Comparison of the diagnostic efficacy between urease and histopathological tests in H. pylori




Infection; Diagnosis; Helicobacter pylori.


  1. pylori infection is globally prevalent, varying by age, geographic location, and socioeconomic status. In Brazil, it is estimated that it affects around 70% of the population, increasing with age and being lower in the white population, regardless of sex. The objective of this study was to compare the results of histopathological and urease tests in patients, highlighting a higher positivity in the former (42%) compared to previous studies. The analysis of age groups revealed a higher prevalence of positive H. pylori in patients between 30-39 years old, differing from other studies. Regarding gender, a higher incidence was observed in males (47%), similar to previous studies. Dyspeptic symptoms were observed in 48% of patients, but were not directly correlated with H. pylori positivity. Regarding clinical variables, the majority of patients did not have drug allergies (76%) or significant comorbidities, and among those who had comorbidities, systemic arterial hypertension was the most prevalent (73.7%). Clinical tests, especially urease and histopathology, were compared, showing similar results, although the urease test has been suggested as useful in ruling out infection when negative. It is concluded that the combination of both methods can be beneficial. This study contributes to the understanding of the prevalence of H. pylori, highlighting the importance of joint assessment of diagnostic tests and the need for more research on correlations with specific clinical variables.


Bittencourt, P. F., Rocha, G. A., Penna, F. J., & Queiroz, D. M. M. (2006). Gastroduodenal pepti culcer and Helicobacter pylori infection in children and adolescents. J Pediatr., 82(5), 325-334.

Borges, S. S., Ramos, A. F. P. L., Moraes Filho A.V., Braga, C. A. S. B., Carneiro, L. C., & Barbosa, M. S. P. (2019). Prevalência da infecção por Helicobacterpylori em pacientes dispépticos e associação com fatores de riscos clínicos para o desenvolvimento de adenocarcinoma gástrico. ArqGastroenterol., 56(1), 66-70. doi: s0004-2803.201900000-03.

Camiña, H. C., Matos, D. B., Bombarda, G. B, & Foiatto, W. M. (2017). Comparação entre teste da urease e histopatologia na identificação do Helicobacter pylori. GED gastroenterol. endosc. dig., 36(1), 1-6.

Caetano, A., Felix, V. N., Coimbra, F. T. V., & Ganc, A. J. (2008). Helicobacterpylori e doença péptica. Estudo comparativo de métodos diagnósticos. ArqGastroenterol., 45(3), 255-257.

Correa, P.; & Piazuelo, M. B. (2008). Natural history of Helicobacter pylori infection. Dig LiverDis. 40(7), 490-6.

Dietz, J. et al. (2001). Helicobacter pylori: estudo comparativo entre técnicas diagnósticas invasivas. GED, Gastroenterol. Endosc. Digest., 20(2), 36-40. file:///Users/jorgecorreianeto/Downloads/4473-Texto%20do%20Artigo-11322-1-10-20100730.pdf

Guimarães, J., Corvelo, T. C., & Barile, K. A. (2008). Helicobacterpylori: fatores relacionados à sua patogênese. Ver. Para. Med. 22(1).

Hosseininasab, S. A., & Nabavi, A. (2019). Interaction of Helicobacter pylori Infection and Type 2 Diabetes Mellitus. Adv Biomed Res. 8(15), 15. PMid:30993085

Ladeira, M. S., Salvadori, D. M., & Rodrigues, M. A. (2003). Biopatologia do Helicobacter pylori. J Bras Patol Med Lab. ;39(4), 335-42.

Lu, C. L., Chang, F. Y., Chen, T. S., Chen, C. Y., Jiun, K. L., & Lee, S. D. (1998). Helicobacter pylori colonization does not influence the symptomatic response to prokinetic agents in patients with functional dyspepsia. J. Gastroenterol Hepatol. 13, 500-4.

Machida-montani, A., Sasasuki, S., Inoue, M., Natsukawa, S., Shaura, K., & Koizumi, Y. (2004). Association of Helicobacterpylori infection and environmental factors in non-cardiagastriccancer in Japan. GastricCancer., 7(1), 46-56.

Neto, D. J. S., Goncalves, L. M., Castro, V. L., & Guimaraes, A. O. (2020). Acurácia diagnóstica entre teste rápido da urease e estudo histopatológico para detecção de Helicobacterpylori. RevSocBras Clin Med. 18(4), 196-199.

Ornellas, L.C., Cury, M. S., Lima, V. M., & Ferrari, A. P. (2000). Avaliação do teste rápido da urease conservado em geladeira. ArqGastroenterol. 37(3), 155-157.

Parente, J. M., & Parente, M. P. (2010). Contexto epidemiológico atual da infecção por Helicobacterpylori. GED GastroenterolEndosc Dig., 29(3), 86-89.

Parente, J. M. L., Mendes, C. M. M., Ramos, C. V., Medeiros, T. S. G., & Salgado, J. E. A. (2023). Infecção por helicobacterpylori: Revisão integrativa. Revista eletrônica Acervo saúde, 23(6), 1-11. file:///Users/jorgecorreianeto/Downloads/12876-Artigo-155976-1-10-20230626.pdf

Silva, E. A. W. (2014). Estudo do Helicobacter pylori na mucosa gástrica: história clínica, endoscopia digestiva alta, exame anatomopatológico e resposta imune. Universidade de Uberaba.

Siqueira, J. S., Lima, P. S.S., Barreto, A. S., & Quintans- Junior, L. J. (2007). Aspectos Gerais nas Infecções por Helicobacterpylori – Revisão. RBAC, 39(1)9-13.

Tenório, P. P., & Melo, M. R. (2009). Correlação entre a histopatologia e teste da urease para pesquisa de H. pylori em pacientes portadores de gastrite. R. Ci. Méd. Biol. 8(3), 301-306.

Vargas, L. J., et al. (2019). Diagnostic methods of detection of h.pylori infection: systematic review. Para Res Med J. 3(2).



How to Cite

SANTOS, J. S. dos .; AGUIAR, N. R. de . Comparison of the diagnostic efficacy between urease and histopathological tests in H. pylori. Research, Society and Development, [S. l.], v. 13, n. 1, p. e11513144822, 2024. DOI: 10.33448/rsd-v13i1.44822. Disponível em: Acesso em: 27 may. 2024.



Health Sciences