The effects of electronic cigarette use on users' health: An integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v13i3.45359

Keywords:

Electronic cigarette; Nicotine; Effects; Health.

Abstract

Introduction: The electronic cigarette is a nicotine delivery device that has gained popularity since its creation in 2003, both as a smoking cessation method and for recreational use. Its attractiveness, discretion, and variety of flavors spark curiosity, particularly among teenagers and young adults. Despite being prohibited, the marketing of these devices raises concerns, especially due to the lack of clear evidence regarding safety, quality, and effects. Objective: To elucidate the effects that the use of electronic cigarettes can have on users' health. Methodology: This is an integrative review with a qualitative descriptive approach, with data collection conducted from March to October 2023, using the Scielo, PubMed, and LILACS databases. Descriptors in English and Portuguese were used, including "electronic cigarette," "nicotine," "effects," "health," excluding "oral," "dental," "pregnant," and "smoking cessation." Results: Initially, 2,227 articles were identified, and 24 studies were selected after the established criteria. Discussion: Although electronic cigarettes may seem harmless and less toxic than traditional cigarettes, most analyzed articles reported pathological organic modifications and a detrimental relationship in various body systems, particularly pulmonary and cardiovascular, along with other effects such as hemodynamic, immunologic, neoplastic, and toxicological. Conclusion: There is evidence that the use of electronic cigarettes harms health, although data on the subject are limited. Therefore, further studies are needed on the use of electronic cigarettes, focusing primarily on assessing long-term impact, safety, regulation, and public health.

References

Adriaens, K., Gucht, V. D. & Baeyens, F. (2018). IQOSTM vs. e-Cigarette vs. Tobacco Cigarette: A Direct Comparison of Short-Term Effects after Overnight-Abstinence. Int J Environ Res Public Health, 15(12), 2902. https://doi.org/10.3390/ijerph15122902.

Akiyama, Y. & Sherwood, N. (2021). Systematic review of biomarker findings from clinical studies of electronic cigarettes and heated tobacco products. Toxicol Rep, 8, 282-294. https://doi.org/10.1016/j.toxrep.2021.01.014.

Antoniewicz, L., Brynedal, A., Hedman, L., Lundbäck, M. & Bosson, J. A. (2019). Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways. Cardiovasc Toxicol, 19(5), 441-450. https://doi.org/10.1007/s12012-019-09516-x.

Bagale, K. & Kulkarni, R. (2022). A Systematic Review of the Literature Examining the Effects of Cigarette Smoke and e-Cigarette Vapor on the Virulence of Human Pathogenic Bacteria. Int J Environ Res Public Health, 19(19), 12518. https://doi.org/10.3390/ijerph191912518.

Barufaldi, L. A., Guerra, R. L., Albuquerque, R. de C. R. de, Nascimento, A. do, Chança, R. D., Souza, M. C. de. & Almeida, L. M. de. (2021). Risco de iniciação ao tabagismo com o uso de cigarros eletrônicos: revisão sistemática e meta-análise. Ciência & Saúde Coletiva, 26(12), 6089–6103. https://doi.org/10.1590/1413-812320212612.35032020.

Bertoni, N., et al. (2023). Prevalence of electronic nicotine delivery systems and waterpipe use in Brazil: where are we going? Revista Brasileira de Epidemiologia, 24, suppl 2. https://doi.org/10.1590/1980-549720210007.supl.2.

Biondi-Zoccai, G., Sciarretta, S., Bullen, C., Nocella, C., Violi, F., Loffredo, L., Pignatelli, P., Perri, L., Peruzzi, M., Marullo, A. G. M., De Falco, E., Chimenti, I., Cammisotto, V., Valenti, V., Coluzzi, F., Cavarretta, E., Carrizzo, A., Prati, F., Carnevale, R., & Frati, G. (2019). Acute Effects of Heat-Not-Burn, Electronic Vaping, and Traditional Tobacco Combustion Cigarettes: The Sapienza University of Rome-Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR-VAPES) 2 Randomized Trial. Journal of the American Heart Association, 8(6), e010455. https://doi.org/10.1161/JAHA.118.010455.

Bravo-Gutiérrez, O. A., Falfán-Valencia, R., Ramírez-Venegas, A., Sansores, R. H., Ponciano-Rodríguez, G. & Pérez-Rubio, G. (2021). Lung Damage Caused by Heated Tobacco Products and Electronic Nicotine Delivery Systems: A Systematic Review. International Journal of Environmental Research and Public Health, 18(8), 4079. https://doi.org/10.3390/ijerph18084079.

Cahn, Z., & Siegel, M. (2011). Electronic cigarettes as a harm reduction strategy for tobacco control: a step forward or a repeat of past mistakes? J Public Health Policy, 32(1), 16-31. https://doi.org/10.1057/jphp.2010.41.

Cecilio, H., & Oliveira, D. C. (2017). Modelos de revisão integrativa: discussão na pesquisa em Enfermagem. Ciaiq, 2, 764-772.

Chaffee, B. W., Barrington-Trimis, J., Liu, F., Wu, R., McConnell, R., Krishnan-Sarin, S., Leventhal, A. M. & Kong, G. (2021). E-cigarette use and adverse respiratory symptoms among adolescents and Young adults in the United States. Preventive Medicine, 153, 106766. https://doi.org/10.1016/j.ypmed.2021.106766.

Dimitriadis, K., Narkiewicz, K., Leontsinis, I., Konstantinidis, D., Mihas, C., Andrikou, I., Thomopoulos, C., Tousoulis, D. & Tsioufis, K. (2022). Acute Effects of Electronic and Tobacco Cigarette Smoking on Sympathetic Nerve Activity and Blood Pressure in Humans. International Journal of Environmental Research and Public Health, 19(6), 3237. https://doi.org/10.3390/ijerph19063237.

Etter, J. F. & Eissenberg, T. (2015). Níveis de dependência em usuários de cigarros eletrônicos, gomas de nicotina e cigarros de tabaco. Dependência de álcool e drogas, 147, 68. https://doi.org/10.1016/j.drugalcdep.2014.12.007.

Giovacchini, C. X., Crotty Alexander, L. E. & Que, L. G. (2022). Electronic Cigarettes: A Pro-Con Review of the Current Literature. J Allergy Clin Immunol Pract, 10(11), 2843-2851. https://doi.org/10.1016/j.jaip.2022.07.009.

Goniewicz, M. L., Knysak, J., Gawron, M., et al. (2014). Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tobacco Control, 23, 133-139.

Gonzalez, J. E. & Cooke, W. H. (2021). Acute effects of electronic cigarettes on arterial pressure and peripheral sympathetic activity in young nonsmokers. American Journal of Physiology-Heart and Circulatory Physiology, 320(1), H248-H255. https://doi.org/10.1152/ajpheart.00448.2020.

Hod, R., Mohd Nor, N. H. & Maniam, S. (2022). Systematic review on e-cigarette and its effects on weight gain and adipocytes. PLOS ONE, 17(7), e0270818. https://doi.org/10.1371/journal.pone.0270818.

Honeycutt, L., Huerne, K., Miller, A., Wennberg, E., Filion, K. B., Grad, R., Gershon, A. S., Ells, C., Gore, G., Benedetti, A., Thombs, B., & Eisenberg, M. J. (2022). A systematic review of the effects of e-cigarette use on lung function. NPJ Primary Care Respiratory Medicine, 32(1), 45. https://doi.org/10.1038/s41533-022-00311-w.

Instituto Nacional de Câncer José Alencar Gomes da Silva. (2016). Cigarros eletrônicos: o que sabemos? Estudo sobre a composição do vapor e danos à saúde, o papel na redução de danos e no tratamento da dependência de nicotina. Rio de Janeiro: INCA.

Instituto Nacional de Câncer José Alencar Gomes da Silva. (2015). Convenção-Quadro para Controle do Tabaco: texto oficial. Coordenação de elaboração Tânia Maria Cavalcante. 2. reimpr. Rio de Janeiro: INCA.

Kosmider, L., Sobczak, A., Fik, M., Knysak, J., Zaciera, M., Kurek, J., & Goniewicz, M. L. (2014). Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob Res, 16(10), 1319-1326. https://doi.org/10.1093/ntr/ntu078.

Li, X., Zhang, Y., Zhang, R., Chen, F., Shao, L. & Zhang, L. (2022). Association Between E-Cigarettes and Asthma in Adolescents: A Systematic Review and Meta-Analysis. American Journal of Preventive Medicine, 62(6), 953-960. https://doi.org/10.1016/j.amepre.2022.01.015.

Lyytinen, G., Brynedal, A., Anesäter, E., Antoniewicz, L., Blomberg, A., Wallén, H., Bosson, J. A., Hedman, L., Mobarrez, F., Tehrani, S., Lundbäck, M. (2023). Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial. Cardiovascular Toxicology, 23(7-8), 255-264. https://doi.org/10.1007/s12012-023-09802-9.

Ministério da Saúde, Agência Nacional de Vigilância Sanitária. (2009). Resolução de Diretoria Colegiada no. 46, de 28 de agosto de 2009. Diário Oficial da União, 29 de agosto de 2009, Seção 1, p. 45.

Mobarrez, F., Antoniewicz, L., Hedman, L., Bosson, J. A., & Lundbäck, M. (2020). Electronic cigarettes containing nicotine increase endothelial and platelet-derived extracellular vesicles in healthy volunteers. Atherosclerosis, 301, 93-100. https://doi.org/10.1016/j.atherosclerosis.2020.02.010.

Nyilas, S., Bauman, G., Korten, I., Pusterla, O., Singer, F., Ith, M., Groen, C., Schoeni, A., Heverhagen, J. T., Christe, A., Rodondi, N., Bieri, O., Geiser, T., Auer, R., Funke-Chambour, M., & Ebner, L. (2022). MRI shows lung perfusion changes after vaping and smoking. Radiology, 304(1), 195-204. https://doi.org/10.1148/radiol.211327.

Pericot-Valverde, I., Heo, M., Litwin, A. H., Niu, J., & Gaalema, D. E. (2021). Modeling the effect of stress on vaping behavior among young adults: A randomized crossover pilot study. Drug and Alcohol Dependence, 225, 108798. https://doi.org/10.1016/j.drugalcdep.2021.108798.

Rahman, A., Alqaisi, S.,,Alzakhari, R., & Saith, S. (2023). Characterization and summarization of the impact of electronic cigarettes on the cardiovascular system: A systematic review and meta-analysis. Cureus, 15(5), e39528. https://doi.org/10.7759/cureus.39528.

Silva Machado Barradas, A., Oliveira Soares, T., Branco Marinho, A., Sousa dos Santos, R. G., & Izidia Araújo da Silva, L. (2021). Os Riscos Do Uso Do Cigarro eletrônico Entre Os Jovens. Global Clinical Research Journal, 1(1), e8. https://doi.org/10.5935/2763-8847.20210008.

Silva, S. T. da, Martins, M. C., Faria, F. R. de & Cotta, R. M. M. (2014). Combate ao Tabagismo no Brasil: a importância estratégica das ações governamentais. Ciência & Saúde Coletiva, 19(2), 539–552. https://doi.org/10.1590/1413-81232014192.19802012.

Son, Y., Mainelis, G., Delnevo, C., Wackowski, O. A., Schwander, S. & Meng, Q. (2020). Investigating E-Cigarette Particle Emissions and Human Airway Depositions under Various E-Cigarette-Use Conditions. Chemical Research in Toxicology, 33(2), 343-352. https://doi.org/10.1021/acs.chemrestox.9b00243

Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8(1), 102-106.

Thirión-Romero, I., Pérez-Padilla, R., Zabert, G., & Barrientos-Gutiérrez, I. (2019). Respiratory Impact of Electronic Cigarettes and Low-Risk Tobacco. Revista de investigación clínica, 71(1), 17-27. https://doi.org/10.24875/ric.18002616.

Tzortzi, A., Kapetanstrataki, M., Evangelopoulou, V. & Beghrakis, P. (2020). A systematic literature review of e-cigarette-related illness and injury: Not just for the Respirologist. International Journal of Environmental. Research and Public Health, 17(7), 2248. https://doi.org/10.3390/ijerph17072248.

Vital Strategies Brasil... [et al.]. (2023). Inquérito telefônico de fatores de risco para doenças crônicas não transmissíveis em tempos de pandemia – Covitel 2: relatório final. São Paulo, SP: Vital Strategies: Umane.

Voos, N., Smith, D., Kaiser, L., Mahoney, M. C., Bradizza, C. M., Kozlowski, L. T., Benowitz, N. L., O'Connor, R. J., & Goniewicz, M. L. (2020). Effect of e-cigarette flavors on nicotine delivery and puffing topography: Results from a randomized clinical trial of daily smokers. Psychopharmacology (Berl), 237(2), 491-502. https://doi.org/10.1007/s00213-019-05386-x.

Wasfi, R. A., Bang, F., de Groh, M., Champagne, A., Han, A., Lang, J. J., McFaull, S. R., Melvin, A., Pipe, A. L., Saxena, S., Thompson, W., Warner, E., & Prince, S. A. (2022). Chronic health effects associated with electronic cigarette use: A systematic review. Frontiers in Public Health, 10, 959622. https://doi.org/10.3389/fpubh.2022.959622.

Wills, T. A., Soneji, S. S., Choi, K., Jaspers, I., & Tam, E. K. (2021). E-cigarette use and respiratory disorders: An integrative review of converging evidence from epidemiological and laboratory studies. European Respiratory Journal, 57(1), 1901815. https://doi.org/10.1183/13993003.01815-2019.

World Health Organization. (2011). WHO Report on the Global Tobacco Epidemic, 2011. http://www.who.int/tobacco/global_report/en/.

Yan, R., Chen, X L, Xu, Y M. et al. (2021). Efeitos epimutacionais do cigarro eletrônico. Environ Sci Pollut Res, 28(14), 17044–17067. https://doi.org/10.1007/s11356-021-12985-9.

Published

25/03/2024

How to Cite

ROTTA, A. E. de S. .; NASCIMENTO, R. H. do .; DAL PRÁ, P. . The effects of electronic cigarette use on users’ health: An integrative review. Research, Society and Development, [S. l.], v. 13, n. 3, p. e9913345359, 2024. DOI: 10.33448/rsd-v13i3.45359. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/45359. Acesso em: 13 nov. 2024.

Issue

Section

Health Sciences