Overview of scientific publications (2019-2023) on Gastrointestinal Inflammation associated with Orlistat: An integrative review of the literature

Authors

DOI:

https://doi.org/10.33448/rsd-v13i2.44969

Keywords:

Orlistat; Gastroenterology; Gastrointestinal inflammation; Integrative review; Adverse effects.

Abstract

Objective: To conduct an integrative literature review to assess the role of Orlistat in inducing gastrointestinal inflammation, identify the underlying mechanisms, and provide a comprehensive overview of existing studies on the subject from 2019 to 2023. Method: Follows an integrative review approach, aiming to aggregate the results of published research and present them from a research question. Searches were conducted in various databases, including MEDLINE (via the PubMed portal of the National Library of Medicine), LILACS (Latin American and Caribbean Literature in Health Sciences), EMBASE, SCOPUS, and Web of Science. Results: 11 publications were selected for inclusion in the study. This relatively small number of included studies, compared to the initial number (195) of identified publications, reflects the rigor of the selection criteria and the emphasis on the quality and relevance of the data. Regarding the categories, Inflammation Biomarkers, Involved Mediators, Effects at Different Doses, and Impact of Treatment Duration were identified. Conclusion: It is concluded that the personalization of treatment, considering individual characteristics and patient response, is essential to maximize benefits and minimize adverse effects.

References

Almeida, L. N., Ribeiro, R. C., Oliveira, J. S., de Resende, P. P., & de Oliveira Celestino, H. (2023). Cirurgia Bariátrica: Técnicas e Resultados: Revisão das técnicas cirúrgicas no tratamento da obesidade e seus resultados a longo prazo. Brazilian Journal of Implantology and Health Sciences, 5(4), 2580-2594.

Alves, M. R., Rodrigues, V. D., Soares, W. D., & Junior, R. S. M. (2022). Revisão da literatura e suas diferentes características. Editora Científica Digitas, 4, 46-53.

Anderson, J., & Thompson, D. (2020). Mechanisms of Orlistate: A Preclinical Study. Journal of Pharmacological Research, 45(3), 112-120.

Aydin, B., & Onbasi, K. (2021). Lipase inhibitor orlistat: An old but still effective weapon. Med. Sci, 10, 1406-1411.

Braeckmans, M., Brouwers, J., Mols, R., Servais, C., Tack, J., & Augustijns, P. (2022). Orlistat disposition in the human jejunum and the effect of lipolysis inhibition on bile salt concentrations and composition. International Journal of Pharmaceutics, 621, 121807.

Brown, T., & Green, S. (2022). Overarching Trends in Gastrointestinal Research. Annual Review of Gastroenterology, 39(2), 201-215.

Candela, M. F., Arenas, N. E., Caicedo, O., & Malagon, A. (2021). Inhibition of Lipase by Orlistat: Kinetics Combined with In Silico Approaches to Visualize Interactions. Journal of Chemical Education, 98(5), 1762-1767.

Cavalcante, R. B., Calixto, P., & Pinheiro, M. M. K. (2014). Análise de conteúdo: considerações gerais, relações com a pergunta de pesquisa, possibilidades e limitações do método. Informação & sociedade: estudos, 24(1).

Ercole, F. F., Melo, L. S. D., & Alcoforado, C. L. G. C. (2014). Revisão integrativa versus revisão sistemática. Reme: Revista Mineira de Enfermagem, 18(1), 09-11.

Garcia, M., & Fernandez, L. (2018). Efficacy and Safety of Orlistate: Clinical Trials Analysis. International Journal of Obesity Studies, 33(5), 789-802.

Guo, H., Ji, X., Yang, G., & Jin, Y. (2020). Expressão anormal da linfopoietina estromal tímica na mucosa gastrointestinal depacientes com gastroenterite e osinofílica. Jornal de Pediatria, 96, 350-355.

Gusmão, A. B., de Sousa Rocha, S., Ferreira, B. W. R. C., de Sousa Santos, A. K. F., & Macedo, C. L. (2021). Manejo nutricional e farmacológico da obesidade pediátrica: um tratamento multiprofissional. Research, Society and Development, 10(1), e60010111797-e60010111797.

Henrique, D. (2023). O papel da educação permanente em saúde na implementação da linha de cuidado para o sobrepeso e obesidade nas ações da atenção primária: um estudo de caso na região do Grande ABC (Doctoral dissertation, Universidade de São Paulo).

Jarrett, Z. S., Chung-ting, J. K., Wan, W., & Colburn, J. A. (2022). The use of orlistat in an adult with lipoprotein lipase deficiency: a case report. AACE Clinical Case Reports, 8(2), 93-95.

Javed, M., Ahmed, W., Khan, A., & Rabbani, I. (2023). Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model. Foods, 12(21), 3905.

Jesus, C. N. S., de Oliveira Duarte, D. R., Santos, M. B. M., Paes, Q. C. C., Lage, S. R., de Moura, V. A., & Júnior, A. D. F. S. (2023). Pancreatite aguda associada ao uso de orlistate: uma revisão narrativa da literatura: Orlistat Drug-induced Acute pancreatitis: a narrative review of the literature. Revista Científica Eletrônica do Conselho Regional de Farmácia da Bahia, e02012306-e02012306.

Jin, B. R., Kim, H. J., Sim, S. A., Lee, M., & An, H. J. (2021). Anti-obesity drug orlistat alleviates Western-Diet-Driven colitis-associated colon cancer via inhibition of STAT3 and NF-κB-Mediated signaling. Cells, 10(8), 2060.

Katimbwa, D. A., Oh, J., Jang, C. H., & Lim, J. (2022). Orlistat, a competitive lipase inhibitor used as an antiobesity remedy, enhances inflammatory reactions in the intestine. Applied Biological Chemistry, 65(1), 1-10.

Khedr, N. F., Ebeid, A. M., & Khalil, R. M. (2020). New insights into weight management by orlistat in comparison with cinnamon as a natural lipase inhibitor. Endocrine, 67, 109-116.

Kim, Y., & Choi, B. (2022). Unanticipated Effects of Orlistate: Case Reports and Analysis. Clinical Case Studies, 22(1), 45-51.

Lee, H., et al. (2021). Global Research Trends in Pharmacology. World Journal of Pharmaceutical Sciences, 47(6), 654-663.

Murphy, K., & O'Connell, A. (2021). Advances in Experimental and Computational Methods in Pharmacology. Journal of Experimental Pharmacology, 54(4), 321-334.

Murshed, M., Pham, A., Vithani, K., Salim, M., & Boyd, B. J. (2022). Controlling drug release by introducing lipase inhibitor within a lipid formulation. International Journal of Pharmaceutics, 623, 121958.

Patel, R., & Kumar, A. (2019). Impact of Global Events on Medical Research Focus. Medical Research Perspectives, 28(3), 134-140.

Shirai, K., Fujita, T., Tanaka, M., Fujii, Y., Shimomasuda, M., Sakai, S., & Samukawa, Y. (2019). Efficacy and safety of lipase inhibitor orlistat in Japanese with excessive visceral fat accumulation: 24-week, double-blind, randomized, placebo-controlled study. Advances in therapy, 36, 86-100.

Singh, A., & Raj, P. (2023). Exploratory Studies in Medical Research: A New Approach. Indian Journal of Medical Research, 55(1), 100-105.

Smith, J., & Jones, M. (2020). Changing Trends in Scientific Research. Journal of Scientific Exploration, 31(4), 456-469.

Souza, A. P., de Oliveira, B. M., da Silva, E. F. L., da Silva Rocha, G., de Almeida, A. C. G., & Brito, M. A. M. (2023). Atenção farmacêutica no uso indevido de medicamentos para emagrecimento: revisão sistemática. Research, Society and Development, 12(6), e10712642133-e10712642133.

Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8, 102-106.

Uehira, Y., Ueno, H., Miyamoto, J., Kimura, I., Ishizawa, Y., Iijima, H., & Nakazato, M. (2023). Impact of the lipase inhibitor orlistat on the human gut microbiota. Obesity Research & Clinical Practice, 17(5), 411-420.

Zhao, L., & Wang, Y. (2019). Evidence-Based Approaches in Orlistate Research. Chinese Journal of Clinical Pharmacology, 37(2), 213-220.

Downloads

Published

14/02/2024

How to Cite

SILVA, K. L. S. .; REDIG, C. B. .; FURTADO, G. E. M. .; SCHEFFER, G. A. .; FERREIRA, E. O. .; DINIZ, . I. G. .; GUIMARÃES, M. C. M. . Overview of scientific publications (2019-2023) on Gastrointestinal Inflammation associated with Orlistat: An integrative review of the literature. Research, Society and Development, [S. l.], v. 13, n. 2, p. e5113244969, 2024. DOI: 10.33448/rsd-v13i2.44969. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44969. Acesso em: 21 nov. 2024.

Issue

Vol. 13 No. 2

Section

Health Sciences

License

Copyright (c) 2024 Kamila Luana Santos Silva; Carolina Barbosa Redig; Giovanna Eduarda Mauro Furtado; Glaucya Abdalla Scheffer; Eduarda Oliveira Ferreira; Isabela Guerreiro Diniz; Márcia Cristina Monteiro Guimarães

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.