastric cancer screening. Jpn J Clin Oncol, 48(7), 673-683.

Karimi, P., Islami, F., Anandasabapathy, S., Freedman, N. D., & Kamangar, F. (2014). Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer epidemiology, biomarkers & prevention, 23(5), 700-713.

Li, L. F., Chan, R. L. Y., Lu, L., Shen, J., Zhang, L., Wu, W. K. K., ... & Cho, C. H. (2014). Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms. International journal of molecular medicine, 34(2), 372-380.

Machlowska, J., Baj, J., Sitarz, M., Maciejewski, R., & Sitarz, R. (2020). Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies. International journal of molecular sciences, 21(11), 4012.

Morales Díaz, M., Corrales Alonso, S., Vanterpoll Héctor, M., Avalos Rodríguez, R., Salabert Tortolo, I., & Hernández Diaz, O. (2018). Cáncer gástrico: algunas consideraciones sobre factores de riesgo y Helicobacter pylori. Revista médica electrónica, 40(2), 433-444.

Morgan, E., Arnold, M., Camargo, M. C., Gini, A., Kunzmann, A. T., Matsuda, T., ... & Soerjomataram, I. (2022). The current and future incidence and mortality of gastric cancer in 185 countries, 2020–40: A population-based modelling study. EClinicalMedicine, 47.

Pasechnikov, V., Chukov, S., Fedorov, E., Kikuste, I., & Leja, M. (2014). Gastric cancer: prevention, screening and early diagnosis. World journal of gastroenterology: WJG, 20(38), 13842.

Pinheiro, H., Oliveira, C., Seruca, R., & Carneiro, F. (2014). Hereditary diffuse gastric cancer–Pathophysiology and clinical management. Best Practice & Research Clinical Gastroenterology, 28(6), 1055-1068.

Raraz-Vidal, J., Raraz-Vidal, O., Damaso-Mata, B., Cáceres-Collque, E., & Allpas-Gómez, H. L. (2014). Factores relacionados a la metaplasia intestinal en un hospital público en Huánuco. Acta medica peruana, 31(3), 176-180.

Sexton, R. E., Al Hallak, M. N., Diab, M., & Azmi, A. S. (2020). Gastric cancer: a comprehensive review of current and future treatment strategies. Cancer and Metastasis Reviews, 39, 1179-1203.

Singh, S., Varayil, J. E., Devanna, S., Murad, M. H., & Iyer, P. G. (2014). Physical activity is associated with reduced risk of gastric cancer: a systematic review and meta-analysis. Cancer prevention research, 7(1), 12-22.

Sgouras, D. N., Trang, T. T. H., & Yamaoka, Y. (2015). Pathogenesis of Helicobacter pylori infection. Helicobacter, 20, 8-16.

Shah, D., & Bentrem, D. (2022). Environmental and genetic risk factors for gastric cancer. Journal of surgical oncology, 125(7), 1096-1103.

Stefano, K., Marco, M., Federica, G., Laura, B., Barbara, B., Gioacchino, L., & Gian, L. D. A. (2018). Helicobacter pylori, transmission routes and recurrence of infection: state of the art. Acta Bio Medica: Atenei Parmensis, 89(Suppl 8), 72.

Thapa, S., Fischbach, L. A., Delongchamp, R., Faramawi, M. F., & Orloff, M. (2019). Association between dietary salt intake and progression in the gastric precancerous process. Cancers, 11(4), 467.

Wang, Q., Chen, Y., Wang, X., Gong, G., Li, G., & Li, C. (2014). Consumption of fruit, but not vegetables, may reduce risk of gastric cancer: results from a meta-analysis of cohort studies. European Journal of Cancer, 50(8), 1498-1509.

Warren, J. R., & Marshall, B. (1983). Unidentified curved bacilli on gastric epithelium in active chronic gastritis. The lancet, 321(8336), 1273-1275.

Yusefi, A. R., Lankarani, K. B., Bastani, P., Radinmanesh, M., & Kavosi, Z. (2018). Risk factors for gastric cancer: a systematic review. Asian Pacific journal of cancer prevention: APJCP, 19(3), 591.

Published

08/01/2024

How to Cite

SILVA, P. M. do N. .; CORDEIRO, A. de O. .; LIMA, A. V. M. .; PEREIRA, A. L. .; PEREIRA, E. de B. .; SANTOS, M. de O. .; SILVA, R. M. da . Gastric cancer: An approach to its risk factors and prevention. Research, Society and Development, [S. l.], v. 13, n. 1, p. e3813144524, 2024. DOI: 10.33448/rsd-v13i1.44524. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44524. Acesso em: 27 may. 2024.

Issue

Section

Health Sciences