Meningitis and procalcitonin: An integrative review
DOI:
https://doi.org/10.33448/rsd-v13i4.45418Keywords:
Procalcitonin; Meningitis; Diagnosis.Abstract
Meningitis are inflammatory processes of the meninges, connective structures that involve the central nervous system, and can be caused by bacterial, viral and other agents. Early diagnosis as well as its etiological distinction are essential to increase survival. Inflammatory markers such as procalcitonin, although questioned, may be useful in the early diagnosis of this disease. The aim of this study was to evaluate the effectiveness of measuring procalcitonin in biological samples for the diagnosis of acute meningitis. This is an integrative review and 17 original studies published in the last five years were included in this analysis. As a result, procalcitonin seems to have a good predictive value when measured in the CSF and its elevation has a high sensitivity for bacterial infection of the meninges. Its dosage is not available in all emergency care services, which is a limiting factor for its comparison.
References
Ahmed, M. A., Askar, G. A., Farghaly, H. S., et al. (2022). Accuracy of Cerebrospinal Fluid C-Reactive Protein and Multiplex Polymerase Chain Reaction and Serum Procalcitonin in Diagnosis of Bacterial and Viral Meningitis in Children. Acta Neurol Taiwan. 31(2), 61-71.
Aloisio, E., Dolci, A. & Panteghini, M. (2019). Procalcitonin: Between evidence and critical issues. Clin Chim Acta. 496, 7-12.
Alons, I. M., Verheul, R. J., Kuipers, I., et al. (2016). Procalcitonin in cerebrospinal fluid in meningitis: a prospective diagnostic study. Brain Behav. 6(11), e00545.
Babenko, D., Seidullayeva, A., Bayesheva, D., et al. (2021). Ability of Procalcitonin and C-Reactive Protein for Discriminating between Bacterial and Enteroviral Meningitis in Children Using Decision Tree. Biomed Res Int. 5519436.
Chaudhary, S., Bhatta, N. K., Lamsal, M., Chaudhari, R. K. & Khanal, B. (2018). Serum procalcitonin in bacterial & non-bacterial meningitis in children. BMC Pediatr. 18(1), 342.
Dasgupta, K. & Jeong, J. (2019). Developmental biology of the meninges. Genesis. 57(5), e23288.
Dutta, S., Sachdeva, N., Pal, A. & Ray, P. (2022). Cerebrospinal fluid and plasma procalcitonin for the diagnosis of neonatal bacterial meningitis. J Paediatr Child Health. 58(8), 1425-1430.
El Shorbagy, H. H., Barseem, N. F., Abdelghani, W. E., et al. (2018). The value of serum procalcitonin in acute meningitis in children. J Clin Neurosci. 56, 28-33.
Farouk, S., Hussein, T., Basstawy, M. & Abdel Moniem, N. (2019). Cerebrospinal lactate dehydrogenase and serum procalcitonin in the diagnosis of meningitis. Al Azhar Assiut Med J. 17(4), 344.
Julián-Jiménez, A. & Morales-Casado, M. I. (2019). Usefulness of blood and cerebrospinal fluid laboratory testing to predict bacterial meningitis in the emergency department. Utilidad de las determinaciones analíticas en sangre y líquido cefalorraquídeo para predecir meningitis bacterianas en el servicio de urgencias. Neurologia (Engl Ed).34 (2), 105-113.
Kim, H., Roh, Y. H. & Yoon, S. H. (2021). Blood Procalcitonin Level as a Diagnostic Marker of Pediatric Bacterial Meningitis: A Systematic Review and Meta-Analysis. Diagnostics (Basel). 11(5), 846.
Liu, D. B., Zhang, H. P., Yu, K., Lu, Q. B. & Zhu, Z. F. (2018). A study on correlations of procalcitonin and interleukin-6 with viral meningitis. Eur Rev Med Pharmacol Sci. 22(11), 3474-3478.
Moorthy, R. K., Job, V., Rebekah, G. & Rajshekhar, V. (2022). Cerebrospinal Fluid Procalcitonin-A Potential Biomarker for Post-Craniotomy Bacterial Meningitis. Neurol India. 70(2), 721-726.
Nagaraj, M., Bandiya, P., Jagannatha, B., Shivanna, N. & Benakappa, N. (2022). Bandyopadhyay T. Diagnostic Utility of Cerebrospinal Fluid Procalcitonin in Neonatal Meningitis. J Trop Pediatr. 68(3), 43.
Nijman, R. G., Moll, H. A., Smit, F. J., et al. (2014). C-reactive protein, procalcitonin and the lab-score for detecting serious bacterial infections in febrile children at the emergency department: a prospective observational study. Pediatr Infect Dis J. 33(11), e273-e279.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J. & Shitsuka, R. (2018). Metodologia da pesquisa científica. Santa Maria/RS: UFSM. http://repositorio.ufsm.br/handle/1/15824
Qu, X., Kang, Q., Zhao, H., et al. (2020). Levels and clinical significance of cerebrospinal fluid and serum procalcitonin of bacterial meningitis/ventriculitis in patients with aneurysmal subarachnoid hemorrhage after craniocerebral operation. Chin J Contemp Neurol Neurosurg. 20(8), 688-693.
Rajial, T., Batra, P., Harit, D. & Singh, N. P. (2022). Utility of Cerebrospinal Fluid and Serum Procalcitonin for the Diagnosis of Neonatal Meningitis. Am J Perinatol. 39(4), 373-378.
Reshi, Z., Nazir, M., Wani, W., Malik, M., Iqbal, J. & Wajid, S. (2017) Cerebrospinal fluid procalcitonin as a biomarker of bacterial meningitis in neonates. J Perinatol. 37(8), 927-931.
Romain, A. S., Guedj, R., Chosidow, A., et al. (2022). Procalcitonin at 12-36 hours of fever for prediction of invasive bacterial infections in hospitalized febrile neonates. Front Pediatr. 10:968207.
Santotoribio, J. D., Cuadros-Muñoz, J. F. & García-Casares, N. (2018). Comparison of C Reactive Protein and Procalcitonin Levels in Cerebrospinal Fluid and Serum to Differentiate Bacterial from Viral Meningitis. Ann Clin Lab Sci. 48(4), 506-510.
Shokrollahi, M. R., Shabanzadeh, K., Noorbakhsh, S., Tabatabaei, A., Movahedi, Z. & Shamshiri, A. R. (2018). Diagnostic value of CRP, procalcitonin, and ferritin levels in cerebrospinal fluid of children with meningitis. Central Nerv Syst Agents Med Chem. 18(1), 58-62.
Velissaris, D., Pintea, M. & Pantzaris, N., et al. (2018). The Role of Procalcitonin in the Diagnosis of Meningitis: A Literature Review. J Clin Med. 7(6), 148.
Viallon, A., Desseigne, N. & Marjollet, O., et al. (2011). Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis. Crit Care. 15(3), R136.
Waterfield, T., Maney, J. A. & Lyttle, M. D., et al. (2020). Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children. BMC Pediatr. 20(1), 487.
Zhang, G., Yang, C., Kang, X., Gao, Z., Wan, H. & Liu, Y. (2019). The combination of cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 concentrations for the diagnosis of postneurosurgical bacterial meningitis: A prospective study. Ann Clin Biochem. 56(1), 133-140.
Zhang, L., Ma, L. & Zhou, X., et al. (2019) Diagnostic Value of Procalcitonin for Bacterial Meningitis in Children: A Comparison Analysis Between Serum and Cerebrospinal Fluid Procalcitonin Levels. Clin Pediatr (Phila). 58(2), 159-165.
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