Therapeutic potential of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson
DOI:
https://doi.org/10.33448/rsd-v13i1.44732Keywords:
Lippia alba; Biological activity; Essential oil; Lemon balm.Abstract
Brazil is characterized by a rich distribution of flora throughout its territory and excellent biodiversity. In this context, plants, especially those of the Verbenaceae family, have proven to be a valuable source of bioactive compounds with pharmacological potential. This family includes representatives that have shown efficacy against various pathogens, especially those from the genus Lippia L. Its seeds are widely used in folk medicine for their anti-inflammatory, antifungal, antiseptic, antihypertensive, anxiolytic, antileishmanial, antiviral, and digestive properties, among others. This review aims to provide an overview of the therapeutic potential of the Lippia alba species, investigating the parts, components, and biological properties of the plants and highlighting the relevance of this species in the search for natural products for the treatment of various diseases. The studies were selected from 2013 to 2023 through the virtual data platforms Google Scholar, Science Direct, and PubMed, using the search terms: biological activity; ethnopharmacology; Lippia alba; phytochemicals. Through our research, we confirmed that research using the essential oil from the leaves of this species is very popular and has a wide range of pharmacological potential in vitro, in vivo, and in silico. Furthermore, it has been demonstrated that studies on polar and nonpolar extracts of this type are still very rare. Research with other types of samples is envisioned to expand the therapeutic spectrum of the aromatic species.
References
Acero-Godoy, J., Guzmán-Hernández, T., & Muñoz-Ruíz, C. (2019). Documentary review of essential oils obtained from Lippia alba (Verbenaceae) as microbial and antifungal therapeutic alternative. Revista Tecnologia en Marcha, 32(1), 3-11.
Agati, G., Pollastri, S., Azzarello, E., & Tattini, M. (2012). Flavonoids as antioxidants in plants: Location and functional significance. Plant Science, 196(1), 67-76.
Aljaafari, M. N., AlAli, A. O., Baqais, L., Alqubaisy, M., AlAli, M., Molouki, A., & Lim, S. H. E. (2021). An overview of the potential therapeutic applications of essential oils. Molecules, 26(3), 628.
Arias, J. C. S., et al. (2013). Anti-inflammatory effects of the main constituents and epoxides derived from the essential oils obtained from Tagetes lucida, Cymbopogon citratus, Lippia alba and Eucalyptus citriodora. Journal of Essential Oil Research, 25, 186-193.
Aryal, S., Baniya, M. K., Danekhu, K., Kunwar, P., Gurung, R., & Koirala, N. (2019). Total phenolic content, flavonoid content and antioxidant potential of wild vegetables from Western Nepal. Plants, 8(4), 96.
Barbosa, K. B. F., Costa, N. M. B., Almeida, R. C. G., de Paula, S. O., Minim, V. P. R., & Bressan, J. (2010). Estresse oxidativo: conceito, implicações e fatores modulatórios. Revista de Nutrição, 23(4), 629-643.
Bolzani, V. S. (2016). Biodiversidade, bioprospecção e inovação no Brasil. Ciência e Cultura, 68(1), 04-05.
Bugger, H.; Pfeil, C. (2020) Ero mitocondrial na isquemia miocárdica, reperfusão e remodelação. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1866(7), 165768.
Camêlo, L. C. A., et al. (2011). Caracterização morfológica e agronômica de acessos de erva-cidreira brasileira [Lippia alba (Mill.) NE Br.]. Scientia Plena, 7.
Camilo, C. J., et al. (2022). Traditional use of the genus Lippia sp. and pesticidal potential: A review. Biocatalysis and Agricultural Biotechnology, 40, 102296.
Carvalho, A. A., Andrade, L. N., de Sousa, É. B. V., & de Sousa, D. P. (2015). Antitumor phenylpropanoids found in essential oils. BioMed Research International, 2015, 1-21. Chies, C. E., et al. (2013). Antioxidant Effect of Lippia alba (Miller) N. E. Brown. Antioxidants, 2, 194-205.
Cushnie, T., Cushnie, B., & Lamb, A. (2014). Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. International Journal of Antimicrobial Agents, 44(5), 377-386.
Da Silva Lima, A., et al. (2016). Assessment of the repellent effect of Lippia alba essential oil and major monoterpenes on the cattle tick Rhipicephalus microplus. Medical and Veterinary Entomology, 30(1), 73-77.
De Morais, S. M., et al. (2022). Biotechnological potential of essential oils from different chemotypes of Lippia alba (Mill.) NE Br. ex Britton & P. Wilson. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 21(6).
De Souza, R. C., et al. (2017). Antimicrobial and synergistic activity of essential oils of Aloysia triphylla and Lippia alba against Aeromonas spp. Microbial Pathogenesis, 113, 29-33.
Enferm, A. P. (2007). Revisão sistemática X revisão narrativa. Acta paul enferm, 20, 2.
Ferreira, J. J. O. (2015). Propriedades antioxidantes e anti-inflamatórias de frutos da Macaronésia (Madeira e Açores). Dissertação (Mestrado em Ciências Farmacêuticas) - Faculdade de Farmácia, Universidade de Coimbra.
França, I. S. X. de., Souza, J. A. de., Baptista, R. S., & Britto, V. R. de S. (2008). Medicina popular: benefícios e malefícios das plantas medicinais. Revista Brasileira de Enfermagem, 61(2), 201-208.
Gomes, D. S., et al. (2022). Lippia alba and Lippia gracilis essential oils affect the viability and oviposition of Schistosoma mansoni. Acta Tropica, 231, 106434.
Guardo, N. I., et al. (2017). Trypanocidal effects of essential oils from selected medicinal plants. Synergy among the main components. Natural Product Communications, 12.
Hennebelle, T., et al. (2008). Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(2), 256-258.
Leite, P. M., Miranda, A. P., Gomes, I., Rodrigues, M. L., Camargos, L. M., Amorim, J. M., & Castilho, R. O. (2023). Antithrombotic potential of Lippia alba: A mechanistic approach. Journal of Ethnopharmacology, 301, 115744.
Lima Juiz, P. J., et al. (2015). Essential oils and isolated compounds from Lippia alba leaves and flowers: Antimicrobial activity and osteoclast apoptosis. International Journal of Molecular Medicine, 35(1), 211-217.
Lima, D. K. S., & Oliveira Lins, S. R. de. (2020). Avanços e novas descobertas sobre o uso de erva cidreira (Lippia alba) para inovação terapêutica na última década (2010-2020). Brazilian Journal of Development, 6(11), 87916-87934.
Lima, F. O. (2013). Estudo comparativo da bioatividade de compostos fenólicos em plantas medicinais. Tese (Doutorado em Quími ca Analítica) - Universidade Federal de Santa Maria.
Linde, G. A., et al. (2016). Quimiotipos, extracción, composición y aplicaciones del aceite esencial de Lippia alba. Revista Brasileira de Plantas Medicinais, 18, 191-200.
Machado, T. F., et al. (2014). The antimicrobial efficacy of Lippia alba essential oil and its interaction with food ingredients. Brazilian Journal of Microbiology, 45, 699-705.
Machado, T. F., et al. (2014). The antimicrobial efficacy of Lippia alba essential oil and its interaction with food ingredients. Brazilian Journal of Microbiology, 45, 699-705.
Malik, S., et al. (2021). New insights into the biotechnology and therapeutic potential of Lippia alba (Mill.) NE Br. ex P. Wilson. Journal of Essential Oil Research, 33(6), 523-535.
Matsuura, H. N., & Fett-Neto, A. G. (2015). Plant Alkaloids: Main Features, Toxicity, and Mechanisms of Action. In Plant Toxins (pp. 1-15).
Morais, S. M. de, & Vieira, Í. G. P. (2018). Introdução à Prospecção de Produtos Naturais. EDUECE.
Morais, S. M. de, & Vieira, Í. G. P. (2021). Introdução à Prospecção de Produtos Naturais (v. 1). EDUECE.
Morais, S. M., et al. (2013). Correlação entre as atividades antiradical, antiacetilcolinesterase e teor de fenóis totais de extratos de plantas medicinais de farmácias vivas. Revista Brasileira de Plantas Medicinais, 15, 575-582.
Moreno, E. M., et al. (2018). Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide). BMC Complementary and Alternative Medicine, 18, 225.
Nawaz, M., et al. (2020). Modifications of histones in parasites as drug targets. Veterinary Parasitology, 278, 109029.
Nonato, C. de F. A., et al. (2022). Comparative analysis of chemical profiles and antioxidant activities of essential oils obtained from species of Lippia L. by chemometrics. Food Chemistry, 384, 132614.
Nunes, P. C. (2015). Caracterização física, química e avaliação da capacidade antioxidante do fruto jambo vermelho (Syzygium malaccense). Dissertação (Mestrado em Nutrição) - Universidade Federal de Pernambuco.
Oliveira, G. T. D., Ferreira, J. M. S., Rosa, L. H., Siqueira, E. P. D., Johann, S., & Lima, L. A. R. D. S. (2014). In vitro antifungal activities of leaf extracts of Lippia alba (Verbenaceae) against clinically important yeast species. Revista da Sociedade Brasileira de Medicina Tropical, 47, 247-250.
Oliveira, G. T., et al. (2018). Phytochemical characterisation and bioprospection for antibacterial and antioxidante activities of Lippia alba Brown ex Britton & Wilson (Verbenaceae). Natural Product Research, 32, 723-731.
Oliveira, H. W. C. (2011). Cerrado e Plantas Medicinais: Algumas Reflexões sobre o Uso e a Conservação (Trabalho de Conclusão de Curso). Universidade de Brasília, Planaltina.
Ombito, J. O., et al. (2014). A review on the chemistry of some species of genus Lippia (Verbenaceae family). Journal of Scientific and Innovative Research, 3, 460- 466.
Ortega-Cuadros, M., et al. (2019). Exploratory review of the antibacterial and antifungal activity of Lippia alba (Mill.) NE Br (bushy matgrass). Revista Cubana De Plantas Medicinales, 24(1).
Patiño, A. V., et al. (2007). Actividad Antimicrobiana in vitro de volátiles y no volátiles de Lippia alba y extractos orgánicos y acuoso de Justicia Pectoralis cultivadas en diferentes pisos térmicos del Departamento del Tolima. Scientia et Technica, 1(33), 345-348.
Peixoto, M. G., et al. (2015). Acaricidal activity of essential oils from Lippia alba genotypes and its major components carvone, limonene, and citral against Rhipicephalus microplus. Veterinary Parasitology, 210(1-2), 118-122.
Port's, P. S., et al. (2013). The phenolic compounds and the antioxidant potential of infusion of herbs from the Brazilian Am azonian region. Food Research International, 53, 875-881.
Richter, M. F., & Hergenrother, P. J. (2019). The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics. Annals of the New York Academy of Sciences, 1435, 18-38.
Rivera, A. T., et al. (2016). Effect of Lippia alba and Cymbopogon citratus essential oils on biofilms of Streptococcus mutans and cytotoxicity in CHO cells. Journal of Ethnopharmacology, 194, 749-754.
Santos Filho, L. G. D., et al. (2023). Chemical composition and biological activities of the essential oils from Lippia alba and Lippia origanoides. Anais da Academia Brasileira de Ciências, 95.
Santos, A. C. B., et al. (2015). Uso popular de espécies medicinais da família Verbenaceae no Brasil. Revista Brasileira de Plantas Medicinais, 17, 980-991.
Santos, I. G. D. A., et al. (2016). Amebicidal activity of the essential oils of Lippia spp. (Verbenaceae) against Acanthamoeba polyphaga trophozoites. Parasitology Research, 115, 535-540.
Sari, R. (2016). Otimização da extração de compostos fenólicos e avaliação do potencial antioxidante e antibacteriano das fol has de (Tabernae montana catharinensis). (Trabalho de Conclusão de Curso). Universidade Tecnológica Federal do Paraná.
Sarmento-Neto, J. F., Nascimento, L. G. do, Felipe, C. F. B., & Sousa, D. P. de. (2016). Analgesic potential of essential oils. Molecules, 21(1), 20.
Schafrański, K. (2019). Extração e caracterização de compostos fenólicos de folhas de amoreira-preta (Morus nigra L.) e encapsulamento em esferas de alginato. (Dissertação de Mestrado). Universidade Tecnológica Federal do Paraná.
Sena Filho, J. G., et al. (2006). Antimicrobial activity and phytochemical profile from the roots of Lippia alba (Mill.) NE Brown. Revista Brasileira de Farmacognosia, 16, 506-509.
Silva, R. S., Linhares, J. F. P., & da Silva, A. C. (2021). Componentes majoritários de óleos essenciais, partes usadas e fenofases de Lippia alba: uma revisão. International Journal of Development Research, 11(02), 44556-44560.
Silveira, R. de C. da Sá, & Andrade, L. N., & de Oliveira, R. dos R. B., & de Sousa, D. P. (2014). A review on antiinflammatory activity of phenylpropanoids found in essential oils. Molecules, 19(2), 1459-1480.
Simões, C. M. O., Schenkel, E. P., Mello, J. C. P., Mentz, L. A., & Petrovick, P. R. (2017). Farmacognosia: do produto natural ao medicamento. Artmed.
Siqueira-Lima, P. S., et al. (2019). Central nervous system and analgesic profiles of Lippia genus. Revista Brasileira de Farmacognosia, 29, 125–135.
Soares, B. V., & Tavares-Dias, M. (2013). Espécies de Lippia (Verbenaceae), seu potencial bioativo e importância na medicina veterinária e aquicultura. Embrapa Amapá-Artigo em periódico indexado (ALICE).
Souza, R. C., et al. (2017). Antimicrobial and synergistic activity of essential oils of Aloysia triphylla and Lippia alba against Aeromonas spp. Microbial Pathogenesis, 113, 29-33.
Stashenko, E. E., Jaramillo, B. E., & Martínez, J. R. (2004). Comparison of different extraction methods for the analysis of volatile secondary metabolites of Lippia alba (Mill.) NE Brown, grown in Colombia, and evaluation of its in vitro antioxidant activity. Journal of chromatography A, 1025(1), 93-103. Tan, B. L., et al. (2018). Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Frontiers in Pharmacology, 9, 1-28.
Tavares, E. S., et al. (2005). Análise do óleo essencial de folhas de três quimiotipos de Lippia alba (Mill.) N. E. Br. (Verbenaceae) cultivados em condições semelhantes. Revista Brasileira de Farmacognosia, 15, 1-5.
Timóteo, P., et al. (2015). A validated HPLC method for the analysis of herbal teas from three chemotypes of Brazilian Lippia alba. Food Chemistry, 175, 366-373.
Tomazoni, E. Z., et al. (2016). In vitro antifungal activity of four chemotypes of Lippia alba (Verbenaceae) essential oils against Alternaria solani (Pleosporeaceae) isolates. Anais da Academia Brasileira de Ciências, 88, 999-1010.
Trevisan, M. T. S., et al. (2016). Composition of Essential Oils and Ethanol Extracts of the Leaves of Lippia Species: Identification, Quantitation and Antioxidant Capacity. Records of Natural Products, 10, 485-496.
Veeck, A. P. L., et al. (2013). Lipid stability during the frozen storage of fillets from silver catfish exposed in vivo to the essential oil of Lippia alba (Mill.) NE Brown. Journal of the Science of Food and Agriculture, 93(4), 955-960.
Verbel, J. O., et al. (2014). Composition, anti-quorum sensing and antimicrobial activity of essential oils from Lippia alba. Brazilian Journal of Microbiology, 45, 759-767.
Vizzotto, M., Krolow, A. C., & Weber, G. E. B. (2010). Metabólitos secundários encontrados em plantas e sua importância. Embrapa Clima Temperado- Documentos (INFOTECA-E).
Volpe, C. M. O., Villar-Delfino, P. H., dos Anjos, P. M. F., & Nogueira-Machado, J. A. (2018). Morte celular, espécies reativas de oxigênio (ROS) e complicações diabéticas. Morte e Doença Celular, 9(2), 1-9.
Vostinaru, O., Heghes, S. C., & Filip, L. (2020). Safety profile of essential oils. In Essential Oils-Bioactive Compounds, New Perspectives and Applications (pp. 1-13).
Wermuth, D. (2015). Compostos fenólicos e atividade antibacteriana de extratos de folhas de jambeiro vermelho (Syzygium malaccense). (Trabalho de Conclusão de Curso). Universidade Tecnológica Federal do Paraná.
Zhu, L., Luo, M., Zhang, Y., Fang, F., Li, M., An, F., & Zhang, J. (2023). Free radical as a double-edged sword in disease: deriving strategic opportunities for nanotherapeutics. Coordination Chemistry Reviews, 475, 214875.
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Copyright (c) 2024 Daniel Pereira de Oliveira; Felipe Wesley de Vasconcelos Paulino ; Silânia Gonçalves Rodrigues Xavier ; Gladston Roberto Carneiro Júnior ; Sara Ingrid Caetano Gomes Barbosa ; Amanda Batista Nascimento ; Júlio Cesar Sousa Prado ; Raimundo Rigoberto Barbosa Xavier Filho; Thaís Rocha Cavalcante; Milena Lira Furtado
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